메뉴 건너뛰기




Volumn 122, Issue 1-3, 2010, Pages 21-27

Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

Author keywords

11 Hydroxysteroid dehydrogenase; Diabetes; Glucocorticoids; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 3 CHLORO 2 METHYL N [4 [2 (4 METHYL 1 PIPERAZINYL) 2 OXOETHYL] 2 THIAZOLYL]BENZENESULFONAMIDE; CORTISONE; ENZYME INHIBITOR; GLUCOCORTICOID; HYDROCORTISONE; INCB 013739; PF 91575; UNCLASSIFIED DRUG; CARBENOXOLONE;

EID: 77956489883     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.060     Document Type: Review
Times cited : (73)

References (98)
  • 1
    • 0036936562 scopus 로고    scopus 로고
    • Short- and long-term mortality in a prevalent cohort of morbidly obese patients in Italy
    • Brunani A., Palli D., Salvini S., Masala G., Vallone L., Barantani E., et al. Short- and long-term mortality in a prevalent cohort of morbidly obese patients in Italy. Eur. J. Nutr. 2002, 41(4):183-185.
    • (2002) Eur. J. Nutr. , vol.41 , Issue.4 , pp. 183-185
    • Brunani, A.1    Palli, D.2    Salvini, S.3    Masala, G.4    Vallone, L.5    Barantani, E.6
  • 2
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn S.E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003, 46(1):3-19.
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 3
    • 37849002520 scopus 로고    scopus 로고
    • Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus
    • De Ferranti S.D., Osganian S.K. Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus. Diab. Vasc. Dis. Res. 2007, 4(4):285-296.
    • (2007) Diab. Vasc. Dis. Res. , vol.4 , Issue.4 , pp. 285-296
    • De Ferranti, S.D.1    Osganian, S.K.2
  • 4
    • 0030342776 scopus 로고    scopus 로고
    • Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM
    • Friedman T.C., Mastorakos G., Newman T.D., Mullen N.M., Horton E.G., Costello R., et al. Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocr. J. 1996, 43(6):645-655.
    • (1996) Endocr. J. , vol.43 , Issue.6 , pp. 645-655
    • Friedman, T.C.1    Mastorakos, G.2    Newman, T.D.3    Mullen, N.M.4    Horton, E.G.5    Costello, R.6
  • 5
    • 0037135596 scopus 로고    scopus 로고
    • Deciphering the phosphorylation " code" of the glucocorticoid receptor in vivo
    • Wang Z., Frederick J., Garabedian M.J. Deciphering the phosphorylation " code" of the glucocorticoid receptor in vivo. J. Biol. Chem. 2002, 277(29):26573-26580.
    • (2002) J. Biol. Chem. , vol.277 , Issue.29 , pp. 26573-26580
    • Wang, Z.1    Frederick, J.2    Garabedian, M.J.3
  • 6
    • 0027377597 scopus 로고
    • Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor
    • Mason S.A., Housley P.R. Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor. J. Biol. Chem. 1993, 268(29):21501-21504.
    • (1993) J. Biol. Chem. , vol.268 , Issue.29 , pp. 21501-21504
    • Mason, S.A.1    Housley, P.R.2
  • 7
    • 0036721526 scopus 로고    scopus 로고
    • Potentiation of glucocorticoid receptor transcriptional activity by sumoylation
    • Le Drean Y., Mincheneau N., Le Goff P., Michel D. Potentiation of glucocorticoid receptor transcriptional activity by sumoylation. Endocrinology 2002, 143(9):3482-3489.
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3482-3489
    • Le Drean, Y.1    Mincheneau, N.2    Le Goff, P.3    Michel, D.4
  • 8
    • 26644473193 scopus 로고    scopus 로고
    • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone
    • Murphy P.J., Morishima Y., Kovacs J.J., Yao T.P., Pratt W.B. Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J. Biol. Chem. 2005, 280(40):33792-33799.
    • (2005) J. Biol. Chem. , vol.280 , Issue.40 , pp. 33792-33799
    • Murphy, P.J.1    Morishima, Y.2    Kovacs, J.J.3    Yao, T.P.4    Pratt, W.B.5
  • 9
    • 1342294313 scopus 로고    scopus 로고
    • The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein:hsp90 complex
    • Morishima Y., Kanelakis K.C., Murphy P.J., Lowe E.R., Jenkins G.J., Osawa Y., et al. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein:hsp90 complex. J. Biol. Chem. 2003, 278(49):48754-48763.
    • (2003) J. Biol. Chem. , vol.278 , Issue.49 , pp. 48754-48763
    • Morishima, Y.1    Kanelakis, K.C.2    Murphy, P.J.3    Lowe, E.R.4    Jenkins, G.J.5    Osawa, Y.6
  • 10
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt W.B., Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 1997, 18(3):306-360.
    • (1997) Endocr. Rev. , vol.18 , Issue.3 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 11
    • 0038362418 scopus 로고    scopus 로고
    • Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis
    • Medh R.D., Webb M.S., Miller A.L., Johnson B.H., Fofanov Y., Li T., et al. Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics 2003, 81(6):543-555.
    • (2003) Genomics , vol.81 , Issue.6 , pp. 543-555
    • Medh, R.D.1    Webb, M.S.2    Miller, A.L.3    Johnson, B.H.4    Fofanov, Y.5    Li, T.6
  • 12
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases
    • Barnes P.J., Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 1997, 336(15):1066-1071.
    • (1997) N. Engl. J. Med. , vol.336 , Issue.15 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 13
    • 0036108564 scopus 로고    scopus 로고
    • Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
    • Hafezi-Moghadam A., Simoncini T., Yang Z., Limbourg F.P., Plumier J.C., Rebsamen M.C., et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat. Med. 2002, 8(5):473-479.
    • (2002) Nat. Med. , vol.8 , Issue.5 , pp. 473-479
    • Hafezi-Moghadam, A.1    Simoncini, T.2    Yang, Z.3    Limbourg, F.P.4    Plumier, J.C.5    Rebsamen, M.C.6
  • 14
    • 0020565483 scopus 로고
    • Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing's syndrome
    • Taskinen M.R., Nikkila E.A., Pelkonen R., Sane T. Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing's syndrome. J. Clin. Endocrinol. Metab. 1983, 57(3):619-626.
    • (1983) J. Clin. Endocrinol. Metab. , vol.57 , Issue.3 , pp. 619-626
    • Taskinen, M.R.1    Nikkila, E.A.2    Pelkonen, R.3    Sane, T.4
  • 15
    • 1642545652 scopus 로고    scopus 로고
    • Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    • Dolinsky V.W., Douglas D.N., Lehner R., Vance D.E. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem. J. 2004, 378(Pt 3):967-974.
    • (2004) Biochem. J. , vol.378 , Issue.PART 3 , pp. 967-974
    • Dolinsky, V.W.1    Douglas, D.N.2    Lehner, R.3    Vance, D.E.4
  • 16
    • 70350540686 scopus 로고    scopus 로고
    • 11{beta}-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
    • Morgan S.A., Sherlock M., Gathercole L.L., Lavery G.G., Lenaghan C., Bujalska I.J., et al. 11{beta}-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. Diabetes 2009.
    • (2009) Diabetes
    • Morgan, S.A.1    Sherlock, M.2    Gathercole, L.L.3    Lavery, G.G.4    Lenaghan, C.5    Bujalska, I.J.6
  • 17
    • 0023202848 scopus 로고
    • Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner
    • Nechushtan H., Benvenisty N., Brandeis R., Reshef L. Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner. Nucleic Acids Res. 1987, 15(16):6405-6417.
    • (1987) Nucleic Acids Res. , vol.15 , Issue.16 , pp. 6405-6417
    • Nechushtan, H.1    Benvenisty, N.2    Brandeis, R.3    Reshef, L.4
  • 18
    • 34447121352 scopus 로고    scopus 로고
    • Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids
    • Adams C.M. Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J. Biol. Chem. 2007, 282(23):16744-16753.
    • (2007) J. Biol. Chem. , vol.282 , Issue.23 , pp. 16744-16753
    • Adams, C.M.1
  • 19
    • 0026055103 scopus 로고
    • Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors
    • Gregoire F., Genart C., Hauser N., Remacle C. Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors. Exp. Cell Res. 1991, 196(2):270-278.
    • (1991) Exp. Cell Res. , vol.196 , Issue.2 , pp. 270-278
    • Gregoire, F.1    Genart, C.2    Hauser, N.3    Remacle, C.4
  • 20
    • 0023109747 scopus 로고
    • Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells
    • Hauner H., Schmid P., Pfeiffer E.F. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells. J. Clin. Endocrinol. Metab. 1987, 64(4):832-835.
    • (1987) J. Clin. Endocrinol. Metab. , vol.64 , Issue.4 , pp. 832-835
    • Hauner, H.1    Schmid, P.2    Pfeiffer, E.F.3
  • 21
    • 0036875503 scopus 로고    scopus 로고
    • Human adipose tissue under in vitro inhibition of 11beta-hydroxysteroid dehydrogenase type 1: differentiation and metabolism changes
    • Bader T., Zoumakis E., Friedberg M., Hiroi N., Chrousos G.P., Hochberg Z. Human adipose tissue under in vitro inhibition of 11beta-hydroxysteroid dehydrogenase type 1: differentiation and metabolism changes. Horm. Metab. Res. 2002, 34(11-12):752-757.
    • (2002) Horm. Metab. Res. , vol.34 , Issue.11-12 , pp. 752-757
    • Bader, T.1    Zoumakis, E.2    Friedberg, M.3    Hiroi, N.4    Chrousos, G.P.5    Hochberg, Z.6
  • 22
    • 0036204548 scopus 로고    scopus 로고
    • Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
    • Buren J., Liu H.X., Jensen J., Eriksson J.W. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur. J. Endocrinol. 2002, 146(3):419-429.
    • (2002) Eur. J. Endocrinol. , vol.146 , Issue.3 , pp. 419-429
    • Buren, J.1    Liu, H.X.2    Jensen, J.3    Eriksson, J.W.4
  • 23
    • 2942675015 scopus 로고    scopus 로고
    • Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes
    • Lundgren M., Buren J., Ruge T., Myrnas T., Eriksson J.W. Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J. Clin. Endocrinol. Metab. 2004, 89(6):2989-2997.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , Issue.6 , pp. 2989-2997
    • Lundgren, M.1    Buren, J.2    Ruge, T.3    Myrnas, T.4    Eriksson, J.W.5
  • 24
    • 0033820515 scopus 로고    scopus 로고
    • Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction
    • Sakoda H., Ogihara T., Anai M., Funaki M., Inukai K., Katagiri H., et al. Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes 2000, 49(10):1700-1708.
    • (2000) Diabetes , vol.49 , Issue.10 , pp. 1700-1708
    • Sakoda, H.1    Ogihara, T.2    Anai, M.3    Funaki, M.4    Inukai, K.5    Katagiri, H.6
  • 25
    • 0028024916 scopus 로고
    • Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes
    • Turnbow M.A., Keller S.R., Rice K.M., Garner C.W. Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes. J. Biol. Chem. 1994, 269(4):2516-2520.
    • (1994) J. Biol. Chem. , vol.269 , Issue.4 , pp. 2516-2520
    • Turnbow, M.A.1    Keller, S.R.2    Rice, K.M.3    Garner, C.W.4
  • 26
  • 27
    • 2442490613 scopus 로고    scopus 로고
    • The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue
    • Wang Y., Jones V.B., Urs S., Kim S., Soltani-Bejnood M., Quigley N., et al. The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. J. Nutr. 2004, 134(5):1032-1038.
    • (2004) J. Nutr. , vol.134 , Issue.5 , pp. 1032-1038
    • Wang, Y.1    Jones, V.B.2    Urs, S.3    Kim, S.4    Soltani-Bejnood, M.5    Quigley, N.6
  • 28
    • 0018854541 scopus 로고
    • Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids
    • Ashby P., Robinson D.S. Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids. Biochem. J. 1980, 188(1):185-192.
    • (1980) Biochem. J. , vol.188 , Issue.1 , pp. 185-192
    • Ashby, P.1    Robinson, D.S.2
  • 29
    • 0027482040 scopus 로고
    • Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men
    • Fried S.K., Russell C.D., Grauso N.L., Brolin R.E. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J. Clin. Invest. 1993, 92(5):2191-2198.
    • (1993) J. Clin. Invest. , vol.92 , Issue.5 , pp. 2191-2198
    • Fried, S.K.1    Russell, C.D.2    Grauso, N.L.3    Brolin, R.E.4
  • 31
    • 0028037616 scopus 로고
    • Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes
    • Slavin B.G., Ong J.M., Kern P.A. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J. Lipid Res. 1994, 35(9):1535-1541.
    • (1994) J. Lipid Res. , vol.35 , Issue.9 , pp. 1535-1541
    • Slavin, B.G.1    Ong, J.M.2    Kern, P.A.3
  • 32
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena J.A., Roy S., Sarkadi-Nagy E., Kim K.H., Sul H.S. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 2004, 279(45):47066-47075.
    • (2004) J. Biol. Chem. , vol.279 , Issue.45 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3    Kim, K.H.4    Sul, H.S.5
  • 33
    • 0038305987 scopus 로고    scopus 로고
    • Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activation
    • Olswang Y., Blum B., Cassuto H., Cohen H., Biberman Y., Hanson R.W., et al. Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activation. J. Biol. Chem. 2003, 278(15):12929-12936.
    • (2003) J. Biol. Chem. , vol.278 , Issue.15 , pp. 12929-12936
    • Olswang, Y.1    Blum, B.2    Cassuto, H.3    Cohen, H.4    Biberman, Y.5    Hanson, R.W.6
  • 34
    • 0030777777 scopus 로고    scopus 로고
    • Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids
    • Delaunay F., Khan A., Cintra A., Davani B., Ling Z.C., Andersson A., et al. Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. J. Clin. Invest. 1997, 100(8):2094-2098.
    • (1997) J. Clin. Invest. , vol.100 , Issue.8 , pp. 2094-2098
    • Delaunay, F.1    Khan, A.2    Cintra, A.3    Davani, B.4    Ling, Z.C.5    Andersson, A.6
  • 35
    • 0027430929 scopus 로고
    • GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats
    • Ohneda M., Johnson J.H., Inman L.R., Unger R.H. GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats. J. Clin. Invest. 1993, 92(4):1950-1956.
    • (1993) J. Clin. Invest. , vol.92 , Issue.4 , pp. 1950-1956
    • Ohneda, M.1    Johnson, J.H.2    Inman, L.R.3    Unger, R.H.4
  • 36
    • 0030866606 scopus 로고    scopus 로고
    • Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets
    • Lambillotte C., Gilon P., Henquin J.C. Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J. Clin. Invest. 1997, 99(3):414-423.
    • (1997) J. Clin. Invest. , vol.99 , Issue.3 , pp. 414-423
    • Lambillotte, C.1    Gilon, P.2    Henquin, J.C.3
  • 37
    • 0026466915 scopus 로고
    • The morphology and metabolism of intraabdominal adipose tissue in men
    • Marin P., Andersson B., Ottosson M., Olbe L., Chowdhury B., Kvist H., et al. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 1992, 41(11):1242-1248.
    • (1992) Metabolism , vol.41 , Issue.11 , pp. 1242-1248
    • Marin, P.1    Andersson, B.2    Ottosson, M.3    Olbe, L.4    Chowdhury, B.5    Kvist, H.6
  • 38
    • 0033018598 scopus 로고    scopus 로고
    • Cortisol effects on body mass, blood pressure, and cholesterol in the general population
    • Fraser R., Ingram M.C., Anderson N.H., Morrison C., Davies E., Connell J.M. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 1999, 33(6):1364-1368.
    • (1999) Hypertension , vol.33 , Issue.6 , pp. 1364-1368
    • Fraser, R.1    Ingram, M.C.2    Anderson, N.H.3    Morrison, C.4    Davies, E.5    Connell, J.M.6
  • 40
    • 0031800688 scopus 로고    scopus 로고
    • Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution
    • Pasquali R., Biscotti D., Spinucci G., Vicennati V., Genazzani A.D., Sgarbi L., et al. Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution. Clin. Endocrinol. (Oxf.) 1998, 48(5):603-612.
    • (1998) Clin. Endocrinol. (Oxf.) , vol.48 , Issue.5 , pp. 603-612
    • Pasquali, R.1    Biscotti, D.2    Spinucci, G.3    Vicennati, V.4    Genazzani, A.D.5    Sgarbi, L.6
  • 41
    • 0030144120 scopus 로고    scopus 로고
    • Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study
    • Ljung T., Andersson B., Bengtsson B.A., Bjorntorp P., Marin P. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes. Res. 1996, 4(3):277-282.
    • (1996) Obes. Res. , vol.4 , Issue.3 , pp. 277-282
    • Ljung, T.1    Andersson, B.2    Bengtsson, B.A.3    Bjorntorp, P.4    Marin, P.5
  • 42
    • 0026685047 scopus 로고
    • Cortisol secretion in relation to body fat distribution in obese premenopausal women
    • Marin P., Darin N., Amemiya T., Andersson B., Jern S., Bjorntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992, 41(8):882-886.
    • (1992) Metabolism , vol.41 , Issue.8 , pp. 882-886
    • Marin, P.1    Darin, N.2    Amemiya, T.3    Andersson, B.4    Jern, S.5    Bjorntorp, P.6
  • 43
    • 0029035143 scopus 로고
    • Detection of human 11beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts
    • Whorwood C.B., Mason J.I., Ricketts M.L., Howie A.J., Stewart P.M. Detection of human 11beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts. Mol. Cell. Endocrinol. 1995, 110(1-2):R7-R12.
    • (1995) Mol. Cell. Endocrinol. , vol.110 , Issue.1-2
    • Whorwood, C.B.1    Mason, J.I.2    Ricketts, M.L.3    Howie, A.J.4    Stewart, P.M.5
  • 44
    • 0028036675 scopus 로고
    • Epithelial cell localization of type 2 11beta-hydroxysteroid dehydrogenase in rat and human colon
    • Whorwood C.B., Ricketts M.L., Stewart P.M. Epithelial cell localization of type 2 11beta-hydroxysteroid dehydrogenase in rat and human colon. Endocrinology 1994, 135(6):2533-2541.
    • (1994) Endocrinology , vol.135 , Issue.6 , pp. 2533-2541
    • Whorwood, C.B.1    Ricketts, M.L.2    Stewart, P.M.3
  • 45
    • 0023221667 scopus 로고
    • Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
    • Arriza J.L., Weinberger C., Cerelli G., Glaser T.M., Handelin B.L., Housman D.E., et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987, 237(4812):268-275.
    • (1987) Science , vol.237 , Issue.4812 , pp. 268-275
    • Arriza, J.L.1    Weinberger, C.2    Cerelli, G.3    Glaser, T.M.4    Handelin, B.L.5    Housman, D.E.6
  • 46
    • 0023761690 scopus 로고
    • Localisation of 11beta-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
    • Edwards C.R., Stewart P.M., Burt D., Brett L., McIntyre M.A., Sutanto W.S., et al. Localisation of 11beta-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet 1988, 2(8618):986-989.
    • (1988) Lancet , vol.2 , Issue.8618 , pp. 986-989
    • Edwards, C.R.1    Stewart, P.M.2    Burt, D.3    Brett, L.4    McIntyre, M.A.5    Sutanto, W.S.6
  • 47
    • 0029847585 scopus 로고    scopus 로고
    • Urinary free cortisone and the assessment of 11beta-hydroxysteroid dehydrogenase activity in man
    • Palermo M., Shackleton C.H., Mantero F., Stewart P.M. Urinary free cortisone and the assessment of 11beta-hydroxysteroid dehydrogenase activity in man. Clin. Endocrinol. (Oxf.) 1996, 45(5):605-611.
    • (1996) Clin. Endocrinol. (Oxf.) , vol.45 , Issue.5 , pp. 605-611
    • Palermo, M.1    Shackleton, C.H.2    Mantero, F.3    Stewart, P.M.4
  • 48
    • 0030049329 scopus 로고    scopus 로고
    • Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11beta-hydroxysteroid dehydrogenase type 2 gene
    • Stewart P.M., Krozowski Z.S., Gupta A., Milford D.V., Howie A.J., Sheppard M.C., et al. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11beta-hydroxysteroid dehydrogenase type 2 gene. Lancet 1996, 347(8994):88-91.
    • (1996) Lancet , vol.347 , Issue.8994 , pp. 88-91
    • Stewart, P.M.1    Krozowski, Z.S.2    Gupta, A.3    Milford, D.V.4    Howie, A.J.5    Sheppard, M.C.6
  • 49
    • 0031965002 scopus 로고    scopus 로고
    • Regulation of 11beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
    • Ricketts M.L., Shoesmith K.J., Hewison M., Strain A., Eggo M.C., Stewart P.M. Regulation of 11beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J. Endocrinol. 1998, 156(1):159-168.
    • (1998) J. Endocrinol. , vol.156 , Issue.1 , pp. 159-168
    • Ricketts, M.L.1    Shoesmith, K.J.2    Hewison, M.3    Strain, A.4    Eggo, M.C.5    Stewart, P.M.6
  • 50
    • 0028973283 scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase is an exclusive 11beta-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations
    • Jamieson P.M., Chapman K.E., Edwards C.R., Seckl J.R. 11Beta-hydroxysteroid dehydrogenase is an exclusive 11beta-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology 1995, 136(11):4754-4761.
    • (1995) Endocrinology , vol.136 , Issue.11 , pp. 4754-4761
    • Jamieson, P.M.1    Chapman, K.E.2    Edwards, C.R.3    Seckl, J.R.4
  • 51
    • 0036959901 scopus 로고    scopus 로고
    • A switch in dehydrogenase to reductase activity of 11beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells
    • Bujalska I.J., Walker E.A., Hewison M., Stewart P.M. A switch in dehydrogenase to reductase activity of 11beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J. Clin. Endocrinol. Metab. 2002, 87(3):1205-1210.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.3 , pp. 1205-1210
    • Bujalska, I.J.1    Walker, E.A.2    Hewison, M.3    Stewart, P.M.4
  • 52
    • 0028169395 scopus 로고
    • Human kidney 11beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform
    • Stewart P.M., Murry B.A., Mason J.I. Human kidney 11beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J. Clin. Endocrinol. Metab. 1994, 79(2):480-484.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , Issue.2 , pp. 480-484
    • Stewart, P.M.1    Murry, B.A.2    Mason, J.I.3
  • 53
    • 0036932983 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol
    • Bujalska I.J., Walker E.A., Tomlinson J.W., Hewison M., Stewart P.M. 11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol. Endocr. Res. 2002, 28(4):449-461.
    • (2002) Endocr. Res. , vol.28 , Issue.4 , pp. 449-461
    • Bujalska, I.J.1    Walker, E.A.2    Tomlinson, J.W.3    Hewison, M.4    Stewart, P.M.5
  • 54
    • 0028945972 scopus 로고
    • Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase
    • Ozols J. Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase. J. Biol. Chem. 1995, 270(17):10360.
    • (1995) J. Biol. Chem. , vol.270 , Issue.17 , pp. 10360
    • Ozols, J.1
  • 55
    • 18844438379 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11beta-hydroxysteroid dehydrogenase type 1
    • Bujalska I.J., Draper N., Michailidou Z., Tomlinson J.W., White P.C., Chapman K.E., et al. Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11beta-hydroxysteroid dehydrogenase type 1. J. Mol. Endocrinol. 2005, 34(3):675-684.
    • (2005) J. Mol. Endocrinol. , vol.34 , Issue.3 , pp. 675-684
    • Bujalska, I.J.1    Draper, N.2    Michailidou, Z.3    Tomlinson, J.W.4    White, P.C.5    Chapman, K.E.6
  • 56
    • 42449121461 scopus 로고    scopus 로고
    • Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue
    • Bujalska I.J., Hewitt K.N., Hauton D., Lavery G.G., Tomlinson J.W., Walker E.A., et al. Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue. Endocrinology 2008, 149(5):2584-2591.
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2584-2591
    • Bujalska, I.J.1    Hewitt, K.N.2    Hauton, D.3    Lavery, G.G.4    Tomlinson, J.W.5    Walker, E.A.6
  • 57
    • 33646007919 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase knock-out mice lack 11beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
    • Lavery G.G., Walker E.A., Draper N., Jeyasuria P., Marcos J., Shackleton C.H., et al. Hexose-6-phosphate dehydrogenase knock-out mice lack 11beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J. Biol. Chem. 2006, 281(10):6546-6551.
    • (2006) J. Biol. Chem. , vol.281 , Issue.10 , pp. 6546-6551
    • Lavery, G.G.1    Walker, E.A.2    Draper, N.3    Jeyasuria, P.4    Marcos, J.5    Shackleton, C.H.6
  • 58
    • 12144291638 scopus 로고    scopus 로고
    • Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice
    • Morton N.M., Paterson J.M., Masuzaki H., Holmes M.C., Staels B., Fievet C., et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004, 53(4):931-938.
    • (2004) Diabetes , vol.53 , Issue.4 , pp. 931-938
    • Morton, N.M.1    Paterson, J.M.2    Masuzaki, H.3    Holmes, M.C.4    Staels, B.5    Fievet, C.6
  • 59
    • 33745897922 scopus 로고    scopus 로고
    • Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins
    • Ehehalt R., Fullekrug J., Pohl J., Ring A., Herrmann T., Stremmel W. Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins. Mol. Cell. Biochem. 2006, 284(1-2):135-140.
    • (2006) Mol. Cell. Biochem. , vol.284 , Issue.1-2 , pp. 135-140
    • Ehehalt, R.1    Fullekrug, J.2    Pohl, J.3    Ring, A.4    Herrmann, T.5    Stremmel, W.6
  • 60
    • 0031283178 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
    • Kotelevtsev Y., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., et al. 11Beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc. Natl. Acad. Sci. U.S.A. 1997, 94(26):14924-14929.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.26 , pp. 14924-14929
    • Kotelevtsev, Y.1    Holmes, M.C.2    Burchell, A.3    Houston, P.M.4    Schmoll, D.5    Jamieson, P.6
  • 61
  • 62
    • 85047693986 scopus 로고    scopus 로고
    • Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    • Masuzaki H., Yamamoto H., Kenyon C.J., Elmquist J.K., Morton N.M., Paterson J.M., et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J. Clin. Invest. 2003, 112(1):83-90.
    • (2003) J. Clin. Invest. , vol.112 , Issue.1 , pp. 83-90
    • Masuzaki, H.1    Yamamoto, H.2    Kenyon, C.J.3    Elmquist, J.K.4    Morton, N.M.5    Paterson, J.M.6
  • 63
    • 15944394711 scopus 로고    scopus 로고
    • Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    • Kershaw E.E., Morton N.M., Dhillon H., Ramage L., Seckl J.R., Flier J.S. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes 2005, 54(4):1023-1031.
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 1023-1031
    • Kershaw, E.E.1    Morton, N.M.2    Dhillon, H.3    Ramage, L.4    Seckl, J.R.5    Flier, J.S.6
  • 64
    • 2342510149 scopus 로고    scopus 로고
    • Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    • Paterson J.M., Morton N.M., Fievet C., Kenyon C.J., Holmes M.C., Staels B., et al. Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 2004, 101(18):7088-7093.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.18 , pp. 7088-7093
    • Paterson, J.M.1    Morton, N.M.2    Fievet, C.3    Kenyon, C.J.4    Holmes, M.C.5    Staels, B.6
  • 65
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity
    • Stewart P.M., Boulton A., Kumar S., Clark P.M., Shackleton C.H. Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity. J. Clin. Endocrinol. Metab. 1999, 84(3):1022-1027.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , Issue.3 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3    Clark, P.M.4    Shackleton, C.H.5
  • 67
    • 0037902924 scopus 로고    scopus 로고
    • Subcutaneous adipose 11beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians
    • Lindsay R.S., Wake D.J., Nair S., Bunt J., Livingstone D.E., Permana P.A., et al. Subcutaneous adipose 11beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J. Clin. Endocrinol. Metab. 2003, 88(6):2738-2744.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , Issue.6 , pp. 2738-2744
    • Lindsay, R.S.1    Wake, D.J.2    Nair, S.3    Bunt, J.4    Livingstone, D.E.5    Permana, P.A.6
  • 68
    • 4544260173 scopus 로고    scopus 로고
    • Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins
    • Kannisto K., Pietilainen K.H., Ehrenborg E., Rissanen A., Kaprio J., Hamsten A., et al. Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J. Clin. Endocrinol. Metab. 2004, 89(9):4414-4421.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , Issue.9 , pp. 4414-4421
    • Kannisto, K.1    Pietilainen, K.H.2    Ehrenborg, E.3    Rissanen, A.4    Kaprio, J.5    Hamsten, A.6
  • 69
    • 33745186881 scopus 로고    scopus 로고
    • Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
    • Goedecke J.H., Wake D.J., Levitt N.S., Lambert E.V., Collins M.R., Morton N.M., et al. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women. Clin. Endocrinol. (Oxf.) 2006, 65(1):81-87.
    • (2006) Clin. Endocrinol. (Oxf.) , vol.65 , Issue.1 , pp. 81-87
    • Goedecke, J.H.1    Wake, D.J.2    Levitt, N.S.3    Lambert, E.V.4    Collins, M.R.5    Morton, N.M.6
  • 70
    • 1842552244 scopus 로고    scopus 로고
    • Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    • Engeli S., Bohnke J., Feldpausch M., Gorzelniak K., Heintze U., Janke J., et al. Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes. Res. 2004, 12(1):9-17.
    • (2004) Obes. Res. , vol.12 , Issue.1 , pp. 9-17
    • Engeli, S.1    Bohnke, J.2    Feldpausch, M.3    Gorzelniak, K.4    Heintze, U.5    Janke, J.6
  • 71
    • 0036075081 scopus 로고    scopus 로고
    • Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study
    • Paulmyer-Lacroix O., Boullu S., Oliver C., Alessi M.C., Grino M. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J. Clin. Endocrinol. Metab. 2002, 87(6):2701-2705.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.6 , pp. 2701-2705
    • Paulmyer-Lacroix, O.1    Boullu, S.2    Oliver, C.3    Alessi, M.C.4    Grino, M.5
  • 73
    • 0036324073 scopus 로고    scopus 로고
    • Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity
    • Rask E., Walker B.R., Soderberg S., Livingstone D.E., Eliasson M., Johnson O., et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J. Clin. Endocrinol. Metab. 2002, 87(7):3330-3336.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.7 , pp. 3330-3336
    • Rask, E.1    Walker, B.R.2    Soderberg, S.3    Livingstone, D.E.4    Eliasson, M.5    Johnson, O.6
  • 74
    • 14644388141 scopus 로고    scopus 로고
    • Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
    • Sandeep T.C., Andrew R., Homer N.Z., Andrews R.C., Smith K., Walker B.R. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005, 54(3):872-879.
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 872-879
    • Sandeep, T.C.1    Andrew, R.2    Homer, N.Z.3    Andrews, R.C.4    Smith, K.5    Walker, B.R.6
  • 75
    • 33846888049 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients
    • Desbriere R., Vuaroqueaux V., Achard V., Boullu-Ciocca S., Labuhn M., Dutour A., et al. 11Beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring) 2006, 14(5):794-798.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.5 , pp. 794-798
    • Desbriere, R.1    Vuaroqueaux, V.2    Achard, V.3    Boullu-Ciocca, S.4    Labuhn, M.5    Dutour, A.6
  • 76
    • 34250634952 scopus 로고    scopus 로고
    • Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
    • Michailidou Z., Jensen M.D., Dumesic D.A., Chapman K.E., Seckl J.R., Walker B.R., et al. Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring) 2007, 15(5):1155-1163.
    • (2007) Obesity (Silver Spring) , vol.15 , Issue.5 , pp. 1155-1163
    • Michailidou, Z.1    Jensen, M.D.2    Dumesic, D.A.3    Chapman, K.E.4    Seckl, J.R.5    Walker, B.R.6
  • 77
    • 34548621405 scopus 로고    scopus 로고
    • 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization
    • Paulsen S.K., Pedersen S.B., Fisker S., Richelsen B. 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring) 2007, 15(8):1954-1960.
    • (2007) Obesity (Silver Spring) , vol.15 , Issue.8 , pp. 1954-1960
    • Paulsen, S.K.1    Pedersen, S.B.2    Fisker, S.3    Richelsen, B.4
  • 78
    • 69949092969 scopus 로고    scopus 로고
    • Omental adipose tissue 11{beta}-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women
    • Veilleux A., Rheaume C., Daris M., Luu-The V., Tchernof A. Omental adipose tissue 11{beta}-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women. J. Clin. Endocrinol. Metab. 2009, 94(9):3550-3557.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.9 , pp. 3550-3557
    • Veilleux, A.1    Rheaume, C.2    Daris, M.3    Luu-The, V.4    Tchernof, A.5
  • 79
    • 73949158787 scopus 로고    scopus 로고
    • Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients
    • Baudrand R., Carvajal C.A., Riquelme A., Morales M., Solis N., Pizarro M., et al. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. Obes. Surg. 2010, 20(1):77-83.
    • (2010) Obes. Surg. , vol.20 , Issue.1 , pp. 77-83
    • Baudrand, R.1    Carvajal, C.A.2    Riquelme, A.3    Morales, M.4    Solis, N.5    Pizarro, M.6
  • 80
    • 0036882136 scopus 로고    scopus 로고
    • Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
    • Tomlinson J.W., Sinha B., Bujalska I., Hewison M., Stewart P.M. Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J. Clin. Endocrinol. Metab. 2002, 87(12):5630-5635.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.12 , pp. 5630-5635
    • Tomlinson, J.W.1    Sinha, B.2    Bujalska, I.3    Hewison, M.4    Stewart, P.M.5
  • 81
    • 26044458939 scopus 로고    scopus 로고
    • Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes
    • Abdallah B.M., Beck-Nielsen H., Gaster M. Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes. Eur. J. Clin. Invest. 2005, 35(10):627-634.
    • (2005) Eur. J. Clin. Invest. , vol.35 , Issue.10 , pp. 627-634
    • Abdallah, B.M.1    Beck-Nielsen, H.2    Gaster, M.3
  • 82
    • 0037194658 scopus 로고    scopus 로고
    • Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1
    • Barf T., Vallgarda J., Emond R., Haggstrom C., Kurz G., Nygren A., et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J. Med. Chem. 2002, 45(18):3813-3815.
    • (2002) J. Med. Chem. , vol.45 , Issue.18 , pp. 3813-3815
    • Barf, T.1    Vallgarda, J.2    Emond, R.3    Haggstrom, C.4    Kurz, G.5    Nygren, A.6
  • 83
    • 0036432995 scopus 로고    scopus 로고
    • Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
    • Alberts P., Engblom L., Edling N., Forsgren M., Klingstrom G., Larsson C., et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002, 45(11):1528-1532.
    • (2002) Diabetologia , vol.45 , Issue.11 , pp. 1528-1532
    • Alberts, P.1    Engblom, L.2    Edling, N.3    Forsgren, M.4    Klingstrom, G.5    Larsson, C.6
  • 84
    • 0242468543 scopus 로고    scopus 로고
    • Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains
    • Alberts P., Nilsson C., Selen G., Engblom L.O., Edling N.H., Norling S., et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 2003, 144(11):4755-4762.
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4755-4762
    • Alberts, P.1    Nilsson, C.2    Selen, G.3    Engblom, L.O.4    Edling, N.H.5    Norling, S.6
  • 85
    • 41449104843 scopus 로고    scopus 로고
    • Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice
    • Sundbom M., Kaiser C., Bjorkstrand E., Castro V.M., Larsson C., Selen G., et al. Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice. BMC Pharmacol. 2008, 8:3.
    • (2008) BMC Pharmacol. , vol.8 , pp. 3
    • Sundbom, M.1    Kaiser, C.2    Bjorkstrand, E.3    Castro, V.M.4    Larsson, C.5    Selen, G.6
  • 86
    • 23944493717 scopus 로고    scopus 로고
    • 11Beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    • Hermanowski-Vosatka A., Balkovec J.M., Cheng K., Chen H.Y., Hernandez M., Koo G.C., et al. 11Beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J. Exp. Med. 2005, 202(4):517-527.
    • (2005) J. Exp. Med. , vol.202 , Issue.4 , pp. 517-527
    • Hermanowski-Vosatka, A.1    Balkovec, J.M.2    Cheng, K.3    Chen, H.Y.4    Hernandez, M.5    Koo, G.C.6
  • 87
    • 70449473618 scopus 로고    scopus 로고
    • Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis
    • Lloyd D.J., Helmering J., Cordover D., Bowsman M., Chen M., Hale C., et al. Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis. Diabetes Obes. Metab. 2009, 11(7):688-699.
    • (2009) Diabetes Obes. Metab. , vol.11 , Issue.7 , pp. 688-699
    • Lloyd, D.J.1    Helmering, J.2    Cordover, D.3    Bowsman, M.4    Chen, M.5    Hale, C.6
  • 88
    • 35148876079 scopus 로고    scopus 로고
    • 11Beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
    • Berthiaume M., Laplante M., Festuccia W.T., Cianflone K., Turcotte L.P., Joanisse D.R., et al. 11Beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues. Am. J. Physiol. Endocrinol. Metab. 2007, 293(4):E1045-E1052.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , Issue.4
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3    Cianflone, K.4    Turcotte, L.P.5    Joanisse, D.R.6
  • 89
    • 34249775822 scopus 로고    scopus 로고
    • Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1
    • Berthiaume M., Laplante M., Festuccia W., Gelinas Y., Poulin S., Lalonde J., et al. Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 2007, 148(5):2391-2397.
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2391-2397
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.3    Gelinas, Y.4    Poulin, S.5    Lalonde, J.6
  • 90
    • 67349178689 scopus 로고    scopus 로고
    • Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats
    • Berthiaume M., Laplante M., Festuccia W.T., Berger J.P., Thieringer R., Deshaies Y. Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int. J. Obes. (Lond.) 2009, 33(5):601-604.
    • (2009) Int. J. Obes. (Lond.) , vol.33 , Issue.5 , pp. 601-604
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3    Berger, J.P.4    Thieringer, R.5    Deshaies, Y.6
  • 91
    • 67650178262 scopus 로고    scopus 로고
    • 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice
    • Zhang X., Zhou Z., Yang H., Chen J., Feng Y., Du L., et al. 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. Bioorg. Med. Chem. Lett. 2009, 19(15):4455-4458.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.15 , pp. 4455-4458
    • Zhang, X.1    Zhou, Z.2    Yang, H.3    Chen, J.4    Feng, Y.5    Du, L.6
  • 92
    • 0028839840 scopus 로고
    • Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
    • Walker B.R., Connacher A.A., Lindsay R.M., Webb D.J., Edwards C.R. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J. Clin. Endocrinol. Metab. 1995, 80(11):3155-3159.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , Issue.11 , pp. 3155-3159
    • Walker, B.R.1    Connacher, A.A.2    Lindsay, R.M.3    Webb, D.J.4    Edwards, C.R.5
  • 93
    • 0037238379 scopus 로고    scopus 로고
    • Effects of the 11beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    • Andrews R.C., Rooyackers O., Walker B.R. Effects of the 11beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J. Clin. Endocrinol. Metab. 2003, 88(1):285-291.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , Issue.1 , pp. 285-291
    • Andrews, R.C.1    Rooyackers, O.2    Walker, B.R.3
  • 94
    • 33947491197 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis
    • Tomlinson J.W., Sherlock M., Hughes B., Hughes S.V., Kilvington F., Bartlett W., et al. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J. Clin. Endocrinol. Metab. 2007, 92(3):857-864.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , Issue.3 , pp. 857-864
    • Tomlinson, J.W.1    Sherlock, M.2    Hughes, B.3    Hughes, S.V.4    Kilvington, F.5    Bartlett, W.6
  • 95
    • 37349004141 scopus 로고    scopus 로고
    • Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11-hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys
    • Bhat B.G., Hosea N., Fanjul A., Herrera J., Chapman J., Thalacker F., et al. Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11-hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys. J. Pharmacol. Exp. Ther. 2008, 324(1):299-305.
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , Issue.1 , pp. 299-305
    • Bhat, B.G.1    Hosea, N.2    Fanjul, A.3    Herrera, J.4    Chapman, J.5    Thalacker, F.6
  • 96
    • 39049131253 scopus 로고    scopus 로고
    • Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor
    • Courtney R., Stewart P.M., Toh M., Ndongo M.N., Calle R.A., Hirshberg B. Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor. J. Clin. Endocrinol. Metab. 2008, 93(2):550-556.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.2 , pp. 550-556
    • Courtney, R.1    Stewart, P.M.2    Toh, M.3    Ndongo, M.N.4    Calle, R.A.5    Hirshberg, B.6
  • 97
    • 77956459730 scopus 로고    scopus 로고
    • incyte
    • incyte, 2008. http://incyte.com/index.html.
    • (2008)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.