Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11β-hydroxysteroid dehydrogenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 33, 2011, Pages 13722-13727

  Schmid, Janine ^a   Ludwig, Barbara ^a,b,c   Schally, Andrew V ^d,e   Steffen, Anja ^a   Ziegler, Christian G ^a   Block, Norman L ^d,e   Koutmani, Yassemi ^f   Brendel, Mathias D ^a,b   Karalis, Katia P ^f,g   Simeonovic, Charmaine J ^h   Licinio, Julio ^h   Ehrhart Bornstein, Monika ^a,c   Bornstein, Stefan R ^a,c  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h Biology and Environment   (Australia)

Author keywords

Islet proliferation; Metabolic syndrome; Regenerative therapy

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLUCOCORTICOID; GLUCOSE; INSULIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GLUCONEOGENESIS; HORMONE RELEASE; HYPOTHALAMUS; INSULIN RELEASE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; STRESS; UPREGULATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; PITUITARY HORMONE-RELEASING HORMONES; PITUITARY-ADRENAL SYSTEM; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE; RNA, MESSENGER;

RATTUS;

EID: 80052009174     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110965108     Document Type: Article

References (32)

1. Audhya T., Jain R., Hollander C.S. (1991) Receptor-mediated immunomodulation by corticotropin-releasing factor. Cell Immunol 134(1):77-84.
2. Clifton V.L., Owens P.C., Robinson P.J., Smith R. (1995) Identification and characterization of a corticotrophin-releasing hormone receptor in human placenta. Eur J Endocrinol 133:591-597.
3. Perrin M., et al. (1995) Identification of a second corticotropin- releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci USA 92:2969-2973.
4. Seres J., et al. (2004) Corticotropin-releasing hormone system in human adipose tissue. J Clin Endocrinol Metab 89:965-970. (Pubitemid 38269919)
5. Ludwig B., et al. (2010) Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc Natl Acad Sci USA 107:12623-12628.
6. Huising M.O., et al. (2010) CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci USA 107:912-917.
7. Huising M.O., et al. (2011) Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets. Endocrinology 152:138-150.
8. Kageyama K., et al. (2006) Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides 27:1814-1819. (Pubitemid 43866281)
9. Kanno T., Suga S., Nakano K., Kamimura N., Wakui M. (1999) Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells. Diabetes 48:1741-1746. (Pubitemid 29415192)
10. O'Carroll A.M., Howell G.M., Roberts E.M., Lolait S.J. (2008) Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells. J Endocrinol 197:231-239. (Pubitemid 351696236)
11. O'Keane V., et al. (2011) Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women: A pilot study. J Affect Disord 130:300-305.
12. Yi S.S., et al. (2010) Regulatory mechanism of hypothalamo-pituitary- adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes. J Chem Neuroanat 40(2):130-139.
13. Heller M.M., Lee E.S., Koo J.Y. (2011) Stress as an influencing factor in psoriasis. Skin Therapy Lett 16(5):1-4.
14. Brar B.K., Chen A., Perrin M.H., Vale W. (2004) Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Endocrinology 145:1718-1729. (Pubitemid 38402380)
15. Lenzen S., Bailey C.J. (1984) Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr Rev 5:411-434.
16. Surwit R.S., Schneider M.S., Feinglos M.N. (1992) Stress and diabetes mellitus. Diabetes Care 15:1413-1422.
17. Fischer B., et al. (1990) Immunohistochemical localization of the glucocorticoid receptor in pancreatic beta-cells of the rat. Endocrinology 126:2635-2641. (Pubitemid 20173057)
18. Stewart P.M., Krozowski Z.S. (1999) 11 beta-hydroxysteroid dehydrogenase. Vitam Horm 57:249-324.
19. Duplomb L., et al. (2004) Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. Biochem Biophys Res Commun 313:594-599. (Pubitemid 38021871)
20. Alberts P., et al. (2002) Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 45:1528-1532. (Pubitemid 35352046)
21. Hollis G., Huber R. (2011) 11β-Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus. Diabetes Obes Metab 13(1):1-6.
22. Lindsay R.S., Lindsay R.M., Waddell B.J., Seckl J.R. (1996) Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia 39:1299-1305. (Pubitemid 26356057)
23. Houssay B.A. (1949) Nobel Lecture. Available at http://nobelprize.org/ nobel-prizes/medicine/laureates/1947/houssay-lecture.html. Accessed July 27, 2011.
24. Petrusz P., Merchenthaler I., Maderdrut J.L., Vigh S., Schally A.V. (1983) Corticotropin-releasing factor (CRF)-like immunoreactivity in the vertebrate endocrine pancreas. Proc Natl Acad Sci USA 80:1721-1725. (Pubitemid 13136419)
25. Jeong K.H., Sakihara S., Widmaier E.P., Majzoub J.A. (2004) Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. Endocrinology 145:3174-3181. (Pubitemid 38829988)
26. Krause K., Schnitger A., Fimmel S., Glass E., Zouboulis C.C. (2007) Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands. Horm Metab Res 39(2):166-170. (Pubitemid 46535575)
27. Van Raalte D.H., et al. (2010) Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men. Eur J Endocrinol 162:729-735.
28. Morgan S.A., Tomlinson J.W. (2010) 11Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes. Expert Opin Investig Drugs 19:1067-1076.
29. Ge R., Huang Y., Liang G., Li X. (2010) 11Beta-hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: Status and development. Curr Med Chem 17:412-422.
30. Davani B., et al. (2000) Type 1 11beta-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem 275:34841-34844.
31. Hochberg Z., Friedberg M., Yaniv L., Bader T., Tiosano D. (2004) Hypothalamic regulation of adiposity: The role of 11beta-hydroxysteroid dehydrogenase type 1. Horm Metab Res 36:365-369. (Pubitemid 38932091)
32. Muglia L., Jacobson L., Dikkes P., Majzoub J.A. (1995) Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373:427-432.