Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase

Endocrinology

Volumn 148, Issue 12, 2007, Pages 6100-6106

  Lavery, Gareth G ^a   Hauton, David ^a   Hewitt, Kylie N ^a   Brice, Sophie M ^a   Sherlock, Mark ^a   Walker, Elizabeth A ^a   Stewart, Paul M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; INSULIN; LACTIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DIET RESTRICTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INDUCTION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCOGEN SYNTHESIS; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; KNOCKOUT MOUSE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BLOOD GLUCOSE; CARBOHYDRATE DEHYDROGENASES; CORTICOSTERONE; FASTING; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIA; INSULIN; LIVER; LIVER GLYCOGEN; MALE; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 36349033013     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0963     Document Type: Article

References (33)

1. Nordlie RC, Foster JD, Lange AJ 1999 Regulation of glucose production by the liver. Annu Rev Nutr 19:379-406
2. Radziuk J, Pye S 2001 Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes Metab Res Rev 17:250-272
3. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM 2004 11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 25:831-866
4. Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA, Vulliamy TJ 1999 Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression. Blood Cells Mol Dis 25:30-37
5. Banhegyi G, Marcolongo P, Fulceri R, Hinds C, Burchell A, Benedetti A 1997 Demonstration of a metabolically active glucose-6-phosphate pool in the lumen of liver microsomal vesicles. J Biol Chem 272:13584-13590
6. Piccirella S, Czegle I, Lizak B, Margittai E, Senesi S, Papp E, Csala M, Fulceri R, Csermely P, Mandl J, Benedetti A, Banhegyi G 2006 Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem 281:4671-4677
7. Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A 2004 Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 571:129-133
8. Banhegyi G, Benedetti A, Fulceri R, Senesi S 2004 Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem 279:27017-27021
9. Bujalska IJ, Draper N, Michailidou Z, Tomlinson JW, White PC, Chapman KE, Walker EA, Stewart PM 2005 Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11β-hydroxysteroid dehydrogenase type 1. J Mol Endocrinol 34:675-684
10. Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC, Stewart PM 2006 Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem 281:6546-6551
11. Bujalska IJ, Kumar S, Hewison M, Stewart PM 1999 Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β- hydroxysteroid dehydrogenase. Endocrinology 140:3188-3196
12. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ 1997 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoidinducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929
13. Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, Mullins JJ, Seckl JR 2001 Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276:41293-41300
14. Alberts P, Engblom L, Edling N, Forsgren M, Klingstrom G, Larsson C, Ronquist-Nii Y, Ohman B, Abrahmsen L 2002 Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 45:1528-1532
15. Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingstrom G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Bjorkstrand E, Abrahmsen LB 2003 Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 144:4755-4762
16. Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hernandez M, Koo GC, Le Grand CB, Li Z, Metzger JM, Mundt SS, Noonan H, Nunes CN, Olson SH, Pikounis B, Ren N, Robertson N, Schaeffer JM, Shah K, Springer MS, Strack AM, Strowski M, Wu K, Wu T, Xiao J, Zhang BB, Wright SD, Thieringer R 2005 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 202:517-527
17. Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CH, McKiernan P, Elias E, Chou JY, Stewart PM 2007 11β-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose-6-phosphate, provides evidence for a novel link between glucose metabolism and HPA axis function. J Biol Chem 282:27030-27036
18. Holness MJ, Palmer TN, Sugden MC 1988 Suppression of hepatic glucose output after glucose re-feeding in the gsd/gsd rat. Biochem J 252:928-929
19. Postle AD, Bloxham DP 1980 The use of tritiated water to measure absolute rates of hepatic glycogen synthesis. Biochem J 192:65-73
20. Gibbons GF, Pullinger CR, Munday MR, Williamson DH 1983 Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat. Biochem J 212:843-848
21. Knight BL, Hebbachi A, Hauton D, Brown AM, Wiggins D, Patel DD, Gibbons GF 2005 A role for PPARα in the control of SREBP activity and lipid synthesis in the liver. Biochem J 389:413-421
22. Vernon RG, Walker DG 1972 Gluconeogenesis from lactate in the developing rat. Studies in vivo. Biochem J 127:531-537
23. Vernon RG, Walker DG 1972 Glucose metabolism in the developing rat. Studies in vivo. Biochem J 127:521-529
24. Hohorst HJ, Arese P, Bartels H, Stratmann D, Talke H 1965 L(+) lactic acid and the steady state of cellular red/ox-systems. Ann NY Acad Sci 119:974-994
25. Azain MJ, Kasser TR, Baile CA 1999 A method for the determination of glucose synthesis in isolated bovine hepatocytes. J Nutr Biochem 10:205-209
26. Petrescu I, Bojan O, Saied M, Barzu O, Schmidt F, Kuhnle HF 1979 Determination of phosphoenolpyruvate carboxykinase activity with deoxyguanosine 5′-diphosphate as nucleotide substrate. Anal Biochem 96:279-281
27. Gerin I, Van SE 2002 Evidence for glucose-6-phosphate transport in rat liver microsomes. FEBS Lett 517:257-260
28. Czegle I, Piccirella S, Senesi S, Csala M, Mandl J, Banhegyi G, Fulceri R, Benedetti A 2006 Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. Mol Cell Endocrinol 248:24-25
29. McCormick KL, Wang X, Mick GJ 2006 Evidence that the 11β-hydroxysteroid dehydrogenase (11β-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes. J Biol Chem 281:341-347
30. Opherk C, Tronche F, Kellendonk C, Kohlmuller D, Schulze A, Schmid W, Schutz G 2004 Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol 18:1346-1353
31. Greenberg CC, Jurczak MJ, Danos AM, Brady MJ 2006 Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways. Am J Physiol Endocrinol Metab 291:E1-E8
32. van Dijk TH, van der Sluijs FH, Wiegman CH, Baller JF, Gustafson LA, Burger HJ, Herling AW, Kuipers F, Meijer AJ, Reijngoud DJ 2001 Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048. J Biol Chem 276:25727-25735
33. Aiston S, Andersen B, Agius L 2003 Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. Diabetes 52:1333-1339