Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients

Obesity Surgery

Volumn 20, Issue 1, 2010, Pages 77-83

  Baudrand, René ^a   Carvajal, Cristian A ^a   Riquelme, Arnoldo ^a   Morales, Mauricio ^a   Solis, Nancy ^a   Pizarro, Margarita ^a   Escalona, Alex ^a   Boza, Camilo ^a   Pérez, Gustavo ^a   Domínguez, Angélica ^a   Arrese, Marco ^a   Fardella, Carlos E ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

11 hydroxysteroid dehydrogenase; Abdominal obesity; Adipose tissue; Glucocorticoids; Local metabolism; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ALANINE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; BODY MASS; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL EVALUATION; COMPARATIVE STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULINEMIA; INTRAABDOMINAL FAT; LIVER; MALE; METABOLIC DISORDER; MORBID OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SUBCUTANEOUS FAT; ADIPOSE TISSUE; COMORBIDITY; ENZYMOLOGY; METABOLISM; MIDDLE AGED;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOSE TISSUE; ADULT; BODY MASS INDEX; COMORBIDITY; FEMALE; HUMANS; LIVER; MALE; METABOLIC DISEASES; MIDDLE AGED; OBESITY, MORBID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBCUTANEOUS FAT;

EID: 73949158787     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11695-009-9937-0     Document Type: Article

References (52)

1. GM Reaven 1988 Banting lecture. Role of insulin resistance in human disease Diabetes 37 1595 1607 10.2337/diabetes.37.12.1595 1:STN:280: DyaL1M%2Flt12msQ%3D%3D 3056758
2. P Dandona A Aljada A Chaudhuri, et al. 2005 Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation Circulation 111 1448 1454 10.1161/01.CIR.0000158483.13093.9D 15781756 (Pubitemid 40396812)
3. PA Tataranni 2005 Metabolic syndrome: is there a pathophysiological common denominator? World Rev Nutr Diet 94 75 83 10.1159/000088221 1:CAS:528:DC%2BD2MXht1CmsLvJ 16145253
4. National Cholesterol Education Program 2001 Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA 285 2486 2497 10.1001/jama.285.19.2486
5. KG Alberti P Zimmet J Shaw 2006 Metabolic syndrome-a new world-wide definition. A consensus statement from the international diabetes federation Diabet Med 23 469 480 10.1111/j.1464-5491.2006.01858.x 1:STN:280: DC%2BD283lslGgsQ%3D%3D 16681555
6. PM Gholam L Flancbaum JT Machan, et al. 2007 Nonalcoholic fatty liver disease in severely obese subjects Am J Gastroenterol 102 399 408 10.1111/j.1572-0241.2006.01041.x 1:CAS:528:DC%2BD2sXivF2ksb0%3D 17311652 (Pubitemid 46160554)
7. W Salgado Junior JS Santos AK Sankarankutty, et al. 2006 Nonalcoholic fatty liver disease and obesity Acta Cir Bras 21 Suppl 1 72 78 17013519
8. IJ Bujalska S Kumar PM Stewart 1997 Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349 1210 1213 10.1016/S0140-6736(96)11222-8 1:STN:280:DyaK2s3nslGmug%3D%3D 9130942
9. IM Siminialayi PC Emem-Chioma 2004 Glucocorticoids and the insulin resistance syndrome Niger J Med 13 330 335 1:STN:280:DC%2BD2crlt1egsQ%3D%3D 15523856
10. Z Krozowski KX Li K Koyama, et al. 1999 The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes J Steroid Biochem Mol Biol 69 391 401 10.1016/S0960-0760(99)00074-6 1:CAS:528:DyaK1MXktlOmu78%3D 10419017 (Pubitemid 29305561)
11. ML Ricketts JM Verhaeg I Bujalska, et al. 1998 Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues J Clin Endocrinol Metab 83 1325 1335 10.1210/jc.83.4.1325 1:CAS:528: DyaK1cXitlyntLc%3D 9543163 (Pubitemid 28496416)
12. JW Tomlinson EA Walker IJ Bujalska, et al. 2004 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 25 831 866 10.1210/er.2003-0031 1:CAS:528:DC%2BD2cXhtVSjtrnJ 15466942 (Pubitemid 39366049)
13. IJ Bujalska EA Walker JW Tomlinson, et al. 2002 11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol Endocr Res 28 449 461 10.1081/ERC-120016822 1:CAS:528:DC%2BD3sXhtVSgtr0%3D 12530648 (Pubitemid 36042500)
14. AG Atanasov LG Nashev RA Schweizer 2004 et al Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase FEBS Lett 571 129 133 10.1016/j.febslet.2004.06.065 1:CAS:528:DC%2BD2cXmtVWjt7c%3D 15280030 (Pubitemid 38992936)
15. L Freeman M Hewison SV Hughes, et al. 2005 Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells Blood 106 2042 2049 10.1182/blood-2005-01-0186 1:CAS:528:DC%2BD2MXhtVWksLrP 15941907 (Pubitemid 41291718)
16. H Masuzaki J Paterson H Shinyama, et al. 2001 A transgenic model of visceral obesity and the metabolic syndrome Science 294 2166 2170 10.1126/science.1066285 1:CAS:528:DC%2BD3MXptVOmsbs%3D 11739957 (Pubitemid 33150673)
17. JM Paterson NM Morton C Fievet, et al. 2004 Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice Proc Natl Acad Sci U S A 101 7088 7093 10.1073/pnas.0305524101 1:CAS:528:DC%2BD2cXktFeqsLo%3D 15118095 (Pubitemid 38596447)
18. NM Morton JM Paterson H Masuzaki, et al. 2004 Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice Diabetes 53 931 938 10.2337/diabetes.53.4.931 1:CAS:528:DC%2BD2cXivFyqsL8%3D 15047607 (Pubitemid 38436604)
19. L Alberti A Girola L Gilardini, et al. 2007 Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects Int J Obes (Lond) 31 1826 1831 10.1038/sj.ijo.0803677 1:CAS:528:DC%2BD2sXhtlCrsbjJ (Pubitemid 350174630)
20. SK Paulsen SB Pedersen S Fisker, et al. 2007 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization Obesity (Silver Spring) 15 1954 1960 10.1038/oby.2007.233 1:CAS:528: DC%2BD2sXhtVGrtbfM
21. BR Walker R Andrew 2006 Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease Ann N Y Acad Sci 1083 165 184 10.1196/annals.1367.012 1:CAS:528:DC%2BD2sXmslKrtA%3D%3D 17148739 (Pubitemid 44955472)
22. G Valsamakis A Anwar JW Tomlinson, et al. 2004 11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus J Clin Endocrinol Metab 89 4755 4761 10.1210/jc.2003-032240 1:CAS:528:DC%2BD2cXnslWgsr8%3D 15356090 (Pubitemid 39244498)
23. M Berthiaume M Laplante WT Festuccia, et al. 2007 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues Am J Physiol Endocrinol Metab 293 E1045 E1052 10.1152/ajpendo.00276.2007 1:CAS:528:DC%2BD2sXht1WltbbM 17666487 (Pubitemid 47535836)
24. AG Atanasov A Odermatt 2007 Readjusting the glucocorticoid balance: an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity? Endocr Metab Immune Disord Drug Targets 7 125 140 10.2174/ 187153007780832082 1:CAS:528:DC%2BD2sXmtFGlsL4%3D 17584152
25. JW Tomlinson I Bujalska PM Stewart, et al. 2000 The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis Endocr Res 26 711 722 10.3109/07435800009048591 1:CAS:528:DC%2BD3MXotlKjsw%3D%3D 11196447
26. B Mariniello V Ronconi S Rilli, et al. 2006 Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome Eur J Endocrinol 155 435 441 10.1530/eje.1.02228 1:CAS:528: DC%2BD28XhtVClur%2FE 16914598 (Pubitemid 44463950)
27. R Desbriere V Vuaroqueaux V Achard, et al. 2006 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients Obesity (Silver Spring) 14 794 798 10.1038/oby.2006.92 1:CAS:528:DC%2BD28XotlKlu7Y%3D
28. R Basu RJ Singh A Basu, et al. 2004 Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-hsd) type 1 pathway Diabetes 53 2051 2059 10.2337/diabetes.53.8.2051 1:CAS:528:DC%2BD2cXmtFGqtrw%3D 15277385 (Pubitemid 38970754)
29. R Munoz C Carvajal A Escalona, et al. 2009 11beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients Obes Surg 19 764 770 10.1007/s11695-008-9616-6 18592327
30. F Carrasco J Klaassen K Papapietro, et al. 2005 A proposal of guidelines for surgical management of obesity Rev Med Chil 133 699 706 16075135
31. AM Acosta M Escalona A Miz, et al. 2002 Determination of the insulin resistance index by the Homeostasis Model Assessment in a population of Metropolitan Region in Chile Rev Med Chil 130 11 1227 1231 1:CAS:528: DC%2BD3sXnvVaqsg%3D%3D 12587504
32. SM Grundy JI Cleeman SR Daniels, et al. 2005 Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement Circulation 112 2735 2752 10.1161/CIRCULATIONAHA.105.169404 16157765 (Pubitemid 41532612)
33. DE Kleiner EM Brunt M Van Natta, et al. 2005 Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 1313 1321 10.1002/hep.20701 15915461 (Pubitemid 40770284)
34. MW Pfaffl 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 e45 10.1093/nar/29.9.e45 1:STN:280:DC%2BD38nis12jtw%3D%3D 11328886
35. ME Altuna SM Lelli LC de Viale San Martin, et al. 2006 Effect of stress on hepatic 11beta-hydroxysteroid dehydrogenase activity and its influence on carbohydrate metabolism Can J Physiol Pharmacol 84 977 984 10.1139/Y06-046 1:CAS:528:DC%2BD2sXht1Ggu78%3D 17218963 (Pubitemid 46256339)
36. MC Holmes Y Kotelevtsev JJ Mullins, et al. 2001 Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes Mol Cell Endocrinol 171 15 20 10.1016/S0303-7207(00)00386-5 1:CAS:528:DC%2BD3MXnsVWquw%3D%3D 11165006 (Pubitemid 32098193)
37. JR Seckl NM Morton KE Chapman, et al. 2004 Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue Recent Prog Horm Res 59 359 393 10.1210/rp.59.1.359 1:CAS:528:DC%2BD2cXisFKhtLs%3D 14749510
38. EA Walker PM Stewart 2003 11beta-hydroxysteroid dehydrogenase: unexpected connections Trends Endocrinol Metab 14 334 339 10.1016/S1043-2760(03)00134-6 1:CAS:528:DC%2BD3sXms1yntbY%3D 12946876 (Pubitemid 37093131)
39. C Boza A Riquelme L Ibanez, et al. 2005 Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass Obes Surg 15 1148 1153 10.1381/0960892055002347 16197788 (Pubitemid 41390213)
40. JM Paterson JR Seckl JJ Mullins 2005 Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice Am J Physiol Regul Integr Comp Physiol 289 R642 R652 1:CAS:528:DC%2BD2MXhtVWktrrJ 16105819
41. PL Liew WJ Lee YC Lee, et al. 2006 Hepatic histopathology of morbid obesity: concurrence of other forms of chronic liver disease Obes Surg 16 1584 1593 10.1381/096089206779319392 17217634 (Pubitemid 46032811)
42. J Arun RH Clements AJ Lazenby, et al. 2006 The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to women Obes Surg 16 1351 1358 10.1381/096089206778663715 17059746 (Pubitemid 44671809)
43. RC Andrews O Rooyackers BR Walker 2003 Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes J Clin Endocrinol Metab 88 285 291 10.1210/jc.2002-021194 1:CAS:528:DC%2BD3sXkvVCjtA%3D%3D 12519867 (Pubitemid 36115179)
44. K Kannisto KH Pietilainen E Ehrenborg, et al. 2004 Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins J Clin Endocrinol Metab 89 4414 4421 10.1210/jc.2004-0153 1:CAS:528:DC%2BD2cXnslWht74%3D 15356040 (Pubitemid 39244448)
45. KA Hughes SP Webster BR Walker 2008 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity Expert Opin Investig Drugs 17 481 496 10.1517/13543784.17.4.481 1:CAS:528: DC%2BD1cXjs1Kgtbw%3D 18363514 (Pubitemid 351578167)
46. TC Friedman G Mastorakos TD Newman, et al. 1996 Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM Endocr J 43 645 655 10.1507/endocrj.43.645 1:STN:280:DyaK2s3jtVSnsw%3D%3D 9075604
47. J Jezkova J Marek M Prazny, et al. 2003 Effect of hypercortisolism on development of atherosclerotic changes in blood vessels Vnitr Lek 49 656 667 1:STN:280:DC%2BD3svlslWnsw%3D%3D 14518092
48. C Yoshida Y Miyachi 2001 Lipid metabolism in Cushing's syndrome Nippon Rinsho 59 Suppl 3 177 180 11347053
49. AM Nuotio-Antar DL Hachey AH Hasty 2007 Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice Am J Physiol Endocrinol Metab 293 E1517 E1528 10.1152/ajpendo.00522.2007 1:CAS:528:DC%2BD2sXhsVGls73F 17878220 (Pubitemid 350255101)
50. G Wolf 2002 Glucocorticoids in adipocytes stimulate visceral obesity Nutr Rev 60 148 151 10.1301/00296640260093823 12030279 (Pubitemid 34525610)
51. DJ Wake E Rask DE Livingstone, et al. 2003 Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity J Clin Endocrinol Metab 88 3983 3988 10.1210/jc.2003-030286 1:CAS:528:DC%2BD3sXmsFOku70%3D 12915696 (Pubitemid 37034555)
52. U Turpeinen H Markkanen T Sane, et al. 2006 Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry Scand J Clin Lab Invest 66 147 159 10.1080/00365510500474504 1:CAS:528:DC%2BD28XisVaqt7g%3D 16537248