Human adipose tissue under in vitro inhibition of 11β-hydroxysteroid dehydrogenase type 1: Differentiation and metabolism changes

Hormone and Metabolic Research

Volumn 34, Issue 11-12, 2002, Pages 752-757

  Bader, T ^a   Zoumakis, E ^a   Friedberg, M ^a   Chrousos, G P ^a   Hochberg, Z ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b MEYER CHILDREN S HOSPITAL   (Israel)

Author keywords

11 HSD 1; Carbenoxolone; Cortisone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; CARBENOXOLONE; CORTISONE; DEXAMETHASONE; GLYCYRRHIZA EXTRACT; HYDROCORTISONE; LEPTIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIPID METABOLISM; NORMAL HUMAN; OBESITY; OMENTUM; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; SEX DIFFERENCE; SUBCUTANEOUS FAT; TISSUE DISTRIBUTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOCYTES; ADIPOSE TISSUE; ADULT; CARBENOXOLONE; CELL DIFFERENTIATION; CELL DIVISION; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; LEPTIN; MIDDLE AGED; STEM CELLS;

GLYCYRRHIZA;

EID: 0036875503     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-38255     Document Type: Article

References (15)

1. Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC. Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. Journal of Endocrinology 1998; 156: 159- 168
2. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and metabolic syndrome. Science 2001; 294: 2166 - 2170
3. Stewart PM, Boulton A, Kumar S, Clark PM, Shacldeton CH. Cortisol metabolism in human obesity: impaired cortisone → cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 1999; 84: 1022 - 1027
4. Tiosano D, Eisenstadt I, Militianu D, Shackleton CHL, Chrousos GP, Hochberg Z. 11β-hydroxysteroid dehydrogenase activity in hypothalamic obesity. J Clin Endocrinol Metab 2003; 88: 385 - 393
5. Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE. 11 Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated. J Steroid Biochem Mol Biol 1998; 64: 251 - 260
6. Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: The roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 1999; 140: 3188 - 3196
7. Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC. Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. Journal of Endocrinology 1998; 156: 159 - 168
8. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z. Modulation of 11β-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab 2003; 88: 379- 384
9. Bujalska IJ, Walker EA, Hewison M, Stewart PM. A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab 2002; 87: 1205 - 1210
10. Dembinska-Kiec A, Pallapies D, Simmet T, Peskar BM, Peskar BA. Effect of carbenoxolone on the biological activity of nitric oxide: relation to gastroprotection. Br J Pharmacol 1991; 104: 811 - 816
11. Nagayama S, Jono H, Suzaki H, Sakai K, Tsuruya E, Yamatsu I, Isohama Y, Miyata T, Kai H. Carbenoxolone, a new inducer of heat shock protein 70. Life Sci 2001; 69: 2867 - 2873
12. Chaytor AT, Marsh WL, Hutcheson IR, Griffith TM. Comparison of glycyrrhetinic acid isoforms and carbenoxolone as inhibitors of EDHF-type relaxations mediated via gap junctions. Endothelium 2000; 7: 265 - 278
13. Umezawa A, Hata J. Expression of gap-junctional protein (connexin 43 or alpha 1 gap junction) is down-regulated at the transcriptional level during adipocyte differentiation of H-1/A marrow stromal cells. Cell Struct Funct 1992; 17: 177 - 184
14. MacDougald OA, Lane MD. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995; 64: 345 - 373
15. Bronnegard M, Reynisdottir S, Marcus C, Stierna P, Arner P. Effect of glucocorticosteroid treatment on glucocorticoid receptor expression in human adipocytes. J Clin Endocrinol Metab 1995; 80: 3608 - 3612