Discovery and structure-guided drug design of inhibitors of 11β-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3682-3685

  Lepifre, Franck ^a   Christmann Franck, Serge ^a   Roche, Didier ^a   Leriche, Caroline ^a   Carniato, Denis ^a   Charon, Christine ^a   Bozec, Sophie ^a   Doare, Liliane ^a   Schmidlin, Fabien ^a   Lecomte, Marc ^a   Valeur, Eric ^a  

^a Merck KGaA France   (France)

Author keywords

11 Hydroxysteroid dehydrogenase type I inhibitors; Hit to Lead process; Parallel synthesis; Spiro carboxamide; Structure guided drug design

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; ENZYME INHIBITOR; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AMIDES; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66349124660     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.123     Document Type: Article

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