Can 11β-hydroxysteroid dehydrogenase activity predict the sensitivity of bone to therapeutic glucocorticoids in inflammatory bowel disease?

Calcified Tissue International

Volumn 89, Issue 3, 2011, Pages 246-251

  Cooper, Mark S ^a   Kriel, Hashir ^b   Sayers, Adrian ^b   Fraser, William D ^c   Williams, Amanda M ^b   Stewart, Paul M ^a   Probert, Chris S ^b   Tobias, Jonathan H ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bone turnover marker; DXA; Glucocorticoid; Osteoporosis; Steroid hormone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; AMINO TERMINAL TELOPEPTIDE; CARBOXY TERMINAL TELOPEPTIDE; CORTISONE; HYDROCORTISONE; PREDNISOLONE; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

ADULT; ARTICLE; BONE DENSITY; BONE TURNOVER; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; CORTICOSTEROID RELEASE; CROHN DISEASE; CROSS-SECTIONAL STUDY; ENTERITIS; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RELAPSE; REMISSION; ULCERATIVE COLITIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADULT; ANTI-INFLAMMATORY AGENTS; BONE AND BONES; BONE RESORPTION; DRUG RESISTANCE; DRUG TOXICITY; FEMALE; GLUCOCORTICOIDS; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 80052733581     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-011-9512-2     Document Type: Article

References (20)

1. TP van Staa HG Leufkens L Abenhaim B Zhang C Cooper 2000 Use of oral corticosteroids and risk of fractures J Bone Miner Res 15 993 1000 10841167 10.1359/jbmr.2000.15.6.993 (Pubitemid 30350061)
2. MS Cooper 2004 Sensitivity of bone to glucocorticoids Clin Sci (Lond) 107 111 123 10.1042/CS20040070 1:CAS:528:DC%2BD2cXlvFGqt7w%3D (Pubitemid 39070927)
3. MS Cooper EA Walker R Bland WD Fraser M Hewison PM Stewart 2000 Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone Bone 27 375 381 10962348 10.1016/S8756-3282(00)00344-6 1:CAS:528:DC%2BD3cXmtVGjsbs%3D (Pubitemid 30658120)
4. JW Tomlinson EA Walker IJ Bujalska N Draper GG Lavery MS Cooper M Hewison PM Stewart 2004 11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 25 831 866 15466942 10.1210/er.2003-0031 1:CAS:528:DC%2BD2cXhtVSjtrnJ (Pubitemid 39366049)
5. MS Cooper EH Rabbitt PE Goddard WA Bartlett M Hewison PM Stewart 2002 Osteoblastic 11β hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure J Bone Miner Res 17 979 986 12054173 10.1359/jbmr.2002.17.6.979 1:CAS:528:DC%2BD38Xks1WktLk%3D (Pubitemid 34535135)
6. MS Cooper A Blumsohn PE Goddard WA Bartlett CH Shackleton R Eastell M Hewison PM Stewart 2003 11β-Hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone J Clin Endocrinol Metab 88 3874 3877 12915682 10.1210/jc.2003-022025 1:CAS:528:DC%2BD3sXmsFOktbc%3D (Pubitemid 37034541)
7. KE Chapman AE Coutinho M Gray JS Gilmour JS Savill JR Seckl 2009 The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response Mol Cell Endocrinol 301 123 131 18973788 10.1016/j.mce.2008.09.031 1:CAS:528:DC%2BD1MXit1Ohu7k%3D
8. MH Kriel JH Tobias TJ Creed M Lockett J Linehan A Bell R Przemioslo JE Smithson TN Brooklyn WD Fraser CS Probert 2010 Use of risedronate to prevent bone loss following a single course of glucocorticoids: findings from a proof-of-concept study in inflammatory bowel disease Osteoporos Int 21 507 513 19484170 10.1007/s00198-009-0960-8 1:CAS:528:DC%2BC3cXhslehtro%3D
9. JH Tobias MR Sasi R Greenwood CS Probert 2004 Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy Aliment Pharmacol Ther 20 951 957 15521842 10.1111/j.1365-2036.2004.02207.x 1:STN:280:DC%2BD2crltVShsQ%3D%3D (Pubitemid 39593276)
10. R Hardy EH Rabbitt A Filer P Emery M Hewison PM Stewart NJs Gittoes CD Buckley K Raza MS Cooper 2008 Local and systemic glucocorticoid metabolism in inflammatory arthritis Ann Rheum Dis 67 1204 1210 18420938 10.1136/ard.2008. 090662 1:CAS:528:DC%2BD1cXhtFGhtL7I
11. J Bryndova S Zbankova M Kment J Pacha 2004 Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue Scand J Gastroenterol 39 549 553 15223679 10.1080/00365520410004659 1:CAS:528:DC%2BD2cXltFWlsLk%3D (Pubitemid 38916260)
12. JP Stegk B Ebert HJ Martin E Maser 2009 Expression profiles of human 11beta-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases Mol Cell Endocrinol 301 104 108 19022342 10.1016/j.mce.2008.10.030 1:CAS:528:DC%2BD1MXit1Ohu7o%3D
13. S Zbankova J Bryndova P Leden M Kment A Svec J Pacha 2007 11beta-Hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis J Gastroenterol Hepatol 22 1019 1023 17608848 10.1111/j.1440-1746.2006.04529.x 1:CAS:528:DC%2BD2sXpsFars7s%3D (Pubitemid 47019846)
14. M Palermo CH Shackleton F Mantero PM Stewart 1996 Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man Clin Endocrinol (Oxf) 45 605 611 10.1046/j.1365-2265.1996.00853.x 1:CAS:528:DyaK2sXjt1SgsA%3D%3D (Pubitemid 26411362)
15. MS Cooper I Bujalska E Rabbitt EA Walker R Bland MC Sheppard M Hewison PM Stewart 2001 Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation J Bone Miner Res 16 1037 1044 11393780 10.1359/jbmr.2001.16.6.1037 1:CAS:528:DC%2BD3MXkt1Oqsro%3D (Pubitemid 32467147)
16. JW Tomlinson J Moore MS Cooper I Bujalska M Shahmanesh C Burt A Strain M Hewison PM Stewart 2001 Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines Endocrinology 142 1982 1989 11316764 10.1210/en.142.5.1982 1:CAS:528: DC%2BD3MXjt1aktbc%3D (Pubitemid 32405956)
17. RS Hardy A Filer MS Cooper G Parsonage K Raza DL Hardie EH Rabbitt PM Stewart CD Buckley M Hewison 2006 Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation Arthritis Res Ther 8 R108 16846535 10.1186/ar1993
18. RH Straub D Vogl V Gross B Lang J Scholmerich T Andus 1998 Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease Am J Gastroenterol 93 2197 2202 9820396 10.1111/j.1572-0241.1998.00535.x 1:CAS:528:DyaK1cXnsFGnsLw%3D (Pubitemid 29076874)
19. MS Cooper PM Stewart 2009 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation J Clin Endocrinol Metab 94 4645 4654 19837912 10.1210/jc.2009-1412 1:CAS:528:DC%2BD1MXhsFyltLjE
20. FA Sylvester N Wyzga JS Hyams PM Davis T Lerer K Vance G Hawker AM Griffiths 2007 Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease Inflamm Bowel Dis 13 42 50 17206638 10.1002/ibd.20006 (Pubitemid 46080008)