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Volumn 84, Issue 3, 1999, Pages 1022-1027

Cortisol metabolism in human obesity: Impaired cortisone → cortisol conversion in subjects with central adiposity

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOTROPIN; CORTISONE; CORTISONE ACETATE; DEXAMETHASONE; HYDROCORTISONE; INSULIN; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

EID: 0032990860     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.3.1022     Document Type: Article
Times cited : (406)

References (43)
  • 1
    • 0039379120 scopus 로고    scopus 로고
    • Obesity
    • Björntorp P. 1997 Obesity. Lancet. 350:423-426.
    • (1997) Lancet , vol.350 , pp. 423-426
    • Björntorp, P.1
  • 2
    • 0029972402 scopus 로고    scopus 로고
    • The regulation of adipose tissue distribution in humans
    • Björntorp P. 1996 The regulation of adipose tissue distribution in humans. Int J Obes. 20:291-302.
    • (1996) Int J Obes , vol.20 , pp. 291-302
    • Björntorp, P.1
  • 4
    • 0024489441 scopus 로고
    • Body fat distribution measured with CT: Correlation in healthy subjects, patients with anorexia nervosa, and patients with Cushing's syndrome
    • Mayo-Smith W, Hayes CW, Biller BMK, Klibanski A, Rosenthal H, Rosenthal DI. 1989 Body fat distribution measured with CT: correlation in healthy subjects, patients with anorexia nervosa, and patients with Cushing's syndrome. Radiology 170:515-518.
    • (1989) Radiology , vol.170 , pp. 515-518
    • Mayo-Smith, W.1    Hayes, C.W.2    Biller, B.M.K.3    Klibanski, A.4    Rosenthal, H.5    Rosenthal, D.I.6
  • 7
    • 0027503864 scopus 로고
    • Altered adrenocorticotropin and Cortisol secretion in abdominal obesity: Implications for the insulin resistance syndrome
    • Hautenen A, Adlercreutz H. 1993 Altered adrenocorticotropin and Cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J Intern Med. 234:461-469.
    • (1993) J Intern Med. , vol.234 , pp. 461-469
    • Hautenen, A.1    Adlercreutz, H.2
  • 8
    • 0030144120 scopus 로고    scopus 로고
    • Inhibition of Cortisol secretion by dexamethasone in relation to body fat distribution: A dose-response study
    • Ljung T, Amdersson B, Bengtsson B-A, Björntorp P. 1996 Inhibition of Cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res. 4:277-282.
    • (1996) Obes Res. , vol.4 , pp. 277-282
    • Ljung, T.1    Amdersson, B.2    Bengtsson, B.-A.3    Björntorp, P.4
  • 9
    • 0026685047 scopus 로고
    • Cortisol secretion in relation to body fat distribution in obese pre-menopausal women
    • Marin P, Darin N, Amemiya T, Anderson B, Jern S, Björntorp P. 1992 Cortisol secretion in relation to body fat distribution in obese pre-menopausal women. Metabolism. 41:882-886.
    • (1992) Metabolism , vol.41 , pp. 882-886
    • Marin, P.1    Darin, N.2    Amemiya, T.3    Anderson, B.4    Jern, S.5    Björntorp, P.6
  • 10
    • 0000934190 scopus 로고
    • Study of adrenocortical function in obesity
    • Migeon CJ, Green OC, Eckert JP. 1963 Study of adrenocortical function in obesity. Metabolism. 12:718-739.
    • (1963) Metabolism , vol.12 , pp. 718-739
    • Migeon, C.J.1    Green, O.C.2    Eckert, J.P.3
  • 11
    • 0027185253 scopus 로고
    • The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution
    • Pasquali R, Cantobelli S, Casimirri F, et al. 1993 The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab. 77:341-346.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 341-346
    • Pasquali, R.1    Cantobelli, S.2    Casimirri, F.3
  • 12
    • 0027249267 scopus 로고
    • Is hypothalamic-pituitary-adrenal hyperactivity important in the pathogenesis of excessive abdominal fat distribution?
    • Streeteen DHP. 1993 Is hypothalamic-pituitary-adrenal hyperactivity important in the pathogenesis of excessive abdominal fat distribution? J Clin Endocrinol Metab. 77:339-340.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 339-340
    • Streeteen, D.H.P.1
  • 13
    • 0029893578 scopus 로고    scopus 로고
    • 11β-hydoxysteroid dehydrogenase: Implications for clinical medicine
    • Stewart PM. 1996 11β-Hydoxysteroid dehydrogenase: implications for clinical medicine. Clin Endocrinol (Oxf). 44:493-499.
    • (1996) Clin Endocrinol (Oxf). , vol.44 , pp. 493-499
    • Stewart, P.M.1
  • 14
  • 15
    • 0026095840 scopus 로고
    • The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
    • Tannin GM, Agarwal AK, Monder C, New MI, White PC. 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem. 266:16653-16658.
    • (1991) J Biol Chem. , vol.266 , pp. 16653-16658
    • Tannin, G.M.1    Agarwal, A.K.2    Monder, C.3    New, M.I.4    White, P.C.5
  • 16
    • 0031046241 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess
    • White PC, Mune T, Agarwal AK. 1997 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev. 18:135-156.
    • (1997) Endocr Rev. , vol.18 , pp. 135-156
    • White, P.C.1    Mune, T.2    Agarwal, A.K.3
  • 17
    • 0023760499 scopus 로고
    • Syndrome of apparent mineralocorticoid excess: A defect in the cortisol-cortisone shuttle
    • Stewart PM, Corrie JET, Shackleton CHL, Edwards CRW. 1988 Syndrome of apparent mineralocorticoid excess: a defect in the cortisol-cortisone shuttle. J Clin Invest. 82:340-349.
    • (1988) J Clin Invest. , vol.82 , pp. 340-349
    • Stewart, P.M.1    Corrie, J.E.T.2    Shackleton, C.H.L.3    Edwards, C.R.W.4
  • 18
    • 0031965002 scopus 로고    scopus 로고
    • Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
    • Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC, Stewart PM. 1998 Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J Endocrinol. 156:159-168.
    • (1998) J Endocrinol. , vol.156 , pp. 159-168
    • Ricketts, M.L.1    Shoesmith, K.J.2    Hewison, M.3    Strain, A.4    Eggo, M.C.5    Stewart, P.M.6
  • 20
    • 0030964319 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: Effect on aromatase activity
    • Yang K, Khalil MW, Strutt BJ, Killinger DW. 1997 11β-Hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: effect on aromatase activity. J Steroid Biochem Mol Biol. 60:247-253.
    • (1997) J Steroid Biochem Mol Biol. , vol.60 , pp. 247-253
    • Yang, K.1    Khalil, M.W.2    Strutt, B.J.3    Killinger, D.W.4
  • 21
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Gushing's disease of the omentum?"
    • Bujalska IJ, Kumar S, Stewart PM. 1997 Does central obesity reflect "Gushing's disease of the omentum?" Lancet. 349:1210-1213.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 22
    • 0027414682 scopus 로고
    • Mass spectrometry in the diagnosis of steroid-related disorders and hypertension research
    • Shackleton CHL. 1993 Mass spectrometry in the diagnosis of steroid-related disorders and hypertension research. J Steroid Biochem Mol Biol. 45:127-140.
    • (1993) J Steroid Biochem Mol Biol. , vol.45 , pp. 127-140
    • Shackleton, C.H.L.1
  • 23
    • 0029847585 scopus 로고    scopus 로고
    • Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man
    • Palermo M, Shackleton CHL, Mantero F, Stewart PM. 1996 Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf). 45:605-611.
    • (1996) Clin Endocrinol (Oxf). , vol.45 , pp. 605-611
    • Palermo, M.1    Shackleton, C.H.L.2    Mantero, F.3    Stewart, P.M.4
  • 24
    • 0025176537 scopus 로고
    • Mineralocorticoid activity of carbenoxolone: Contrasting effects of carbenoxolone, and liquorice on 11β-hydroxysteroid dehydrogenase activity in man
    • Stewart PM, Wallace AM, Atherden SM, Shearing C, Edwards CRW. 1990 Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone, and liquorice on 11β-hydroxysteroid dehydrogenase activity in man. Clin Sci. 78:49-54.
    • (1990) Clin Sci. , vol.78 , pp. 49-54
    • Stewart, P.M.1    Wallace, A.M.2    Atherden, S.M.3    Shearing, C.4    Edwards, C.R.W.5
  • 25
    • 0031596094 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction
    • Shams M, Kilby MD, Somerset DA, et al. 1998 11β-Hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction. Hum Reprod. 13:799-804.
    • (1998) Hum Reprod. , vol.13 , pp. 799-804
    • Shams, M.1    Kilby, M.D.2    Somerset, D.A.3
  • 26
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985 Homeostasis model assessment: insulin resistance and β cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412-419.
    • (1985) Diabetologia. , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 27
    • 0026755484 scopus 로고
    • Sex-and menopause-associated changes in body fat distribution
    • Ley CJ, Lees B, Stevenson JC. 1992 Sex-and menopause-associated changes in body fat distribution. Am J Clin Nutr. 55:950-954.
    • (1992) Am J Clin Nutr. , vol.55 , pp. 950-954
    • Ley, C.J.1    Lees, B.2    Stevenson, J.C.3
  • 28
    • 0021966456 scopus 로고
    • A new defect in the peripheral conversion of cortisone to Cortisol
    • Phillipou G, Higgins BA. 1985 A new defect in the peripheral conversion of cortisone to Cortisol. J Steroid Biochem. 22:435-436.
    • (1985) J Steroid Biochem. , vol.22 , pp. 435-436
    • Phillipou, G.1    Higgins, B.A.2
  • 29
    • 0029797770 scopus 로고    scopus 로고
    • Apparent cortisone reductase deficiency: A unique form of hypercortisolism
    • Phillipov G, Palermo M, Shackleton CHL. 1996 Apparent cortisone reductase deficiency: a unique form of hypercortisolism. J Clin Endocrinol Metab. 81:3855-3860.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3855-3860
    • Phillipov, G.1    Palermo, M.2    Shackleton, C.H.L.3
  • 30
    • 0015968653 scopus 로고
    • Intercomparison of four methods for measuring Cortisol production
    • Zumoff B, Fukushima DK, Hellman L. 1974 Intercomparison of four methods for measuring Cortisol production. J Clin Endocrinol Metab. 38:169-175.
    • (1974) J Clin Endocrinol Metab , vol.38 , pp. 169-175
    • Zumoff, B.1    Fukushima, D.K.2    Hellman, L.3
  • 31
    • 0027958129 scopus 로고
    • Hyperandrogenism in polycystic ovary syndrome: Evidence of dysregulation of 11β-hydroxysteroid dehydrogenase
    • Rodin A, Thakkar H, Taylor N, Clayton R. 1994 Hyperandrogenism in polycystic ovary syndrome: evidence of dysregulation of 11β-hydroxysteroid dehydrogenase. N Engl J Med. 330:460-465.
    • (1994) N Engl J Med. , vol.330 , pp. 460-465
    • Rodin, A.1    Thakkar, H.2    Taylor, N.3    Clayton, R.4
  • 32
    • 0031869516 scopus 로고    scopus 로고
    • Sexual dimorphism in 11β-hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; A study in hypopituitary subjects
    • Weaver JU, Taylor N, Monson JP, Wood PJ, Kelly WF. 1998 Sexual dimorphism in 11β-hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects. Clin Endocrinol (Oxf). 49:13-20.
    • (1998) Clin Endocrinol (Oxf). , vol.49 , pp. 13-20
    • Weaver, J.U.1    Taylor, N.2    Monson, J.P.3    Wood, P.J.4    Kelly, W.F.5
  • 33
    • 0031784958 scopus 로고    scopus 로고
    • Obesity and gender influence Cortisol secretion and metabolism in man
    • Andrew R, Phillip DIW, Walker BR. 1998 Obesity and gender influence Cortisol secretion and metabolism in man. J Clin Endocrinol Metab. 83:1806-1809.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1806-1809
    • Andrew, R.1    Phillip, D.I.W.2    Walker, B.R.3
  • 34
    • 0020561197 scopus 로고
    • Influence of thyroid function on the in vivo cortisol-cortisone equilibrium in man
    • Zumoff B, Bradlow HL, Levin J, Fukushima DK. 1983 Influence of thyroid function on the in vivo cortisol-cortisone equilibrium in man. J Steroid Biochem. 18:437-440.
    • (1983) J Steroid Biochem. , vol.18 , pp. 437-440
    • Zumoff, B.1    Bradlow, H.L.2    Levin, J.3    Fukushima, D.K.4
  • 35
    • 0027515493 scopus 로고
    • Tissue-specific effects of thyroid hormone on 11β-hydroxysteroid dehydrogenase expression in the rat
    • Whorwood CB, Sheppard MC, Stewart PM. 1993 Tissue-specific effects of thyroid hormone on 11β-hydroxysteroid dehydrogenase expression in the rat. J Steroid Biochem Mol Biol. 46:539-547.
    • (1993) J Steroid Biochem Mol Biol. , vol.46 , pp. 539-547
    • Whorwood, C.B.1    Sheppard, M.C.2    Stewart, P.M.3
  • 36
    • 0026051922 scopus 로고
    • Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: Enzymatic modulation of glucocorticoid action
    • Hammami MM, Siiteri PK. 1991 Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. J Clin Endocrinol Metab. 73:326-334.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 326-334
    • Hammami, M.M.1    Siiteri, P.K.2
  • 37
    • 0028973283 scopus 로고
    • 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physicochemical and hormonal manipulations
    • Jamieson P, Chapman KE, Edwards CRW, Seckl JR. 1995 11β-Hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology. 136:4754-4761.
    • (1995) Endocrinology , vol.136 , pp. 4754-4761
    • Jamieson, P.1    Chapman, K.E.2    Edwards, C.R.W.3    Seckl, J.R.4
  • 38
    • 0031283178 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity and stress
    • Kotelevtsev Y, Holmes MC, Burchell A, et al. 1997 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity and stress. Proc Natl Acad Sci USA. 94:14924-14929.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14924-14929
    • Kotelevtsev, Y.1    Holmes, M.C.2    Burchell, A.3
  • 39
    • 0027300128 scopus 로고
    • Direct inhibition of ovarian steroidogenesis by Cortisol and the modulatory role of 11β-hydroxysteroid dehydrogenase
    • Michael AE, Pester LA, Curtis P, Shaw RW, Edwards CRW, Cooke BA. 1993 Direct inhibition of ovarian steroidogenesis by Cortisol and the modulatory role of 11β-hydroxysteroid dehydrogenase. Clin Endocrinol (Oxf). 38:641-644.
    • (1993) Clin Endocrinol (Oxf). , vol.38 , pp. 641-644
    • Michael, A.E.1    Pester, L.A.2    Curtis, P.3    Shaw, R.W.4    Edwards, C.R.W.5    Cooke, B.A.6
  • 40
    • 0028176908 scopus 로고
    • 11β-hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells
    • Monder C, Miroff Y, Marandici A, Hardy M. 1994 11β-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology. 134:1199-1204.
    • (1994) Endocrinology , vol.134 , pp. 1199-1204
    • Monder, C.1    Miroff, Y.2    Marandici, A.3    Hardy, M.4
  • 41
    • 0027175394 scopus 로고
    • Licorice inhibits 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action
    • Whorwood CB, Sheppard MC, Stewart PM. 1993 Licorice inhibits 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 132:2287-2292.
    • (1993) Endocrinology , vol.132 , pp. 2287-2292
    • Whorwood, C.B.1    Sheppard, M.C.2    Stewart, P.M.3
  • 42
    • 0029670812 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity
    • Rajan V, Edwards CRW, Seckl JR. 1996 11β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci. 16:65-70.
    • (1996) J Neurosci. , vol.16 , pp. 65-70
    • Rajan, V.1    Edwards, C.R.W.2    Seckl, J.R.3
  • 43
    • 0028839840 scopus 로고
    • Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
    • Walker BR, Connacher AA, Lindsay M, Webb DJ, Edwards CRW. 1995 Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab. 80:3155-3159.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3155-3159
    • Walker, B.R.1    Connacher, A.A.2    Lindsay, M.3    Webb, D.J.4    Edwards, C.R.W.5


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