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Volumn 7, Issue 2, 2012, Pages

A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CD68 ANTIGEN; CORTISONE ACETATE; DEXAMETHASONE; HYDROCORTISONE; MESSENGER RNA; STEROID 5ALPHA REDUCTASE;

EID: 84857403547     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029531     Document Type: Article
Times cited : (90)

References (44)
  • 1
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: the mist gradually clears
    • de Alwis NM, Day CP, (2008) Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol 48 (Suppl 1): S104-S112.
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • de Alwis, N.M.1    Day, C.P.2
  • 2
    • 0346728586 scopus 로고    scopus 로고
    • Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography
    • Rockall AG, Sohaib SA, Evans D, Kaltsas G, Isidori AM, et al. (2003) Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography. Eur J Endocrinol 149: 543-548.
    • (2003) Eur J Endocrinol , vol.149 , pp. 543-548
    • Rockall, A.G.1    Sohaib, S.A.2    Evans, D.3    Kaltsas, G.4    Isidori, A.M.5
  • 3
    • 0036117963 scopus 로고    scopus 로고
    • Acute severe steatohepatitis related to prednisolone therapy
    • Dourakis SP, Sevastianos VA, Kaliopi P, (2002) Acute severe steatohepatitis related to prednisolone therapy. Am J Gastroenterol 97: 1074-1075.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1074-1075
    • Dourakis, S.P.1    Sevastianos, V.A.2    Kaliopi, P.3
  • 4
    • 0032747485 scopus 로고    scopus 로고
    • Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis
    • Nanki T, Koike R, Miyasaka N, (1999) Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis. Am J Gastroenterol 94: 3379.
    • (1999) Am J Gastroenterol , vol.94 , pp. 3379
    • Nanki, T.1    Koike, R.2    Miyasaka, N.3
  • 5
    • 0032965030 scopus 로고    scopus 로고
    • De novo lipogenesis in humans: metabolic and regulatory aspects
    • Hellerstein MK, (1999) De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr 53 (Suppl 1): S53-S65.
    • (1999) Eur J Clin Nutr , vol.53 , Issue.SUPPL. 1
    • Hellerstein, M.K.1
  • 6
    • 0025068856 scopus 로고
    • Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin
    • Norrheim L, Sorensen H, Gautvik K, Bremer J, Spydevold O, (1990) Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin. Biochim Biophys Acta 1051: 319-323.
    • (1990) Biochim Biophys Acta , vol.1051 , pp. 319-323
    • Norrheim, L.1    Sorensen, H.2    Gautvik, K.3    Bremer, J.4    Spydevold, O.5
  • 7
    • 1642545652 scopus 로고    scopus 로고
    • Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    • Dolinsky VW, Douglas DN, Lehner R, Vance DE, (2004) Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J 378: 967-974.
    • (2004) Biochem J , vol.378 , pp. 967-974
    • Dolinsky, V.W.1    Douglas, D.N.2    Lehner, R.3    Vance, D.E.4
  • 8
    • 0015432606 scopus 로고
    • Tissue effects of glucocorticoids
    • Baxter JD, Forsham PH, (1972) Tissue effects of glucocorticoids. Am J Med 53: 573-589.
    • (1972) Am J Med , vol.53 , pp. 573-589
    • Baxter, J.D.1    Forsham, P.H.2
  • 9
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity
    • Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH, (1999) Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84: 1022-1027.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3    Clark, P.M.4    Shackleton, C.H.5
  • 10
    • 43849098723 scopus 로고    scopus 로고
    • A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
    • Bujalska IJ, Gathercole LL, Tomlinson JW, Darimont C, Ermolieff J, et al. (2008) A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. J Endocrinol 197: 297-307.
    • (2008) J Endocrinol , vol.197 , pp. 297-307
    • Bujalska, I.J.1    Gathercole, L.L.2    Tomlinson, J.W.3    Darimont, C.4    Ermolieff, J.5
  • 11
    • 77955630861 scopus 로고    scopus 로고
    • The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
    • Rosenstock J, Banarer S, Fonseca VA, Inzucchi SE, Sun W, et al. (2010) The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care 33: 1516-1522.
    • (2010) Diabetes Care , vol.33 , pp. 1516-1522
    • Rosenstock, J.1    Banarer, S.2    Fonseca, V.A.3    Inzucchi, S.E.4    Sun, W.5
  • 12
    • 33745771031 scopus 로고    scopus 로고
    • Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome
    • Tomlinson JW, Stewart PM, (2005) Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome. Nat Clin Pract Endocrinol Metab 1: 92-99.
    • (2005) Nat Clin Pract Endocrinol Metab , vol.1 , pp. 92-99
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 13
    • 61449225726 scopus 로고    scopus 로고
    • Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis
    • Konopelska S, Kienitz T, Hughes B, Pirlich M, Bauditz J, et al. (2009) Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis. Clin Endocrinol (Oxf) 70: 554-560.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 554-560
    • Konopelska, S.1    Kienitz, T.2    Hughes, B.3    Pirlich, M.4    Bauditz, J.5
  • 14
    • 33644956181 scopus 로고    scopus 로고
    • Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease
    • Targher G, Bertolini L, Rodella S, Zoppini G, Zenari L, et al. (2006) Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf) 64: 337-341.
    • (2006) Clin Endocrinol (Oxf) , vol.64 , pp. 337-341
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Zoppini, G.4    Zenari, L.5
  • 15
    • 10744221420 scopus 로고    scopus 로고
    • Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver
    • Westerbacka J, Yki-Jarvinen H, Vehkavaara S, Hakkinen AM, Andrew R, et al. (2003) Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab 88: 4924-4931.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4924-4931
    • Westerbacka, J.1    Yki-Jarvinen, H.2    Vehkavaara, S.3    Hakkinen, A.M.4    Andrew, R.5
  • 17
    • 0025176537 scopus 로고
    • Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man
    • Stewart PM, Wallace AM, Atherden SM, Shearing CH, Edwards CR, (1990) Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Sci (Lond) 78: 49-54.
    • (1990) Clin Sci (Lond) , vol.78 , pp. 49-54
    • Stewart, P.M.1    Wallace, A.M.2    Atherden, S.M.3    Shearing, C.H.4    Edwards, C.R.5
  • 18
    • 0029847585 scopus 로고    scopus 로고
    • Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man
    • Palermo M, Shackleton CH, Mantero F, Stewart PM, (1996) Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf) 45: 605-611.
    • (1996) Clin Endocrinol (Oxf) , vol.45 , pp. 605-611
    • Palermo, M.1    Shackleton, C.H.2    Mantero, F.3    Stewart, P.M.4
  • 19
    • 0027414682 scopus 로고
    • Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research
    • Shackleton CH, (1993) Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research. J Steroid Biochem Mol Biol 45: 127-140.
    • (1993) J Steroid Biochem Mol Biol , vol.45 , pp. 127-140
    • Shackleton, C.H.1
  • 20
    • 0031762902 scopus 로고    scopus 로고
    • Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues
    • Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, et al. (1998) Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 83: 1325-1335.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1325-1335
    • Ricketts, M.L.1    Verhaeg, J.M.2    Bujalska, I.3    Howie, A.J.4    Rainey, W.E.5
  • 21
    • 33646007919 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
    • Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, et al. (2006) Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem 281: 6546-6551.
    • (2006) J Biol Chem , vol.281 , pp. 6546-6551
    • Lavery, G.G.1    Walker, E.A.2    Draper, N.3    Jeyasuria, P.4    Marcos, J.5
  • 22
    • 0023890340 scopus 로고
    • A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system
    • Burchell A, Hume R, Burchell B, (1988) A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system. Clin Chim Acta 173: 183-191.
    • (1988) Clin Chim Acta , vol.173 , pp. 183-191
    • Burchell, A.1    Hume, R.2    Burchell, B.3
  • 23
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 24
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, et al. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170.
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3    Morton, N.M.4    Mullins, J.J.5
  • 25
    • 0035798621 scopus 로고    scopus 로고
    • Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice
    • Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, et al. (2001) Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276: 41293-41300.
    • (2001) J Biol Chem , vol.276 , pp. 41293-41300
    • Morton, N.M.1    Holmes, M.C.2    Fievet, C.3    Staels, B.4    Tailleux, A.5
  • 26
    • 2342510149 scopus 로고    scopus 로고
    • Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    • Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, et al. (2004) Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc Natl Acad Sci U S A 101: 7088-7093.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7088-7093
    • Paterson, J.M.1    Morton, N.M.2    Fievet, C.3    Kenyon, C.J.4    Holmes, M.C.5
  • 27
    • 84857439089 scopus 로고    scopus 로고
    • Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet
    • S0026-0495(09)00292-3
    • Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, et al. (2009) Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet. Metabolism S0026-0495(09)00292-3.
    • (2009) Metabolism
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3    Berger, J.P.4    Thieringer, R.5
  • 28
    • 48249143656 scopus 로고    scopus 로고
    • Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss
    • Tomlinson JW, Finney J, Hughes BA, Hughes SV, Stewart PM, (2008) Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss. Diabetes 57: 1536-1543.
    • (2008) Diabetes , vol.57 , pp. 1536-1543
    • Tomlinson, J.W.1    Finney, J.2    Hughes, B.A.3    Hughes, S.V.4    Stewart, P.M.5
  • 29
    • 69949094554 scopus 로고    scopus 로고
    • Increased 5{alpha}-reductase activity and adrenocortical drive in women with polycystic ovary syndrome
    • Vassiliadi DA, Barber TM, Hughes BA, McCarthy MI, Wass JA, et al. (2009) Increased 5{alpha}-reductase activity and adrenocortical drive in women with polycystic ovary syndrome. J Clin Endocrinol Metab 94 (9): 3558-3566.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.9 , pp. 3558-3566
    • Vassiliadi, D.A.1    Barber, T.M.2    Hughes, B.A.3    McCarthy, M.I.4    Wass, J.A.5
  • 30
    • 0021645975 scopus 로고
    • Immunocytochemical localization of glucocorticoid receptor in target cells
    • Antakly T, Eisen HJ, (1984) Immunocytochemical localization of glucocorticoid receptor in target cells. Endocrinology 115: 1984-1989.
    • (1984) Endocrinology , vol.115 , pp. 1984-1989
    • Antakly, T.1    Eisen, H.J.2
  • 31
    • 33744958894 scopus 로고    scopus 로고
    • Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
    • Gilmour JS, Coutinho AE, Cailhier JF, Man TY, Clay M, et al. (2006) Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. J Immunol 176: 7605-7611.
    • (2006) J Immunol , vol.176 , pp. 7605-7611
    • Gilmour, J.S.1    Coutinho, A.E.2    Cailhier, J.F.3    Man, T.Y.4    Clay, M.5
  • 32
    • 33846413216 scopus 로고    scopus 로고
    • Augmentation of 11beta-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages-role of 11beta-HSD1 in pro-inflammatory properties in macrophages
    • Ishii T, Masuzaki H, Tanaka T, Arai N, Yasue S, et al. (2007) Augmentation of 11beta-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages-role of 11beta-HSD1 in pro-inflammatory properties in macrophages. FEBS Lett 581: 349-354.
    • (2007) FEBS Lett , vol.581 , pp. 349-354
    • Ishii, T.1    Masuzaki, H.2    Tanaka, T.3    Arai, N.4    Yasue, S.5
  • 33
    • 63149169012 scopus 로고    scopus 로고
    • Macrophages in hepatitis B and hepatitis C virus infections
    • Heydtmann M, (2009) Macrophages in hepatitis B and hepatitis C virus infections. J Virol 83: 2796-2802.
    • (2009) J Virol , vol.83 , pp. 2796-2802
    • Heydtmann, M.1
  • 34
    • 50249168853 scopus 로고    scopus 로고
    • Local and systemic glucocorticoid metabolism in inflammatory arthritis
    • Hardy R, Rabbitt EH, Filer A, Emery P, Hewison M, et al. (2008) Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis 67: 1204-1210.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1204-1210
    • Hardy, R.1    Rabbitt, E.H.2    Filer, A.3    Emery, P.4    Hewison, M.5
  • 35
    • 34347407061 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis
    • Zbankova S, Bryndova J, Leden P, Kment M, Svec A, et al. (2007) 11beta-hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis. J Gastroenterol Hepatol 22: 1019-1023.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1019-1023
    • Zbankova, S.1    Bryndova, J.2    Leden, P.3    Kment, M.4    Svec, A.5
  • 36
    • 33845888031 scopus 로고    scopus 로고
    • Intravascular glucocorticoid metabolism during inflammation and injury in mice
    • Dover AR, Hadoke PW, Macdonald LJ, Miller E, Newby DE, et al. (2007) Intravascular glucocorticoid metabolism during inflammation and injury in mice. Endocrinology 148: 166-172.
    • (2007) Endocrinology , vol.148 , pp. 166-172
    • Dover, A.R.1    Hadoke, P.W.2    Macdonald, L.J.3    Miller, E.4    Newby, D.E.5
  • 37
    • 12344334475 scopus 로고    scopus 로고
    • Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis
    • Rae MT, Niven D, Ross A, Forster T, Lathe R, et al. (2004) Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. J Endocrinol 183: 19-28.
    • (2004) J Endocrinol , vol.183 , pp. 19-28
    • Rae, M.T.1    Niven, D.2    Ross, A.3    Forster, T.4    Lathe, R.5
  • 38
    • 0034743960 scopus 로고    scopus 로고
    • Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation
    • Cooper MS, Bujalska I, Rabbitt E, Walker EA, Bland R, et al. (2001) Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 16: 1037-1044.
    • (2001) J Bone Miner Res , vol.16 , pp. 1037-1044
    • Cooper, M.S.1    Bujalska, I.2    Rabbitt, E.3    Walker, E.A.4    Bland, R.5
  • 39
    • 60249089422 scopus 로고    scopus 로고
    • The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
    • Chapman KE, Coutinho AE, Gray M, Gilmour JS, Savill JS, et al. (2009) The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response. Mol Cell Endocrinol 301: 123-131.
    • (2009) Mol Cell Endocrinol , vol.301 , pp. 123-131
    • Chapman, K.E.1    Coutinho, A.E.2    Gray, M.3    Gilmour, J.S.4    Savill, J.S.5
  • 40
    • 0034730762 scopus 로고    scopus 로고
    • C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways
    • Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, et al. (2000) C/EBP regulates hepatic transcription of 11beta-hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J Biol Chem 275: 30232-30239.
    • (2000) J Biol Chem , vol.275 , pp. 30232-30239
    • Williams, L.J.1    Lyons, V.2    MacLeod, I.3    Rajan, V.4    Darlington, G.J.5
  • 41
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5
  • 42
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, et al. (2004) Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 40: 185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3    Guicciardi, M.E.4    Bronk, S.F.5
  • 43
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, et al. (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11: 183-190.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5
  • 44
    • 43949144244 scopus 로고    scopus 로고
    • Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease
    • Ahmed A, Saksena S, Sherlock M, Olliff SP, Elias E, et al. (2008) Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease. Clin Endocrinol (Oxf) 68: 898-903.
    • (2008) Clin Endocrinol (Oxf) , vol.68 , pp. 898-903
    • Ahmed, A.1    Saksena, S.2    Sherlock, M.3    Olliff, S.P.4    Elias, E.5


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