The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances

Journal of Steroid Biochemistry and Molecular Biology

Volumn 125, Issue 1-2, 2011, Pages 143-147

  Zhao, Binghai ^a,b   Lian, Qingquan ^c   Chu, Yanhui ^a   Hardy, Dianne O ^b   Li, Xiao Kun ^d   Ge, Ren Shan ^b,c  

^a MUDANJIANG MEDICAL UNIVERSITY   (China)

^b POPULATION COUNCIL   (United States)

^c Second Affiliated Hospital   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

11 Hydroxysteroid dehydrogenase 2; Human kidney; Perfluorinated substances; Perfluoroalkyl acids; Perfluorobutyl sulphonate; Perfluorohexyl sulfonate; Perfluorooctanoic acid; Perfluorooctyl sulphonate

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; GLUCOCORTICOID; PERFLUORO COMPOUND; PERFLUOROALKYL SUBSTANCE; PERFLUOROBUTANE SULFONATE; PERFLUOROHEXANESULFONATE; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOCORTICOID METABOLISM; HUMAN; IC 50; INHIBITION KINETICS; KIDNEY MICROSOME; MALE; NONHUMAN; RAT; STEROID METABOLISM;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ENDOCRINE DISRUPTORS; FLUOROCARBONS; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; RATS;

RATTUS;

EID: 79957770534     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.12.017     Document Type: Article

References (36)

1. 2OH: kinetics and mechanism of reaction with OH Environ. Sci. Technol. 40 6 2006 1862 1868
2. C. Lau, J.L. Butenhoff, and J.M. Rogers The developmental toxicity of perfluoroalkyl acids and their derivatives Toxicol. Appl. Pharmacol. 198 2 2004 231 241 (Pubitemid 38952836)
3. Xu J.F L., D.M. Krenitsky, A.M. Seacat, J.L. Butenhoff, and M.W. Anders Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450 Chem. Res. Toxicol. 17 6 2004 767 775 (Pubitemid 38856337)
4. G.W. Olsen, J.M. Burris, D.J. Ehresman, J.W. Froehlich, A.M. Seacat, J.L. Butenhoff, and L.R. Zobel Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers Environ. Health Perspect. 115 9 2007 1298 1305 (Pubitemid 47471253)
5. C.P. Chengelis, J.B. Kirkpatrick, N.R. Myers, M. Shinohara, P.L. Stetson, and D.W. Sved Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats Reprod. Toxicol. 27 3-4 2009 400 406
6. M.E. Austin, B.S. Kasturi, M. Barber, K. Kannan, P.S. MohanKumar, and S.M. MohanKumar Neuroendocrine effects of perfluorooctane sulfonate in rats Environ. Health Perspect. 111 12 2003 1485 1489 (Pubitemid 37120827)
7. L. Zheng, G.H. Dong, Y.H. Jin, and Q.C. He Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL/6 mice Arch. Toxicol. 83 7 2009 679 689
8. J.R. Revollo, and J.A. Cidlowski Mechanisms generating diversity in glucocorticoid receptor signaling Ann. N. Y. Acad. Sci. 1179 2009 167 178
9. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, M.S. Cooper, M. Hewison, and P.M. Stewart 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr. Rev. 25 5 2004 831 866 (Pubitemid 39366049)
10. P.C. White, T. Mune, F.M. Rogerson, K.M. Kayes, and A.K. Agarwal Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. [Review] [43 refs] Steroids 62 1 1997 83 88 (Pubitemid 27065446)
11. P.C. White, T. Mune, T Mune, A.K. Agarwal, and A.K. Agarwal 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess Endocr. Rev. 18 1 1997 135 156 (Pubitemid 27076458)
12. R. Benediktsson, R.S. Lindsay, J. Noble, J.R. Seckl, and C.R. Edwards Glucocorticoid exposure in utero: new model for adult hypertension Lancet 341 8841 1993 339 341 (Pubitemid 23039701)
13. C.S. Wyrwoll, J.R. Seckl, and M.C. Holmes Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice Endocrinology 150 3 2009 1287 1293
14. G.X. Hu, H. Lin, C.M. Sottas, D.J. Morris, M.P. Hardy, and R.S. Ge Inhibition of 11beta-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in Leydig cells J. Androl. 29 3 2008 345 351 (Pubitemid 351669024)
15. V. Lakshmi, and C. Monder Extraction of 11 beta-hydroxysteroid dehydrogenase from rat liver microsomes by detergents J. Steroid Biochem. 22 3 1985 331 340 (Pubitemid 15089135)
16. R.S. Ge, H.B. Gao, V.L. Nacharaju, G.L. Gunsalus, and M.P. Hardy Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat Leydig cells Endocrinology 138 6 1997 2435 2442 (Pubitemid 27215247)
17. E.P. Gomez-Sanchez, V. Ganjam, Y.J. Chen, Y. Liu, M.Y. Zhou, C. Toroslu, D.G. Romero, M.D. Hughson, A. de Rodriguez, and C.E. Gomez-Sanchez Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol Am. J. Physiol. Endocrinol. Metab. 285 2 2003 E272 279
18. F.M. Hekster, A.M.P. de Voogt, C.M. Pijinenburg, R.W.P.M. Laane, Perfluoroalkylated substances:aquatic environmental assessment., Report RIKZ/2002.043, Prepared at the University of Amsterdam and RIKZ (The State Institute for Coast and Sea), 2002. p. 99.
19. T.A. Slotkin, E.A. MacKillop, R.L. Melnick, K.A. Thayer, and F.J. Seidler Developmental neurotoxicity of perfluorinated chemicals modeled in vitro Environ. Health. Perspect. 116 6 2008 716 722 (Pubitemid 351943925)
20. W. Hu, P.D. Jones, W. DeCoen, L. King, P. Fraker, J. Newsted, and J.P. Giesy Alterations in cell membrane properties caused by perfluorinated compounds Comp. Biochem. Physiol. C Toxicol. Pharmacol. 135 1 2003 77 88 (Pubitemid 36644994)
21. S.C. Chang, D.J. Ehresman, J.A. Bjork, K.B. Wallace, G.A. Parker, D.G. Stump, and J.L. Butenhoff Gestational and lactational exposure to potassium perfluorooctanesulfonate (K + PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression Reprod. Toxicol. 27 3-4 2009 387 399
22. A.G. Atanasov, L.G. Nashev, S. Tam, M.E. Baker, and A. Odermatt Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids Environ. Health Perspect. 113 11 2005 1600 1606 (Pubitemid 41614918)
23. A.A. Jensen, and H. Leffers Emerging endocrine disrupters: perfluoroalkylated substances Int. J. Androl. 31 2 2008 161 169 (Pubitemid 351341398)
24. G.W. Olsen, K.J. Hansen, L.A. Stevenson, J.M. Burris, and J.H. Mandel Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals Environ. Sci. Technol. 37 5 2003 888 891 (Pubitemid 36504788)
25. J.R. Seckl, M.C. Hansen, and L.A. Holmes Mechanisms of disease: glucocorticoids, their placental metabolism and fetal programming of adult pathophysiology Nat. Clin. Pract. Endocrinol. Metab. 3 6 2007 479 488 (Pubitemid 46808745)
26. E. Kajantie, L. Dunkel, U. Turpeinen, U.H. Stenman, P.J. Wood, M. Nuutila, and S. Andersson Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants J. Clin. Endocrinol. Metab. 88 1 2003 493 500 (Pubitemid 36115207)
27. R. Benediktsson, A.A. Calder, C.R. Edwards, and J.R. Seckl Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure Clin. Endocrinol. (Oxf.) 46 2 1997 161 166 (Pubitemid 27122161)
28. J.L. Butenhoff, D.J. Ehresman, S.C. Chang, G.A. Parker, and D.G. Stump Gestational and lactational exposure to potassium perfluorooctanesulfonate (K + PFOS) in rats: developmental neurotoxicity Reprod. Toxicol. 27 3-4 2009 319 330
29. C. Fei, J.K. McLaughlin, L. Lipworth, and J. Olsen Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy Environ. Health Perspect. 116 10 2008 1391 1395
30. N. Washino, Y. Saijo, S. Sasaki, S. Kato, S. Ban, K. Konishi, R. Ito, A. Nakata, Y. Iwasaki, K. Saito, H. Nakazawa, and R. Kishi Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth Environ. Health Perspect. 117 4 2009 660 667
31. K. Betts PFOS and PFOA in humans: new study links prenatal exposure to lower birth weight Environ. Health Perspect. 115 11 2007 A550
32. R.S. Lindsay, R.M. Lindsay, B.J. Waddell, and J.R. Seckl Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone Diabetologia 39 11 1996 1299 1305 (Pubitemid 26356057)
33. U.N. Joensen, R. Bossi, H. Leffers, A.A. Jensen, N.E. Skakkebaek, and N. Jorgensen Do perfluoroalkyl compounds impair human semen quality? Environ. Health Perspect. 117 6 2009 923 927
34. Y. Honda, S. Ohno, and S. Nakajin Leydig cells from neonatal pig testis abundantly express 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2 and effectively inactivate cortisol to cortisone J. Steroid. Biochem. Mol. Biol. 108 1-2 2008 91 101 (Pubitemid 351173817)
35. A.L. Albiston, V.R. Obeyesekere, R.E. Smith, and Z.S. Krozowski Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme Mol. Cell. Endocrinol. 105 2 1994 R11 17
36. R.S. Ge, Q. Dong, E.M. Niu, C.M. Sottas, D.O. Hardy, J.F. Catterall, S.A. Latif, D.J. Morris, and M.P. Hardy 11beta-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate Endocrinology 146 6 2005 2657 2664 (Pubitemid 40695568)