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Volumn 32, Issue 3, 2012, Pages 392-399

Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease

Author keywords

11beta HSD1; Fatty liver; Glucocorticoids; Liver steatosis; Non alcoholic

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE;

EID: 84856679119     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02685.x     Document Type: Article
Times cited : (48)

References (45)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 77951286204 scopus 로고    scopus 로고
    • Recent advances in nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol 2010; 26: 202-8.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 202-208
    • Cheung, O.1    Sanyal, A.J.2
  • 3
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-85.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 4
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso G, Gambino R, Cassader M, Pagano G. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 2011; 43: 617-49.
    • (2011) Ann Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 5
    • 77952785795 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease from pathogenesis to management: an update
    • Musso G, Gambino R, Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obes Rev 2010; 11: 430-45.
    • (2010) Obes Rev , vol.11 , pp. 430-445
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 6
    • 77958183243 scopus 로고    scopus 로고
    • Novel insights into the pathophysiology of nonalcoholic fatty liver disease
    • Feldstein AE. Novel insights into the pathophysiology of nonalcoholic fatty liver disease. Semin Liver Dis 2010; 30: 391-401.
    • (2010) Semin Liver Dis , vol.30 , pp. 391-401
    • Feldstein, A.E.1
  • 9
    • 33846184713 scopus 로고    scopus 로고
    • Insulin resistance: cause or consequence of nonalcoholic steatohepatitis?
    • Ahima RS. Insulin resistance: cause or consequence of nonalcoholic steatohepatitis? Gastroenterology 2007; 132: 444-6.
    • (2007) Gastroenterology , vol.132 , pp. 444-446
    • Ahima, R.S.1
  • 10
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider KM, Kahn SE. Review: The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2006; 91: 4753-61.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 11
    • 0036103602 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002; 17(Suppl.): S186-90.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.SUPPL.
    • Angulo, P.1    Lindor, K.D.2
  • 13
    • 77953216292 scopus 로고    scopus 로고
    • Fatty liver disease: the hepatic manifestation of metabolic syndrome
    • Gastaldelli A. Fatty liver disease: the hepatic manifestation of metabolic syndrome. Hypertens Res 2010; 33: 546-7.
    • (2010) Hypertens Res , vol.33 , pp. 546-547
    • Gastaldelli, A.1
  • 14
    • 54049091645 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome
    • Boppidi H, Daram SR. Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome. Postgrad Med 2008; 120: E01-7.
    • (2008) Postgrad Med , vol.120
    • Boppidi, H.1    Daram, S.R.2
  • 15
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
    • Van Der Poorten D, Milner KL, Hui J, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008; 48: 449-57.
    • (2008) Hepatology , vol.48 , pp. 449-457
    • Van Der Poorten, D.1    Milner, K.L.2    Hui, J.3
  • 16
    • 33751215200 scopus 로고    scopus 로고
    • Cortisol-cause and cure for metabolic syndrome?
    • Walker BR. Cortisol-cause and cure for metabolic syndrome? Diabet Med 2006; 23: 1281-8.
    • (2006) Diabet Med , vol.23 , pp. 1281-1288
    • Walker, B.R.1
  • 17
    • 33749064918 scopus 로고    scopus 로고
    • Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome
    • Mariniello B, Ronconi V, Rilli S, et al. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol 2006; 155: 435-41.
    • (2006) Eur J Endocrinol , vol.155 , pp. 435-441
    • Mariniello, B.1    Ronconi, V.2    Rilli, S.3
  • 18
    • 2942589264 scopus 로고    scopus 로고
    • Portal and peripheral cortisol levels in obese humans
    • Aldhahi W, Mun E, Goldfine AB. Portal and peripheral cortisol levels in obese humans. Diabetologia 2004; 47: 833-6.
    • (2004) Diabetologia , vol.47 , pp. 833-836
    • Aldhahi, W.1    Mun, E.2    Goldfine, A.B.3
  • 19
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 1997; 349: 1210-3.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 20
    • 0032977322 scopus 로고    scopus 로고
    • The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes
    • Krozowski Z, Li KX, Koyama K, et al. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes. J Steroid Biochem Mol Biol 1999; 6: 391-401.
    • (1999) J Steroid Biochem Mol Biol , vol.6 , pp. 391-401
    • Krozowski, Z.1    Li, K.X.2    Koyama, K.3
  • 21
    • 4043077286 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    • Tomlinson JW, Walker EA, Bujalska IJ, et al. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 2004; 25: 831-66.
    • (2004) Endocr Rev , vol.25 , pp. 831-866
    • Tomlinson, J.W.1    Walker, E.A.2    Bujalska, I.J.3
  • 22
    • 3342998410 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase
    • Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A. Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 2004; 3: 129-33.
    • (2004) FEBS Lett , vol.3 , pp. 129-133
    • Atanasov, A.G.1    Nashev, L.G.2    Schweizer, R.A.3    Frick, C.4    Odermatt, A.5
  • 23
    • 63249083541 scopus 로고    scopus 로고
    • Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans
    • Stimson RH, Andersson J, Andrew R, et al. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes 2009; 58: 46-53.
    • (2009) Diabetes , vol.58 , pp. 46-53
    • Stimson, R.H.1    Andersson, J.2    Andrew, R.3
  • 24
    • 61449225726 scopus 로고    scopus 로고
    • Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis
    • Konopelska S, Kienitz T, Hughes B, et al. Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis. Clin Endocrinol 2009; 70: 554-60.
    • (2009) Clin Endocrinol , vol.70 , pp. 554-560
    • Konopelska, S.1    Kienitz, T.2    Hughes, B.3
  • 25
    • 43849110089 scopus 로고    scopus 로고
    • Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
    • Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 2008; 197: 189-204.
    • (2008) J Endocrinol , vol.197 , pp. 189-204
    • Macfarlane, D.P.1    Forbes, S.2    Walker, B.R.3
  • 26
    • 73949158787 scopus 로고    scopus 로고
    • Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients
    • Baudrand R, Carvajal CA, Riquelme A, et al. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. Obes Surg 2010; 20: 77-83.
    • (2010) Obes Surg , vol.20 , pp. 77-83
    • Baudrand, R.1    Carvajal, C.A.2    Riquelme, A.3
  • 27
    • 78651089694 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease
    • Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2011; 8: 35-44.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 35-44
    • Hebbard, L.1    George, J.2
  • 28
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3
  • 29
    • 0036877848 scopus 로고    scopus 로고
    • Determination of the insulin resistance index by the homeostasis model assessment in a population of metropolitan region in Chile
    • Acosta AM, Escalona M, Maiz A, Pollak F, Leighton F. [Determination of the insulin resistance index by the homeostasis model assessment in a population of metropolitan region in Chile]. Rev Med Chil 2002; 130: 1227-31.
    • (2002) Rev Med Chil , vol.130 , pp. 1227-1231
    • Acosta, A.M.1    Escalona, M.2    Maiz, A.3    Pollak, F.4    Leighton, F.5
  • 30
    • 27444443876 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement
    • Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 2005; 112: 2735-52.
    • (2005) Circulation , vol.112 , pp. 2735-2752
    • Grundy, S.M.1    Cleeman, J.I.2    Daniels, S.R.3
  • 31
    • 0037008087 scopus 로고    scopus 로고
    • Updated definitions of healthy ranges for serum alanine aminotransferase levels
    • Prati D, Taioli E, Zanella A, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10.
    • (2002) Ann Intern Med , vol.137 , pp. 1-10
    • Prati, D.1    Taioli, E.2    Zanella, A.3
  • 32
    • 77349106466 scopus 로고    scopus 로고
    • The surgical treatment of metabolic disease and morbid obesity
    • Fontana MA, Wohlgemuth SD. The surgical treatment of metabolic disease and morbid obesity. Gastroenterol Clin North Am 2010; 39: 125-33.
    • (2010) Gastroenterol Clin North Am , vol.39 , pp. 125-133
    • Fontana, M.A.1    Wohlgemuth, S.D.2
  • 33
    • 72449133267 scopus 로고    scopus 로고
    • Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
    • Morton NM. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease. Mol Cell Endocrinol 2010; 316: 154-64.
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 154-164
    • Morton, N.M.1
  • 34
    • 1642545652 scopus 로고    scopus 로고
    • Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    • Dolinsky VW, Douglas DN, Lehner R, Vance DE. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J 2004; 3: 967-74.
    • (2004) Biochem J , vol.3 , pp. 967-974
    • Dolinsky, V.W.1    Douglas, D.N.2    Lehner, R.3    Vance, D.E.4
  • 35
    • 77956489883 scopus 로고    scopus 로고
    • Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
    • Gathercole LL, Stewart PM. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes. J Steroid Biochem Mol Biol 2010; 3: 21-7.
    • (2010) J Steroid Biochem Mol Biol , vol.3 , pp. 21-27
    • Gathercole, L.L.1    Stewart, P.M.2
  • 36
    • 50049104872 scopus 로고    scopus 로고
    • The glucocorticoid receptor controls hepatic dyslipidemia through Hes1
    • Lemke U, Krones-Herzig A, Berriel Diaz M, et al. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab 2008; 8: 212-23.
    • (2008) Cell Metab , vol.8 , pp. 212-223
    • Lemke, U.1    Krones-Herzig, A.2    Berriel Diaz, M.3
  • 37
    • 79957633868 scopus 로고    scopus 로고
    • Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11beta-hydroxysteroid dehydrogenase type 1
    • Man TY, Michailidou Z, Gokcel A, et al. Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11beta-hydroxysteroid dehydrogenase type 1. Am J Physiol Endocrinol Metab 2011; 300: E1076-84.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Man, T.Y.1    Michailidou, Z.2    Gokcel, A.3
  • 39
    • 36448973807 scopus 로고    scopus 로고
    • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects
    • Alberti L, Girola A, Gilardini L, et al. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects. Int J Obes 2007; 31: 1826-31.
    • (2007) Int J Obes , vol.31 , pp. 1826-1831
    • Alberti, L.1    Girola, A.2    Gilardini, L.3
  • 40
    • 0030342776 scopus 로고    scopus 로고
    • Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM
    • Friedman TC, Mastorakos G, Newman TD, et al. Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocr J 1996; 43: 645-55.
    • (1996) Endocr J , vol.43 , pp. 645-655
    • Friedman, T.C.1    Mastorakos, G.2    Newman, T.D.3
  • 41
    • 75949084447 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension
    • Campino C, Carvajal CA, Cornejo J, et al. 11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension. Endocrine 2010; 37: 106-14.
    • (2010) Endocrine , vol.37 , pp. 106-114
    • Campino, C.1    Carvajal, C.A.2    Cornejo, J.3
  • 42
    • 69349094184 scopus 로고    scopus 로고
    • Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease
    • Bose M, Olivan B, Laferrere B. Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes 2009; 16: 340-6.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 340-346
    • Bose, M.1    Olivan, B.2    Laferrere, B.3
  • 43
    • 63249128191 scopus 로고    scopus 로고
    • Liver is the site of splanchnic cortisol production in obese nondiabetic humans
    • Basu R, Basu A, Grudzien M, et al. Liver is the site of splanchnic cortisol production in obese nondiabetic humans. Diabetes 2009; 58: 39-45.
    • (2009) Diabetes , vol.58 , pp. 39-45
    • Basu, R.1    Basu, A.2    Grudzien, M.3
  • 44
    • 67349217688 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients
    • Munoz R, Carvajal C, Escalona A, et al. 11beta-hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients. Obes Surg 2009; 19: 764-70.
    • (2009) Obes Surg , vol.19 , pp. 764-770
    • Munoz, R.1    Carvajal, C.2    Escalona, A.3
  • 45
    • 77955590502 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
    • Morgan SA, Tomlinson JW. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes. Expert Opin Investig Drugs 2010; 19: 1067-76.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 1067-1076
    • Morgan, S.A.1    Tomlinson, J.W.2


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