Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 4, 1998, Pages 1325-1335

  Ricketts, Marie L ^d   Verhaeg, Julie M ^d   Bujalska, Iwona ^d   Howie, Alexander J ^a   Rainey, William E ^b   Stewart, Paul M ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE;

ADIPOSE TISSUE; ADRENAL GLAND; ARTICLE; DECIDUA; ENZYME LOCALIZATION; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; OVARY; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADIPOSE TISSUE; ADRENAL GLANDS; ADULT; BLOTTING, WESTERN; DECIDUA; FEMALE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LIVER; ORGAN SPECIFICITY; OVARY;

OVIS ARIES;

EID: 0031762902     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.4.1325     Document Type: Article

References (37)

1. Tannin GM, Agarwal AK, Monder C, New MI, White PC. 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localisation. J Biol Chem. 266:16653-16658.
2. Albiston AL, Obeyesekene VR, Smith RE, Krozowski ZS. 1994 Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol. 105:R11-R17.
3. Stewart PM, Murry BA, Mason JI. 1994 Human kidney 11β-hydroxysteroid dehydrogenase is a high affinity NAD-dependent enzyme and differs from the cloned "type 1" isoform. J Clin Endocrinol Metab. 79:480-484.
4. Jamieson PM, Chapman KE, Edwards CRW, Seckl JR. 1995 11β-Hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology. 136:4754-4761.
5. Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC, Stewart PM. 1998 Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J Endocrinol. 156:159-168.
6. Brown RW, Chapman KE, Edwards CRW, Seckl JR. 1993 Human placental 11β-hydroxysteroid dehydrogenase: partial purification of and evidence for a distinct NAD-dependent isoform. Endocrinology. 132:2614-2621.
7. Wilson RC, Harbison MD, Krozowski ZS, et al. 1995 Several homozygous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess. J Clin Endocrinol Metab. 80:3145-3150.
8. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. 1995 Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nat Genet. 10:394-399.
9. Stewart PM, Krozowski ZS, Gupta A, et al. 1996 Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene. Lancet. 347:88-91.
10. Monder C, Lakshmi V. 1990 Corticosteroid 11β-dehydrogenase of rat tissues: immunological studies. Endocrinology. 126:2435-2443.
11. Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM. 1995 Detection of human 11β-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localisation of the type 2 isoform to renal collecting ducts. Mol Cell Endocrinol. 110:R7-R12.
12. Shimojo M, Ricketts ML, Petrelli MD, et al. 1997 Immunodetection of 11β-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization. Endocrinology. 138:1305-1311.
13. Lakshmi V, Monder C. 1988 Purification and characterisation of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology. 123:2390-2398.
14. Edwards CRW, Stewart PM, Burt D, et al. 1988 Localisation of 11β-hydroxysteroid dehydrogenase: tissue specific protector of the mineralocorticoid receptor. Lancet. 2:986-989.
15. Funder JW, Pearce PT, Smith R, Smith AI. 1988 Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science. 242:583-585.
16. Whorwood CB, Franklyn JA, Sheppard MC, Stewart PM. 1982 Tissue localisation of 11β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor. J Steroid Biochem Mol Biol. 41:21-28.
17. Whorwood CB, Sheppard MC, Stewart PM. 1993 Licorice inhibits 11β-hydroxysteroid dehydrogenase messanger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 132:2287-2292.
18. Monder C, Miroff Y, Marandici A, Hardy MP. 1994 11β-hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology. 134:1199-1204.
19. Rajan V, Edwards CRW, Seckl JR. 1996 11β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci. 16:65-70.
20. Bujalska IJ, Kumar S, Stewart PM. 1997 Does central obesity reflect "Cushing's disease of the omentum?" Lancet. 349:1210-1213.
21. Sigal SH, Brill S, Fiorino A. 1992 The liver as a stem cell and lineage system. Am J Physiol. 263:G139-G148.
22. Stewart PM, Wallace AM, Atherden SM, Shearing CH, Edwards CRW. 1990 Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice activity in man. Clin Sci. 78:49-54.
23. Shimojo M, Whorwood CB, Stewart PM. 1996 11β-hydroxysteroid dehydrogenase in the rat adrenal. J Mol Endocrinol. 17:121-130.
24. Cole TJ, Blendy JA, Monaghan AP, et al. 1995 Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell-development and severely retards lung maturation. Genes Dev. 9:1608-1621.
25. Matkovic L, Gomez-Sanchez CE, Lantos CP. 1995 Inhibition of aldosterone formation by cortisol in rat adrenal mitochondria. Steroids. 60:447-452.
26. Benediktsson R, Yau JLW, Brett LP, Cooke BE, Edwards CRW, Seckl JR. 1992 11β-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte. J Endocrinol. 135:53-58.
27. Michael AE, Pester LA, Curtis P, Shaw RW, Edwards CRW, Cooke BA. 1993 Direct inhibition of ovarian steroidogenesis by cortisol and the modulatory role of 11β-hydroxysteroid dehydrogenase. Clin Endocrinol (Oxf). 38:641-644.
28. Tetsuka M, Thomas FJ, Thomas MJ, Anderson RA, Mason JI, Hillier SG. 1997 Differential expression of messenger ribonucleic acids encoding 11β-hydroxysteroid dehydrogenase. Types 1 and 2 in human granulosa cells. J Clin Endocrinol Metab. 82:2006-2009.
29. Murphy BEP. 1981 Specificity of human 11β-hydroxysteroid dehydrogenase. J Steroid Biochem. 14:807-809.
30. Owen EJ, Holownia P, Conway G, Jacobs HS, Honour JW. 1992 11β-Hydroxyandrostenedione in plasma, follicular fluid, and granulosa cells of women with normal and polycystic ovaries. Fertil Steril. 58:713-718.
31. Michael AE, Gregory L, Walker SM, et al. 1993 Ovarian 11β-hydroxysteroid dehydrogenase: potential predictor of conception by in-vitro fertilisation and embryo transfer. Lancet. 342:711-712.
32. Stewart PM, Murry BA, Mason JI. 1994 Type 2 11β-hydroxysteroid dehydrogenase in human fetal tissues. J Clin Endocrinol Metab. 78:1529-1531.
33. Sun K, Yang K, Challis JRG. 1997 Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 in human placenta and fetal membranes. J Clin Endocrinol Metab. 82:300-305.
34. Clark DA, Slapsys R, Croy BA, Krcek J, Rossant J. 1984 Local active suppression by suppressor cells in the decidua: a review. Am J Reprod Immunol. 5:78-83.
35. Snyder DS, Unanue ER. 1982 Corticosteroids inhibit murine macrophage la expression and interleukin 1 production. J Immunol. 129:1803-1805.
36. Bronnegard M, Reynisdottir S, Marcus C, Stierna P, Arner P. 1995 Effect of glucocorticoid treatment on glucocorticoid receptor expression in human adipocytes. J Clin Endocrinol Metab. 80:3608-3612.
37. Hauner H, Entenmann G, Wabitsch M, et al. 1989 Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest. 84:1663-1670.