-
1
-
-
66349099340
-
Fatty acid metabolism: Target for metabolic syndrome
-
Wakil SJ, Abu-Elheiga LA (2009) Fatty acid metabolism: target for metabolic syndrome. J Lipid Res 50 (Suppl): S138-S143.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Wakil, S.J.1
Abu-Elheiga, L.A.2
-
2
-
-
0026569612
-
Acetyl-coenzyme A carboxylase mRNA metabolism in the rat liver
-
López-Casillas F, Ponce-Castañeda MV, Kim KH. Mao J, DeMayo FJ (1992) Acetyl-coenzyme A carboxylase mRNA metabolism in the rat liver. Metabolism 41: 201-207.
-
(1992)
Metabolism
, vol.41
, pp. 201-207
-
-
López-Casillas, F.1
Ponce-Castañeda, M.V.2
Kim, K.H.3
Mao, J.4
Demayo, F.J.5
-
3
-
-
0025299901
-
Effects of nutrients and hormones on transcriptional and posttranscriptional regulation of acetyl-CoA carboxylase in rat liver
-
Katsurada A, Iritani N, Fukuda H, Matsumura Y, Nishimoto N, Noguchi T, Tanaka T (1990) Effects of nutrients and hormones on transcriptional and posttranscriptional regulation of acetyl-CoA carboxylase in rat liver. Eur J Biochem 190: 435-441.
-
(1990)
Eur J Biochem
, vol.190
, pp. 435-441
-
-
Katsurada, A.1
Iritani, N.2
Fukuda, H.3
Matsumura, Y.4
Nishimoto, N.5
Noguchi, T.6
Tanaka, T.7
-
4
-
-
0022462402
-
Fatty acid inhibition of hormonal induction of acetyl-coenzyme A carboxylase in hepatocyte monolayers
-
Salati LM, Clarke SD (1986) Fatty acid inhibition of hormonal induction of acetyl-coenzyme A carboxylase in hepatocyte monolayers. Arch Biochem Biophys 246: 82-89.
-
(1986)
Arch Biochem Biophys
, vol.246
, pp. 82-89
-
-
Salati, L.M.1
Clarke, S.D.2
-
5
-
-
0029041316
-
Human acetyl-CoA carboxylase: Characterization, molecular cloning, and evidence for two isoforms
-
Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ (1995) Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci USA 92: 4011-4015.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4011-4015
-
-
Abu-Elheiga, L.1
Jayakumar, A.2
Baldini, A.3
Chirala, S.S.4
Wakil, S.J.5
-
6
-
-
0030939116
-
Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms
-
Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ (1997) Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem 272: 10669-10677.
-
(1997)
J Biol Chem
, vol.272
, pp. 10669-10677
-
-
Abu-Elheiga, L.1
Almarza-Ortega, D.B.2
Baldini, A.3
Wakil, S.J.4
-
7
-
-
0034652297
-
The subcellular localization of acetyl-CoA carboxylase 2
-
Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ (2000) The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci USA 97: 1444-1449.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1444-1449
-
-
Abu-Elheiga, L.1
Brinkley, W.R.2
Zhong, L.3
Chirala, S.S.4
Woldegiorgis, G.5
Wakil, S.J.6
-
8
-
-
33744781581
-
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis
-
Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ (2006) Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci USA 103: 8552-8557.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8552-8557
-
-
Mao, J.1
Demayo, F.J.2
Li, H.3
Abu-Elheiga, L.4
Gu, Z.5
Shaikenov, T.E.6
Kordari, P.7
Chirala, S.S.8
Heird, W.C.9
Wakil, S.J.10
-
9
-
-
33847117593
-
Expression, purification, and characterization of human acetyl-CoA carboxylase 2
-
Kim KW, Yamane H (2006) Expression, purification, and characterization of human acetyl-CoA carboxylase 2. Protein Expr Purif 53: 16-23.
-
(2006)
Protein Expr Purif
, vol.53
, pp. 16-23
-
-
Kim, K.W.1
Yamane, H.2
-
10
-
-
36749052873
-
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
-
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI (2007) Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 104: 16480-16485.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 16480-16485
-
-
Choi, C.S.1
Savage, D.B.2
Abu-Elheiga, L.3
Liu, Z.X.4
Kim, S.5
Kulkarni, A.6
Distefano, A.7
Hwang, Y.J.8
Reznick, R.M.9
Codella, R.10
Zhang, D.11
Cline, G.W.12
Wakil, S.J.13
Shulman, G.I.14
-
11
-
-
0037934709
-
Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5'-untranslated mRNA region
-
Mao J, Chirala SS, Wakil SJ (2003) Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region. Proc Natl Acad Sci USA 100: 7515-7520.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7515-7520
-
-
Mao, J.1
Chirala, S.S.2
Wakil, S.J.3
-
12
-
-
14044261409
-
Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues
-
Oh SY, Lee MY, Kim JM, Yoon S, Shin S, Park YN, Ahn YH, Kim KS (2005) Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues. J Biol Chem 280: 5909-5916.
-
(2005)
J Biol Chem
, vol.280
, pp. 5909-5916
-
-
Oh, S.Y.1
Lee, M.Y.2
Kim, J.M.3
Yoon, S.4
Shin, S.5
Park, Y.N.6
Ahn, Y.H.7
Kim, K.S.8
-
13
-
-
0034804783
-
Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
-
Shimano H (2001) Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40: 439-452.
-
(2001)
Prog Lipid Res
, vol.40
, pp. 439-452
-
-
Shimano, H.1
-
14
-
-
0037072732
-
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceriderich very low density lipoprotein particles
-
Grefhorst A, Elzinga BM, Voshol PJ, Plösch T, Kok T, Bloks VW, van der Sluijs FH, Havekes LM, Romijn JA, Verkade HJ, Kuipers F (2002) Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceriderich very low density lipoprotein particles. J Biol Chem 277: 34182-34190.
-
(2002)
J Biol Chem
, vol.277
, pp. 34182-34190
-
-
Grefhorst, A.1
Elzinga, B.M.2
Voshol, P.J.3
Plösch, T.4
Kok, T.5
Bloks, V.W.6
van der Sluijs, F.H.7
Havekes, L.M.8
Romijn, J.A.9
Verkade, H.J.10
Kuipers, F.11
-
15
-
-
0043210499
-
Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
-
Oh SY, Park SK (2003) Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver. J Biol Chem 278: 28410-28407.
-
(2003)
J Biol Chem
, vol.278
, pp. 28410-28407
-
-
Oh, S.Y.1
Park, S.K.2
-
16
-
-
40549125618
-
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
-
Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C (2008) ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118: 956-964.
-
(2008)
J Clin Invest
, vol.118
, pp. 956-964
-
-
Denechaud, P.D.1
Bossard, P.2
Lobaccaro, J.M.3
Millatt, L.4
Staels, B.5
Girard, J.6
Postic, C.7
-
17
-
-
0030978451
-
Regulation of the rat proopiomelanocortin gene expression in AtT-20 cells. I: Effects of the common secretagogues
-
Aoki Y, Iwasaki Y, Katahira M, Oiso Y, Saito H (1997) Regulation of the rat proopiomelanocortin gene expression in AtT-20 cells. I: Effects of the common secretagogues. Endocrinology 138: 1923-1929.
-
(1997)
Endocrinology
, vol.138
, pp. 1923-1929
-
-
Aoki, Y.1
Iwasaki, Y.2
Katahira, M.3
Oiso, Y.4
Saito, H.5
-
18
-
-
0019822910
-
Induction of acetyl-CoA carboxylase in primary rat hepatocyte cultures by glucose and insulin
-
Katz NR, Ick M (1981) Induction of acetyl-CoA carboxylase in primary rat hepatocyte cultures by glucose and insulin. Biochem Biophys Res Commun 100: 703-709.
-
(1981)
Biochem Biophys Res Commun
, vol.100
, pp. 703-709
-
-
Katz, N.R.1
Ick, M.2
-
19
-
-
0024803713
-
Regulation of acetyl CoA carboxylase mRNA in rat liver by high carbohydrate diet and insulin
-
Choi DH, Choi JH, Whang SK, Kim YS (1989) Regulation of acetyl CoA carboxylase mRNA in rat liver by high carbohydrate diet and insulin. Yonsei Med J 30: 235-245.
-
(1989)
Yonsei Med J
, vol.30
, pp. 235-245
-
-
Choi, D.H.1
Choi, J.H.2
Whang, S.K.3
Kim, Y.S.4
-
20
-
-
0026601378
-
Nutritional and hormonal regulation of mRNA levels of lipogenic enzymes in primary cultures of rat hepatocytes
-
Fukuda H, Katsurada A, Iritani N (1992) Nutritional and hormonal regulation of mRNA levels of lipogenic enzymes in primary cultures of rat hepatocytes. J Biochem 111: 25-30.
-
(1992)
J Biochem
, vol.111
, pp. 25-30
-
-
Fukuda, H.1
Katsurada, A.2
Iritani, N.3
-
21
-
-
0016692353
-
Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids
-
Diamant S, Shafrir E (1975) Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids. Eur J Biochem 53: 541-546.
-
(1975)
Eur J Biochem
, vol.53
, pp. 541-546
-
-
Diamant, S.1
Shafrir, E.2
-
22
-
-
0028075339
-
Glucocorticoid action and the clinical features of Cushing's syndrome
-
Yanovski JA, Cutler GB Jr (1994) Glucocorticoid action and the clinical features of Cushing's syndrome. Endocrinol Metab Clin North Am 23: 487-509.
-
(1994)
Endocrinol Metab Clin North Am
, vol.23
, pp. 487-509
-
-
Yanovski, J.A.1
Cutler Jr., G.B.2
-
23
-
-
0346728586
-
Hepatic steatosis in Cushing's syndrome: A radiological assessment using computed tomography
-
Rockall AG, Sohaib SA, Evans D, Kaltsas G, Isidori AM, Monson JP, Besser GM, Grossman AB, Reznek RH (2003) Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography. Eur J Endocrinol 149: 543-548.
-
(2003)
Eur J Endocrinol
, vol.149
, pp. 543-548
-
-
Rockall, A.G.1
Sohaib, S.A.2
Evans, D.3
Kaltsas, G.4
Isidori, A.M.5
Monson, J.P.6
Besser, G.M.7
Grossman, A.B.8
Reznek, R.H.9
-
24
-
-
33845398283
-
Transcriptional regulation by insulin: From the receptor to the gene
-
Mounier C, Posner BI (2006) Transcriptional regulation by insulin: from the receptor to the gene. Can J Physiol Pharmacol 84: 713-724.
-
(2006)
Can J Physiol Pharmacol
, vol.84
, pp. 713-724
-
-
Mounier, C.1
Posner, B.I.2
-
25
-
-
0027490174
-
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein recaptor gene
-
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (1993) SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein recaptor gene. Cell 75: 187-197.
-
(1993)
Cell
, vol.75
, pp. 187-197
-
-
Yokoyama, C.1
Wang, X.2
Briggs, M.R.3
Admon, A.4
Wu, J.5
Hua, X.6
Goldstein, J.L.7
Brown, M.S.8
-
26
-
-
0028963743
-
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
-
Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM (1995) Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol 15: 2582-2588.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2582-2588
-
-
Kim, J.B.1
Spotts, G.D.2
Halvorsen, Y.D.3
Shih, H.M.4
Ellenberger, T.5
Towle, H.C.6
Spiegelman, B.M.7
-
27
-
-
38849122775
-
Liver X receptors (LXRs). Part I: Structure, function, regulation of activity, and role in lipid metabolism
-
Wójcicka G, Jamroz-Wiśniewska A, Horoszewicz K, Bełtowski J (2007) Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism. Postepy Hig Med Dosw 61: 736-759.
-
(2007)
Postepy Hig Med Dosw
, vol.61
, pp. 736-759
-
-
Wójcicka, G.1
Jamroz-Wiśniewska, A.2
Horoszewicz, K.3
Bełtowski, J.4
-
28
-
-
33846208252
-
The nuclear receptor LXR is a glucose sensor
-
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E (2007) The nuclear receptor LXR is a glucose sensor. Nature 445: 219-223.
-
(2007)
Nature
, vol.445
, pp. 219-223
-
-
Mitro, N.1
Mak, P.A.2
Vargas, L.3
Godio, C.4
Hampton, E.5
Molteni, V.6
Kreusch, A.7
Saez, E.8
-
29
-
-
8144229872
-
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
-
Ishii S, Iizuka, Miller BC, Uyeda K (2004) Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci USA 101: 15597-15602.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15597-15602
-
-
Ishii, S.1
Iizuka, M.B.C.2
Uyeda, K.3
-
30
-
-
38449087713
-
ChREBP, a transcriptional regulator of glucose and lipid metabolism
-
Postic C, Dentin R (2007) ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 27: 179-192.
-
(2007)
Annu Rev Nutr
, vol.27
, pp. 179-192
-
-
Postic, C.1
Dentin, R.2
-
31
-
-
33845586655
-
ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells
-
Da Silva Xavier G, Rutter GA, Diraison F, Andreolas C, Leclerc I (2006) ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res 47: 2482-1491.
-
(2006)
J Lipid Res
, vol.47
, pp. 2482-1491
-
-
da Silva Xavier, G.1
Rutter, G.A.2
Diraison, F.3
Andreolas, C.4
Leclerc, I.5
-
32
-
-
29644446917
-
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism
-
Tsatsos NG, Towle HC (2006) Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism. Biochem Biophys Res Commun 340: 449-456.
-
(2006)
Biochem Biophys Res Commun
, vol.340
, pp. 449-456
-
-
Tsatsos, N.G.1
Towle, H.C.2
-
33
-
-
0037155935
-
Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
-
Tobin KA, Ulven SM, Schuster GU, Steineger HH, Andresen SM, Gustafsson JA, Nebb HI (2002) Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem 277: 10691-10697.
-
(2002)
J Biol Chem
, vol.277
, pp. 10691-10697
-
-
Tobin, K.A.1
Ulven, S.M.2
Schuster, G.U.3
Steineger, H.H.4
Andresen, S.M.5
Gustafsson, J.A.6
Nebb, H.I.7
-
34
-
-
39849090597
-
Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11β-hydroxysteroid dehydrogenase type 1) gene
-
Iwasaki Y, Takayasu S, Nishiyama M, Tsugita M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Hashimoto K (2008) Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11β-hydroxysteroid dehydrogenase type 1) gene. Mol Cell Endocrinol 285: 10-18.
-
(2008)
Mol Cell Endocrinol
, vol.285
, pp. 10-18
-
-
Iwasaki, Y.1
Takayasu, S.2
Nishiyama, M.3
Tsugita, M.4
Taguchi, T.5
Asai, M.6
Yoshida, M.7
Kambayashi, M.8
Hashimoto, K.9
-
35
-
-
68549139946
-
The pathogenetic role of cortisol in the metabolic syndrome: A hypothesis
-
Anagnostis P, Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP (2009) The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab 94: 2692-2701.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 2692-2701
-
-
Anagnostis, P.1
Athyros, V.G.2
Tziomalos, K.3
Karagiannis, A.4
Mikhailidis, D.P.5
-
36
-
-
18144396604
-
Treating the metabolic syndrome: Acetyl-CoA carboxylase inhibition
-
Harwood HJ Jr (2005) Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition. Expert Opin Ther Targets 9: 267-281.
-
(2005)
Expert Opin Ther Targets
, vol.9
, pp. 267-281
-
-
Harwood Jr., H.J.1
-
37
-
-
67650462508
-
Review of recent acetyl-CoA carboxylase inhibitor patents: Mid-2007-2008
-
Corbett JW (2009) Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008. Expert Opin Ther Pat 19: 943-956.
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 943-956
-
-
Corbett, J.W.1
|