Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

Diabetologia

Volumn 45, Issue 11, 2002, Pages 1528-1532

  Alberts, P ^a   Engblom, L ^a   Edling, N ^a   Forsgren, M ^a   Klingstrom, G ^b   Larsson, C ^b   Ronquist Nii, Y ^a   Ohman, B ^a   Abrahmsen, L ^a  

^a Department of Biology ^*  (Sweden)

^b BIOVITRUM AB   (Sweden)

Author keywords

11 HSD1; Blood glucose; Diabetes; Gluconeogenesis; Glucose 6 phosphatase; Hydroxysteroid dehydrogenases; Hyperglycaemia; Oral pharmacotherapy; Pharmacology; Phosphoenolpyruvate carboxykinase GTP

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 3 CHLORO 2 METHYL N (4 (2 (4 METHYL 1 PIPERAZINYL) 2 OXOETHYL) 1,3 THIAZOL 2 YL)BENZENESULFONAMIDE; 3-CHLORO-2-METHYL-N-(4-(2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL)-1,3-THIAZOL-2-YL)BENZENESULFONAMIDE; ENZYME INHIBITOR; HSD11B1 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIPERAZINE DERIVATIVE; PRIMER DNA; SULFONAMIDE; THIAZOLE DERIVATIVE; 3 CHLORO 2 METHYL N [4 [2 (4 METHYL 1 PIPERAZINYL) 2 OXOETHYL] 1,3 THIAZOL 2 YL]BENZENESULFONAMIDE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LIVER; MALE; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BODY WEIGHT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD INTAKE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; LIVER FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; DNA PRIMERS; ENZYME INHIBITORS; HYDROXYSTEROID DEHYDROGENASES; HYPERGLYCEMIA; LIVER; MALE; MICE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIPERAZINES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES; THIAZOLES;

EID: 0036432995     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0959-6     Document Type: Article

References (24)

1. DeFronzo RA “1997” Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 5: 177-269
2. Britton SW, Silvette H “1932” Effects of cortico-adrenal extract on carbohydrate metabolism in normal animals. Am J Physiol 100: 693-700
3. Long CNH, Katzin B, Fry EG “1940” The adrenal cortex and carbohydrate metabolism. Endocrinology 26: 309-344
4. Rizza RA, Mandarino LJ, Gerich JE “1982” Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 54: 131-138
5. Friedman JE, Yun JS, Patel YM, McGrane MM, Hanson RW “1993” Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase “GTP” gene transcription during diabetes. J Biol Chem 268: 12952-12957
6. Hanson RW, Reshef L “1997” Regulation of phosphoenol-pyruvate carboxykinase “GTP” gene expression. Annu Rev Biochem 66: 581-611
7. Edwards CR, Stewart PM, Burt D et al. “1988” Localisation of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet ii: 986-989
8. Funder JW, Pearce PT, Smith R, Smith AI “1988” Mineral-ocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science 242: 583-585
9. Seckl JR, Chapman KE “1997” The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action. Medical and physiological aspects of the 11β-hydroxysteroid dehydrogenase system. Eur J Biochem 249: 361-364
10. Stewart PM, Krozowski ZS “1999” 11β-hydroxysteroid dehydrogenase. Vitam Horm 57: 249-324
11. Nobel S, Abrahmsen L, Oppermann U “2001” Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones. Eur J Biochem 268: 4113-4125
12. Rask E, Olsson T, Soderberg S et al. “2001” Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86: 1418-1421
13. Davani B, Khan A, Hult M et al. “2000” Type 1 11β-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem 275: 34841-34844
14. Brown RW, Chapman K, Edwards CRW, Seckl JR “1993” Human placental 11β-hydroxysteroid dehydrogenase: Evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinol 132: 2614-2621
15. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS “1994” Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105: R11-R17
16. Naray-Fejes-Toth A, Fejes-Toth G “1995” Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells. Endocrinology 136: 2579-2586
17. Kotelevtsev Y, Brown RW, Fleming S et al. “1999” Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2. J Clin Invest 103: 683-689
18. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CRW “1995” Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 80: 3155-3159
19. Kotelevtsev Y, Holmes MC, Burchell A et al. “1997” 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94: 14924-14929
20. Masuzaki H, Paterson J, Shinyama H et al. “2001” A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170
21. Holmes MC, Kotelevtsev Y, Mullins JJ, Seckl JR “2001” Phenotypic analysis of mice bearing targeted deletions of 11β-hydroxysteroid dehydrogenases 1 and 2 genes. Mol Cell Endocrinol 171: 15-20
22. Jellinck PH, Monder C, McEwen BS, Sakai RR “1993” Differential inhibition of 11β-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J Steroid Biochem Mol Biol 46: 209-213
23. Whorwood CB, Sheppard MC, Stewart PM “1993” Licorice inhibits 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocortocoid hormone action. Endocrinology 132: 2287-2293
24. Sandeep TC, Walker BR “2001” Pathophysiology of modulation of local glucocorticoid levels by 11β-hydroxysteroid dehydrogenases. Trends Endocrinol Metab 12: 446-453