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Volumn 100, Issue 8, 1997, Pages 2094-2098

Pancreatic β cells are important targets for the diabetogenic effects of glucocorticoids

Author keywords

Glucocorticoid receptor; Glucocorticoid sensitivity; Insulin release; Non insulin dependent diabetes mellitus; Transgenic mice

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE; INSULIN;

EID: 0030777777     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119743     Document Type: Article
Times cited : (284)

References (41)
  • 1
    • 0026110135 scopus 로고
    • β-cells in type II diabetes mellitus
    • Porte, D. 1990. β-cells in type II diabetes mellitus. Diabetes. 40:166-180.
    • (1990) Diabetes , vol.40 , pp. 166-180
    • Porte, D.1
  • 3
    • 0021437995 scopus 로고
    • Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans
    • Lenzen, S., and C.J. Bailey. 1984. Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr. Rev. 5:411-434.
    • (1984) Endocr. Rev. , vol.5 , pp. 411-434
    • Lenzen, S.1    Bailey, C.J.2
  • 5
    • 0023905415 scopus 로고
    • Effects of glucocorticoids on carbohydrate metabolism
    • McMahon, M., J. Gerich, and R. Rizza. 1988. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab. Rev. 4:17-30.
    • (1988) Diabetes Metab. Rev. , vol.4 , pp. 17-30
    • McMahon, M.1    Gerich, J.2    Rizza, R.3
  • 6
    • 0018575289 scopus 로고
    • Direct effect of corticosterone upon insulin secretion studied by three different techniques
    • Billaudel, B., and B.C.J. Sutter. 1979. Direct effect of corticosterone upon insulin secretion studied by three different techniques. Horm. Metab. Res. 11:555-560.
    • (1979) Horm. Metab. Res. , vol.11 , pp. 555-560
    • Billaudel, B.1    Sutter, B.C.J.2
  • 7
    • 0018837190 scopus 로고
    • Effect of corticosterone on insulin and glucagon secretion by isolated perfused rat pancreas
    • Barseghian, C., and R. Levine. 1980. Effect of corticosterone on insulin and glucagon secretion by isolated perfused rat pancreas. Endocrinology. 106: 547-552.
    • (1980) Endocrinology , vol.106 , pp. 547-552
    • Barseghian, C.1    Levine, R.2
  • 8
    • 0022608081 scopus 로고
    • Effect of adrenal steroids on insulin secretion from cultured islets of Langerhans
    • Pierluissi, J., P.O. Navas, and S.J.H. Ashcroft. 1986. Effect of adrenal steroids on insulin secretion from cultured islets of Langerhans. Diabetologia. 29: 119-121.
    • (1986) Diabetologia , vol.29 , pp. 119-121
    • Pierluissi, J.1    Navas, P.O.2    Ashcroft, S.J.H.3
  • 9
    • 0030866606 scopus 로고    scopus 로고
    • Direct glucocorticoid inhibition of insulin secretion
    • Lambillotte, C., P. Gilon, and J.-C. Henquin. 1997. Direct glucocorticoid inhibition of insulin secretion. J. Clin. Invest. 99:414-423.
    • (1997) J. Clin. Invest. , vol.99 , pp. 414-423
    • Lambillotte, C.1    Gilon, P.2    Henquin, J.-C.3
  • 10
    • 0031033882 scopus 로고    scopus 로고
    • Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic β cells
    • Gremlich, S., R. Roduit, and B. Thorens. 1997. Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic β cells. J. Biol. Chem. 272:3216-3222.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3216-3222
    • Gremlich, S.1    Roduit, R.2    Thorens, B.3
  • 11
    • 0027358385 scopus 로고
    • Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans
    • Dinneen, S., A. Alzaid, J. Miles, and R. Rizza. 1993. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. J. Clin. Invest. 91:2283-2290.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2283-2290
    • Dinneen, S.1    Alzaid, A.2    Miles, J.3    Rizza, R.4
  • 13
    • 0025371914 scopus 로고
    • Immunohistochemical localization of the glucocorticoid receptor in pancreatic β-cells of the rat
    • Fisher, B., U. Rausch, P. Wollny, H. Westphal, J. Seitz, and G. Aumüller. 1990. Immunohistochemical localization of the glucocorticoid receptor in pancreatic β-cells of the rat. Endocrinology. 126:2635-2641.
    • (1990) Endocrinology , vol.126 , pp. 2635-2641
    • Fisher, B.1    Rausch, U.2    Wollny, P.3    Westphal, H.4    Seitz, J.5    Aumüller, G.6
  • 14
    • 0029618368 scopus 로고
    • Steroid hormone receptors: Many actors in search of a plot
    • Beato, M., P. Herrlich, and G. Schütz. 1995. Steroid hormone receptors: many actors in search of a plot. Cell. 83:851-857.
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schütz, G.3
  • 16
    • 0023066651 scopus 로고
    • Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity
    • Vanderbilt, J.N., R. Miesfeld, B.A. Maler, and K.R. Yamamoto. 1987. Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol. Endocrinol. 1:68-74.
    • (1987) Mol. Endocrinol. , vol.1 , pp. 68-74
    • Vanderbilt, J.N.1    Miesfeld, R.2    Maler, B.A.3    Yamamoto, K.R.4
  • 17
    • 0024411352 scopus 로고
    • The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response
    • Dong, Y., M. Aronsson, J.-Å. Gustafsson, and S. Okret. 1989. The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response. J. Biol. Chem. 264:13679-13683.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13679-13683
    • Dong, Y.1    Aronsson, M.2    Gustafsson, J.-Å.3    Okret, S.4
  • 18
    • 0026543152 scopus 로고
    • Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
    • Pepin, M.-C., F. Pothier, and N. Barden. 1992. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature (Lond.). 355:725-728.
    • (1992) Nature (Lond.) , vol.355 , pp. 725-728
    • Pepin, M.-C.1    Pothier, F.2    Barden, N.3
  • 21
    • 0021071029 scopus 로고
    • Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes
    • Walker, M.D., T. Edlund, A.M. Boulet, and W.J. Rutter. 1983. Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature (Lond.). 306:557-561.
    • (1983) Nature (Lond.) , vol.306 , pp. 557-561
    • Walker, M.D.1    Edlund, T.2    Boulet, A.M.3    Rutter, W.J.4
  • 22
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
    • Karlsson, O., T. Edlund, J.B. Moss, W.J. Rutter, and M.D. Walker. 1987. A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. USA. 84:8819-8823.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.D.5
  • 24
    • 0026551309 scopus 로고
    • Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    • Göttlicher, M., E. Widmark, Q. Li, and J.-Å. Gustafsson. 1992. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA. 89:4653-4657.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4653-4657
    • Göttlicher, M.1    Widmark, E.2    Li, Q.3    Gustafsson, J.-Å.4
  • 29
    • 0039829851 scopus 로고
    • Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • Schuit, F.C., P.A. In't Veld, and D.G. Pipeleers. 1988. Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc. Natl. Acad. Sci. USA. 85:3865-3869.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 30
    • 0002955624 scopus 로고
    • Mechanisms of insulin secretion
    • Oxford University Press, Oxford
    • Ashcroft, F.M., and S.J.H. Ashcroft. 1992. Mechanisms of insulin secretion. In Insulin. Oxford University Press, Oxford, 97-150.
    • (1992) Insulin , pp. 97-150
    • Ashcroft, F.M.1    Ashcroft, S.J.H.2
  • 31
    • 0028959405 scopus 로고
    • Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone
    • Khan, A., C. Hong-Lie, and B.R. Landau. 1995. Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone. Endocrinology. 136:1934-1938.
    • (1995) Endocrinology , vol.136 , pp. 1934-1938
    • Khan, A.1    Hong-Lie, C.2    Landau, B.R.3
  • 32
    • 0026801953 scopus 로고
    • Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice
    • Khan, A., C.-G. Östenson, P.-O. Berggren, and S. Efendic. 1992. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. Am. J. Physiol. 263:E663-E666.
    • (1992) Am. J. Physiol. , vol.263
    • Khan, A.1    Östenson, C.-G.2    Berggren, P.-O.3    Efendic, S.4
  • 33
    • 0025719222 scopus 로고
    • Peptide contents of neuropeptide Y. vasoactive intestinal polypeptide, and β-calcitonin gene-related peptide and their messenger ribonucleic acids after dexamethasone treatment in the isolated rat islets of Langerhans
    • Jamal, H., P.M. Jones, J. Byrne, K. Suda, M.A. Ghatei, S.M. Knase, and S.R. Bloom. 1991. Peptide contents of neuropeptide Y. vasoactive intestinal polypeptide, and β-calcitonin gene-related peptide and their messenger ribonucleic acids after dexamethasone treatment in the isolated rat islets of Langerhans. Endocrinology. 129:3372-3380.
    • (1991) Endocrinology , vol.129 , pp. 3372-3380
    • Jamal, H.1    Jones, P.M.2    Byrne, J.3    Suda, K.4    Ghatei, M.A.5    Knase, S.M.6    Bloom, S.R.7
  • 35
    • 0028851027 scopus 로고
    • Insulin-stimulated glucose uptake is enhanced in sedentary and endurance-trained low insulin responders
    • Pigon, J., S. Efendic, C.-G. Östenson, L. Lam, M. Vranic, and A.A. Giacca. 1995. Insulin-stimulated glucose uptake is enhanced in sedentary and endurance-trained low insulin responders. Am. J. Physiol. 268:E1046-E1050.
    • (1995) Am. J. Physiol. , vol.268
    • Pigon, J.1    Efendic, S.2    Östenson, C.-G.3    Lam, L.4    Vranic, M.5    Giacca, A.A.6
  • 36
    • 0014709570 scopus 로고
    • Levels of plasma insulin during cortisone glucose tolerance tests in "nondiabetic" relatives of diabetic patients. Implications of diminished insulin secretory reserve in subclinical diabetes
    • Rull, J.A., J.W. Conn, J.C. Floyd, and S.S. Fajans. 1970. Levels of plasma insulin during cortisone glucose tolerance tests in "nondiabetic" relatives of diabetic patients. Implications of diminished insulin secretory reserve in subclinical diabetes. Diabetes. 19:1-10.
    • (1970) Diabetes , vol.19 , pp. 1-10
    • Rull, J.A.1    Conn, J.W.2    Floyd, J.C.3    Fajans, S.S.4
  • 37
    • 0026686216 scopus 로고
    • The diabetogenic effects of glucocorticoids are more pronounced in low- than highinsulin responders
    • Wajngot, A., A. Giacca, V. Grill, M. Vranic, and S. Efendic. 1992. The diabetogenic effects of glucocorticoids are more pronounced in low-than highinsulin responders. Proc. Natl. Acad. Sci. USA. 89:6035-6039.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6035-6039
    • Wajngot, A.1    Giacca, A.2    Grill, V.3    Vranic, M.4    Efendic, S.5
  • 38
    • 0009413342 scopus 로고
    • The prediabetic state. A concept of dynamic resistance to a genetic diabetogenic influence
    • Coon, J.W., and S.S. Fajans. 1961. The prediabetic state. A concept of dynamic resistance to a genetic diabetogenic influence. Am. J. Med. 31:839-850.
    • (1961) Am. J. Med. , vol.31 , pp. 839-850
    • Coon, J.W.1    Fajans, S.S.2
  • 39
    • 0021440736 scopus 로고
    • Aspects of the pathogenesis of type 2 diabetes
    • Efendic, S., R. Luft, and A. Wajngot. 1984. Aspects of the pathogenesis of type 2 diabetes. Endocr. Rev. 5:395-408.
    • (1984) Endocr. Rev. , vol.5 , pp. 395-408
    • Efendic, S.1    Luft, R.2    Wajngot, A.3
  • 40
    • 0030026713 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
    • Bamberger, C.M., H.M. Schulte, and G.P. Chrousos. 1996. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr. Rev. 17:245-261.
    • (1996) Endocr. Rev. , vol.17 , pp. 245-261
    • Bamberger, C.M.1    Schulte, H.M.2    Chrousos, G.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.