Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes

Journal of Endocrinology

Volumn 156, Issue 1, 1998, Pages 159-168

  Ricketts, M L ^a   Shoesmith, K J ^a   Hewison, M ^a   Strain, A ^a   Eggo, M C ^a   Stewart, P M ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; HYDROCORTISONE RELEASE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADOLESCENT; ADULT; ANIMALS; BLOTTING, NORTHERN; CARBENOXOLONE; CELLS, CULTURED; CHILD; CORTICOSTERONE; CORTISONE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; ISOENZYMES; LIVER; MALE; MIDDLE AGED; PROGESTERONE; RATS; RATS, WISTAR; RNA, MESSENGER; SPECIES SPECIFICITY; TRIIODOTHYRONINE;

EID: 0031965002     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1560159     Document Type: Article

References (45)

1. Agarwal AK, Monder C, Eckstein B & White PC 1989 Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. Journal of Biological Chemistry 264 18939-18943.
2. Albiston AL, Obeyesekene VR, Smith RE & Krozowski ZS 1994 Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Molecular and Cellular Endocrinology 105 R11-R17.
3. Bissell DM & Guzelian PS 1980 Phenotypic stability of adult rat hepatocytes in primary monolayer cultures. Annals of the New York Academy of Sciences 349 128-137.
4. Braun L, Mead JE, Panzica M, Mikumio R, Bell GI & Fausto N 1988 Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proceedings of the National Academy of Sciences of the USA 85 1539-1543.
5. Brown RW, Chapman KE, Edwards CRW & Seckl JR 1993 Human placental 11β-hydroxysteroid dehydrogenase: partial purification of and evidence for a distinct NAD-dependent isoform. Endocrinology 132 2614-2621.
6. Bujalska IJ, Shimojo M, Howie A & Stewart PM 1997 Human 11β-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue. Steroids 62 77-82.
7. Casey ML, MacDonald PC & Andersson S 1994 17β-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. Journal of Clinical Investigation 94 2135-2141.
8. Chan YL, Guttell R, Noller HF & Wool I 1984 The nucleotide sequence of a rat 18S ribosomal ribonucleic acid. Journal of Biological Chemistry 259 224-230.
9. Chomczynski P & Sacchi N 1987 Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162 156-159.
10. Clarke RJ, Thaventhiran L, Michael AE, Antoniw JW & Cooke BA 1995 A possible physiological significance of the inhibition of 11β-hydroxysteroid dehydrogenase by progesterone and other ovarian steroids in human granulosa-lutein cells. Journal of Endocrinology 147 (Suppl) P95.
11. Edwards CRW, Stewart PM, Burt D, Brett L, McIntyre MA, Sutanto WS, deKloet R & Monder C 1988 Localisation of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet ii 986-989.
12. Hellman L, Bradlow HL, Zumoff B & Gallagher TF 1961 The influence of thyroid hormone on hydrocortisone production and metabolism. Journal of Clinical Endocrinology and Metabolism 21 1231-1247.
13. Ismail T, Howl J, Wheatley M, McMaster P, Neuberger JM & Strain AJ 1991 Growth of normal human hepatocytes in primary culture-effect of hormones and growth factors on DNA synthesis. Hepatology 14 1076-1082.
14. Jamieson PM, Chapman KE, Edwards CRW & Seckl JR 1995 11β-Hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology 136 4754-4761.
15. Koerner DR & Hellman L 1964 Effect of thyroxine administration on the 11β-hydroxysteroid dehydrogenases in rat liver and kidney. Endocrinology 75 592-601.
16. Krozowski ZS 1992 11β-Hydroxysteroid dehydrogenase and the short chain alcohol dehydrogenase superfamily. Molecular and Cellular Endocrinology 84 C25-C31.
17. Lakshmi V & Monder C 1988 Purification and characterisation of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 123 2390-2398.
18. Low SC, Assaad SN, Rajan V, Chapman KE, Edwards CRW & Seckl JR 1993 Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney. Journal of Endocrinology 139 27-35.
19. Monder C & Shackleton CHL 1984 11β-Hydroxysteroid dehydrogenase: fact or fancy? Steroids 44 383-417.
20. Monder C, Stewart PM, Lakshmi V, Valentino R, Burt D & Edwards CRW 1989 Licorice inhibits corticosteroid 11β-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 125 1046-1053.
21. Monder C, Miroff Y, Marandici A & Hardy M 1994 11β-Hydroxysteroid dehydrogenase alleviates glucocorticoidmediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology 134 1199-1204.
22. Mune T, Rogerson FM, Nikkila H, Agarwal AK & White PC 1995 Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nature Genetics 10 394-399.
23. Nikkila H, Tannin GM, New MI, Taylor NF, Kalaitzoglou G, Monder C & White PC 1993 Defects in the HSD11 gene encoding 11β-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency. Journal of Clinical Endocrinology and Metabolism 77 687-691.
24. Pasquarette MM, Stewart PM, Ricketts ML, Imaishi K & Mason JI 1996 Regulation of 11β-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells, Journal of Molecular Endocrinology 16 269-275.
25. Phillipou G & Higgins BA 1985 A new defect in the peripheral conversion of cortisone to cortisol. Journal of Steroid Biochemistry 22 435-436.
26. Poutanen M, Isomaa V, Peltoketo H & Vikho R 1995 Role of 17β-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis. Journal of Steroid Biochemistry and Molecular Biology 55 525-532.
27. Rajan V, Edwards CRW & Seckl JR 1996 11β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. Journal of Neuroscience 16 65-70.
28. Rodin A, Thakkar H, Taylor N & Clayton R 1994 Hyperandrogenism of polycystic ovary syndrome: evidence of dysregulation of 11β-hydroxysteroid dehydrogenase. New England Journal of Medicine 330 460-465.
29. Seglen PO 1976 Preparation of isolated rat liver cells. In Methods in Cell Biology, vol 13, pp 29-83. Ed DM Prescott. New York: Academic Press.
30. Shimojo M, Whorwood CB & Stewart PM 1996 11β-Hydroxysteroid dehydrogenase in the rat adrenal. Journal of Molecular Endocrinology 17 121-130.
31. Stewart PM, Wallace AM, Atherden SM, Shearing CH & Edwards CRW 1990 Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice activity in man. Clinical Science 78 49-54.
32. Stewart PM, Burra P, Shackleton CHL, Sheppard MC & Elias E 1993 11β-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease. Journal of Clinical Endocrinology and Metabolism 76 748-751.
33. Stewart PM, Murry BA & Mason JI 1994 Human kidney 11β-hydroxysteroid dehydrogenase is a high affinity NAD-dependent enzyme and differs from the cloned type 1 isoform. Journal of Clinical Endocrinology and Metabolism 79 480-484.
34. Stewart PM, Krozowski ZS, Gupta A, Milford DV, Howie AJ, Sheppard MC & Whorwood CB 1996 Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene. Lancet 347 88-91.
35. Strain AJ, Ismail T, Tsubouchi H, Hishida T, Kitamura N, Uhara Y & McMaster P 1991 Native and recombinant human hepatocyte growth factor are highly potent promoters of DNA synthesis in both human and rat hepatocyte. Journal of Clinical Investigation 87 1853-1857.
36. Tannin GM, Agarwal AK, Monder C, New MI & White PC 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Journal of Biological Chemistry 266 16653-16658.
37. Tremblay Y & Beaudoin C 1993 Regulation of 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic AMP and phorbol myristate acetate in human choriocarcinoma cells. Molecular Endocrinology 7 355-364.
38. Walker BR, Campbell JC, Fraser R, Stewart PM & Edwards CRW 1992 Mineralocorticoid excess and inhibition of 11β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clinical Endocrinology 37 483-492.
39. Walker BR, Connacher AA, Lindsay RM, Webb DJ & Edwards CRW 1995 Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. Journal of Clinical Endocrinology and Metabolism 80 3155-3159.
40. Whorwood CB, Sheppard MC & Stewart PM 1993a Licorice inhibits 11β-hydroxysteroid dehydrogenase messenger RNA levels and potentiates glucocorticoid hormone action. Endocrinology 132 2287-2292.
41. Whorwood CB, Sheppard MC & Stewart PM 1993b Tissue specific effects of thyroid hormone on 11β-hydroxysteroid dehydrogenase gene expression. Journal of Steroid Biochemistry and Molecular Biology 46 539-547.
42. Whorwood CB, Mason JI, Ricketts ML, Howie AJ & Stewart PM 1995 Detection of human 11β-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts. Molecular and Cellular Endocrinology 110 R7-R12.
43. Wilson RC, Krozowski ZS, Li K, Obeyesekere VR, Razzaghy-Azar M, Harbison MD, Wei JQ, Shackleton CHL, Funder JW & New MI 1995 A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess. Journal of Clinical Endocrinology and Metabolism 80 2263-2266.
44. Zhou MY, Gomez-Sanchez EP, Cox DL, Cosby D & Gomez-Sanchez CE 1995 Cloning, expression and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11β-hydroxysteroid dehydrogenase. Endocrinology 136 3729-3734.
45. Zumoff B, Bradlow HL, Levin J & Fukushima DK 1983 Influence of thyroid hormone on the in vivo cortisol-cortisone equilibrium in man. Journal of Steroid Biochemistry 18 437-440.