Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1

Journal of Medicinal Chemistry

Volumn 45, Issue 18, 2002, Pages 3813-3815

  Barf, Tjeerd ^a   Vallgårda, Jerk ^b   Emond, Rikard ^a   Häggström, Charlotta ^a   Kurz, Guido ^a   Nygren, Alf ^c   Larwood, Vivienne ^d   Mosialou, Erifili ^e   Axelsson, Kent ^e   Olsson, Rolf ^e   Engblom, Lars ^a   Edling, Naimie ^a   Rönquist Nii, Yuko ^a   Öhman, Birgitta ^a   Alberts, Peteris ^a   Abrahmsén, Lars ^a  

^a Biovitrum ^*  (Sweden)

^b Biovitrum   (Sweden)

^c Departments of Chemical Technologies   (Sweden)

^d ABBOTT LABORATORIES   (United Kingdom)

^e Biovitrum   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR; 3 CHLORO 2 METHYL N [4 [2 (4 METHYL 1 PIPERAZINYL) 2 OXOETHYL] 2 THIAZOLYL]BENZENESULFONAMIDE; ANTIDIABETIC AGENT; BVT 14225; CARBENOXOLONE; DIETHYLAMINE; N METHYLPIPERAZINAMIDE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFONAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; GLUCONEOGENESIS; HUMAN; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACOKINETICS; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BLOOD GLUCOSE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; HYPOGLYCEMIC AGENTS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES;

EID: 0037194658     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025530f     Document Type: Article

References (13)

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