Local metabolism of glucocorticoids and its role in rat adjuvant arthritis

Molecular and Cellular Endocrinology

Volumn 323, Issue 2, 2010, Pages 155-160

  Ergang, Peter ^a   Leden, Pavel ^a,b   Vagnerová, Karla ^a   Klusoňová, Petra ^a   Mikšík, Ivan ^a   Jurčovičová, Jana ^b,c   Kment, Milan ^b   Pácha, Jiří ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

11 Hydroxysteroid dehydrogenase regulation; Arthritis; Lewis rats

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CARBENOXOLONE; CORTICOSTERONE; CYCLOOXYGENASE 2; CYTOKINE; ETANERCEPT; GLUCOCORTICOID; MESSENGER RNA; MIFEPRISTONE; OSTEOPONTIN; OXIDOREDUCTASE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RU 468; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 11BETA HYDROXYSTEROID DEHYDROGENASE; ANTIULCER AGENT; HORMONE ANTAGONIST; ISOENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEEDBACK SYSTEM; INFLAMMATION; LYMPH NODE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION; RNA EXTRACTION; STEROID METABOLISM; SYNOVIOCYTE; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; GENETICS; HUMAN; LEWIS RAT; METABOLISM; SYNOVIUM;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ANTI-ULCER AGENTS; ARTHRITIS, EXPERIMENTAL; CARBENOXOLONE; CELLS, CULTURED; CYTOKINES; GLUCOCORTICOIDS; HORMONE ANTAGONISTS; HUMANS; ISOENZYMES; MALE; MIFEPRISTONE; RATS; RATS, INBRED LEW; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 77952951067     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.03.003     Document Type: Article

References (45)

1. Boettger M.K., Hensellek S., Richter F., Gajda M., Stöckigt R., von Barchet G.S., Bräuer R., Schaible H.G. Antinociceptive effects of tumor necrosis factor α neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target. Arthritis Rheum. 2008, 58:2368-2378.
2. Brennan F.M., McInnes I.B. Evidence that cytokines play a role in rheumatoid arthritis. J. Clin. Invest. 2008, 118:3537-3545.
3. Calvino B., Maillet S., Pradelles P., Besson J.M., Couraud J.Y. Variation of substance P-like immunoreactivity in plasma and cerebrospinal fluid in the course of arthritis induced by Freund adjuvant in rats, a model for the study of chronic pain. C. R. Acad. Sci. III 1999, 312:427-432.
4. Chapman K.E., Coutinho A.E., Gray M., Gilmour J.S., Savill J.S., Seckl J.R. The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response. Mol. Cell. Endocrinol. 2009, 301:123-131.
5. Cooper M.S., Walker E.A., Bland R., Fraser W.D., Hewison M., Stewart P.M. Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone. Bone 2000, 27:375-381.
6. Cooper M.S., Bujalska I., Rabbitt E., Walker E.A., Bland R., Sheppard M.C., Hewison M., Stewart P.M. Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J. Bone Miner. Res. 2001, 16:1037-1044.
7. Coxon A., Bolon B., Estrada J., Kaufman S., Scully S., Rattan A., Duryea D., Hu Y.L., Rex K., Pacheco E., Van G., Zach D., Feige U. Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis. Arthritis Rheum. 2002, 46:2604-2612.
8. Davidson J.S., Baumgarten I.M. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J. Pharmacol. Exp. Ther. 1988, 246:1104-1107.
9. Draper N., Stewart P.M. 11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J. Endocrinol. 2005, 186:251-271.
10. Earp J.C., Dubois D.C., Molano D.S., Pyszczynski N.A., Keller C.E., Almon R.R., Jusko W.J. Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. J. Pharmacol. Exp. Ther. 2008, 326:532-545.
11. Ergang P., Leden P., Bryndová J., Žbánková Š., Mikšík I., Kment M., Pácha J. Glucocorticoid availability in colonic inflammation of rat. Dig. Dis. Sci. 2008, 53:2160-2167.
12. Escher G., Galli I., Vishwanath B.S., Frey B.M., Frey F.J. Tumor necrosis factor α and interleukin 1β enhance the cortisone/cortisol shuttle. J. Exp. Med. 1997, 186:189-198.
13. Firestein G.S., Zvaifler N.J. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 1987, 30:864-871.
14. Gilmour J.S., Coutinho A.E., Cailhier J.F., Man T.Y., Clay M., Thomas G., Harris H.J., Mullins J.J., Seckl J.R., Savill J.S., Chapman K.E. Local amplification of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. J. Immunol. 2006, 176:7605-7611.
15. Haas C.S., Creighton C.J., Pi X., Maine I., Koch A.E., Haines G.K., Ling S., Chinnaiyan A.M., Holoshitz J. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Arthritis Rheum. 2006, 54:2047-2060.
16. Hardy R.S., Filer A., Cooper M.S., Parsonage G., Raza K., Hardie D.L., Rabbitt E.H., Stewart P.M., Buckley C.D., Hewison M. Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation. Arthritis Res. Ther. 2006, 8:R108-R118.
17. Hardy R., Rabbitt E.H., Filer A., Emery P., Hewison M., Stewart P.M., Gittoes N.J., Buckley C.D., Raza K., Cooper M.S. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann. Rheum. Dis. 2008, 67:1204-1210.
18. Hennebold J.D., Ryu S.Y., Mu H.H., Galbraith A., Daynes R.A. 11β-Hydroxysteroid dehydrogenase modulation of glucocorticoid activities in lymphoid organs. Am. J. Physiol. 1996, 270:R1296-R1306.
19. Hu G.X., Lin H., Sottas C.M., Morris D.J., Hardy M.P., Ge R.S. Inhibition of 11β-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in Leydig cells. J. Androl. 2008, 29:345-351.
20. Inglis J.J., Nissim A., Lees D.M., Hunt S.P., Chernajovsky Y., Kidd B.L. The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation. Arthritis Res. Ther. 2005, 7:R807-R816.
21. Kamiyama K., Matsuda N., Yamamoto S., Takano K., Takano Y., Yamazaki H., Kageyama S., Yokoo H., Nagata T., Hatakeyama N., Tsukada K., Hattori Y. Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone. Am. J. Physiol. 2008, 295:L998-L1006.
22. Karalis K., Crofford L., Wilder R.L., Chrousos G.P. Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease-susceptible Lewis rats and inflammatory disease-resistant Fischer rats. Endocrinology 1995, 136:3107-3112.
23. Kirwan J.R. The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The arthritis and rheumatism council low-dose glucocorticoid study group. N. Engl. J. Med. 1995, 333:142-146.
24. Klusoňová P., Řeháková L., Borchert G., Vagnerová K., Neckář J., Ergang P., Mikšík I., Kolář F., Pácha J. Chronic intermittent hypoxia induces 11β-hydroxysteroid dehydrogenase in rat heart. Endocrinology 2009, 150:4270-4277.
25. Kruisbeek A.M. Isolation and Fractionation of Mononuclear Cell Population. Vol. 1: Current Protocols in Immunology 2000, John Wiley & Sons, Inc., New York, pp. 3.1.1-3.1.5.
26. Liu Y., Nakagawa Y., Wang Y., Liu L., Du H., Wang W., Ren X., Lutfy K., Friedman T.C. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J. Mol. Endocrinol. 2008, 41:53-64.
27. Makrygiannakis D., af Klint E., Catrina S.B., Botusan I.R., Klareskog E., Klareskog L., Ulfgren A.K., Catrina A.I. Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Arthritis Rheum. 2006, 54:1463-1472.
28. Matemba S.F., Lie A., Ransjö M. Regulation of osteoclastogenesis by gap junction communication. J. Cell. Biochem. 2006, 99:528-537.
29. McMullen S., Langley-Evans S.C. Sex-specific effects of prenatal low-protein and carbenoxolone exposure on renal angiotensin receptor expression in rats. Hypertension 2005, 46:1374-1380.
30. Miller S.C., Rapier S.H., Holtsclaw L.I., Turner B.B. Effects of psychological stress on joint inflammation and adrenal function during induction of arthritis in the Lewis rat. Neuroimmunomodulation 1995, 2:329-338.
31. Ošlejšková L., Grigorian M., Gay S., Neidhart M., Šenolt L. The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behaviour of rheumatoid arthritis synovial fibroblasts. Ann. Rheum. Dis. 2008, 67:1499-1504.
32. Pácha J., Mikšík I., Mrnka L., Zemanová Z., Bryndová J., Mazancová K., Kučka M. Corticosteroid regulation of colonic ion transport during postnatal development: methods for corticosteroid analysis. Physiol. Res. 2004, 53(Suppl. 1):S63-S80.
33. Sandeep T.C., Andrew R., Homer N.Z., Andrews R.C., Smith K., Walker B.R. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005, 54:872-879.
34. Schmidt M., Weidler C., Neumann H., Anders S., Schölmerich J., Straub R.H. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system?. Arthritis Rheum. 2005, 52:1711-1720.
35. Sternberg E.M., Hill J.M., Chrousos G.P., Kamilaris T., Listwak S.J., Gold P.W., Wilder R.L. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc. Natl. Acad. Sci. U.S.A. 1989, 86:2374-2378.
36. Tomlinson J.W., Moore J., Cooper M.S., Bujalska I., Shahmanesh M., Burt C., Strain A., Hewison M., Stewart P.M. Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 2001, 142:1982-1989.
37. Tomlinson J.W., Sherlock M., Hughes B., Hughes S.V., Kilvington F., Bartlett W., Courtney R., Rejto P., Carley W., Stewart P.M. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J. Clin. Endocrinol. Metab. 2007, 92:857-864.
38. Vagnerová K., Kverka M., Klusoňová P., Ergang P., Mikšík I., Tlaskalová-Hogenová H., Pácha J. Intestinal inflammation modulates expression of 11β-hydroxysteroid dehydrogenase in murine gut. J. Endocrinol. 2006, 191:497-1503.
39. Wang K.X., Denhardt D.T. Osteopontin: role in immune regulation and stress responses. Cytokine Growth Factor Rev. 2008, 19:333-345.
40. Watanabe S., Yamakami J., Tsuchiya M., Terajima T., Kizu J., Hori S. Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. J. Pharmacol. Sci. 2008, 106:566-570.
41. Webster J.I., Tonelli L., Sternberg E.M. Neuroendocrine regulation of immunity. Annu. Rev. Immunol. 2002, 20:125-163.
42. Whorwood C.B., Sheppard M.C., Stewart P.M. Licorice inhibits 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology 1993, 132:2287-2292.
43. Young M.J., Moussa L., Dilley R., Funder J.W. Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11β-hydroxysteroid dehydrogenase inactivation. Endocrinology 2003, 144:1121-1125.
44. Žbánková S., Bryndová J., Leden P., Kment M., Švec A., Pácha J. 11β-Hydroxysteroid dehydrogenase 1 and 2 expression in colon from patiens with ulcerative colitis. J. Gastroenterol. Hepatol. 2007, 22:1019-1123.
45. Zwerina J., Hayer S., Tohidast-Akrad M., Bergmeister H., Redlich K., Feige U., Dunstan C., Kollias G., Steiner G., Smolen J., Schett G. Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum. 2004, 50:277-290.