Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

Molecular and Cellular Endocrinology

Volumn 301, Issue 1-2, 2009, Pages 109-116

  Hult, Malin ^a   Ortsäter, Henrik ^b   Schuster, Gertrud ^a   Graedler, Florian ^c   Beckers, Johannes ^c   Adamski, Jerzy ^c,e   Ploner, Alexander ^a   Jörnvall, Hans ^a   Bergsten, Peter ^b   Oppermann, Udo ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

11Beta hydroxysteroid dehydrogenase; Glucocorticoid; Glucose stimulated insulin secretion; inflammation; Insulin resistance

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; DEHYDROCORTICOSTERONE; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ARTICLE; GENE CONTROL; INSULIN RELEASE; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SHORT COURSE THERAPY; SIGNAL TRANSDUCTION; STRESS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CORTICOSTERONE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 60249098462     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.09.038     Document Type: Article

References (41)

1. Ashcroft F.M., Proks P., Smith P.A., Ammala C., Bokvist K., and Rorsman P. Stimulus-secretion coupling in pancreatic beta cells. J. Cell. Biochem. 55 Suppl. (1994) 54-65
2. Benjamini Y., Drai D., Elmer G., Kafkafi N., and Golani I. Controlling the false discovery rate in behavior genetics research. Behav. Brain Res. 125 (2001) 279-284
3. Berger J., Tanen M., Elbrecht A., Hermanowski-Vosatka A., Moller D.E., Wright S.D., and Thieringer R. Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. J. Biol. Chem. 276 (2001) 12629-12635
4. 2+ and pancreatic B-cell function. Biochem. Soc. Trans. 22 (1994) 12-18
5. Bergsten P., and Hellman B. Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes 42 (1993) 670-674
6. Brunstedt J., and Nielsen J.H. Direct long-term effect of hydrocortisone on insulin and glucagon release from mouse pancreatic islets in tissue culture. Acta Endocrinol. (Copenh.) 96 (1981) 498-504
7. Davani B., Khan A., Hult M., Martensson E., Okret S., Efendic S., Jornvall H., and Oppermann U.C. Type 1 11beta-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J. Biol. Chem. 275 (2000) 34841-34844
8. Davani B., Portwood N., Bryzgalova G., Reimer M.K., Heiden T., Ostenson C.G., Okret S., Ahren B., Efendic S., and Khan A. Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes. Diabetes 53 Suppl. 1 (2004) S51-S59
9. Davies T.H., Ning Y.M., and Sanchez E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J. Biol. Chem. 277 (2002) 4597-4600
10. Delaunay F., Khan A., Cintra A., Davani B., Ling Z.C., Andersson A., Ostenson C.G., Gustafsson J., Efendic S., and Okret S. Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. J. Clin. Invest. 100 (1997) 2094-2098
11. Deng Y., Bhattacharya S., Swamy O.R., Tandon R., Wang Y., Janda R., and Riedel H. Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action. J. Biol. Chem. 278 (2003) 39311-39322
12. Denny W.B., Valentine D.L., Reynolds P.D., Smith D.F., and Scammell J.G. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141 (2000) 4107-4113
13. Drobyshev A.L., Machka C., Horsch M., Seltmann M., Liebscher V., Hrabe de Angelis M., and Beckers J. Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringencies. Nucleic Acids Res. 31 (2003) pp. E1-1
14. Dudoit S., Shaffer J.P., and Boldrick J.C. Multiple testing in microarray experiments. Stat. Sci. 18 (2003) 71-103
15. Duplomb L., Lee Y., Wang M.Y., Park B.H., Takaishi K., Agarwal A.K., and Unger R.H. Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. Biochem. Biophys. Res. Commun. 313 (2004) 594-599
16. Ghanaat-Pour H., Huang Z., Lehtihet M., and Sjoholm A. Global expression profiling of glucose-regulated genes in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. J. Mol. Endocrinol. 39 (2007) 135-150
17. Hedge P., Qi R., Abernathy K., Gay C., Dharap S., Gaspard R., Hughes J., Snesrud E., Lee E., and Quackenbush J. A concise guide to cDNA microarray analysis. Biotechniques 29 (2000) 548-556
18. Itoh N., and Okamoto H. Translational control of proinsulin synthesis by glucose. Nature 283 (1980) 100-102
19. Jeong I.K., Oh S.H., Kim B.J., Chung J.H., Min Y.K., Lee M.S., Lee M.K., and Kim K.W. The effects of dexamethasone on insulin release and biosynthesis are dependent on the dose and duration of treatment. Diabetes Res. Clin. Pract. 51 (2001) 163-171
20. Johansson U., Olsson A., Gabrielsson S., Nilsson B., and Korsgren O. Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation. Biochem. Biophys. Res. Commun. 308 (2003) 474-479
21. Karlsson S., Ostlund B., Myrsen-Axcrona U., Sundler F., and Ahren B. Beta cell adaptation to dexamethasone-induced insulin resistance in rats involves increased glucose responsiveness but not glucose effectiveness. Pancreas 22 (2001) 148-156
22. Kawai, A. and Kuzuya, N., 1974. Proceedings: Stimulatory action of glucocorticoids on insulin secretion. Nippon Naibunpi Gakkai Zasshi 50, 226.
23. Kawai A., and Kuzuya N. On the role of glucocorticoid in glucose-induced insulin secretion. Horm. Metab. Res. 9 (1977) 361-365
24. Khan A., Ostenson C.G., Berggren P.O., and Efendic S. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. Am. J. Physiol. 263 (1992) E663-E666
25. 2+ responses to glucose in pancreatic beta-cells. J. Endocrinol. 197 (2008) 221-229
26. Lambillotte C., Gilon P., and Henquin J.C. Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J. Clin. Invest. 99 (1997) 414-423
27. Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur. J. Biochem. 259 (1999) 3-17
28. Leibiger B., Moede T., Schwarz T., Brown G.R., Kohler M., Leibiger I.B., and Berggren P.O. Short-term regulation of insulin gene transcription by glucose. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9307-9312
29. Lenzen S., and Bailey C.J. Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr. Rev. 5 (1984) 411-434
30. Oppermann U. Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?. Endocr. Metab. Immune Disord. Drug Targets 6 (2006) 259-269
31. Oppermann U.C., Persson B., and Jornvall H. Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. Eur. J. Biochem. 249 (1997) 355-360
32. Ortsater H., Alberts P., Warpman U., Engblom L.O., Abrahmsen L., and Bergsten P. Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans. Diabetes Metab. Res. Rev. 21 (2005) 359-366
33. Stulnig T.M., Oppermann U., Steffensen K.R., Schuster G.U., and Gustafsson J.A. Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes 51 (2002) 2426-2433
34. Stulnig T.M., Steffensen K.R., Gao H., Reimers M., Dahlman-Wright K., Schuster G.U., and Gustafsson J.A. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol. 62 (2002) 1299-1305
35. Swali A., Walker E.A., Lavery G.G., Tomlinson J.W., and Stewart P.M. 11beta-hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia 51 (2008) 2003-2011
36. Tomlinson J.W., and Stewart P.M. Modulation of glucocorticoid action and the treatment of type-2 diabetes. Best Pract. Res. Clin. Endocrinol. Metab. 21 (2007) 607-619
37. Tseng C.C., and Zhang X.Y. Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. Endocrinology 141 (2000) 947-952
38. Walker B.R., and Seckl J.R. 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease. Expert. Opin. Ther. Targets 7 (2003) 771-783
39. Willi S.M., Kennedy A., Brant B.P., Wallace P., Rogers N.L., and Garvey W.T. Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes. Diabetes Res. Clin. Pract. 58 (2002) 87-96
40. Willi S.M., Kennedy A., Wallace P., Ganaway E., Rogers N.L., and Garvey W.T. Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes 51 (2002) 2895-2902
41. Yang Y.H., Dudoit S., Luu P., Lin D.M., Peng V., Ngai J., and Speed T.P. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30 (2002) e15