Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy- 1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344)

Biochemical Pharmacology

Volumn 81, Issue 8, 2011, Pages 1028-1035

  Park, Ji Seon ^a   Rhee, Sang Dal ^a   Kang, Nam Sook ^a   Jung, Won Hoon ^a   Kim, Hee Youn ^a   Kim, Jun Hyoung ^a   Kang, Seung Kyu ^a   Cheon, Hyae Gyeong ^a   Ahn, Jin Hee ^a   Kim, Ki Young ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

11 Hydroxysteroid dehydrogenase type 1; Adipogenesis; Glucose tolerance; Metabolic syndrome; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 2 (3 BENZOYL) 4 HYDROXY 1,1 DIOXO 2H 1,2 BENZOTHIAZINE 2 YL 1 PHENYLETHANONE; ANTIDIABETIC AGENT; CORTISONE; ENZYME INHIBITOR; FATTY ACID BINDING PROTEIN 4; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; KR 66344; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CELL DIFFERENTIATION; DRUG EFFECT; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; MOUSE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; CORTISONE; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; LEPTIN; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; MUSCLE FIBERS, SKELETAL; OBESITY; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZINES;

EID: 79952992498     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.01.020     Document Type: Article

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