Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure

Diabetes

Volumn 61, Issue 3, 2012, Pages 642-652

  Turban, Sophie ^a   Liu, Xiaoxia ^a   Ramage, Lynne ^a   Webster, Scott P ^a   Walker, Brian R ^a   Dunbar, Donald R ^a   Mullins, John J ^a   Seckl, Jonathan R ^a   Morton, Nicholas M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CELL FUNCTION; CELL SPECIFICITY; CONTROLLED STUDY; GLUCOSE TOLERANCE; HEAT SHOCK; HOMOZYGOSITY; INSULIN RELEASE; INTRACELLULAR SIGNALING; LIPID DIET; MALE; METABOLIC DISORDER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; PALMITIC ACID;

EID: 84863155270     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1054     Document Type: Article

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