Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled Type 2 diabetic patients

Diabetic Medicine

Volumn 22, Issue 9, 2005, Pages 1146-1150

  Targher, Giovanni ^a,b   Bertolini, L ^a   Zoppini, G ^b   Zenari, L ^a   Falezza, G ^a  

^a SACRO CUORE DON CALABRIA HOSPITAL   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Cortisol secretion; Hepatic steatosis; Metabolic syndrome; Type 2 diabetes

Indexed keywords

DEXAMETHASONE; HEMOGLOBIN A1C; HYDROCORTISONE; INSULIN; TRIACYLGLYCEROL;

ADULT; AGE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC DIET; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN RESISTANCE; LOGISTIC REGRESSION ANALYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; PREDICTION; SCORING SYSTEM; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION;

BLOOD GLUCOSE; DEXAMETHASONE; DIABETES MELLITUS, TYPE 2; FATTY LIVER; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN RESISTANCE; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM;

EID: 24044436526     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01583.x     Document Type: Article

References (21)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
2. Medina J, Fernandez-Salazar LI, Garcia-Buey L, Moreno-Otero R. Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis. Diabetes Care 2004; 27: 2057-2066.
3. Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect 'Cushing's disease of the omentum'? Lancet 1997; 349: 1210-1213.
4. Stulnig TM, Waldhausl W. 11β-hydroxysteroid dehydrogenase type 1 in obesity and type 2 diabetes. Diabetologia 2004; 47: 1-11.
5. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 7: 2166-2170.
6. Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, Mullins JJ et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 2001; 276: 41293-41300.
7. Cigolini M, Targher G, Agostino G, Tonoli M, Muggeo M, De Sandre G. Liver steatosis and its relation to plasma haemostatic factors in apparently healthy males. Role of the metabolic syndrome. Thromb Haemost 1996; 76: 69-73.
8. Joseph AE, Saverymuttu SH, al-Sam S, Cook MG, Maxwell JD. Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol 1991; 43: 26-31.
9. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 2003; 88: 5593-5602.
10. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere BM et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63.
11. Westerbacka J, Yki-Jarvinen H, Vehkavaara S, Hakkinen AM, Andrew R, Wake DJ et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5β-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab 2003; 88: 4924-4931.
12. Saruc M, Yuceyar H, Ayhan S, Turkel N, Tuzcuoglu I, Can M. The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women. A hyperinsulinemic euglycemic insulin clamp study. Hepato-Gastroenterology 2003; 50: 771-774.
13. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21: 697-738.
14. Fasshauer M, Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia 2003; 46: 1594-1603.
15. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-2556.
16. Bjorntorp P, Rosmond R. Hypothalamic origin of the metabolic syndrome. Ann NY Acad Sci 1999; 18: 297-307.
17. Bjorntorp P. Neuroendocrine perturbations as a cause of insulin resistance. Diabetes Metab Res Rev 1999; 15: 427-441.
18. Rosmond R. The glucocorticoid receptor gene and its association to metabolic syndrome. Obes Res 2002; 10: 1078-1086.
19. Kawai S, Ichikawa Y, Homma M. Differences in metabolic properties among cortisol, prednisolone, and dexamethasone in liver and renal diseases: accelerated metabolism of dexamethasone in renal failure. J Clin Endocrinol Metab 1985; 60: 848-854.
20. Kutemeyer S, Schurmeyer TH, von zur Muhlen A. Effect of liver damage on the pharmacokinetics of dexamethasone. Eur J Endocrinol 1994; 131: 594-597.
21. Orbach O, Schussler GC. Increased serum cortisol binding in chronic active hepatitis. Am J Med 1989; 86: 39-42.