메뉴 건너뛰기




Volumn 148, Issue 5, 2007, Pages 2391-2397

Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11β-hydroxysteroid dehydrogenase type 1

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; ACYL COENZYME A DESATURASE; DGAT1 PROTEIN, RAT; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR; FAS ANTIGEN; FAS PROTEIN, MOUSE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOLIPASE A; UNCLASSIFIED DRUG;

EID: 34249775822     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1199     Document Type: Article
Times cited : (75)

References (50)
  • 1
    • 0036095101 scopus 로고    scopus 로고
    • Glucocorticoids in adipocytes stimulate visceral obesity
    • Wolf G 2002 Glucocorticoids in adipocytes stimulate visceral obesity. Nutr Rev 60:148-151
    • (2002) Nutr Rev , vol.60 , pp. 148-151
    • Wolf, G.1
  • 3
    • 1542675142 scopus 로고    scopus 로고
    • Tissue-specific glucocorticoid reactivating enzyme, 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1): A promising drug target for the treatment of metabolic syndrome
    • Masuzaki H, Flier JS 2003 Tissue-specific glucocorticoid reactivating enzyme, 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1): a promising drug target for the treatment of metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord 3:255-262
    • (2003) Curr Drug Targets Immune Endocr Metabol Disord , vol.3 , pp. 255-262
    • Masuzaki, H.1    Flier, J.S.2
  • 4
    • 0141739647 scopus 로고    scopus 로고
    • Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action
    • Stewart PM 2003 Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action. Eur J Endocrinol 149:163-168
    • (2003) Eur J Endocrinol , vol.149 , pp. 163-168
    • Stewart, P.M.1
  • 5
    • 85047683614 scopus 로고    scopus 로고
    • Minireview: 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific amplifier of glucocorticoid action
    • Seckl JR, Walker BR 2001 Minireview: 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific amplifier of glucocorticoid action. Endocrinology 142:1371-1376
    • (2001) Endocrinology , vol.142 , pp. 1371-1376
    • Seckl, J.R.1    Walker, B.R.2
  • 7
    • 0033305631 scopus 로고    scopus 로고
    • Differentiation of adipose stromal cells: The roles of glucocorticoids and 11β- hydroxysteroid dehydrogenase
    • Bujalska IJ, Kumar S, Hewison M, Stewart PM 1999 Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β- hydroxysteroid dehydrogenase. Endocrinology 140:3188-3196
    • (1999) Endocrinology , vol.140 , pp. 3188-3196
    • Bujalska, I.J.1    Kumar, S.2    Hewison, M.3    Stewart, P.M.4
  • 8
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska IJ, Kumar S, Stewart PM 1997 Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349:1210-1213
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 9
    • 0034463972 scopus 로고    scopus 로고
    • Understanding the role of glucocorticoids in obesity: Tissue-specific alterations of corticosterone metabolism in obese Zucker rats
    • Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, Walker BR 2000 Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology 141:560-563
    • (2000) Endocrinology , vol.141 , pp. 560-563
    • Livingstone, D.E.1    Jones, G.C.2    Smith, K.3    Jamieson, P.M.4    Andrew, R.5    Kenyon, C.J.6    Walker, B.R.7
  • 11
    • 0036075081 scopus 로고    scopus 로고
    • Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: An in situ hybridization study
    • Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M 2002 Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab 87:2701-2705
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2701-2705
    • Paulmyer-Lacroix, O.1    Boullu, S.2    Oliver, C.3    Alessi, M.C.4    Grino, M.5
  • 14
    • 0035798621 scopus 로고    scopus 로고
    • Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
    • Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, Mullins JJ, Seckl JR 2001 Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276:41293-41300
    • (2001) J Biol Chem , vol.276 , pp. 41293-41300
    • Morton, N.M.1    Holmes, M.C.2    Fievet, C.3    Staels, B.4    Tailleux, A.5    Mullins, J.J.6    Seckl, J.R.7
  • 16
    • 0008092276 scopus 로고
    • Metabolism of different adipose tissues in vivo in the rat
    • Li M, Yang S, Bjorntorp P 1993 Metabolism of different adipose tissues in vivo in the rat. Obes Res 1:459-468
    • (1993) Obes Res , vol.1 , pp. 459-468
    • Li, M.1    Yang, S.2    Bjorntorp, P.3
  • 21
    • 4344598315 scopus 로고    scopus 로고
    • Lipid metabolic enzymes: Emerging drug targets for the treatment of obesity
    • Shi Y, Burn P 2004 Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat Rev Drug Discov 3:695-710
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 695-710
    • Shi, Y.1    Burn, P.2
  • 23
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH 1957 A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 24
    • 0028825991 scopus 로고
    • Intravenous lipid emulsions: Removal mechanisms as compared to chylomicrons
    • Hultin M, Carneheim C, Rosenqvist K, Olivecrona T 1995 Intravenous lipid emulsions: removal mechanisms as compared to chylomicrons. J Lipid Res 36:2174-2184
    • (1995) J Lipid Res , vol.36 , pp. 2174-2184
    • Hultin, M.1    Carneheim, C.2    Rosenqvist, K.3    Olivecrona, T.4
  • 25
    • 0345369744 scopus 로고    scopus 로고
    • Response of adipose tissue lipoprotein lipase to the cephalic phase of insulin secretion
    • Picard F, Naïmi N, Richard D, Deshaies Y 1999 Response of adipose tissue lipoprotein lipase to the cephalic phase of insulin secretion. Diabetes 48:452-459
    • (1999) Diabetes , vol.48 , pp. 452-459
    • Picard, F.1    Naïmi, N.2    Richard, D.3    Deshaies, Y.4
  • 26
    • 0028960787 scopus 로고
    • Skeletal muscle utilization of free fatty acids in women with visceral obesity
    • Colberg SR, Simoneau JA, Thaete FL, Kelley DE 1995 Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95:1846-1853
    • (1995) J Clin Invest , vol.95 , pp. 1846-1853
    • Colberg, S.R.1    Simoneau, J.A.2    Thaete, F.L.3    Kelley, D.E.4
  • 27
    • 0035111323 scopus 로고    scopus 로고
    • Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: Analysis of 11β-HSD-1-deficient mice
    • Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC 2001 Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11β-HSD-1-deficient mice. Endocrinology 142:114-120
    • (2001) Endocrinology , vol.142 , pp. 114-120
    • Harris, H.J.1    Kotelevtsev, Y.2    Mullins, J.J.3    Seckl, J.R.4    Holmes, M.C.5
  • 28
    • 0018349371 scopus 로고
    • Hormonal regulation of hepatic soluble phosphatidate phosphohydrolase. Induction by cortisol in vivo and in isolated perfused rat liver
    • Lehtonen MA, Savolainen MJ, Hassinen IE 1979 Hormonal regulation of hepatic soluble phosphatidate phosphohydrolase. Induction by cortisol in vivo and in isolated perfused rat liver. FEBS Lett 99:162-166
    • (1979) FEBS Lett , vol.99 , pp. 162-166
    • Lehtonen, M.A.1    Savolainen, M.J.2    Hassinen, I.E.3
  • 29
    • 0018248912 scopus 로고
    • The effects of cortisol, corticotropin and thyroxine on the synthesis of glycerolipids and on the phosphatidate phosphohydrolase activity in rat liver
    • Glenny HP, Brindley DN 1978 The effects of cortisol, corticotropin and thyroxine on the synthesis of glycerolipids and on the phosphatidate phosphohydrolase activity in rat liver. Biochem J 176:777-784
    • (1978) Biochem J , vol.176 , pp. 777-784
    • Glenny, H.P.1    Brindley, D.N.2
  • 30
    • 0014092638 scopus 로고
    • Effect of adrenalcortical hormones on release of triglycerides and glucose by liver
    • Klausner H, Heimberg M 1967 Effect of adrenalcortical hormones on release of triglycerides and glucose by liver. Am J Physiol 212:1236-1246
    • (1967) Am J Physiol , vol.212 , pp. 1236-1246
    • Klausner, H.1    Heimberg, M.2
  • 31
    • 0015993904 scopus 로고
    • Ultrastructural and physiological evidence for corticosteroid-induced alterations in hepatic production of very low density lipoprotein particles
    • Reaven EP, Kolterman OG, Reaven GM 1974 Ultrastructural and physiological evidence for corticosteroid-induced alterations in hepatic production of very low density lipoprotein particles. J Lipid Res 15:74-83
    • (1974) J Lipid Res , vol.15 , pp. 74-83
    • Reaven, E.P.1    Kolterman, O.G.2    Reaven, G.M.3
  • 32
    • 26844451645 scopus 로고    scopus 로고
    • Transgenic mice with 11β-hydroxysteroid dehydrogenase type 1 overexpression in adipocytes develop fatty liver disease
    • Afdhal NH, Mazusaki H, Turner B, Nasser I, Flier J 2002 Transgenic mice with 11β-hydroxysteroid dehydrogenase type 1 overexpression in adipocytes develop fatty liver disease. Hepatology 36:216A
    • (2002) Hepatology , vol.36
    • Afdhal, N.H.1    Mazusaki, H.2    Turner, B.3    Nasser, I.4    Flier, J.5
  • 34
    • 0025299388 scopus 로고
    • Portal adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
    • Bjorntorp P 1990 "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10:493-496
    • (1990) Arteriosclerosis , vol.10 , pp. 493-496
    • Bjorntorp, P.1
  • 35
    • 0026650744 scopus 로고
    • Effects of insulin and dexamethasone on lipoprotein lipase in human adipose tissue
    • Appel B, Fried SK 1992 Effects of insulin and dexamethasone on lipoprotein lipase in human adipose tissue. Am J Physiol 262:E695-E699
    • (1992) Am J Physiol , vol.262
    • Appel, B.1    Fried, S.K.2
  • 36
    • 0018854541 scopus 로고
    • Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids
    • Ashby P, Robinson DS 1980 Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids. Biochem J 188:185-192
    • (1980) Biochem J , vol.188 , pp. 185-192
    • Ashby, P.1    Robinson, D.S.2
  • 37
    • 0031007874 scopus 로고    scopus 로고
    • The tissue-specific expression of lipoprotein lipase: Implications for energy and lipoprotein metabolism
    • Zechner R 1997 The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism. Curr Opin Lipidol 8:77-88
    • (1997) Curr Opin Lipidol , vol.8 , pp. 77-88
    • Zechner, R.1
  • 38
    • 1542404084 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in body weight regulation
    • Dobrzyn A, Ntambi JM 2004 The role of stearoyl-CoA desaturase in body weight regulation. Trends Cardiovasc Med 14:77-81
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 77-81
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 40
    • 0034468978 scopus 로고    scopus 로고
    • DGAT and triglyceride synthesis: A new target for obesity treatment?
    • Chen HC, Farese RV, Jr 2000 DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc Med 10:188-192
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 188-192
    • Chen, H.C.1    Farese Jr, R.V.2
  • 41
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW 2004 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279:48968-48975
    • (2004) J Biol Chem , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 42
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS 2004 Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279:47066-47075
    • (2004) J Biol Chem , vol.279 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3    Kim, K.H.4    Sul, H.S.5
  • 44
    • 0014198482 scopus 로고
    • Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue
    • Ballard FJ, Hanson RW, Leveille GA 1967 Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue. J Biol Chem 242:2746-2750
    • (1967) J Biol Chem , vol.242 , pp. 2746-2750
    • Ballard, F.J.1    Hanson, R.W.2    Leveille, G.A.3
  • 45
    • 20644460348 scopus 로고    scopus 로고
    • Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C
    • Chakravarty K, Cassuto H, Reshef L, Hanson RW 2005 Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C. Crit Rev Biochem Mol Biol 40:129-154
    • (2005) Crit Rev Biochem Mol Biol , vol.40 , pp. 129-154
    • Chakravarty, K.1    Cassuto, H.2    Reshef, L.3    Hanson, R.W.4
  • 46
    • 0037312845 scopus 로고    scopus 로고
    • PPAR-γ activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: Mechanisms for modulation of postprandial lipemia and differential adipose accretion
    • Laplante M, Sell H, MacNaul KL, Richard D, Berger JP, Deshaies Y 2003 PPAR-γ activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Diabetes 52:291-299
    • (2003) Diabetes , vol.52 , pp. 291-299
    • Laplante, M.1    Sell, H.2    MacNaul, K.L.3    Richard, D.4    Berger, J.P.5    Deshaies, Y.6
  • 47
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson JR, Kreisberg RA, Felts PW 1966 Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci USA 56:247-254
    • (1966) Proc Natl Acad Sci USA , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 48
    • 33746232372 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-α: Independent and interactive roles in the regulation of lipid metabolism
    • Sampath H, Ntambi JM 2006 Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-α: independent and interactive roles in the regulation of lipid metabolism. Curr Opin Clin Nutr Metab Care 9:84-88
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , pp. 84-88
    • Sampath, H.1    Ntambi, J.M.2
  • 50
    • 0034455281 scopus 로고    scopus 로고
    • Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary
    • Meijer OC, Steenbergen PJ, De Kloet ER 2000 Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary. Endocrinology 141:2192-2199
    • (2000) Endocrinology , vol.141 , pp. 2192-2199
    • Meijer, O.C.1    Steenbergen, P.J.2    De Kloet, E.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.