Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 10, 2005, Pages 5656-5662

  Giordano, Roberta ^a   Bo, Mario ^a,b,c   Pellegrino, Micaela ^a   Vezzari, Marco ^b   Baldi, Matteo ^a   Picu, Andreea ^a   Balbo, Marcella ^a   Bonelli, Lorenza ^a   Migliaretti, Giuseppe ^a   Ghigo, Ezio ^a   Arvat, Emanuela ^a,c  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANRENOIC ACID; CORTICOTROPIN; HYDROCORTISONE; MINERALOCORTICOID RECEPTOR; PLACEBO; PRASTERONE;

ADULT; AGED; AGING; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; HIPPOCAMPUS; HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STIMULATION;

ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; AGING; ALDOSTERONE ANTAGONISTS; CANRENOATE POTASSIUM; CIRCADIAN RHYTHM; DEHYDROEPIANDROSTERONE; DRUG RESISTANCE; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE; STIMULATION, CHEMICAL;

EID: 26244458148     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0105     Document Type: Article

References (45)

1. Orth DN 1992 Corticotropin-releasing hormone in humans. Endocr Rev 13:164-191
2. Gaillard RC, Al Damluji S 1987 Stress and the pituitary-adrenal axis. Bailliere Clin Endocrinol Metab 1:319-354
3. Jacobson L, Sapolsky R 1991 The role of hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12:118-134
4. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M 1998 Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269-301
5. Funder JW 1997 Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance. Annu Rev Med 48:231-240
6. Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H 1998 The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans. J Clin Endocrinol Metab 83:3339-3345
7. Dodt C, Kern W, Fehm HL, Born J 1993 Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humans. Neuroendocrinology 58:570-574
8. Deuschle M, Weber B, Colla M, Muller M, Kniest A, Heuser I 1998 Mineralocorticoid receptor also modulates basal activity of hypothalamus- pituitary-adrenocortical system in humans. Neuroendocrinology 68:355-360
9. Arvat E, Maccagno B, Giordano R, Pellegrino M, Broglio F, Gianotti L, Maccario M, Camanni F, Ghigo E 2001 Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans. J Clin Endocrinol Metab 86:3176-3181
10. Wellhoener P, Born J, Fehm HL, Dodt C 2004 Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans. J Clin Endocrinol Metab 89:5048-5052
11. Wiedemann K, Lauer C, Pollmacher T, Holsboer F 1994 Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males. Am J Physiol 267:E109-E114
12. Sapolsky RM, Krey LC, McEwen B 1986 The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 7:284-301
13. Seeman TE, Robbins RJ 1994 Aging and hypothalamic-pituitary-adrenal response to challenge in humans. Endocr Rev 15:233-260
14. Wang PS, Lo MJ, Kau MM 1997 Glucocorticoids and aging. J Form Med Association 96:792-801
15. Sherman B, Wysham C, Pfohl B 1985 Age-related changes in the circadian rhythm of plasma cortisol in man. J Clin Endocrinol Metab 61:439-443
16. Dodt C, Theine K, Uthgenannt D, Born J, Fehm HL 1994 Basal secretory activity of the hypothalamo-pituitary-adrenocortical axis is enhanced in healthy elderly. An assessment during undisturbed night-time sleep. Eur J Endocrinol 131:443-450
17. Van Cauter E, Leproult R, Kupfer DJ 1996 Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 81:2468-2473
18. Born J, Ditschuneit I, Schreiber M, Dodt C, Fehm HL 1995 Effects of age and gender on pituitary-adrenocortical responsiveness in humans. Eur J Endocrinol 132:705-711
19. Pavlov EP, Harman SM, Chrousos GP, Loriaux DL, Blackman MR 1986 Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men. J Clin Endocrinol Metab 62:767-772
20. Vermeulen A, Deslypere JP, Schelfhout W, Verdonck L, Rubens R 1982 Adrenocortical function in old age: response to acute adrenocorticotropin stimulation. J Clin Endocrinol Metab 54:187-191
21. Roberts NA, Barton RN, Horan MA 1990 Aging and the sensitivity of the adrenal gland to physiological doses of ACTH in man. J Endocrinology 126:507-513
22. Parker CR, Slayden SM, Azziz R, Crabbe SL, Hines GA, Boots LR, Bae S 2000 Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Metab 85:48-54
23. Giordano R, Di Vito L, Lanfranco F, Broglio F, Benso A, Gianotti L, Grottoli S, Ghigo E, Arvat E 2001 Elderly subjects show severe impairment of dehydroepiandrosterone sulphate and reduced sensitivity of cortisol and aldosterone response to the stimulatory effect of ACTH(1-24). Clin Endocrinol (Oxf) 55:259-265
24. Kovacs KJ, Makara GB 1988 Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 474:205-210
25. Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER 1998 Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139:1789-1793
26. Wilkinson CW, Peskind ER, Raskind MA 1997 Decreased hypothalamic- pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging. Neuroendocrinology 65:79-90
27. Boscaro M, Paoletta V, Scarpa E, Barzon L, Fusaro P, Fallo F, Sonino N 1998 Age-related changes in glucocorticoid fast feedback inhibition of adrenocorticotropin in man. J Clin Endocrinol Metab 83:1380-1383
28. Orentreich N, Brind JL, Rizer RL, Vogelman JK 1984 Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59:551-555
29. Liu CH, Laughlin GA, Fischer UG, Yen SSC 1990 Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20-desmolase enzymatic activity. J Clin Endocrinol Metab 71:900-906
30. Baulieu EE 1996 Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metab 81:3147-3151
31. Labrie F, Belanger A, Cusan L, Gomez JL, Candas B 1997 Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82:2396-2402
32. Mazza E, Maccario M, Ramunni J, Gauna C, Bertagna A, Barberis AM, Patroncini S, Messina M, Ghigo E 1999 Dehydroepiandrosterone sulfate levels in women. Relationships with age, body mass index and insulin levels. J Endocrinol Invest 22:681-687
33. Parker CR, Mixon RL, Brissie RM, Grizzle WE 1997 Aging alters zonation in the adrenal cortex of men. J Clin Endocrinol Metab 82:3898-3901
34. Ravaglia G, Forti P, Maioli F, Boschi F, Bernardi M, Pratelli L, Pizzoferrato A, Gasbarrini G 1996 The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab 81:1173-1178
35. Deuschle M, Gotthardt U, Schweiger U, Weber B, Korner A, Schmider J, Standhardt H, Lammers CH, Heuser I 1997 With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sci 61:2239-2246
36. Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH 2004 Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. J Clin Endocrinol Metab 89:281-287
37. Waltman C, Blackman MR, Chrousos GP, Riemann C, Harman SM 1991 Spontaneous and glucocorticoid-inhibited adrenocorticotropic hormone and cortisol secretion are similar in healthy young and old men. J Clin Endocrinol Metab 73:495-502
38. Dodt C, Dittmann J, Hruby J, Spath-Schwalbe E, Born J, Schuttler R, Fehm HL 1991 Different regulation of adrenocorticotropin and cortisol secretion in young, mentally healthy elderly and patients with senile dementia of Alzheimer's type. J Clin Endocrinol Metab 72:272-276
39. Touitou Y, Sulon J, Bogdan A, Touitou C, Reinberg A, Beck H, Sodoyez JC, Demey-Ponsart E, Van Cauwenberge H 1982 Adrenal circadian system in young and elderly human subjects: a comparative study. J Endocrinol 93:201-210
40. Orth DN, Kowacs WJ 1992 The adrenal cortex. In: Wilson JD, Foster DW, eds. Williams textbook of endocrinology. Philadelphia: Saunders Co.; 534-544
41. Aimaretti G, Baffoni C, Ambrosio MR, Maccario M, Corneli G, Bellone S, Gasperi M, Degli Uberti E, Ghigo E 2000 DHEA-S levels in hypopituitaric patients with severe GH deficiency are strongly reduced across lifespan. Comparison with IGF-I levels before and during rhGH replacement. J Endocrinol Invest 23:5-11
42. Huizenga NATM, Koper JW, De Lange P, Pols HAP, Stolk RP, Grobbee DE, De Jong FH, Lamberts SWJ 1998 Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab 83:47-54
43. Cheng SC, Suzuki K, Sadee W, Harding BW 1976 Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11β- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinology 99:1097-1106
44. Oelkers W 1996 Dose-response aspects in the clinical assessment of the hypothalamo-pituitary-adrenal axis, and the low-dose adrenocorticotropin test. Eur J Endocrinol 135:27-33
45. Arvat E, Di Vito L, Lanfranco F, Maccario M, Baffoni C, Rossetto R, Aimaretti G, Camanni F, Ghigo E 2000 Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study. J Clin Endocrinol Metab 85:3141-3146