-
1
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
-
Abel E.D., Peroni O., Kim J.K., Kim Y.B., Boss O., Hadro E., Minnemann T., Shulman G.I., and Kahn B.B. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409 (2001) 729-733
-
(2001)
Nature
, vol.409
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
Kim, Y.B.4
Boss, O.5
Hadro, E.6
Minnemann, T.7
Shulman, G.I.8
Kahn, B.B.9
-
2
-
-
0033515761
-
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
-
Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J., Hotta K., Shimomura I., Nakamura T., Miyaoka K., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257 (1999) 79-83
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, pp. 79-83
-
-
Arita, Y.1
Kihara, S.2
Ouchi, N.3
Takahashi, M.4
Maeda, K.5
Miyagawa, J.6
Hotta, K.7
Shimomura, I.8
Nakamura, T.9
Miyaoka, K.10
-
4
-
-
0036790535
-
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia
-
Boord J.B., Maeda K., Makowski L., Babaev V.R., Fazio S., Linton M.F., and Hotamisligil G.S. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1686-1691
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 1686-1691
-
-
Boord, J.B.1
Maeda, K.2
Makowski, L.3
Babaev, V.R.4
Fazio, S.5
Linton, M.F.6
Hotamisligil, G.S.7
-
5
-
-
4544298808
-
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice
-
Boord J.B., Maeda K., Makowski L., Babaev V.R., Fazio S., Linton M.F., and Hotamisligil G.S. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110 (2004) 1492-1498
-
(2004)
Circulation
, vol.110
, pp. 1492-1498
-
-
Boord, J.B.1
Maeda, K.2
Makowski, L.3
Babaev, V.R.4
Fazio, S.5
Linton, M.F.6
Hotamisligil, G.S.7
-
6
-
-
0032214652
-
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
-
Bruning J.C., Michael M.D., Winnay J.N., Hayashi T., Horsch D., Accili D., Goodyear L.J., and Kahn C.R. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2 (1998) 559-569
-
(1998)
Mol. Cell
, vol.2
, pp. 559-569
-
-
Bruning, J.C.1
Michael, M.D.2
Winnay, J.N.3
Hayashi, T.4
Horsch, D.5
Accili, D.6
Goodyear, L.J.7
Kahn, C.R.8
-
7
-
-
0142164965
-
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
-
Chavez J.A., and Summers S.A. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419 (2003) 101-109
-
(2003)
Arch. Biochem. Biophys.
, vol.419
, pp. 101-109
-
-
Chavez, J.A.1
Summers, S.A.2
-
8
-
-
0037067570
-
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
-
Cohen P., Miyazaki M., Socci N.D., Hagge-Greenberg A., Liedtke W., Soukas A.A., Sharma R., Hudgins L.C., Ntambi J.M., and Friedman J.M. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297 (2002) 240-243
-
(2002)
Science
, vol.297
, pp. 240-243
-
-
Cohen, P.1
Miyazaki, M.2
Socci, N.D.3
Hagge-Greenberg, A.4
Liedtke, W.5
Soukas, A.A.6
Sharma, R.7
Hudgins, L.C.8
Ntambi, J.M.9
Friedman, J.M.10
-
9
-
-
4344639664
-
Microdetermination of long-chain fatty acids in plasma and tissues
-
Dole V.P., and Meinertz H. Microdetermination of long-chain fatty acids in plasma and tissues. J. Biol. Chem. 235 (1960) 2595-2599
-
(1960)
J. Biol. Chem.
, vol.235
, pp. 2595-2599
-
-
Dole, V.P.1
Meinertz, H.2
-
10
-
-
0031974818
-
Overweight and obesity in the United States: prevalence and trends, 1960-1994
-
Flegal K.M., Carroll M.D., Kuczmarski R.J., and Johnson C.L. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int. J. Obes. Relat. Metab. Disord. 22 (1998) 39-47
-
(1998)
Int. J. Obes. Relat. Metab. Disord.
, vol.22
, pp. 39-47
-
-
Flegal, K.M.1
Carroll, M.D.2
Kuczmarski, R.J.3
Johnson, C.L.4
-
11
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
12
-
-
0035852760
-
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
-
Fruebis J., Tsao T.S., Javorschi S., Ebbets-Reed D., Erickson M.R., Yen F.T., Bihain B.E., and Lodish H.F. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA 98 (2001) 2005-2010
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 2005-2010
-
-
Fruebis, J.1
Tsao, T.S.2
Javorschi, S.3
Ebbets-Reed, D.4
Erickson, M.R.5
Yen, F.T.6
Bihain, B.E.7
Lodish, H.F.8
-
13
-
-
0020545022
-
A radiochemical procedure for the assay of fatty acid binding by proteins
-
Glatz J.F., and Veerkamp J.H. A radiochemical procedure for the assay of fatty acid binding by proteins. Anal. Biochem. 132 (1983) 89-95
-
(1983)
Anal. Biochem.
, vol.132
, pp. 89-95
-
-
Glatz, J.F.1
Veerkamp, J.H.2
-
14
-
-
0037197693
-
Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA
-
Gomez F.E., Miyazaki M., Kim Y.C., Marwah P., Lardy H.A., Ntambi J.M., and Fox B.G. Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry 41 (2002) 5473-5482
-
(2002)
Biochemistry
, vol.41
, pp. 5473-5482
-
-
Gomez, F.E.1
Miyazaki, M.2
Kim, Y.C.3
Marwah, P.4
Lardy, H.A.5
Ntambi, J.M.6
Fox, B.G.7
-
15
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., Karin M., and Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 420 (2002) 333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
16
-
-
0029847504
-
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
-
Hotamisligil G.S., Johnson R.S., Distel R.J., Ellis R., Papaioannou V.E., and Spiegelman B.M. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 (1996) 1377-1379
-
(1996)
Science
, vol.274
, pp. 1377-1379
-
-
Hotamisligil, G.S.1
Johnson, R.S.2
Distel, R.J.3
Ellis, R.4
Papaioannou, V.E.5
Spiegelman, B.M.6
-
17
-
-
0034880181
-
Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR
-
Kaushik V.K., Young M.E., Dean D.J., Kurowski T.G., Saha A.K., and Ruderman N.B. Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am. J. Physiol. Endocrinol. Metab. 281 (2001) E335-E340
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.281
-
-
Kaushik, V.K.1
Young, M.E.2
Dean, D.J.3
Kurowski, T.G.4
Saha, A.K.5
Ruderman, N.B.6
-
18
-
-
0037315168
-
Role of the fatty acid binding protein mal1 in obesity and insulin resistance
-
Maeda K., Uysal K.T., Makowski L., Gorgun C.Z., Atsumi G., Parker R.A., Bruning J., Hertzel A.V., Bernlohr D.A., and Hotamisligil G.S. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52 (2003) 300-307
-
(2003)
Diabetes
, vol.52
, pp. 300-307
-
-
Maeda, K.1
Uysal, K.T.2
Makowski, L.3
Gorgun, C.Z.4
Atsumi, G.5
Parker, R.A.6
Bruning, J.7
Hertzel, A.V.8
Bernlohr, D.A.9
Hotamisligil, G.S.10
-
19
-
-
0034959752
-
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
-
Makowski L., Boord J.B., Maeda K., Babaev V.R., Uysal K.T., Morgan M.A., Parker R.A., Suttles J., Fazio S., Hotamisligil G.S., and Linton M.F. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat. Med. 7 (2001) 699-705
-
(2001)
Nat. Med.
, vol.7
, pp. 699-705
-
-
Makowski, L.1
Boord, J.B.2
Maeda, K.3
Babaev, V.R.4
Uysal, K.T.5
Morgan, M.A.6
Parker, R.A.7
Suttles, J.8
Fazio, S.9
Hotamisligil, G.S.10
Linton, M.F.11
-
20
-
-
0032779351
-
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances
-
Matsuzawa Y., Funahashi T., and Nakamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann. N Y Acad. Sci. 892 (1999) 146-154
-
(1999)
Ann. N Y Acad. Sci.
, vol.892
, pp. 146-154
-
-
Matsuzawa, Y.1
Funahashi, T.2
Nakamura, T.3
-
21
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., and Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
22
-
-
1842405349
-
Leptin directly alters lipid partitioning in skeletal muscle
-
Muoio D.M., Dohm G.L., Fiedorek Jr. F.T., Tapscott E.B., Coleman R.A., and Dohn G.L. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46 (1997) 1360-1363
-
(1997)
Diabetes
, vol.46
, pp. 1360-1363
-
-
Muoio, D.M.1
Dohm, G.L.2
Fiedorek Jr., F.T.3
Tapscott, E.B.4
Coleman, R.A.5
Dohn, G.L.6
-
23
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., and Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004) 457-461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
24
-
-
0037040994
-
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
-
Razani B., Combs T.P., Wang X.B., Frank P.G., Park D.S., Russell R.G., Li M., Tang B., Jelicks L.A., Scherer P.E., and Lisanti M.P. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277 (2002) 8635-8647
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8635-8647
-
-
Razani, B.1
Combs, T.P.2
Wang, X.B.3
Frank, P.G.4
Park, D.S.5
Russell, R.G.6
Li, M.7
Tang, B.8
Jelicks, L.A.9
Scherer, P.E.10
Lisanti, M.P.11
-
25
-
-
0035936763
-
New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
-
Saltiel A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104 (2001) 517-529
-
(2001)
Cell
, vol.104
, pp. 517-529
-
-
Saltiel, A.R.1
-
26
-
-
0032882081
-
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice
-
Scheja L., Makowski L., Uysal K.T., Wiesbrock S.M., Shimshek D.R., Meyers D.S., Morgan M., Parker R.A., and Hotamisligil G.S. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes 48 (1999) 1987-1994
-
(1999)
Diabetes
, vol.48
, pp. 1987-1994
-
-
Scheja, L.1
Makowski, L.2
Uysal, K.T.3
Wiesbrock, S.M.4
Shimshek, D.R.5
Meyers, D.S.6
Morgan, M.7
Parker, R.A.8
Hotamisligil, G.S.9
-
28
-
-
0030829812
-
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
-
Shimano H., Shimomura I., Hammer R.E., Herz J., Goldstein J.L., Brown M.S., and Horton J.D. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100 (1997) 2115-2124
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2115-2124
-
-
Shimano, H.1
Shimomura, I.2
Hammer, R.E.3
Herz, J.4
Goldstein, J.L.5
Brown, M.S.6
Horton, J.D.7
-
29
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman G.I. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106 (2000) 171-176
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
30
-
-
0035158444
-
Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique
-
Sjogren K., Hellberg N., Bohlooly Y.M., Savendahl L., Johansson M.S., Berglindh T., Bosaeus I., and Ohlsson C. Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique. J. Nutr. 131 (2001) 2963-2966
-
(2001)
J. Nutr.
, vol.131
, pp. 2963-2966
-
-
Sjogren, K.1
Hellberg, N.2
Bohlooly, Y.M.3
Savendahl, L.4
Johansson, M.S.5
Berglindh, T.6
Bosaeus, I.7
Ohlsson, C.8
-
32
-
-
0034655590
-
Leptin-specific patterns of gene expression in white adipose tissue
-
Soukas A., Cohen P., Socci N.D., and Friedman J.M. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 14 (2000) 963-980
-
(2000)
Genes Dev.
, vol.14
, pp. 963-980
-
-
Soukas, A.1
Cohen, P.2
Socci, N.D.3
Friedman, J.M.4
-
33
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman B.M., and Flier J.S. Obesity and the regulation of energy balance. Cell 104 (2001) 531-543
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
34
-
-
0034676629
-
Cytokines in alcoholic and nonalcoholic steatohepatitis
-
Tilg H., and Diehl A.M. Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. 343 (2000) 1467-1476
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1467-1476
-
-
Tilg, H.1
Diehl, A.M.2
-
35
-
-
0034907579
-
Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles
-
Tong P., Khayat Z.A., Huang C., Patel N., Ueyama A., and Klip A. Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles. J. Clin. Invest. 108 (2001) 371-381
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 371-381
-
-
Tong, P.1
Khayat, Z.A.2
Huang, C.3
Patel, N.4
Ueyama, A.5
Klip, A.6
-
36
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal K.T., Wiesbrock S.M., Marino M.W., and Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389 (1997) 610-614
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
37
-
-
0034457430
-
Improved glucose and lipid metabolism in genetically obese mice lacking aP2
-
Uysal K.T., Scheja L., Wiesbrock S.M., Bonner-Weir S., and Hotamisligil G.S. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141 (2000) 3388-3396
-
(2000)
Endocrinology
, vol.141
, pp. 3388-3396
-
-
Uysal, K.T.1
Scheja, L.2
Wiesbrock, S.M.3
Bonner-Weir, S.4
Hotamisligil, G.S.5
-
38
-
-
0032792665
-
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
-
Winder W.W., and Hardie D.G. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am. J. Physiol. 277 (1999) E1-10
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Winder, W.W.1
Hardie, D.G.2
-
39
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7 (2001) 941-946
-
(2001)
Nat. Med.
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
Kubota, N.5
Hara, K.6
Mori, Y.7
Ide, T.8
Murakami, K.9
Tsuboyama-Kasaoka, N.10
-
40
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., and Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293 (2001) 1673-1677
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
41
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P., Alberti K.G., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 (2001) 782-787
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
|