Lack of association of the 11β-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 1, 2007, Pages 359-362

  Smit, Pauline ^a   Dekker, Marieke J H J ^a   De Jong, Frank Jan ^a   Van Den Beld, Annewieke W ^a   Koper, Jan W ^a   Pols, Huibert A P ^a   Brinkmann, Albert O ^a   De Jong, Frank H ^a   Breteler, Monique M B ^a   Lamberts, Steven W J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; GALACTOSE 6 PHOSPHATE DEHYDROGENASE; GALACTOSE-6-PHOSPHATE DEHYDROGENASE; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DEMENTIA; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENOTYPE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SYSTOLIC BLOOD PRESSURE; WAIST HIP RATIO; ADRENAL GLAND; AGED; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADRENAL GLANDS; AGED; ANDROGENS; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; CARBOHYDRATE DEHYDROGENASES; CORTISONE REDUCTASE; DEMENTIA; GLUCOSE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; WAIST-HIP RATIO;

EID: 33846106489     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1349     Document Type: Article

References (15)

1. Stewart PM, Krozowski ZS 1999 11 β-Hydroxysteroid dehydrogenase. Vitam Horm 57:249-324
2. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH 1999 Cortisol metabolism in human obesity: impaired cortisone3cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84:1022-1027
3. Bujalska I, Shimojo M, Howie A, Stewart PM 1997 Human 11 β-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue. Steroids 62:77-82
4. Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A 2004 Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 571:129-133
5. Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM 2003 Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet 34:434-439
6. Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC, Stewart PM 2005 Hexose-6-phosphate dehydrogenase knockout mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem 281:6546-6551
7. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA 1991 Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol 7:403-422
8. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW 2000 Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
9. Mazess RB, Barden HS, Bisek JP, Hanson J 1990 Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 51:1106-1112
10. Gotfredsen A, Jensen J, Borg J, Christiansen C 1986 Measurement of lean body mass and total body fat using dual photon absorptiometry. Metabolism 35:88-93
11. Stolk RP, Pols HA, Lamberts SW, de Jong PT, Hofman A, Grobbee DE 1997 Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study. Am J Epidemiol 145:24-32
12. Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A 1998 Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 147:574-580
13. San Millan JL, Botella-Carretero JI, Alvarez-Blasco F, Luque-Ramirez M, Sancho J, Moghetti P, Escobar-Morreale HF 2005 A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome. J Clin Endocrinol Metab 90:4157-4162
14. White PC 2005 Genotypes at 11β-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample. J Clin Endocrinol Metab 90:5880-5883
15. Gambineri A, Vicennati V, Genghini S, Tomassoni F, Pagotto U, Pasquali R, Walker BR 2006 Genetic variation in 11β-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome. J Clin Endocrinol Metab 91:2295-2302