Regulation of 11β-HSD genes in human adipose tissue: Influence of central obesity and weight loss

Obesity Research

Volumn 12, Issue 1, 2004, Pages 9-17

  Engeli, Stefan ^a,c   Böhnke, Jana ^a   Feldpausch, Mareike ^a   Gorzelniak, Kerstin ^a   Heintze, Ute ^a   Janke, Jürgen ^a   Luft, Friedrich C ^a   Sharma, Arya M ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b MCMASTER UNIVERSITY   (Canada)

^c Franz Volhard Klinik   (Germany)

Author keywords

11 hydroxysteroid dehydrogenase type 1; Adipose tissue; Central obesity; Cortisol; Metabolic syndrome

Indexed keywords

ANIMALIA;

11BETA HYDROXYSTEROID DEHYDROGENASE; HYDROCORTISONE; MESSENGER RNA;

ADIPOCYTE; ADIPOSE TISSUE; AGED; ARTICLE; BODY CONSTITUTION; CROSS-SECTIONAL STUDY; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MIDDLE AGED; OBESITY; POSTMENOPAUSE; WEIGHT REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOCYTES; ADIPOSE TISSUE; AGED; BODY CONSTITUTION; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEOSTASIS; HUMANS; HYDROCORTISONE; INSULIN RESISTANCE; MIDDLE AGED; OBESITY; POSTMENOPAUSE; RNA, MESSENGER; WEIGHT LOSS;

EID: 1842552244     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.3     Document Type: Article

References (35)

1. Andrews RC, Herlihy O, Livingstone DEW, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab. 2002;87:5587-93.
2. Rosmond R, Björntorp P. Blood pressure in relation to obesity, insulin and the hypothalamic-pituitary-adrenal axis in Swedish men. J Hypertens. 1998;16:1721-6.
3. Rosmond R, Björntorp P. The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men. Int J Obes Relat Metab Disord. 1998;22:1184-96.
4. Joyner JM, Hutley LJ, Cameron DP. Glucocorticoid receptors in human preadipocytes: regional and gender differences. J Endocrinol. 2000;166:145-52.
5. Rebuffé-Scrive M, Brönnegard M, Nilsson A, Eldh J, Gustafsson JA, Björntorp P. Steroid hormone receptors in human adipose tissues. J Clin Endocrinol Metab. 1990;71:1215-9.
6. Hauner H, Entenmann G, Wabitsch M, et al. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest. 1989;84:1663-70.
7. Gaillard D, Wabitsch M, Pipy B, Négrel R. Control of terminal differentiation of adipose precursor cells by glucocorticoids. J Lipid Res. 1991;32:569-79.
8. Fried SK, Russell CD, Grauso NL, Brolin RE. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest. 1993;92:2191-8.
9. Morange PE, Aubert J, Peiretti F, et al. Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue. Diabetes. 1999;48:890-5.
10. Gorzelniak K, Engeli S, Janke J, Luft FC, Sharma AM. Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension. J Hypertens. 2002;20:965-73.
11. Rebuffé-Scrive M, Krotkiewski M, Elfverson J, Björntorp P. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. J Clin Endocrinol Metab. 1988;67:1122-8.
12. Stewart PM, Krozowski ZS. 11 beta-Hydroxysteroid dehydrogenase. Vitam Horm. 1999;57:249-324.
13. Sandeep TC, Walker BR. Pathophysiology of modulation of local glucocorticoid levels by 11β-hydroxysteroid dehydrogenases. Trends Endocrinol Metab. 2001;12:446-53.
14. Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet. 1997;349:1210-3.
15. Ricketts ML, Verhaeg JM, Bujalska IJ, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab. 1998;83:1325-35.
16. Yang K, Khalil MW, Strutt BJ, Killinger DW. 11 beta-Hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: effect on aromatase activity. J Steroid Biochem Mol Biol. 1997;60:247-53.
17. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab. 2002;87:2701-5.
18. Katz JR, Mohamed-Ali V, Wood PJ, Yudkin JS, Coppack SW. An in vivo study of the cortisol-cortisone shuttle in subcutaneous abdominal adipose tissue. Clin Endocrinol. 1999;50:63-8.
19. Rask E, Walker BR, Söderberg S, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 2002;87:3330-6.
20. Rask E, Olsson T, Söderberg S, et al. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab. 2001;86:1418-21.
21. Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294:2166-70.
22. Heilmann P, Heide J, Hundertmark S, Schöneshöfer M. Administration of glycyrrhetinic acid: significant correlation between serum levels and the cortisol/cortisone ratio in serum and urine. Exp Clin Endocrinol Diabetes. 1999;107:370-8.
23. Tomlinson JW, Bujalska I, Stewart PM, Cooper MS. The role of 11 β-hydroxysteroid dehydrogenase in central obesity and osteoporosis. Endocr Res. 2000;26:711-22.
24. Wake DJ, Rask E, Livingstone DEW, Söderberg S, Olsson T, Walker BR. Local and systemic impact of transcriptional up-regulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab. 2003;88:3983-8.
25. Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab. 2003;88:2738-44.
26. Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM. Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab. 2002;87:5630-5.
27. Bujalska IJ, Walker EA, Hewison M, Stewart PM. A switch in dehydrogenase to reductase activity of 11β-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab. 2002;87:1205-10.
28. Morton NM, Holmes MC, Fievet C, et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem. 2001;276:41293-300.
29. Andrews RC, Rooyackers O, Walker BR. Effects of the 11β- hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab. 2003;88:285-91.
30. Masuzaki H, Yamamoto H, Kenyon CJ, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest. 2003;112:83-90.
31. Massiéra F, Bloch-Faure M, Ceiler D, et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001;15:2727-9.
32. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone to cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 1999;84:1022-7.
33. Tomlinson JW, Moore J, Cooper MS, et al. Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology. 2001;142:1982-9.
34. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z. Modulation of 11β-hydroxy steroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab. 2003;88:385-93.
35. Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology. 1999;140:3188-96.