11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 26, 1997, Pages 14924-14929

  Kotelevtsev, Yuri ^a   Holmes, Megan C ^a   Burchell, Ann ^b   Houston, Pamela M ^b   Schmoll, Dieter ^b   Jamieson, Pauline ^a   Best, Ruth ^a   Brown, Roger ^a   Edwards, Christopher R W ^a   Seckl, Jonathan R ^a   Mullins, John J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; CORTICOTROPIN; DEHYDROCORTICOSTERONE; GLUCOCORTICOID; GLUCOSE 6 PHOSPHATASE; HYDROCORTISONE; MESSENGER RNA; OXIDOREDUCTASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RECEPTOR; HYDROXYSTEROID DEHYDROGENASE;

ADRENAL HYPERPLASIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; GLUCONEOGENESIS; HYPERGLYCEMIA; MOUSE; NONHUMAN; NORTHERN BLOTTING; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; STRESS; ANIMAL; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; GLUCOCORTICOIDS; HUMANS; HYDROXYSTEROID DEHYDROGENASES; HYPERGLYCEMIA; MICE; MICE, KNOCKOUT; OBESITY; STRESS;

EID: 0031283178     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.26.14924     Document Type: Article

References (52)

1. Miller, W. L. & Tyrrell, J. B. (1995) in Endocrinology and Metabolism, eds. Felig, P., Baxter, J. D. & Frohman, L. (McGraw Hill, New York), 3rd Ed., pp. 555-711.
2. Evans, R. M. (1988) Science 240, 889-895.
3. Albiston, A. L., Obeyesekere, V. R., Smith, R. E. & Krozowski, Z. S. (1994) Mol. Cell. Endocrinol. 105, R11-R17.
4. Brown, R. W., Chapman, K. E, Kotelevtsev, Y., Leckie, C., Lindsay, R. S., Lyons, V., Murad, P., Mullins, J. J., Edwards, C. R. W. & Seckl, J. R. (1996) Biochem. J. 313, 1007-1017.
5. Edwards, C. R. W., Stewart, P. M., Burt, D., Brett, L., McIntyre, M. A., Sutanto, W. S., de Kloet, E. R. & Monder, C. (1988) Lancet 2, 986-989.
6. Funder, J. W., Pearce, P. T., Smith, R. & Smith, A. I. (1988) Science 242, 583-585.
7. Wilson, R. C., Krozowski, Z. S., Lee, K., Obeyesekere, V. R., Razzaghy-Azar, M., Harbison, M. D., Wei, J. Q., Shackleton, C., Funder, J. W. & New, M. I. (1995) J. Clin. Endocrinol. Metab. 80, 2263-2266.
8. Mune, T., Rogerson, F., Nikkila, H., Agarwal, A. K. & White, P. C. (1995) Nat. Genet. 10, 394-399.
9. Stewart, P. M., Krozowski, Z. S., Gupta, A., Milford, D. V., Howie, A. J., Sheppard, M. C. & Whorwood, C. B. (1996) Lancet 347, 88-91.
10. Lakshmi, V. & Monder, C. (1988) Endocrinology 123, 2390-2398.
11. Agarwal, A. K., Monder, C., Eckstein, B. & White, P. C. (1989) J. Biol. Chem. 264, 18939-18943.
12. Whorwood, C. B., Franklyn, J. A., Sheppard, M. C. & Stewart, P. M. (1991) J. Steroid. Biochem. Mol. Biol. 41, 21-28.
13. Low, S. C., Chapman, K. E., Edwards, C. R. W. & Seckl, J. R. (1994) J. Mol. Endocrinol. 13, 167-174.
14. Duperrex, H., Kenouch, S., Gaegeler, H.-P., Seckl, J. R., Edwards, C. R. W., Farman, N. & Rossier, B. C. (1993) Endocrinology 132, 612-619.
15. Jamieson, P. M., Chapman, K. E., Edwards, C. R. W. & Seckl, J. R. (1995) Endocrinology 136, 4754-4761.
16. Rajan, V., Edwards, C. R. W. & Seckl, J. R. (1996) J. Neurosci. 16, 65-70.
17. Hundertmark, S., Buhler, H., Ragosch, V., Dinkelborg, L., Arabin, B. & Weitzel, H. K. (1995) Endocrinology 136, 2573-2578.
18. Brem, A. S., Bina, R. B., King, T. & Morris, D. J. (1995) Steroids 60, 406-410.
19. Rajan, V., Chapman, K. E., Lyons, V., Jamieson, P., Mullins, J. J., Edwards, C. R. W. & Seckl, J. R. (1995) J. Steroid Biochem. Mol. Biol. 52, 141-147.
20. Clark, A. F., Sharp, M. G. F., Morley, S. D., Fleming, S., Peters, J. & Mullins, J. J. (1997) J. Biol. Chem. 272, 18185-18190.
21. Low, S. C., Moisan, M.-P., Edwards, C. R. W. & Seckl, J. R. (1994) J. Neuroendocrinol. 6, 285-290.
22. Brown, R. W., Chapman K. E., Edwards C. R. W. & Seckl, J. R. (1993) Endocrinology 132, 2614-2621.
23. Shackleton, C. H. L. & Honour, J. (1976) Clin. Chim. Acta. 69, 267-283.
24. Best, R. & Walker, B. R. (1997) Clin. Endocrinol. 47, 231-236.
25. MacPhee, I. A. M., Antoni, F. A. & Mason, D. W. (1989) J. Exp. Med. 169, 431-445.
26. Lindsay, R. S., Lindsay, R. M., Waddell, B. & Seckl, J. R. (1996) Diabetologia 39, 1299-1305.
27. Blair, J. N. & Burchell, A. (1988) Biochem. Biophys. Acta 964, 161-167.
28. Burchell, A., Hume, R. & Burchell, B. (1988) Clin. Chim. Acta 173, 183-192.
29. Petrescu, I., Bojan, O., Saied, M., Barzu, O., Schmidt, F. & Kuhnle, H. F. (1979) Anal. Biochem. 96, 279-281.
30. Davidson, T. A. & Arion, W. J. (1987) Arch. Biochem. Biophys. 156-157.
31. Van Handel, E. (1965) Anal. Biochem. 11, 256-265.
32. Peterson, G. L. (1977) Anal. Biochem. 83, 346-356.
33. Ikemoto, S., Thompson, K. S., Takahashi, M., Itakura, H., Lane, M. D. & Ezaki, O. (1995) Proc. Natl. Acad. Sci. USA 92, 3096-3099.
34. Diaz, R., Brown, R. W. & Seckl, J. R. (1997) J. Neurosci., in press.
35. Lindsay, R. S., Lindsay, R. M., Edwards, C. R. W. & Seckl, J. R. (1996) Hypertension 27, 1200-1204.
36. Brown, R. W., Diaz, R., Robson, A. C., Kotelevtsev, Y., Mullins, J. J., Kaufman, M. H. & Seckl, J. R. (1996) Endocrinology 137, 794-797.
37. Phillips, M. D., Lakshmi, V. & Monder, C. (1989) Endocrinology 125, 209-216.
38. Benediktsson, R., Yau, J. L. W., Low, S. C., Brett, L., Cooke, B. A., Edwards, C. R. W. & Seckl, J. R. (1992) J. Endocrinol. 135, 53-58.
39. Monder, C., Miroff, Y., Marandici, A. & Hardy, M. P. (1994) Endocrinology 134, 1199-1204.
40. Walker, B. R., Campbell, J. C., Fraser, R., Stewart, P. M. & Edwards, C. R. W. (1992) Clin. Endocrinology 37, 483-492.
41. Phillipou, G. & Higgins, B. A. (1985) J. Steroid Biochem. 22, 435-436.
42. Moisan, M.-P., Seckl, J. R. & Edwards, C. R. W. (1990) Endocrinology 127, 1450-1455.
43. Sakai, R. R., Lakshmi, V., Monder, C. & McEwen, B. S. (1992) J. Neuroendocrinol. 4, 101-106.
44. Seckl, J. R., Dow, R. C., Low, S. C., Edwards, C. R. W. & Fink, G. (1993) J. Endocrinol. 136, 471-477.
45. Pilkis, S. J. & Granner, D. K. (1992) Annu. Rev. Physiol. 54, 885-909.
46. Imai, E., Stromstedt, P. E., Quinn, P. G., Carlstedt-Duke, J., Gustafsson, J.-A. & Granner, D. K. (1990) Mol. Cell. Biol. 10, 4712-4719.
47. Lange, A. J., Argaud, D., Eimaghrabi, M. R., Pan, W. S., Maitra, S. R. & Pilkis, S. J. (1994) Biochem. Biophys. Res. Commun. 201, 302-309.
48. Cole, T. J., Blendy, J. A., Monaghan, A. P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K. & Schutz, G. (1995) Genes Dev. 9, 1608-1621.
49. Imai, E., Miner, J. A., Mitchell, K. R., Yamamoto, K. R. & Granner, D. K. (1993) J. Biol. Chem. 268, 5353-5356.
50. Gayrard, V., Alvinerie, M. & Toutain, P. L. (1996) Domest. Anim. Endocrinol. 13, 35-45.
51. Meikle, A. W. (1989) in Endocrinology, ed. DeGroot, L. J. (Saunders, Philadelphia), pp. 1610-1632.
52. Walker, B. R., Connacher, A. A., Lindsay, R. M., Webb, D. J. & Edwards, C. R. W. (1995) J. Clin. Endocrinol. Metab. 80, 3155-3159.