Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end osteocytes by glucocorticoids potential mechanisms of their deleterious effects on bone

Journal of Clinical Investigation

Volumn 102, Issue 2, 1998, Pages 274-282

  Weinstein, Robert S ^a,b   Jilka, Robert L ^a   Michael Parfitt, A ^a   Manolagas, Stavros C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Bone formation; Bone marrow cells; Osteoclasts; Osteoporosis; Remodeling

Indexed keywords

GLUCOCORTICOID; OSTEOCALCIN; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLAST TRANSFORMATION; BONE DISEASE; BONE TURNOVER; CANCELLOUS BONE; CELL MATURATION; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; OSTEOMETRY; OSTEOPOROSIS; PRIORITY JOURNAL;

EID: 0032528180     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2799     Document Type: Article

References (53)

1. Cushing, H. 1932. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull. Johns Hopkins Hosp. 50: 137-195.
2. Lukert, B. 1996. Glucocorticoid-induced osteoporosis. In Osteoporosis. R. Marcus, D. Feldman, and J. Kelsey, editors. Academic Press, San Diego, CA. 801-820.
3. Fitzpatrick, L.A. 1994. Glucocorticoid-induced osteoporosis. In Osteoporosis. R. Marcus, editor. Blackwell Scientific Publications, Boston, MA. 202-226.
4. Reid, I.R. 1989. Pathogenesis and treatment of steroid osteoporosis. Clin. Endocrinol. 30:83-103.
5. Dempster, D. 1989. Bone histomorphometry in glucocorticoid-induced osteoporosis. J. Bone Miner. Res. 4:137-141.
6. Mankin, H.J. 1992. Nontraumatic necrosis of bone (osteonecrosis). N. Engl. J. Med. 326:1473-1479.
7. Jilka, R.L., R.S. Weinstein, K. Takahashi, A.M. Parfitt, and S.C. Manolagas. 1996. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J. Clin. Invest. 97:1732-1740.
8. Jilka, R.L., R.S. Weinstein, T. Bellido, A.M. Parfitt, and S.C. Manolagas. 1998. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 13:793-802.
9. Weinstein, R.S., R.L. Jilka, A.M. Parfitt, and S.C. Manolagas. 1997. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology. 138: 4013-4021.
10. Frey, F.J. 1987. Kinetics and dynamics of prednisolone. Endocr. Rev. 8: 453-473.
11. Cope, C.L. 1972. The synthetic analogues. In Adrenal Steroids and Disease. Lippincott, Philadelphia, PA. 488-491.
12. Broulik, P.D., and L. Stárka. 1997. Effect of antiandrogens casodex and epitestosterone on bone composition in mice. Bone (Tarrytown). 20:473-475.
13. Weinstein, R.S., and N.H. Bell. 1988. Diminished rates of bone formation in normal black adults. N. Engl. J. Med. 319:1698-1701.
14. Parfitt, A.M., M.K. Drezner, F.H. Glorieux, J.A. Kanis, H. Malluche, P.J. Meunier, S.M. Ott, and R.R. Recker. 1987. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2:595-610.
15. Parfitt, A.M., C.H.E. Mathews, A.R. Villanueva, M. Kleerekoper, B. Frame, and D.S. Rao. 1983. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanism of bone loss. J. Clin. Invest. 72:1396-1409.
16. Bellows, C.G., J.E. Aubin, and J.N.M. Heersche. 1991. Initiation and progression of mineralization of bone nodules formed in vivo: the role of alkaline phosphatase and organic phosphate. Bone Miner. 14:27-40.
17. Owen, M. 1985. Lineage of osteogenic cells and their relationship to the stromal system. In Bone and Mineral Research. Volume 3. W.A. Peck, editor. Elsevier, Amsterdan. 1-25.
18. Falla, N., P. Van Vlasselaer, J. Bierkens, B. Borremans, G. Schoeters, and U. Van Gorp. 1993. Characterization of a 5-fluorouracil-enriched osteoprogenitor population of the murine bone marrow. Blood. 82:3580-3591.
19. Tomkinson, A., J. Reeve, R.W. Shaw, and B.S. Noble. 1997. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J. Clin. Endocrinol. Metab. 82:3128-3135.
20. Lynch, M.P., C. Capparelli, J.L. Stein, G.S. Stein and J.B. Lian. 1998. Apoptosis during bone-like tissue development in vitro. J. Cell. Biochem. 68: 31-49.
21. StatCorp. 1995. Stata Statistical Software Release 4.0. Stata Corporation, College Station, TX. 1-1601.
22. Jilka, R.L., G. Hangoc, G. Girasole, G. Passeri, D.C. Williams, J.S. Abrams, B. Boyce, H. Broxmeyer, and S.C. Manolagas. 1992. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 257: 88-91.
23. King, C.S., E.C. Weir, C.W. Gundberg, J. Fox, and K.L. Insogna. 1996. Effects of continuous glucocorticoid infusion on bone metabolism in the rat. Calcif. Tissue Int. 59:184-191.
24. Li, M., Y. Shen, B.P. Halloran, B.D. Baumann, K. Miller, and T.J. Wronski. 1996. Skeletal response to corticosteroid deficiency and excess in growing male rats. Bone (Tarrytown). 19:81-88.
25. Quarles, L.D. 1992. Prednisone-induced osteopenia in beagles: variable effects mediated by differential suppression of bone formation. Am. J. Physiol. (Endocrinol. Metab.). 263:E136-E141.
26. Grardel, B., B. Sutter, B. Flautre, E. Viguier, F. Lavaste, and P. Hardouin. 1994. Effects of glucocorticoids on skeletal growth in rabbits evalualed by dual-photon absorptiometry, microscopic connectivity and vertebral compressive strength. Osteoporosis Int. 4:204-210.
27. Kawai, K., A. Tamaki, and K. Hirohata. 1985. Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head. J. Bone Joint Surg. 67A:755-762.
28. Deloffre, P., D. Hans, C. Rumelhart, D. Mitton, Y. Tsouderos, and P.J. Meunier. 1995. Comparison between bone-density and bone strength in glucocorticoid-treated aged ewes. Bone (Tarrytown). 17:409S-414S.
29. Chavassieux, P., A. Buffet, P. Vergnaud, P. Garnero, and P.J. Meunier. 1997. Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Bone (Tarrytown). 20:451-455.
30. Newman, E., A.S. Turner, and J.D. Wark. 1995. The potential of sheep for the study of osteopenia: current status and comparison with other animal models. Bone (Tarrytown). 16:277S-284S.
31. Dempster, D.W., B.S. Moonga, L.S. Stein, W.R. Horbert, and T. Antakly. 1997. Glucocorticoids inhibit bone resorption by isolated osteoclasts by enhancing apoptosis. J. Endocrinol. 154:397-406.
32. Conaway, H.H., D. Grigorie, and U.H. Lerner. 1996. Stimulation of neonatal mouse calvarial bone resorption by the glucocorticoids hydrocortisone and dexamethasone. J. Bone Miner. Metab. 11:1419-1429.
33. Bellows, C.G., J.E. Aubin, and J.N.M. Heersche. 1987. Physiological concentrations of glucocorticoids stimulate formation of bone nodules from isolated rat calvarial cells in vitro. Endocrinology. 121:1985-1992.
34. Lian, J.B., V. Shalhoub, F. Aslam, B. Frenkel, J. Green, M. Hamrah, G.S. Stein, and J.L. Stein. 1997. Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression. Endocrinology. 138:2117-2127.
35. Stanton, B., G. Giebisch, G. Klein-Robbenhaar, J. Wade, and R.A. De-Fronzo. 1985. Effects of adrenalectomy and chronic corticosteroid replacement on potassium transport in rat kidney. J. Clin. Invest. 75:1317-1326.
36. Borchard, R.E., C.D. Barnes, and L.G. Eltherington. 1992. Drug Dosage in Laboratory Animals: A Handbook. CRC Press, Inc., Boca Raton, FL. 514-517.
37. Kleiber, M. 1961. The Fire of Life: An Introduction to Animal Energetics. John Wiley & Sons, Inc., New York. 177-230.
38. Klein, M., A.R. Villanueva, and H.M. Frost. 1965. A quantitative histological study of rib from 18 patients treated with adrenal cortical steroids. Acta Orthop. Scand. 35:171-184.
39. Bressot, C., P.J. Meunier, M.C. Chapuy, E. Lejeune, C. Edouard, and A.J. Darby. 1979. Histomorphometric profile, pathophysiology and reversibility of corticosteroid-induced osteoporosis. Metab. Bone Dis. Relat. Res. 1:303-311.
40. Parfitt, A.M., A.R. Villanueva, J. Foldes, and D.S. Rao. 1995. Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J. Bone Miner. Res. 10:466-473.
41. Parfitt, A.M. 1994. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human hone. J. Cell. Biochem. 55:273-286.
42. Manolagas, S.C., R.L. Jilka, T. Bellido, C.A. O'Brien, and A.M. Parfitt. 1996. Interleukin-6-type cytokines and their receptors. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego, CA. 701-713.
43. Parfitt, A.M. 1990. Bone-forming cells in clinical conditions. In Bone: A Treatise, Vol. 1. The Osteoblast and Osteocyte. B.K. Hall, editor. Telford and CRC Press, Boca Raton, FL. 351-429.
44. Bursch, W., S. Paffe, B. Putz, and R. Schulte-Hermann. 1990. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis. 11:847-583.
45. Cline, M.J. 1974. Drugs and phagocytes. N. Engl. J. Med. 291:1187-1188.
46. Gohel, A., and G. Gronowicz. 1997. Glucocorticoids induce apoptosis in osteoblasts in mice by the regulation of BCL-2, BAX and other cell cycle factors J. Bone Miner. Res. 12(Suppl. 1):S284. (Abstr.)
47. Frost, H.M. 1960. In vivo osteocyte cell death. J. Bone Joint Surg. 42A: 138-143.
48. Frost, H.M. 1960. Micropetrosis. J. Bone Joint Surg. 42A:144-150.
49. Dunstan, C.R., N.M. Somers, and R.A. Evans. 1993. Osteocyte death and hip fracture. Calcif. Tissue Int. 53:S113-S117.
50. Aarden, E.M., E.H. Burger, and P.J. Nijweide. 1994. Function of osteocytes in bone. J. Cell. Biochem. 55:287-299.
51. Noble, B.S., H. Stevens, N. Loveridge, and J. Reeve. 1997. Identification of apoptotic osteocytes in normal and pathological human bone. Bone (Tarrytown). 20:273-282.
52. Ficat, R.P. 1985. Idiopathic necrosis of the femoral head. J. Bone Joint Surg. 67B:3-9.
53. Felson, D.T., and J.J. Anderson. 1987. Across-study evaluation of association between steroid dose and bolus steroids and avascular necrosis of bone. Lancet. I:902-905.