Partial deficiency or short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice

Journal of Neuroscience

Volumn 30, Issue 41, 2010, Pages 13867-13872

  Sooy, Karen ^b   Webster, Scott P ^b   Noble, June ^b   Binnie, Margaret ^b   Walker, Brian R ^b   Seckl, Jonathan R ^a,b   Yau, Joyce L W ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTICOSTERONE; ENZYME INHIBITOR; PLACEBO; UE 1961; UNCLASSIFIED DRUG; [N [3 [4 [4 [(4AR,8AR) 3,4,4A,5,6,7,8,8A OCTAHYDRO H QUINOLINE 1 CARBONYL] 2 THIENYL] 1 PIPERIDYL] 3 OXOPROPYL]METHANESULFONAMIDE];

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COMPARATIVE STUDY; CONGENIC STRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; GENE INACTIVATION; HETEROZYGOTE; LIFELONG LEARNING; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RADIOIMMUNOASSAY; TIME;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AGING; ANALYSIS OF VARIANCE; ANIMALS; COGNITION; CORTICOSTERONE; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, KNOCKOUT; RADIOIMMUNOASSAY; TIME FACTORS;

EID: 77958067558     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2783-10.2010     Document Type: Article

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