Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 18, 2004, Pages 7088-7093

  Paterson, Janice M ^a   Morton, Nicholas M ^b   Fievet, Catherine ^c   Kenyon, Christopher J ^b   Holmes, Megan C ^b   Staels, Bart ^c   Seckl, Jonathan R ^b   Mullins, John J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANGIOTENSINOGEN; APOLIPOPROTEIN E; GLUCOCORTICOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DYSLIPIDEMIA; FATTY LIVER; GENE OVEREXPRESSION; HYPERTENSION; INSULIN RESISTANCE; METABOLIC SYNDROME X; MOUSE; MYOTONIC DYSTROPHY; NONHUMAN; NORTHERN BLOTTING; OBESITY; PRIORITY JOURNAL; SERUM RESPONSIVE ELEMENT; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; APOLIPOPROTEINS E; CORTICOSTERONE; HYPERINSULINISM; LIPID METABOLISM; LIVER; MICE;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 2342510149     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0305524101     Document Type: Article

References (57)

1. Seckl, J. R. & Walker, B. R. (2001) Endocrinology 142, 1371-1376.
2. Montague, C. T. & O'Rahilly, S. (2000) Diabetes 49, 883-888.
3. Hautanen, A., Raikkonen, K. & Adlercreutz, H. (1997) J. Intern. Med. 241, 451-461.
4. Jamieson, P. M., Chapman, K. E. & Seckl, J. R. (1999) J. Steroid Biochem. Mol. Biol. 68, 245-250.
5. Livingstone, D. E., Kenyon, C. J. & Walker, B. R. (2000) J. Endocrinol. 167, 533-539.
6. Rask, E., Olsson, T., Soderberg, S., Andrew, R., Livingstone, D. E., Johnson, O. & Walker, B. R. (2001) J. Clin. Endocrinol. Metab. 86, 1418-1421.
7. Paulmyer-Lacroix, O., Boullu, S., Oliver, C., Alessi, M. C. & Grino, M. (2002) J. Clin. Endocrinol. Metab. 87, 2701-2705.
8. Tomlinson, J. W., Sinha, B., Bujalska, I., Hewison, M. & Stewart, P. M. (2002) J. Clin. Endocrinol. Metab. 87, 5630-5635.
9. Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R. & Flier, J. S. (2001) Science 294, 2166-2170.
10. Masuzaki, H., Yamamoto, H., Kenyon, C. J., Elmquist, J. K., Morton, N. M., Paterson, J. M., Shinyama, H., Sharp, M. G., Fleming, S., Mullins, J. J., et al. (2003) J. Clin. Invest. 112, 83-90.
11. Kotelevtsev, Y., Holmes, M. C., Burchell, A., Houston, P. M., Schmoll, D., Jamieson, P., Best, R., Brown, R., Edwards, C. R., Seckl, J. R. & Mullins, J. J. (1997) Proc. Natl. Acad. Sci. USA 94, 14924-14929.
12. Morton, N. M., Holmes, M. C., Fievet, C., Staels, B., Tailleux, A., Mullins, J. J. & Seckl, J. R. (2001) J. Biol. Chem. 276, 41293-41300.
13. Jamieson, P. M., Chapman, K. E., Edwards, C. R. & Seckl, J. R. (1995) Endocrinology 136, 4754-4761.
14. Andrew, R., Gale, C. R., Walker, B. R., Seckl, J. R. & Martyn, C. N. (2002) Exp. Clin. Endocrinol. Diabetes 110, 284-290.
15. Rask, E., Walker, B. R., Soderberg, S., Livingstone, D. E., Eliasson, M., Johnson, O., Andrew, R. & Olsson, T. (2002) J. Clin. Endocrinol. Metab. 87, 3330-3336.
16. Johansson, A., Andrew, R., Forsberg, H., Cederquist, K., Walker, B. R. & Olsson, T. (2001) J. Clin. Endocrinol. Metab. 86, 4276-4283.
17. Fan, J., Wang, J., Bensadoun, A., Lauer, S. J., Dang, Q., Mahley, R. W. & Taylor, J. M. (1994) Proc. Natl. Acad. Sci. USA 91, 8724-8728.
18. MacPhee, I. A., Antoni, F. A. & Mason, D. W. (1989) J. Exp. Med. 169, 431-445.
19. Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J. & Mangelsdorf, D. J. (2000) Mol. Cell 6, 507-515.
20. Shimano, H., Shimomura, I., Hammer, R. E., Herz, J., Goldstein, J. L., Brown, M. S. & Horton, J. D. (1997) J. Clin. Invest. 100, 2115-2124.
21. Kalinyak, J. E., Dorin, R. I., Hoffman, A. R. & Perlman, A. J. (1987) J. Biol. Chem. 262, 10441-44.
22. Xu, R. B., Liu, Z. M. & Zhao, Y. (1991) Neuroendocrinology 53, Suppl. 1, 31-36.
23. Peters, J. M., Hennuyer, N., Staels, B., Fruchart, J. C., Fievet, C., Gonzalez, F. J. & Auwerx, J. (1997) J. Biol. Chem. 272, 27307-27312.
24. Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., et al. (1999) J. Biol. Chem. 274, 35832-35839.
25. Joseph, S. B., Laffitte, B. A., Patel, P. H., Watson, M. A., Matsukuma, K. E., Walczak, R., Collins, J. L., Osborne, T. F. & Tontonoz, P. (2002) J. Biol. Chem. 277, 11019-11025.
26. Leone, T. C., Weinheimer, C. J. & Kelly, D. P. (1999) Proc. Natl. Acad. Sci. USA 96, 7473-7478.
27. Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J. & Wahli, W. (1994) J. Biol. Chem. 269, 24527-24530.
28. Pandak, W. M., Heuman, D. M., Redford, K., Stravitz, R. T., Chiang, J. Y., Hylemon, P. B. & Vlahcevic, Z. R. (1997) J. Lipid Res. 38, 2483-2491.
29. Castro Cabezas, M., Halkes, C. J. & Erkelens, D. W. (2001) Nutr. Metab. Cardiovasc. Dis. 11, 134-142.
30. Smithies, O. & Kim, H. S. (1994) Proc. Natl. Acad. Sci. USA 91, 3612-3615.
31. Ruderman, N., Chisholm, D., Pi-Sunyer, X. & Schneider, S. (1998) Diabetes 47, 699-713.
32. Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G. & Melchionda, N. (2001) Diabetes 50, 1844-1850.
33. Bremer, J. (2001) Prog. Lipid Res. 40, 231-268.
34. Giorgino, F., Almahfouz, A., Goodyear, L. J. & Smith, R. J. (1993) J. Clin. Invest. 91, 2020-2030.
35. Stewart, P. M., Toogood, A. A. & Tomlinson, J. W. (2001) Horm. Res. 56, Suppl. 1, 1-6.
36. Olefsky, J. M., Johnson, J., Liu, F., Jen, P. & Reaven, G. M. (1975) Metabolism 24, 517-527.
37. Saad, M. J., Folli, F. & Kahn, C. R. (1995) Endocrinology 136, 1579-1588.
38. Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) Nature 413, 131-138.
39. Bernal-Mizrachi, C., Weng, S., Feng, C., Finck, B. N., Knutsen, R. H., Leone, T. C., Coleman, T., Mecham, R. P., Kelly, D. P. & Semenkovich, C. F. (2003) Nat. Med. 9, 1069-1075.
40. McGarry, J. D. (1992) Science 258, 766-770.
41. Taskinen, M. R., Nikkila, E. A., Pelkonen, R. & Sane, T. (1983) J. Clin. Endocrinol. Metab. 57, 619-626.
42. Stulnig, T. M., Oppermann, U., Steffensen, K. R., Schuster, G. U. & Gustafsson, J. A. (2002) Diabetes 51, 2426-2433.
43. Hermanowski-Vosatka, A., Gerhold, D., Mundt, S. S., Loving, V. A., Lu, M., Chen, Y., Elbrecht, A., Wu, M., Doebber, T., Kelly, L., et al. (2000) Biochem. Biophys. Res. Commun. 279, 330-336.
44. Ide, T., Shimano, H., Yoshikawa, T., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Yatoh, S., Iizuka, Y., Tomita, S., et al. (2003) Mol. Endocrinol. 17, 1255-1267.
45. Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., et al. (2003) Mol. Endocrinol. 17, 1240-1254.
46. Kurihara, I., Shibata, H., Suzuki, T., Ando, T., Kobayashi, S., Hayashi, M., Saito, I. & Saruta, T. (2002) Mol. Cell. Endocrinol. 189, 181-189.
47. Li, X., Wong, J., Tsai, S. Y., Tsai, M. J. & O'Malley, B. W. (2003) Mol. Cell. Biol. 23, 3763-3773.
48. Song, C. & Liao, S. (2000) Endocrinology 141, 4180-4184.
49. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E. & Mangelsdorf, D. J. (1998) Cell 93, 693-704.
50. Pineda Torra, I., Claudel, T., Duval, C., Kosykh, V., Fruchart, J. C. & Staels, B. (2003) Mol. Endocrinol. 17, 259-272.
51. Alberts, P., Engblom, L., Edling, N., Forsgren, M., Klingstrom, G., Larsson, C., Ronquist-Nii, Y., Ohman, B. & Abrahmsen, L. (2002) Diabetologia 45, 1528-1532.
52. Fletcher, J. M. (1986) Biochem. J. 238, 459-463.
53. Freedman, M. R., Horwitz, B. A. & Stem, J. S. (1986) Am. J. Physiol. 250, R595-R607.
54. Zambon, A., Deeb, S. S., Pauletto, P., Crepaldi, G. & Brunzell, J. D. (2003) Curr. Opin. Lipidol. 14, 179-189.
55. Chang, E. & Perlman, A. J. (1987) Endocrinology 121, 513-519.
56. Kim, H. S., Krege, J. H., Kluckman, K. D., Hagaman, J. R., Hodgin, J. B., Best, C. F., Jennette, J. C., Coffman, T. M., Maeda, N. & Smithies, O. (1995) Proc. Natl. Acad. Sci. USA 92, 2735-2739.
57. Jain, S., Tang, X., Narayanan, C. S., Agarwal, Y., Peterson, S. M., Brown, C. D., Ott, J. & Kumar, A. (2002) J. Biol. Chem 277, 36889-36896.