Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats

Hormone and Metabolic Research

Volumn 43, Issue 4, 2011, Pages 275-281

  Rafacho, A ^a,b,c   Abrantes, J L F ^b   Ribeiro, D L ^a,d   Paula, F M ^b   Pinto, M E ^a   Boschero, A C ^b   Bosqueiro, J R ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^d FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

beta cell proliferation; dexamethasone; glucocorticoid; insulin resistance; insulin secretion; short and long term treatment

Indexed keywords

CD2 ANTIGEN; CYCLIN DEPENDENT KINASE 4; DEXAMETHASONE; GLUCOSE; INSULIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; LONG TERM CARE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; TREATMENT DURATION;

ANIMALS; CELL PROLIFERATION; DEXAMETHASONE; GLUCOSE; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; TIME;

RATTUS;

EID: 79953272271     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0030-1269896     Document Type: Article

References (23)

1. Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002 96 23-43 (Pubitemid 35346616)
2. Andrews RC, Walker BR. Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci 1999 96 513-523 (Pubitemid 29237902)
3. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993 42 1663-1672 (Pubitemid 23318125)
4. Karlsson S, Ostlund B, Myrsén-Axcrona U, Sundler F, Ahrén B. Beta cell adaptation to dexamethasone-induced insulin resistance in rats involves increased glucose responsiveness but not glucose effectiveness. Pancreas 2001 22 148-156 (Pubitemid 32179169)
5. Nicod N, Giusti V, Besse C, Tappy L. Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers. Obes Res 2003 11 625-631 (Pubitemid 41151613)
6. Rafacho A, Cestari TM, Taboga SR, Boschero AC, Bosqueiro JR. High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab 2009 296 E681-E689
7. Rafacho A, Marroquí L, Taboga SR, Abrantes JL, Silveira LR, Boschero AC, Carneiro EM, Bosqueiro JR, Nadal A, Quesada I. Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology 2010 151 85-95
8. Rafacho A, Giozzet VA, Boschero AC, Bosqueiro JR. Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance. Pancreas 2008 36 284-293 (Pubitemid 351440934)
9. Rafacho A, Roma LP, Taboga SR, Boschero AC, Bosqueiro JR. Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets. Can J Physiol Pharmacol 2007 85 536-545 (Pubitemid 47309800)
10. Beith JL, Alejandro EU, Johnson JD. Insulin stimulates primary beta-cell proliferation via Raf -1 kinase. Endocrinology 2008 149 2251-2260 (Pubitemid 351574508)
11. Rafacho A, Ribeiro DL, Boschero AC, Taboga SR, Bosqueiro JR. Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats. Int J Exp Pathol 2008 89 264-275 (Pubitemid 352019179)
12. Kawai A, Kuzuya N. On the role of glucocorticoid in glucose-induced insulin secretion. Horm Metab Res 1977 9 361-365 (Pubitemid 8196613)
13. Burén J, Lai YC, Lundgren M, Eriksson JW, Jensen J. Insulin action and signalling in fat and muscle from dexamethasone-treated rats. Arch Biochem Biophys 2008 474 91-101
14. Mokuda O, Sakamoto Y, Ikeda T, Mashiba H. Sensitivity and responsiveness of glucose output to insulin in isolated perfused liver from dexamethasone-treated rats. Horm Metab Res 1991 23 53-55
15. Beard JC, Halter JB, Best JD, Pfeifer MA, Porte D Jr. Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men. Am J Physiol 1984 247 E592-E596 (Pubitemid 15219551)
16. Novelli M, De Tata V, Bombara M, Lorenzini A, Masini M, Pollera M, Bergamini E, Masiello P. Insufficient adaptive capability of pancreatic endocrine function in dexamethasone-treated ageing rats. J Endocrinol 1999 162 425-432 (Pubitemid 29447436)
17. Sood A, Ismail-Beigi F. Effect of dexamethasone on insulin secretion: Examination of some underlying mechanisms. Endocr Pract 2010 29 1-24
18. Qi D, Pulinilkunnil T, An D, Ghosh S, Abrahani A, Pospisilik JA, Brownsey R, Wambolt R, Allard M, Rodrigues B. Single-dose dexamethasone induces whole-body insulin resistance and alters both cardiac fatty acid and carbohydrate metabolism. Diabetes 2004 53 1790-1797 (Pubitemid 38857037)
19. Zakrzewska KE, Cusin I, Stricker-Kongrad A, Boss O, Ricquier D, Jeanrenaud B, Rohner-Jeanrenaud F. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 1999 48 365-370 (Pubitemid 29061112)
20. Angelini N, Rafacho A, Boschero AC, Bosqueiro JR. Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats. Diabetes Res Clin Pract 2010 87 184-191
21. Ahrén B. Evidences that autonomic mechanisms contribute to the adaptive increase in insulin secretion during dexamethasone-induced insulin resistance in humans. Diabetologia 2008 51 1018-1024
22. Rafacho A, Quallio S, Ribeiro DL, Taboga SR, Paula FM, Boschero AC, Bosqueiro JR. The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Acta Physiol 2010 200 223-235
23. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001 50 Suppl 1 S154-S159 (Pubitemid 32148243)