11β-hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation

Molecular Endocrinology

Volumn 19, Issue 3, 2005, Pages 621-631

  Eijken, M ^a   Hewison, M ^b   Cooper, M S ^b   De Jong, F H ^a   Chiba, H ^c   Stewart, P M ^b   Uitterlinden, A G ^a   Pols, H A P ^a   Van Leeuwen, J P T M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTEROID; CORTISONE; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; ALKALINE PHOSPHATASE; AZO COMPOUND; CCAAT ENHANCER BINDING PROTEIN ALPHA; DNA; GLUCOCORTICOID RECEPTOR; LUCIFERASE; MESSENGER RNA; OIL RED O;

ARTICLE; BONE METABOLISM; CELL DIFFERENTIATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STEROIDOGENESIS; BIOSYNTHESIS; BONE; CELL LINE; CYTOLOGY; DOSE RESPONSE; METABOLISM; REPORTER GENE; TIME;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ALKALINE PHOSPHATASE; AZO COMPOUNDS; BONE AND BONES; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINE; CORTISONE; DEXAMETHASONE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; LUCIFERASES; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TIME FACTORS;

EID: 14844328091     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0212     Document Type: Article

References (44)

1. Cheng SL, Zhang SF, Avioli LV 1996 Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells. J Cell Biochem 61:182-193
2. Iba K, Chiba H, Sawada N, Hirota S, Ishii S, Mori M 1995 Glucocorticoids induce mineralization coupled with bone protein expression without influence on growth of a human osteoblastic cell line. Cell Struct Funct 20:319-330
3. Herbertson A, Aubin JE 1995 Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. J Bone Miner Res 10:285-294
4. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1998 Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274-282
5. Weinstein RS 2001 Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord 2:65-73
6. Canalis E 1996 Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 81: 3441-3447
7. Hirayama T, Sabokbar A, Athanasou NA 2002 Effect of corticosteroids on human osteoclast formation and activity. J Endocrinol 175:155-163
8. Pockwinse SM, Stein JL, Lian JB, Stein GS 1995 Developmental stage-specific cellular respqnses to vitamin D and glucocorticoids during differentiation of the osteoblast phenotype: interrelationship of morphology and gene expression by in situ hybridization. Exp Cell Res 216:244-260
9. Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B 2000 Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem 275:19992-20001
10. Ishida Y, Heersche JN 1998 Glucocorticoid-induced osteoporosis: both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation. J Bone Miner Res 13:1822-1826
11. Liesegang P, Romalo G, Sudmann M, Wolf L, Schweikert HU 1994 Human osteoblast-like cells contain specific, saturable, high-affinity glucocorticoid, androgen, estrogen, and 1α,25-dihydroxycholecalciferol receptors. J Androl 15:194-199
12. Heinrichs AA, Bortell R, Rahman S, Stein JL, Alnemri ES, Litwack G, Lian JB, Stein GS 1993 Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter. Biochemistry 32:11436-11444
13. Peterkofsky B, Gosiewska A, Singh K, Pearlman S, Mahmoodian F 1999 Species differences in cis-elements of the proα1(I) procollagen promoter and their binding proteins. J Cell Biochem 73:408-422
14. Parrelli JM, Meisler N, Cutroneo KR 1998 Identification of a glucocorticoid response element in the human transforming growth factor β1 gene promoter. Int J Biochem Cell Biol 30:623-627
15. Schmidt TJ, Meyer AS 1994 Autoregulation of corticosteroid receptors. How, when, where, and why? Receptor 4:229-257
16. Kino T, De Martino MU, Charmandari E, Mirani M, Chrousos GP 2003 Tissue glucocorticoid resistance/hypersensitivity syndromes. J Steroid Biochem Mol Biol 85: 457-467
17. Stewart PM, Krozowski ZS 1999 11β-Hydroxysteroid dehydrogenase. Vitam Horm 57:249-324
18. Tannin GM, Agarwal AK, Monder C, New MI, White PC 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266:16653-16658
19. Seckl JR, Walker BR 2001 Minireview: 11β-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action. Endocrinology 142: 1371-1376
20. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS 1994 Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-7
21. Edwards CR, Stewart PM, Burt D, Brett L, McIntyre MA, Sutanto WS, de Kloet ER, Monder C 1988 Localisation of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet 2:986-989
22. Bland R, Worker CA, Noble BS, Eyre LJ, Bujalska IJ, Sheppard MC, Stewart PM, Hewison M 1999 Characterization of 11β-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines. J Endocrinol 161:455-464
23. Cooper MS, Walker EA, Bland R, Fraser WD, Hewison M, Stewart PM 2000 Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone. Bone 27:375-381
24. Cooper MS, Hewison M, Stewart PM 1999 Glucocorticoid activity, inactivity and the osteoblast. J Endocrinol 163:159-164.
25. Canalis E, Delany AM 2002 11β-Hydroxysteroid dehydrogenase, an amplifier of glucocorticoid action in osteoblasts. J Bone Miner Res 17:987-990
26. Cooper MS, Rabbitt EH, Goddard PE, Bartlett WA, Hewison M, Stewart PM 2002 Osteoblastic 11β-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure. J Bone Miner Res 17:979-986
27. Cooper MS, Blumsohn A, Goddard PE, Bartlett WA, Shackleton CH, Eastell R, Hewison M, Stewart PM 2003 11β-Hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. J Clin Endocrinol Metab 88:3874-3877
28. Liu YJ, Nakagawa Y, Nasuda K, Saegusa H, Igarashi Y 1996 Effect of growth hormone, insulin and dexamethasone on 11β-hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes. Life Sci 59:227-234
29. Bujalska IJ, Kumar S, Hewison M, Stewart PM 1999 Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 140:3188-3196
30. Hammami MM, Siiteri PK 1991 Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. J Clin Endocrinol Metab 73:326-334
31. Jamieson PM, Chapman KE, Seckl JR 1999 Tissue- and temporal-specific regulation of 11β-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo. J Steroid Biochem Mol Biol 68:245-250
32. Shen J, Montecino M, Lian JB, Stein GS, Van Wijnen AJ, Stein JL 2002 Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J Biol Chem 277:20284-20292
33. Lian JB, Stein GS 2003 The temporal and spatial subnuclear organization of skeletal gene regulatory machinery: integrating multiple levels of transcriptional control. Calcif Tissue Int 72:631-637
34. Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, Poli V, Seckl JR, Chapman KE 2000 C/EBP regulates hepatic transcription of 11β -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J Biol Chem 275:30232-30239
35. Delany AM, Durant D, Canalis E 2001 Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol 15:1781-1789
36. Pereira RC, Delany AM, Canalis E 2002 Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone 30:685-691
37. Wake DJ, Walker BR 2004 11β-Hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Mol Cell Endocrinol 215:45-54
38. Bujalska IJ, Walker EA, Hewison M, Stewart PM 2002 A switch in dehydrogenase to reductase activity of 11β-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab 87:1205-1210
39. Dunn JF, Nisula BC, Rodbard D 1981 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53:58-68
40. Gruber CJ, Tschugguel W, Schneeberger C, Huber JC 2002 Production and actions of estrogens. N Engl J Med 346:340-352
41. Janssen JM, Bland R, Hewison M, Coughtrie MW, Sharp S, Arts J, Pols HA, van Leeuwen JP 1999 Estradiol formation by human osteoblasts via multiple pathways: relation with osteoblast function. J Cell Biochem 75:528-537
42. Justesen J, Mosekilde L, Holmes M, Stenderup K, Gasser J, Mullins JJ, Seckl JR, Kassem M 2004 Mice deficient in 11β-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. Endocrinology 145:1916-1925
43. Sher LB, Woitge HW, Adams DJ, Gronowicz GA, Krozowski Z, Harrison JR, Kream BE 2004 Transgenic expression of 11β-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Endocrinology 145: 922-929
44. Chiba H, Sawada N, Ono T, Ishii S, Mori M 1993 Establishment and characterization of a simian virus 40-immortalized osteoblastic cell line from normal human bone. Jpn J Cancer Res 84:290-297