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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4146-4149

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)

(10) Wang, Haixia a Robl, Jeffrey A a Hamann, Lawrence G a Simpkins, Ligaya a Golla, Rajasree a Li, Yi Xin a Seethala, Ramakrishna a Zvyaga, Tatyana a Gordon, David A a Li, James J a

a BRISTOL MYERS SQUIBB (United States)

Author keywords

11 HSD 1 inhibitors; PXR; Triazolopyridine; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; OXIDOREDUCTASE INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STABILITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; MOUSE; NONHUMAN; PROCESS OPTIMIZATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ENZYME INHIBITORS; HUMANS; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79959914089 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.05.101 Document Type: Article

Times cited : (26)

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