Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5722-5732

  Ye, Yang liang ^a   Zhou, Zhou ^a   Zou, Han jun ^a   Shen, Yu ^a   Xu, Ti fei ^a   Tang, Jing ^a   Yin, Hua zhong ^b   Chen, Min li ^b   Leng, Ying ^a   Shen, Jian hua ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

11 HSD1 inhibitors; Molecular modeling; PPAR agonists; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR; 3 [4 [2 AMINO 6 (4 BENZOYLPIPERAZIN 1 YL)PYRIMIDIN 4 YLOXY]PHENYL] 2 METHYL 2 PHENOXYPROPIONIC ACID; 3 [4 [2 AMINO 6 (4 BENZYLPIPERAZIN 1 YL)PYRIMIDIN 4 YLOXY]PHENYL] 2 METHYL 2 PHENOXYPROPIONIC ACID; GLUTAMATE SODIUM; GLYCYRRHIZIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY FAT; CELL STRAIN 3T3; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; MAXIMUM PLASMA CONCENTRATION; MOLECULAR MODEL; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; TRIACYLGLYCEROL BLOOD LEVEL;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FATS; HUMANS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; MICE; MODELS, MOLECULAR; OBESITY; PHENYLPROPIONATES; PPAR GAMMA; RATS; RATS, WISTAR;

MUS; RATTUS;

EID: 67651094103     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.082     Document Type: Article

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