Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: The Framingham heart study

Journal of the American Geriatrics Society

Volumn 51, Issue 9, 2003, Pages 1237-1243

  Payette, Hélène ^a,b,f   Roubenoff, Ronenn ^a,b   Jacques, Paul F ^b   Dinarello, Charles A ^c   Wilson, Peter W F ^d   Abad, Leslie W ^a,b   Harris, Tamara ^e  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO HOSPITAL   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f UNIVERSITY INSTITUTE OF GERIATRICS OF SHERBROOKE   (Canada)

Author keywords

Cytokine; Growth hormone; Population based; Predictors; Sarcopenia

Indexed keywords

INTERLEUKIN 6; SOMATOMEDIN C;

AGED; ARTICLE; BIOENERGY; BODY COMPOSITION; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ELDERLY CARE; FEMALE; HEALTH STATUS; HUMAN; IMPEDANCE; INDEPENDENCE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; METABOLIC RATE; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; POPULATION RESEARCH; PROGNOSIS; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; SEX DIFFERENCE; UNITED STATES;

ADIPOSE TISSUE; AGE FACTORS; AGED; AGED, 80 AND OVER; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; COHORT STUDIES; ELECTRIC IMPEDANCE; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; LINEAR MODELS; MALE; PROGNOSIS; RADIOIMMUNOASSAY; RESIDENCE CHARACTERISTICS; SEX FACTORS; TIME FACTORS;

EID: 0042333313     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2003.51407.x     Document Type: Article

References (51)

1. Holloszy JO. Workshop on sarcopenia: Muscle atrophy in old age. J Gerontol A Biol Sci Med Sci 1995;50A(special issue):1-161.
2. Rosenberg IH. Sarcopenia. Origins and clinical relevance. J Nutr 1997;127:990S-991S.
3. Baumgartner RN, Koetler KM, Gallagher D et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998;147:755-763.
4. Poehlman E, Toth M, Fonong T. Exercise, substrate utilisation and energy requirements in the elderly. Int J Obes Relat Metab Disord 1995;19(Suppl. 4):S93-S96.
5. Melton LJ, Khosla S, Crowson CS et al. Epidemiology of sarcopenia. J Am Geriatr Soc 2000;48:625-630.
6. Gallagher D, Ruts E, Visser M et al. Weight stability masks sarcopenia in elderly men and women. Am J Physiol Endocrinol Metab 2000;279:E366-E375.
7. Abbasi A, Duthie E, Sheldahl L et al. Association of dehydroepiandrosterone sulfate, body composition, and physical fitness in independent community-dwelling older men and women. J Am Geriatr Soc 1998;46:263-273.
8. Baumgartner RN, Waters DL, Gallagher D et al. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 1999;107:123-136.
9. Roubenoff R, Hughes VA. Sarcopenia. Current concepts. J Gerontol A Biol Sci Med Sci 2000;55A:M716-M724.
10. Fryburg D, Bartet E. Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans. Metabolism 1993;42:1223-1227.
11. Martin FC, Yeo AL, Sonksen PH. Growth hormone secretion in the elderly Ageing and the somatopause. Baillieres Clin Endocrinol Metab 1997;11:223-250.
12. Roubenoff F, Rall LC, Beldhuis JD et al. The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: The role of fat mass and leptin. J Clin Endocrinol Metab 1998;83:1502-1506.
13. Copeland KC, Colletti RB, Devlin JD et al. The relation between insulin-like growth factor-1, adiposity and aging. Metabolism 1990;39:584-587.
14. Harris TB, Kiel D, Roubenoff R et al. Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: The Framingham Heart Study. J Am Geriatr Soc 1997;45:133-139.
15. Sun G, Gagnon J, Chagnon YC et al. Association and linkage between an insulin-like growth factor-1 gene polymorphism and fat-free mass in the HERITAGE Family Study. Int J Obes Relat Metab Disord 1999;23:929-935.
16. Thompson JL, Butterfield GE, Marcus R et al. The effects of recombinant human insulin-like growth factor-1 and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 1995;80:1845-1852.
17. Papadakis MA, Grady D, Black D et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996;124:708-716.
18. Moldawer LL, Rogy MA, Lowry SF. The role of cytokines in cancer cachexia. J Parenter Enteral Nutr 1992;16(Suppl.):43S-49S.
19. Roubenoff R, Roubenoff RA, Cannon JG et al. Rheumatoid cachexia: Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379-2386.
20. Yeh SS, Schuster MW. Geriatric cachexia: The role of cytokines. Am J Clin Nutr 1999;70:183-197.
21. Roubenoff R, Harris TB, Abad LW et al. Monocyte cytokine production in an elderly population: Effect of age and inflammation. J Gerontol A Biol Sci Med Sci 1998;53A:M20-M26.
22. Fagiolo U, Cossarizza A, Scala E et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 1993;23:2375-2389.
23. Ershler WB, Sun WH, Binkley N. The role of interleukin-6 in certain age-related diseases. Drug Aging 1994;5:358-365.
24. Visser M, Pahor M, Taaffe DR et al. Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women: The Health ABC Study. J Gerontol A Biol Sci Med Sci 2002;57A:M326-M332.
25. Cohen HJ, Pieper CF, Harris T et al. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci 1997;52A:M201-M208.
26. Taeffe DR, Harris TB, Ferrucci L et al. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons MacArthur Studies of Successful Aging. J Gerontol A Biol Sci Med Sci 2000;55A:M709-M715.
27. Ferrucci L, Harris TB, Guralnik JM et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 1999;47:639-646.
28. Cohen HJ. Editorial: In search of the underlying mechanisms of frailty. J Gerontol A Biol Sci Med Sci 2000;55A:M706-M708.
29. Abbasi AA, Mattson DE, Duthie EH et al. Predictors of lean body mass and total adipose mass in community-dwelling elderly men and women. Am J Med Sci 1998;315:188-193.
30. Ellis KJ, Bell SJ, Chertow GM et al. Bioelectrical impedance methods in clinical research: A follow-up to the NIH Technology Assessment Conference. Nutrition 1999;15:874-880.
31. Roubenoff R, Baumgartner RN, Harris TB et al. Application of bioelectrical impedance analysis to elderly populations. J Gerontol A Biol Sci Med Sci 1997;52A:M129-M136.
32. Gallagher D, Visser M, De Meersman RE et al. Appendicular skeletal muscle mass. Effects of age, gender, and ethnicity. J Appl Physiol 1997;83:229-239.
33. Hintz RL, Liu F, Chang D et al. A sensitive radioimmunoassay for somatomedin-C/insulin-like growth factor-I based on synthetic insulin-like growth factor 57-70. Horm Metab Res 1988;20:344-347.
34. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med 1993;153:154-183.
35. Radloff LS. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385-401.
36. Jette AM, Branch LG. The Framingham disability study: II. Physical disability among the aging. Am J Public Health 1981;71:1211-1216.
37. Rosow I, Breslau N. A Guttman health scale for the aged. J Gerontol 1966;21:556-559.
38. Lawton MP, Brody EM. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-186.
39. Nagi SZ. An epidemiology of disability among adults in the United States. Milbank Mem Fund Q 1976;54:439-468.
40. Willet WC, Sampson L, Stampfer MJ et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985;122:51-65.
41. Cronbach LJ, Furby L. How should we measure 'change' or should we. Psych Bull 1970;74:68-80.
42. Kleinbaum DG, Kupper LL, Muller KE. Applied Regression Analysis and Other Multivariate Methods, 2nd Ed. Boston, MA: PWS-Kent Publishing Co., 1988.
43. Beekman AT, Deeg DJ, van Limbeek J et al. Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): Results from a community based sample of older adults in the Netherlands. Psychol Med 1997;27:231-235.
44. Kuczmarski MF, Kuczmarski RJ, Najjar M. Descriptive anthropometric reference data for older Americans. J Am Diet Assoc 2000;100:59-66.
45. National Research Council. Recommended Dietary Allowances, 10th Ed. Washington, DC: National Academy Press, 1989.
46. Kehayias JJ, Fiatarone MA, Zhuang H et al. Total body potassium and body fat: Relevance to aging. Am J Clin Nutr 1997;66:904-910.
47. Forbes GB. Longitudinal changes in adult fat-free mass influence of body weight. Am J Clin Nutr 1999;70:1025-1031.
48. Abad LW, Schmitz HR, Parker R et al. Cytokine responses differ by compartment and wasting status in patients with HIV infection and healthy controls. Cytokine 2002;18:286-293.
49. Manolagas SC, Bellido T, Jilka RL. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. Int J Immunopharmacol 1995;17:109-116.
50. Volpato S, Guralnik JM, Ferrucci L et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women. The Women's Health and Aging Study. Circulation 2001;103:947-953.
51. Newman AB, Yanez D, Harris T et al. Weight change in old age and its association with mortality. J Am Geriatr Soc 2001;49:1309-1318.