Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016

Journal of Organic Chemistry

Volumn 76, Issue 17, 2011, Pages 7048-7055

  Wan, Zhao Kui ^a   Chenail, Eva ^a   Li, Huan Qiu ^a   Kendall, Christopher ^a   Wang, Youchu ^a   Gingras, Stéphane ^a   Xiang, Jason ^a   Massefski, Walter W ^a   Mansour, Tarek S ^a   Saiah, Eddine ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; CHIRAL TERTIARY ALCOHOLS; CLINICAL DATA; CLINICAL STUDY; DIHYDROXYLATION; GLUCOCORTICOID RECEPTOR; HYDROXYSTEROID DEHYDROGENASE; IN-VIVO; METABOLIC SYNDROMES; RESEARCH PROGRAMS; SCALABLE SYNTHESIS; SIGNALING PATHWAYS; THERAPEUTIC TARGETS; TRIFLUOROMETHYL; TYPE-2 DIABETES;

DEHYDROGENATION;

1,1,1 TRIFLUORO 2 [3 [4 [4 FLUORO 2 (TRIFLUOROMETHYL)PHENYL] 2 METHYLPIPERAZIN 1 YLSULFONYL]PHENYL]PROPAN 2 OL; EPOXIDE; HSD 016; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; DIHYDROXYLATION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; SHARPLESS EPOXIDATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADMINISTRATION, ORAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PIPERAZINES; PROPANOLS;

EID: 80052138643     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo200958a     Document Type: Article

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