A simple matter of life and death-The trials of postnatal beta-cell mass regulation

International Journal of Endocrinology

Volumn 2012, Issue , 2012, Pages

  Tarabra, Elena ^a   Pelengaris, Stella ^a   Khan, Michael ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CHOLECYSTOKININ; FATTY ACID; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; GLYCOGEN SYNTHASE KINASE 3; HEPATOCYTE NUCLEAR FACTOR 1BETA; INSULIN; JANUS KINASE; LEPTIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGENIC DIFFERENTIATION FACTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTA LACTOGEN; PROLACTIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN B; SOMATOMEDIN C; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; UNINDEXED DRUG;

CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SIZE; CELL SURVIVAL; DIABETES MELLITUS; DRUG EFFECT; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPOTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84861054514     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2012/516718     Document Type: Review

References (271)

1. Dor Y., Melton D. A., How important are adult stem cells for tissue maintenance? Cell Cycle 2004 3 9 1104 1106 (Pubitemid 40268622)
2. Rhodes C. J., Type 2 diabetesa matter of -cell life and death? Science 2005 307 5708 380 384 (Pubitemid 40139973)
3. Bonner-Weir S., Islet growth and development in the adult Journal of Molecular Endocrinology 2000 24 3 297 302 (Pubitemid 30415003)
4. Duvillié B., Currie C., Chrones T., Bucchini D., Jami J., Joshi R. L., Hill D. J., Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to -cell hyperplasia in mutant mice lacking insulin Endocrinology 2002 143 4 1530 1537 (Pubitemid 34274384)
5. Bernal-Mizrachi E., Wen W., Stahlhut S., Welling C. M., Permutt M. A., Islet cell expression of constitutively active Akt1/PKB induces striking hypertrophy, hyperplasia, and hyperinsulinemia Journal of Clinical Investigation 2001 108 11 1631 1638 (Pubitemid 33144873)
6. Butler A. E., Janson J., Bonner-Weir S., Ritzel R., Rizza R. A., Butler P. C., -cell deficit and increased -cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 1 102 110 (Pubitemid 36042113)
7. Georgia S., Bhushan A., cell replication is the primary mechanism for maintaining postnatal cell mass Journal of Clinical Investigation 2004 114 7 963 968 (Pubitemid 39578724)
8. Mathis D., Vence L., Benoist C., -cell death during progression to diabetes Nature 2001 414 6865 792 798
9. Saltiel A. R., Kahn C. R., Insulin signalling and the regulation of glucose and lipid metabolism Nature 2001 414 6865 799 806 (Pubitemid 34000783)
10. Swenne I., Andersson A., Effect of genetic background on the capacity for islet cell replication in mice Diabetologia 1984 27 4 464 467 (Pubitemid 14022686)
11. Ackermann A. M., Gannon M., Molecular regulation of pancreatic -cell mass development, maintenance, and expansion Journal of Molecular Endocrinology 2007 38 1-2 193 206 (Pubitemid 46351603)
12. Okada T., Chong W. L., Hu J., Hinault C., Michael M. D., Krtzfeldt J., Yin C., Holzenberger M., Stoffel M., Kulkarni R. N., Insulin receptors in -cells are critical for islet compensatory growth response to insulin resistance Proceedings of the National Academy of Sciences of the United States of America 2007 104 21 8977 8982 (Pubitemid 47175422)
13. Terauchi Y., Takamoto I., Kubota N., Matsui J., Suzuki R., Komeda K., Hara A., Toyoda Y., Miwa I., Aizawa S., Tsutsumi S., Tsubamoto Y., Hashimoto S., Eto K., Nakamura A., Noda M., Tobe K., Aburatani H., Nagai R., Kadowaki T., Glucokinase and IRS-2 are required for compensatory cell hyperplasia in response to high-fat diet-induced insulin resistance Journal of Clinical Investigation 2007 117 1 246 257 (Pubitemid 46048470)
14. Fernandez-Valverde S. L., Taft R. J., Mattick J. S., MicroRNAs in -cell biology, insulin resistance, diabetes and its complications Diabetes 2011 60 7 1825 1831
15. Poy M. N., Hausser J., Trajkovski M., Braun M., Collins S., Rorsman P., Zavolan M., Stoffel M., miR-375 maintains normal pancreatic -and -cell mass Proceedings of the National Academy of Sciences of the United States of America 2009 106 14 5813 5818
16. Li Y., Xu X., Liang Y., Liu S., Xiao H., Li F., Cheng H., Fu Z., miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression International Journal of Clinical and Experimental Pathology 2010 3 3 254 264
17. Ouaamari A. E., Baroukh N., Martens G. A., Lebrun P., Pipeleers D., Van Obberghen E., MiR-375 targets 3′l-phosphoinositide-dependent protein Kinase-1 and regulates glucose-induced biological responses in pancreatic -Cells Diabetes 2008 57 10 2708 2717
18. Xia H. Q., Pan Y., Peng J., Lu G. X., Over-expression of miR375 reduces glucose-induced insulin secretion in Nit-1 cells Molecular Biology Reports 2011 38 5 3061 3665
19. McCarthy M. I., Genomics, type 2 diabetes, and obesity The New England Journal of Medicine 2010 363 24 2339 2350
20. World Health Organization, Diabetes Fact Sheet no. 312. 2011, http://www.who.int/mediacentre/factsheets/fs312/en/index.html
21. Shaw J. E., Sicree R. A., Zimmet P. Z., Global estimates of the prevalence of diabetes for 2010 and 2030 Diabetes Research and Clinical Practice 2010 87 1 4 14
22. Levy J., Atkinson A. B., Bell P. M., McCance D. R., Hadden D. R., Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the belfast diet study Diabetic Medicine 1998 15 4 290 296 (Pubitemid 28168508)
23. Turner R., Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) The Lancet 1998 352 9131 837 853 (Pubitemid 28416718)
24. Turner R., Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) The Lancet 1998 352 9131 854 865 (Pubitemid 28416719)
25. Shamoon H., Duffy H., Fleischer N., Engel S., Saenger P., Strelzyn M., Litwak M., Wylie-Rosett J., Farkash A., Geiger D., Engel H., Fleischman J., Pompi D., Ginsberg N., Glover M., Brisman M., Walker E., Thomashunis A., Gonzalez J., The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The New England Journal of Medicine 1993 329 14 977 986 (Pubitemid 23307905)
26. Richter B., Bandeira-Echtler E., Bergerhoff K., Clar C., Ebrahim S. H., Rosiglitazone for type 2 diabetes mellitus Cochrane Database of Systematic Reviews (Online) 2007 3, article CD006063
27. Dor Y., Brown J., Martinez O. I., Melton D. A., Adult pancreatic -cells are formed by self-duplication rather than stem-cell differentiation Nature 2004 429 6987 41 46 (Pubitemid 38620543)
28. Montanya E., Nacher V., Biarnes M., Soler J., Linear correlation between -cell mass and body weight throughout the lifespan in Lewis rats. Role of -cell hyperplasia and hypertrophy Diabetes 2000 49 8 1341 1346 (Pubitemid 30624235)
29. Nielsen J. H., Galsgaard E. D., Mldrup A., Friedrichsen B. N., Billestrup N., Hansen J. A., Lee Y. C., Carlsson C., Regulation of -cell mass by hormones and growth factors Diabetes 2001 50 1, supplement S25 S29
30. Butler A. E., Janson J., Soeller W. C., Butler P. C., Increased -cell apoptosis prevents adaptive increase in -cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid Diabetes 2003 52 9 2304 2314 (Pubitemid 37059501)
31. Gagliardino J. J., Del Zotto H., Massa L., Flores L. E., Borelli M. I., Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors Journal of Endocrinology 2003 177 2 249 259 (Pubitemid 36656398)
32. Steil G. M., Trivedi N., Jonas J. C., Hasenkamp W. M., Sharma A., Bonner-Weir S., Weir G. C., Adaptation of -cell mass to substrate oversupply: enhanced function with normal gene expression American Journal of Physiology 2001 280 5 E788 E796
33. Bernard C., Berthault M. F., Saulnier C., Ktorza A., Neogenesis vs. apoptosis as main components of pancreatic cell mass changes in glucose-infused normal and mildly diabetic adult rats FASEB Journal 1999 13 10 1195 1205 (Pubitemid 29300365)
34. Bernard C., Thibault C., Berthault M. F., Magnan C., Saulnier C., Portha B., Pralong W. F., Pénicaud L., Ktorza A., Pancreatic -cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement Diabetes 1998 47 7 1058 1065 (Pubitemid 28294548)
35. Bonner-Weir S., Deery D., Leahy J. L., Weir G. C., Compensatory growth of pancreatic -cells in adult rats after short-term glucose infusion Diabetes 1989 38 1 49 53 (Pubitemid 19021816)
36. Paris M., Bernard-Kargar C., Berthault M. F., Bouwens L., Ktorza A., Specific and combined effects of insulin and glucose on functional pancreatic -cell mass in vivo in adult rats Endocrinology 2003 144 6 2717 2727 (Pubitemid 36629925)
37. Laybutt D. R., Glandt M., Xu G., Ahn Y. B., Trivedi N., Bonner-Weir S., Weir G. C., Critical reduction -cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes The Journal of Biological Chemistry 2003 278 5 2997 3005 (Pubitemid 36801207)
38. Swenne I., The role of glucose on the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells Diabetes 1982 31 9 754 760 (Pubitemid 12062863)
39. Topp B. G., McArthur M. D., Finegood D. T., Metabolic adaptations to chronic glucose infusion in rats Diabetologia 2004 47 9 1602 1610 (Pubitemid 39371643)
40. Porat S., Weinberg-Corem N., Tornovsky-Babaey S., Schyr-Ben-Haroush R., Hija A., Stolovich-Rain M., Dadon D., Granot Z., Ben-Hur V., White P., Girard C. A., Karni R., Kaestner K. H., Ashcroft F. M., Magnuson M. A., Saada A., Grimsby J., Glaser B., Dor Y., Control of pancreatic cell regeneration by glucose metabolism Cell Metabolism 2011 13 4 440 449
41. Hoorens A., van de Casteele M., Klppel G., Pipeleers D., Glucose promotes survival of rat pancreatic cells by activating synthesis of proteins which suppress a constitutive apoptotic program Journal of Clinical Investigation 1996 98 7 1568 1574 (Pubitemid 26327866)
42. Jonas J. C., Sharma A., Hasenkamp W., Ilkova H., Patan G., Laybutt R., Bonner-Weir S., Weir G. C., Chronic hyperglycemia triggers loss of pancreatic cell differentiation in an animal model of diabetes The Journal of Biological Chemistry 1999 274 20 14112 14121
43. Grill V., Bjrklund A., Overstimulation and -cell function Diabetes 2001 50 supplement 1 S122 S124
44. Maedler K., Sergeev P., Ris F., Oberholzer J., Joller-Jemelka H. I., Spinas G. A., Kaiser N., Halban P. A., Donath M. Y., Glucose-induced cell production of IL-1 contributes to glucotoxicity in human pancreatic islets Journal of Clinical Investigation 2002 110 6 851 860
45. Tanaka Y., Tran P. O. T., Harmon J., Robertson R. P., A role for glutathione peroxidase in protecting pancreatic cells against oxidative stress in a model of glucose toxicity Proceedings of the National Academy of Sciences of the United States of America 2002 99 19 12363 12368
46. Pelengaris S., Khan M., Evan G. I., Suppression of Myc-induced apoptosis in cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression Cell 2002 109 3 321 334 (Pubitemid 34606875)
47. Laybutt D. R., Weir G. C., Kaneto H., Lebet J., Palmiter R. D., Sharma A., Bonner-Weir S., Overexpression of c-Myc in -cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes Diabetes 2002 51 6 1793 1804 (Pubitemid 34564292)
48. Pelengaris S., Khan M., The many faces of c-MYC Archives of Biochemistry and Biophysics 2003 416 2 129 136 (Pubitemid 36945150)
49. Kaiser N., Leibowitz G., Nesher R., Glucotoxicity and -cell failure in type 2 diabetes mellitus Journal of Pediatric Endocrinology and Metabolism 2003 16 1 5 22 (Pubitemid 37259087)
50. Clark A., Wells C. A., Buley I. D., Cruickshank J. K., Vanhegan R. I., Matthews D. R., Cooper G. J. S., Holman R. R., Turner R. C., Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes Diabetes Research 1988 9 4 151 159 (Pubitemid 19105415)
51. Klppel G., Lhr M., Habich K., Oberholzer M., Heitz P. U., Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited Survey and Synthesis of Pathology Research 1985 4 2 110 125
52. Sakuraba H., Mizukami H., Yagihashi N., Wada R., Hanyu C., Yagihashi S., Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients Diabetologia 2002 45 1 85 96 (Pubitemid 34118546)
53. Yoon K. H., Ko S. H., Cho J. H., Lee J. M., Ahn Y. B., Song K. H., Yoo S. J., Kang M. I., Cha B. Y., Lee K. W., Son H. Y., Kang S. K., Kim H. S., Lee I. K., Bonner-Weir S., Selective -cell loss and -cell expansion in patients with type 2 diabetes mellitus in Korea Journal of Clinical Endocrinology and Metabolism 2003 88 5 2300 2308 (Pubitemid 36549911)
54. Andersson A., The influence of hyperglycaemia, hyperinsulinaemia and genetic background on the fate of intrasplenically implanted mouse islets Diabetologia 1983 25 3 269 272 (Pubitemid 13002126)
55. Guillen C., Navarro P., Robledo M., Valverde A. M., Benito M., Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic -cells Endocrinology 2006 147 4 1959 1968
56. Koiter T. R., Wijkstra S., van der Schaaf-Verdonk G. C. J., Moes H., Schuiling G. A., Pancreatic beta-cell function and islet-cell proliferation: effect of hyperinsulinaemia Physiology and Behavior 1995 57 4 717 721
57. Movassat J., Saulnier C., Portha B., -cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus Diabete et Metabolisme 1995 21 5 365 370 (Pubitemid 26018858)
58. Guz Y., Nasir I., Teitelman G., Regeneration of pancreatic cells from intra-islet precursor cells in an experimental model of diabetes Endocrinology 2001 142 11 4956 4968 (Pubitemid 33022372)
59. Otani K., Kulkarni R. N., Baldwin A. C., Krutzfeldt J., Ueki K., Stoffel M., Kahn C. R., Polonsky K. S., Reduced -cell mass and altered glucose sensing impair insulin-secretory function in IRKO mice American Journal of Physiology 2004 286 1 E41 E49
60. Blume N., Skouv J., Larsson L. I., Hoist J. J., Madsen O. D., Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis Journal of Clinical Investigation 1995 96 5 2227 2235
61. Flatt P. R., Tan K. S., Bailey C. J., Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas British Journal of Cancer 1986 54 4 685 692 (Pubitemid 17182700)
62. Flier S. N., Kulkarni R. N., Kahn C. R., Evidence for a circulating islet cell growth factor in insulin-resistant states Proceedings of the National Academy of Sciences of the United States of America 2001 98 13 7475 7480 (Pubitemid 32567973)
63. Miyaura C., Chen L., Appel M., Alam T., Inman L., Hughes S. D., Milburn J. L., Unger R. H., Newgard C. B., Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet -cell mass Molecular Endocrinology 1991 5 2 226 234 (Pubitemid 21923686)
64. Giacca A., Xiao C., Oprescu A. I., Carpentier A. C., Lewis G. F., Lipid-induced pancreatic -cell dysfunction: focus on in vivo studies American Journal of Physiology 2011 300 2 E255 E262
65. Poitout V., Glucolipotoxicity of the pancreatic -cell: myth or reality? Biochemical Society Transactions 2008 36 5 901 904
66. Zhou Y. P., Grill V. E., Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle Journal of Clinical Investigation 1994 93 2 870 876 (Pubitemid 24072831)
67. Zhou Y. P., Grill V., Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans Journal of Clinical Endocrinology and Metabolism 1995 80 5 1584 1590
68. Oprescu A. I., Bikopoulos G., Naassan A., Allister E. M., Tang C., Park E., Uchino H., Lewis G. F., Fantus I. G., Rozakis-Adcock M., Wheeler M. B., Giacca A., Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo Diabetes 2007 56 12 2927 2937 (Pubitemid 350223627)
69. Carpentier A., Mittelman S. D., Bergman R. N., Giacca A., Lewis G. F., Prolonged elevation of plasma free fatty acids impairs pancreatic -cell function in obese nondiabetic humans but not in individuals with type 2 Diabetes 2000 49 3 399 408 (Pubitemid 30131785)
70. Carpentier A., Mittelman S. D., Lamarche B., Bergman R. N., Giacca A., Lewis G. F., Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation American Journal of Physiology 1999 276 6 E1055 E1066
71. Kashyap S., Belfort R., Gastaldelli A., Pratipanawatr T., Berria R., Pratipanawatr W., Bajaj M., Mandarino L., DeFronzo R., Cusi K., A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes Diabetes 2003 52 10 2461 2474 (Pubitemid 37210533)
72. Xiao C., Giacca A., Carpentier A., Lewis G. F., Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans Diabetologia 2006 49 6 1371 1379
73. Sako Y., Grill V. E., A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation Endocrinology 1990 127 4 1580 1589 (Pubitemid 20315212)
74. Elks M. L., Chronic perifusion of rat islets with palmitate suppresses glucose- stimulated insulin release Endocrinology 1993 133 1 208 214 (Pubitemid 23206395)
75. Gremlich S., Bonny C., Waeber G., Thorens B., Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels The Journal of Biological Chemistry 1997 272 48 30261 30269 (Pubitemid 27512230)
76. Briaud I., Harmon J. S., Kelpe C. L., Segu V. B. G., Poitout V., Lipotoxicity of the pancreatic -cell is associated with glucose-dependent esterification of fatty acids into neutral lipids Diabetes 2001 50 2 315 321 (Pubitemid 32127288)
77. Kelpe C. L., Moore P. C., Parazzoli S. D., Wicksteed B., Rhodes C. J., Poitout V., Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis The Journal of Biological Chemistry 2003 278 32 30015 30021 (Pubitemid 36962391)
78. Hagman D. K., Hays L. B., Parazzoli S. D., Poitout V., Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans The Journal of Biological Chemistry 2005 280 37 32413 32418 (Pubitemid 41361852)
79. Pick A., Clark J., Kubstrup C., Levisetti M., Pugh W., Bonner-Weir S., Polonsky K. S., Role of apoptosis in failure of -cell mass compensation for insulin resistance and -cell defects in the male Zucker diabetic fatty rat Diabetes 1998 47 3 358 364 (Pubitemid 28104196)
80. Shimabukuro M., Zhou Y. T., Levi M., Unger R. H., Fatty acid-induced cell apoptosis: a link between obesity and diabetes Proceedings of the National Academy of Sciences of the United States of America 1998 95 5 2498 2502 (Pubitemid 28145970)
81. Cnop M., Hannaert J. C., Hoorens A., Eizirik D. L., Pipeleers D. G., Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation Diabetes 2001 50 8 1771 1777 (Pubitemid 33641595)
82. Maedler K., Spinas G. A., Dyntar D., Moritz W., Kaiser N., Donath M. Y., Distinct effects of saturated and monounsaturated fatty acids on -cell turnover and function Diabetes 2001 50 1 69 76 (Pubitemid 32047983)
83. Lupi R., Dotta F., Marselli L., Del Guerra S., Masini M., Santangelo C., Patané G., Boggi U., Piro S., Anello M., Bergamini E., Mosca F., Di Mario U., Del Prato S., Marchetti P., Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that -cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated Diabetes 2002 51 5 1437 1442 (Pubitemid 34826609)
84. Wrede C. E., Dickson L. M., Lingohr M. K., Briaud I., Rhodes C. J., Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic -cells (INS-1) The Journal of Biological Chemistry 2002 277 51 49676 49684 (Pubitemid 36014411)
85. Piro S., Anello M., Di Pietro C., Lizzio M. N., Patan G., Rabuazzo A. M., Vigneri R., Purrello M., Purrello F., Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress Metabolism 2002 51 10 1340 1347 (Pubitemid 35174157)
86. Maedler K., Oberholzer J., Bucher P., Spinas G. A., Donath M. Y., Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic -cell turnover and function Diabetes 2003 52 3 726 733 (Pubitemid 36323580)
87. Maestre I., Jordn J., Calvo S., Reig J. A., Cea V., Soria B., Prentki M., Roche E., Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the -cell line INS-1 Endocrinology 2003 144 1 335 345 (Pubitemid 36076123)
88. El-Assaad W., Buteau J., Peyot M. L., Nolan C., Roduit R., Hardy S., Joly E., Dbaibo G., Rosenberg L., Prentki M., Saturated fatty acids synergize with elevated glucose to cause pancreatic -cell death Endocrinology 2003 144 9 4154 4163 (Pubitemid 37088771)
89. Jacqueminet S., Briaud I., Rouault C., Reach G., Poitout V., Inhibition of insulin gene expression by long-term exposure of pancreatic cells to palmitate is dependent on the presence of a stimulatory glucose concentration Metabolism 2000 49 4 532 536 (Pubitemid 30196583)
90. Harmon J. S., Gleason C. E., Tanaka Y., Poitout V., Robertson R. P., Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats Diabetes 2001 50 712 2481 2486 (Pubitemid 33642765)
91. Briaud I., Kelpe C. L., Johnson L. M., Tran P. O. T., Poitout V., Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats Diabetes 2002 51 3 662 668 (Pubitemid 34760173)
92. Koshkin V., Wang X., Scherer P. E., Chan C. B., Wheeler M. B., Mitochondrial functional state in clonal pancreatic -cells exposed to free fatty acids The Journal of Biological Chemistry 2003 278 22 19709 19715 (Pubitemid 36799156)
93. Buteau J., Foisy S., Joly E., Prentki M., Glucagon-like peptide 1 induces pancreatic -cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 2003 52 1 124 132 (Pubitemid 36042116)
94. Farilla L., Hongxiang H., Bertolotto C., Kang E., Bulotta A., Mario U. D. I., Perfetti R., Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 2002 143 11 4397 4408 (Pubitemid 35239574)
95. Li Y., Hansotia T., Yusta B., Ris F., Halban P. A., Drueker D. J., Glucagon-like peptide-1 receptor signaling modulates cell apoptosis The Journal of Biological Chemistry 2003 278 1 471 478 (Pubitemid 36043598)
96. Hui H., Nourparvar A., Zhao X., Perfetti R., Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway Endocrinology 2003 144 4 1444 1455 (Pubitemid 36432086)
97. Farilla L., Bulotta A., Hirshberg B., Li Calzi S., Khoury N., Noushmehr H., Bertolotto C., Di Mario U., Harlan D. M., Perfetti R., Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets Endocrinology 2003 144 12 5149 5158 (Pubitemid 37476040)
98. Xu G., Stoffers D. A., Habener J. F., Bonner-Weir S., Exendin-4 stimulates both -cell replication and neogenesis, resulting in increased -cell mass and improved glucose tolerance in diabetic rats Diabetes 1999 48 12 2270 2276 (Pubitemid 30395416)
99. Buteau J., Foisy S., Rhodes C. J., Carpenter L., Biden T. J., Prentki M., Protein kinase C activation mediates glucagon-like peptide-1induced pancreatic -cell proliferation Diabetes 2001 50 10 2237 2243 (Pubitemid 33641907)
100. Perfetti R., Zhou J. I. E., Doyle M. E., Egan J. M., Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats Endocrinology 2000 141 12 4600 4605 (Pubitemid 32055138)
101. Buteau J., Spatz M. L., Accili D., Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic -cell mass Diabetes 2006 55 5 1190 1196 (Pubitemid 44195354)
102. Li Y., Cao X., Li L. X., Brubaker P. L., Edlund H., Drucker D. J., -Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1 Diabetes 2005 54 2 482 491
103. Park S., Dong X., Fisher T. L., Dunn S., Omer A. K., Weir G., White M. F., Exendin-4 uses Irs2 signaling to mediate pancreatic cell growth and function The Journal of Biological Chemistry 2006 281 2 1159 1168
104. Song W. J., Schreiber W. E., Zhong E., Liu F. F., Kornfeld B. D., Wondisford F. E., Hussain M. A., Exendin-4 stimulation of cyclin A2 in -cell proliferation Diabetes 2008 57 9 2371 2381
105. Tschen S. I., Dhawan S., Gurlo T., Bhushan A., Age-dependent decline in -cell proliferation restricts the capacity of -cell regeneration in mice Diabetes 2009 58 6 1312 1320
106. Tourrel C., Bailbé D., Meile M. J., Kergoat M., Portha B., Glucagon-like peptide-1 and exendin-4 stimulate -cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age Diabetes 2001 50 7 1562 1570 (Pubitemid 33639596)
107. Abraham E. J., Leech C. A., Lin J. C., Zulewski H., Habener J. F., Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells Endocrinology 2002 143 8 3152 3161 (Pubitemid 34809888)
108. Xu G., Kaneto H., Lopez-Avalos M. D., Weir G. C., Bonner-Weir S., GLP-1/exendin-4 facilitates -cell neogenesis in rat and human pancreatic ducts Diabetes Research and Clinical Practice 2006 73 1 107 110 (Pubitemid 43765553)
109. Pospisilik J. A., Martin J., Doty T., Ehses J. A., Pamir N., Lynn F. C., Piteau S., Demuth H. U., McIntosh C. H. S., Pederson R. A., Dipeptidyl peptidase IV inhibitor treatment stimulates -cell survival and islet neogenesis in streptozotocin-induced diabetic rats Diabetes 2003 52 3 741 750 (Pubitemid 36323582)
110. Carpenter T., Trautmann M. E., Baron A. D., Kaiser A. M., John Service F., Thompson G. B., Lloyd R. V., Cummings D. E., Shannon M. H., Carlson M. J., Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery The New England Journal of Medicine 2005 353 20 2192 2194 (Pubitemid 41653115)
111. Cummings D. E., Gastric bypass and nesidioblastosistoo much of a good thing for islets? The New England Journal of Medicine 2005 353 3 300 302 (Pubitemid 41058331)
112. Service G. J., Thompson G. B., Service F. J., Andrews J. C., Collazo-Clavell M. L., Lloyd R. V., Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery The New England Journal of Medicine 2005 353 3 249 254 (Pubitemid 41058324)
113. Takiguchi S., Takata Y., Funakoshi A., Miyasaka K., Kataoka K., Fujimura Y., Goto T., Kono A., Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats Gene 1997 197 1-2 169 175 (Pubitemid 27399890)
114. Wang Y., Guo X. H., Effects of GLP-1 treatment on protection of B cells in Otsuka Long-Evans Tokushima fatty rats Beijing da Xue Xue Bao 2006 38 4 375 380
115. Wang Q., Brubaker P., Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice Diabetologia 2002 45 9 1263 1273
116. Green B. D., Lavery K. S., Irwin N., O'Harte F. P.M., Harriott P., Greer B., Bailey C. J., Flatt P. R., Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic -cell function after 3-week daily administration in obese diabetic (ob/ob) mice Journal of Pharmacology and Experimental Therapeutics 2006 318 2 914 921 (Pubitemid 44061268)
117. Kim J. G., Baggio L. L., Bridon D. P., Castaigne J. P., Robitaille M. F., Jetté L., Benquet C., Drucker D. J., Development and characterization of a glucagon-like peptide 1-albumin conjugate the ability to activate the glucagon-like peptide 1 receptor in vivo Diabetes 2003 52 3 751 759 (Pubitemid 36323583)
118. Li Y., Shi C., Lv Q., Zhang H., Li B., Bian G., Huang Q., Zhang W., Xue X., Ren X., Gao H., Sun C., Wang J., Zhang M., GLP-1 C-terminal structures affect its blood glucose lowering-function Journal of Peptide Science 2008 14 7 777 785
119. Mu J., Petrov A., Eiermann G. J., Woods J., Zhou Y. P., Li Z., Zycband E., Feng Y., Zhu L., Roy R. S., Howard A. D., Li C., Thornberry N. A., Zhang B. B., Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes European Journal of Pharmacology 2009 623 13 148 154
120. Maida A., Hansotia T., Longuet C., Seino Y., Drucker D. J., Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice Gastroenterology 2009 137 6 2146 2157
121. Gault V. A., Irwin N., Green B. D., McCluskey J. T., Greer B., Bailey C. J., Harriott P., O'Harte F. P. M., Flatt P. R., Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes Diabetes 2005 54 8 2436 2446 (Pubitemid 41134273)
122. Cheng Q., Law P. K., De Gasparo M., Leung P. S., Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo] acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N- [[2′-(1H-tetrazol-5-yl)-[1,1′- biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes Journal of Pharmacology and Experimental Therapeutics 2008 327 3 683 691
123. Irwin N., Clarke G. C., Green B. D., Greer B., Harriott P., Gault V. A., O'Harte F. P. M., Flatt P. R., Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide Biochemical Pharmacology 2006 72 6 719 728 (Pubitemid 44233552)
124. Kidd G. S., Donowitz M., O'Dorisio T., Cataland S., Newman F., Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Elevated plasma and tissue levels of gastric inhibitory polypeptide and successful management with nicotinic acid The American Journal of Medicine 1979 66 5 883 888
125. Friedrichsen B. N., Neubauer N., Lee Y. C., Gram V. K., Blume N., Petersen J. S., Nielsen J. H., Mldrup A., Stimulation of pancreatic -cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways Journal of Endocrinology 2006 188 3 481 492
126. Ehses J. A., Casilla V. R., Doty T., Pospisilik J. A., Winter K. D., Demuth H. U., Pederson R. A., McIntosh C. H. S., Glucose-dependent insulinotropic polypeptide promotes -(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase Endocrinology 2003 144 10 4433 4445 (Pubitemid 37204843)
127. Trmper A., Trmper K., Hrsch D., Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in (INS-1)-cells Journal of Endocrinology 2002 174 2 233 246
128. Trmper A., Trmper K., Trusheim H., Arnold R., Gke B., Hrsch D., Glucose-dependent insulinotropic polypeptide is a growth factor for (INS-1) cells by pleiotropic signaling Molecular Endocrinology 2001 15 9 1559 1570 (Pubitemid 32826409)
129. Widenmaier S. B., Kim S. J., Yang G. K., de los Reyes T., Nian C., Asadi A., Seino Y., Kieffer T. J., Kwok Y. N., McIntosh C. H. S., A GIP receptor agonist exhibits -cell anti-apoptotic actions in rat models of diabetes resulting in improved -cell function and glycemic control PLoS ONE 2010 5 3, article e9590
130. Hogg J., han V. K. M., Clemmons D. R., Hill D. J., Interactions of nutrients, insulin-like growth factors (IGFs) and IGF-binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of Langerhans Journal of Endocrinology 1993 138 3 401 412 (Pubitemid 23343067)
131. Sieradzki J., Fleck H., Chatterjee A. K., Schatz H., Stimulatory effect of insulin-like growth factor-I on [ 3 H]thymidine incorporation, DNA content and insulin biosynthesis and secretion of isolated pancreatic rat islets Journal of Endocrinology 1988 117 1 59 62
132. Swenne I., Hill D. J., Strain A. J., Milner R. D. G., Growth hormone regulation of somatomedin C/insulin-like growth factor I production and DNA replication in fetal rat islets in tissue culture Diabetes 1987 36 3 288 294 (Pubitemid 18028417)
133. Swenne I., Pancreatic beta-cell growth and diabetes mellitus Diabetologia 1992 35 3 193 201
134. Nielsen J. H., Linde S., Welinder B. S., Billestrup N., Madsen O. D., Growth hormone is a growth factor for the differentiated pancreatic -cell Molecular Endocrinology 1989 3 1 165 173 (Pubitemid 19045687)
135. Billestrup N., Moldrup A., Serup P., Mathews L. S., Norstedt G., Nielsen J. H., Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells Proceedings of the National Academy of Sciences of the United States of America 1990 87 18 7210 7214
136. Hgl S. R., White M. F., Rhodes C. J., Insulin-like growth factor I (IGF-I)-stimulated pancreatic -cell growth is glucose-dependent synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS- 1 cells The Journal of Biological Chemistry 1998 273 28 17771 17779 (Pubitemid 28355120)
137. George M., Ayuso E., Casellas A., Costa C., Devedjian J. C., Bosch F., cell expression of IGF-I leads to recovery from type 1 diabetes Journal of Clinical Investigation 2002 109 9 1153 1163 (Pubitemid 34496593)
138. Petrik J., Pell J. M., Arany E., McDonald T. J., Dean W. L., Reik W., Hill D. J., Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia Endocrinology 1999 140 5 2353 2363 (Pubitemid 30636477)
139. Lu Y., Herrera P. L., Guo Y., Sun D., Tang Z., LeRoith D., Liu J. L., Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes Diabetes 2004 53 12 3131 3141 (Pubitemid 39564488)
140. Devedjian J. C., George M., Casellas A., Pujol A., Visa J., Pelegrn M., Gros L., Bosch F., Transgenic mice overexpressing insulin-like growth factor-II in cells develop type 2 diabetes Journal of Clinical Investigation 2000 105 6 731 740 (Pubitemid 30164111)
141. Kuntz E., Pinget M., Damgé C., Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats Journal of the Pancreas 2004 5 6 464 475 (Pubitemid 41573849)
142. Brelje T. C., Sorenson R. L., Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy Endocrinology 1991 128 1 45 57
143. Lavine J. A., Raess P. W., Davis D. B., Rabaglia M. E., Presley B. K., Keller M. P., Beinfeld M. C., Kopin A. S., Newgard C. B., Attie A. D., Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note Molecular Endocrinology 2010 24 2 464 467
144. Williams K., Abanquah D., Joshi-Gokhale S., Otero A., Lin H., Guthalu N. K., Zhang X., Mozar A., Bisello A., Stewart A. F., Garcia-Ocaa A., Vasavada R. C., Systemic and acute administration of parathyroid hormone-related peptide(136) stimulates endogenous beta cell proliferation while preserving function in adult mice Diabetologia 2011 54 11 2867 2877
145. Fujinaka Y., Sipula D., Garcia-Ocaa A., Vasavada R. C., Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic -cell survival Diabetes 2004 53 12 3120 3130 (Pubitemid 39564487)
146. Vasavada R. C., Cavaliere C., D'Ercole A. J., Dann P., Burtis W. J., Madlener A. L., Zawalich K., Zawalich W., Philbrick W., Stewart A. F., Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia The Journal of Biological Chemistry 1996 271 2 1200 1208 (Pubitemid 26034986)
147. Porter S. E., Sorenson R. L., Dann P., Garcia-Ocana A., Stewart A. F., Vasavada R. C., Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse Endocrinology 1998 139 9 3743 3751 (Pubitemid 28512253)
148. Kondegowda N. G., Joshi-Gokhale S., Harb G., Williams K., Zhang X. Y., Takane K. K., Zhang P., Scott D. K., Stewart A. F., Garcia-Ocaa A., Vasavada R. C., Parathyroid hormone-related protein enhances human -cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression Diabetes 2010 59 12 3131 3138
149. Villanueva-Peacarrillo M. L., Cancelas J., De Miguel F., Redondo A., Valn A., Valverde I., Esbrit P., Parathyroid hormone-related peptide stimulates DNA synthesis and insulin secretion in pancreatic islets Journal of Endocrinology 1999 163 3 403 408 (Pubitemid 30033735)
150. Zhang B., Hosaka M., Sawada Y., Torii S., Mizutani S., Ogata M., Izumi T., Takeuchi T., Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells Diabetes 2003 52 11 2720 2730 (Pubitemid 37339701)
151. Vandegraaff N., Growth factors and beta cell replication The International Journal of Biochemistry Cell Biology 2006 38 5-6 931 950
152. Irako T., Akamizu T., Hosoda H., Iwakura H., Ariyasu H., Tojo K., Tajima N., Kangawa K., Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats Diabetologia 2006 49 6 1264 1273
153. Granata R., Settanni F., Trovato L., Destefanis S., Gallo D., Martinetti M., Ghigo E., Muccioli G., Unacylated as well s acylated ghrelin promotes cell survival and inhibit apoptosis in HIT-T15 pancretic -cells Journal of Endocrinological Investigation 2006 29 9 RC19 RC22
154. Granata R., Settanni F., Biancone L., Trovato L., Nano R., Bertuzzi F., Destefanis S., Annunziata M., Martinetti M., Catapano F., Gh C., Isgaard J., Papotti M., Ghigo E., Muccioli G., Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic -cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling Endocrinology 2007 148 2 512 529 (Pubitemid 46143157)
155. Sayo Y., Murao K., Imachi H., Ming Cao W. E. N., Sato M., Dobashi H., Wong N. C. W., Ishida T., The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells Endocrinology 2002 143 6 2437 2440 (Pubitemid 34521590)
156. Crabtree J. S., Scacheri P. C., Ward J. M., McNally S. R., Swain G. P., Montagna C., Hager J. H., Hanahan D., Edlund H., Magnuson M. A., Garrett-Beal L., Burns A. L., Ried T., Chandrasekharappa S. C., Marx S. J., Spiegel A. M., Collins F. S., Of mice and MEN1: insulinomas in a conditional mouse knockout Molecular and Cellular Biology 2003 23 17 6075 6085 (Pubitemid 37013087)
157. Karnik S. K., Hughes C. M., Gu X., Rozenblatt-Rosen O., McLean G. W., Xiong Y., Meyerson M., Kim S. K., Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c Proceedings of the National Academy of Sciences of the United States of America 2005 102 41 14659 14664 (Pubitemid 41457112)
158. Heit J. J., Karnik S. K., Kim S. K., Intrinsic regulators of pancreatic -cell proliferation Annual Review of Cell and Developmental Biology 2006 22 311 338
159. Heit J. J., Apelqvist A., Gu X., Winslow M. M., Neilson J. R., Crabtree G. R., Kim S. K., Calcineurin/NFAT signalling regulates pancreatic -cell growth and function Nature 2006 443 7109 345 349 (Pubitemid 44435154)
160. Schnepp R. W., Chen Y. X., Wang H., Cash T., Silva A., Diehl J. A., Brown E., Hua X., Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells Cancer Research 2006 66 11 5707 5715 (Pubitemid 43927123)
161. La P., Yang Y., Karnik S. K., Silva A. C., Schnepp R. W., Kim S. K., Hua X., Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1 The Journal of Biological Chemistry 2007 282 43 31332 31340 (Pubitemid 350044893)
162. Liadis N., Salmena L., Kwan E., Tajmir P., Schroer S. A., Radziszewska A., Li X., Sheu L., Eweida M., Xu S., Gaisano H. Y., Hakem R., Woo M., Distinct in vivo roles of Caspase-8 in -cells in physiological and diabetes models Diabetes 2007 56 9 2302 2311 (Pubitemid 47358237)
163. Islam M. S., Morton N. M., Hansson A., Emilsson V., Rat insulinoma-derived pancreatic -cells express a functional leptin receptor that mediates a proliferative response Biochemical and Biophysical Research Communications 1997 238 3 851 855 (Pubitemid 27472665)
164. Okuya S., Tanabe K., Tanizawa Y., Oka Y., Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis Endocrinology 2001 142 11 4827 4830 (Pubitemid 33022358)
165. Shimabukuro M., Wang M. Y., Zhou Y. T., Newgard C. B., Unger R. H., Protection against lipoapoptosis of cells through leptin-dependent maintenance of Bcl-2 expression Proceedings of the National Academy of Sciences of the United States of America 1998 95 16 9558 9561 (Pubitemid 28506270)
166. Brown J. E. P., Dunmore S. J., Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells Diabetes/Metabolism Research and Reviews 2007 23 6 497 502 (Pubitemid 47520908)
167. Islam M. S., Sjholm A., Emilsson V., Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells International Journal of Obesity 2000 24 10 1246 1253
168. Tanabe K., Okuya S., Tanizawa Y., Matsutani A., Oka Y., Leptin induces proliferation of pancreatic cell line MIN6 through activation of mitogen-activated protein kinase Biochemical and Biophysical Research Communications 1997 241 3 765 768 (Pubitemid 28036732)
169. Taniguchi C. M., Emanuelli B., Kahn C. R., Critical nodes in signalling pathways: insights into insulin action Nature Reviews Molecular Cell Biology 2006 7 2 85 96 (Pubitemid 43278292)
170. Kubota N., Terauchi Y., Tobe K., Yano W., Suzuki R., Ueki K., Takamoto I., Satoh H., Maki T., Kubota T., Moroi M., Okada-Iwabu M., Ezaki O., Nagai R., Ueta Y., Kadowaki T., Noda T., Insulin receptor substrate 2 plays a crucial role in cells and the hypothalamus Journal of Clinical Investigation 2004 114 7 917 927 (Pubitemid 39578719)
171. Huypens P. R., Leptin and adiponectin regulate compensatory beta cell growth in accordance to overweight Medical Hypotheses 2007 68 5 1134 1137
172. Maedler K., Sergeev P., Ehses J. A., Mathe Z., Bosco D., Berney T., Dayer J. M., Reinecke M., Halban P. A., Donath M. Y., Leptin modulates cell expression of IL-1 receptor antagonist and release of IL-1 in human islets Proceedings of the National Academy of Sciences of the United States of America 2004 101 21 8138 8143 (Pubitemid 38698067)
173. Guldstrand M., Ahrén B., Adamson U., Improved -cell function after standardized weight reduction in severely obese subjects American Journal of Physiology 2003 284 3 E557 E565
174. Maedler K., Schulthess F. T., Bielman C., Berney T., Bonny C., Prentki M., Donath M. Y., Roduit R., Glucose and leptin induce apoptosis in human -cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB Journal 2008 22 6 1905 1913 (Pubitemid 351811467)
175. Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., Matsuki Y., Murakami M., Ichisaka T., Murakami H., Watanabe E., Takagi T., Akiyoshi M., Ohtsubo T., Kihara S., Yamashita S., Makishima M., Funahashi T., Yamanaka S., Hiramatsu R., Matsuzawa Y., Shimomura I., Visfatin: a protein secreted by visceral fat that Mimics the effects of insulin Science 2005 307 5708 426 430 (Pubitemid 40139988)
176. Chen M. P., Chung F. M., Chang D. M., Tsai J. C.-R., Huang H. F., Shin S. J., Lee Y. J., Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus Journal of Clinical Endocrinology and Metabolism 2006 91 1 295 299 (Pubitemid 43069152)
177. Nielsen J. H., Svensson C., Galsgaard E. D., Mldrup A., Billestrup N., Beta cell proliferation and growth factors Journal of Molecular Medicine 1999 77 1 62 66 (Pubitemid 29146184)
178. Sorenson R. L., Brelje T. C., Adaptation of islets of Langerhans to pregnancy: -cell growth, enhanced insulin secretion and the role of lactogenic hormones Hormone and Metabolic Research 1997 29 6 301 307 (Pubitemid 27293660)
179. Elghazi L., Cras-Méneur C., Czernichow P., Scharfmann R., Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation Proceedings of the National Academy of Sciences of the United States of America 2002 99 6 3884 3889 (Pubitemid 34252200)
180. Freidin M., Asche S., Bargiello T. A., Bennett M. V. L., Abrams C. K., Connexin 32 increases the proliferative response of Schwann cells to neuregulin-1 (Nrg1) Proceedings of the National Academy of Sciences of the United States of America 2009 106 9 3567 3572
181. Lim M. C. C., Maubach G., Zhuo L., TGF- 1 down-regulates connexin 43 expression and gap junction intercellular communication in rat hepatic stellate cells European Journal of Cell Biology 2009 88 12 719 730
182. Naus C. C. G., Bechberger J. F., Zhang Y., Venance L., Yamasaki H., Juneja S. C., Kidder G. M., Giaume C., Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43 Journal of Neuroscience Research 1997 49 5 528 540 (Pubitemid 27381240)
183. Serre-Beinier V., Le Gurun S., Belluardo N., Trovato-Salinaro A., Charollais A., Haefliger J. A., Condorelli D. F., Meda P., Cx36 preferentially connects -cells within pancreatic islets Diabetes 2000 49 5 727 734 (Pubitemid 30339987)
184. Klee P., Lamprianou S., Charollais A., Caille D., Sarro R., Cederroth M., Haefliger J. A., Meda P., Connexin implication in the control of the murine beta-cell mass Pediatric Research 2011 70 2 142 147
185. Winnier G., Blessing M., Labosky P. A., Hogan B. L. M., Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse Genes and Development 1995 9 17 2105 2116
186. Hua H., Zhang Y. Q., Dabernat S., Kritzik M., Dietz D., Sterling L., Sarvetnick N., BMP4 regulates pancreatic progenitor cell expansion through Id2 The Journal of Biological Chemistry 2006 281 19 13574 13580 (Pubitemid 43855271)
187. Fajas L., Annicotte J. S., Miard S., Sarruf D., Watanabe M., Auwerx J., Impaired pancreatic growth, cell mass, and cell function in E2F1-7 (-/-) mice Journal of Clinical Investigation 2004 113 9 1288 1295 (Pubitemid 39069928)
188. Iglesias A., Murga M., Laresgoiti U., Skoudy A., Bernales I., Fullaondo A., Moreno B., Lloreta J., Field S. J., Real F. X., Zubiaga A. M., Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice Journal of Clinical Investigation 2004 113 10 1398 1407 (Pubitemid 39071695)
189. Kushner J. A., Ciemerych M. A., Sicinska E., Wartschow L. M., Teta M., Long S. Y., Sicinski P., White M. F., Cyclins D2 and D1 are essential for postnatal pancreatic -cell growth Molecular and Cellular Biology 2005 25 9 3752 3762 (Pubitemid 40559580)
190. Zhang X., Gaspard J. P., Mizukami Y., Li J., Graeme-Cook F., Chung D. C., Overexpression of cyclin D1 in pancreatic -cells in vivo results in islet hyperplasia without hypoglycemia Diabetes 2005 54 3 712 719 (Pubitemid 40322073)
191. Rane S. G., Dubus P., Mettus R. V., Galbreath E. J., Boden G., Reddy E. P., Barbacid M., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in -islet cell hyperplasia Nature Genetics 1999 22 1 44 54 (Pubitemid 29214803)
192. Marzo N., Mora C., Fabregat M. E., Martn J., Usac E. F., Franco C., Barbacid M., Gomis R., Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes Diabetologia 2004 47 4 686 694 (Pubitemid 38658371)
193. Cozar-Castellano I., Takane K. K., Bottino R., Balamurugan A. N., Stewart A. F., Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1 Diabetes 2004 53 1 149 159 (Pubitemid 38044709)
194. Tsutsui T., Hesabi B., Moons D. S., Pandolfi P. P., Hansel K. S., Koff A., Kiyokawa H., Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity Molecular and Cellular Biology 1999 19 10 7011 7019 (Pubitemid 29441883)
195. Uchida T., Nakamura T., Hashimoto N., Matsuda T., Kotani K., Sakaue H., Kido Y., Hayashi Y., Nakayama K. I., White M. F., Kasuga M., Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice Nature Medicine 2005 11 2 175 182 (Pubitemid 40321353)
196. Jetton T. L., Lausier J., LaRock K., Trotman W. E., Larmie B., Habibovic A., Peshavaria M., Leahy J. L., Mechanisms of compensatory -cell growth in insulin-resistant rats: roles of Akt kinase Diabetes 2005 54 8 2294 2304 (Pubitemid 41134255)
197. Kauffmann-Zeh A., Rodriguez-Viciana P., Ulrich E., Gilbert C., Coffer P., Downward J., Evan G., Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB Nature 1997 385 6616 544 548 (Pubitemid 27074674)
198. Lingohr M. K., Dickson L. M., Wrede C. E., McCuaig J. F., Myers Jr. M. G., Rhodes C. J., IRS-3 inhibits IRS-2-mediated signaling in pancreatic -cells Molecular and Cellular Endocrinology 2003 204 1-2 85 99 (Pubitemid 36871555)
199. Wang Q., Li L., Xu E., Wong V., Rhodes C., Brubaker P. L., Glucagon-like peptitle-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells Diabetologia 2004 47 3 478 487 (Pubitemid 38491244)
200. Cohen P., The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction Philosophical Transactions of the Royal Society B 1999 354 1382 485 495 (Pubitemid 29363323)
201. Belham C., Wu S., Avruch J., Intracellular signalling: PDK1a kinase at the hub of things Current Biology 1999 9 3 R93 R96
202. Lawlor M. A., Alessi D. R., PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? Journal of Cell Science 2001 114 16 2903 2910 (Pubitemid 32821530)
203. Kitamura Y. I., Kitamura T., Kruse J. P., Raum J. C., Stein R., Gu W., Accili D., FoxO1 protects against pancreatic cell failure through NeuroD and MafA induction Cell Metabolism 2005 2 3 153 163
204. Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs W. H., Wright C. V. E., White M. F., Arden K. C., Accili D., The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic cell growth Journal of Clinical Investigation 2002 110 12 1839 1847 (Pubitemid 36076491)
205. Lee C. S., Sund N. J., Vatamaniuk M. Z., Matschinsky F. M., Stoffers D. A., Kaestner K. H., Foxa2 controls Pdx1 gene expression in pancreatic -cells in vivo Diabetes 2002 51 8 2546 2551 (Pubitemid 34827405)
206. Kawamori D., Kaneto H., Nakatani Y., Matsuoka T. A., Matsuhisa M., Hori M., Yamasaki Y., The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation The Journal of Biological Chemistry 2006 281 2 1091 1098
207. Okamoto H., Hribal M. L., Lin H. V., Bennett W. R., Ward A., Accili D., Role of the forkhead protein FoxO1 in cell compensation to insulin resistance Journal of Clinical Investigation 2006 116 3 775 782 (Pubitemid 43326887)
208. Ai J., Duan J., Lv X., Chen M., Yang Q., Sun H., Li Q., Xiao Y., Wang Y., Zhang Z., Tan R., Liu Y., Zhao D., Chen T., Yang Y., Wei Y., Zhou Q., Overexpression of FoxO1 causes proliferation of cultured pancreatic cells exposed to low nutrition Biochemistry 2010 49 1 218 225
209. Withers D. J., Gutierrez J. S., Towery H., Burks D. J., Ren J. M., Previs S., Zhang Y., Bernal D., Pons S., Shulman G. I., Bonner-Weir S., White M. F., Disruption of IRS-2 causes type 2 diabetes in mice Nature 1998 391 6670 900 904 (Pubitemid 28157668)
210. Araki E., Lipes M. A., Patti M. E., Bruning J. C., Haag B., Johnson R. S., Kahn C. R., Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 1994 372 6502 186 190 (Pubitemid 24347839)
211. Hennige A. M., Ozcan U., Okada T., Jhala U. S., Schubert M., White M. F., Kulkarni R. N., Alterations in growth and apoptosis of insulin receptor substrate-1-deficient -cells American Journal of Physiology 2005 289 2 E337 E346
212. Cho H., Thorvaldsen J. L., Chu Q., Feng F., Birnbaum M. J., Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice The Journal of Biological Chemistry 2001 276 42 38349 38352
213. Tuttle R. L., Gill N. S., Pugh W., Lee J. P., Koeberlein B., Furth E. E., Polonsky K. S., Naji A., Birnbaum M. J., Regulation of pancreatic -cell growth and survival by the serine/threonine protein kinase Akt1/PKB Nature Medicine 2001 7 10 1133 1137 (Pubitemid 33010022)
214. Dickson L. M., Rhodes C. J., Pancreatic -cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? American Journal of Physiology 2004 287 2 E192 E198
215. Kulkarni R. N., Jhala U. S., Winnay J. N., Krajewski S., Montminy M., Kahn C. R., PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance Journal of Clinical Investigation 2004 114 6 828 836 (Pubitemid 39578742)
216. Brissova M., Blaha M., Spear C., Nicholson W., Radhika A., Shiota M., Charron M. J., Wright C. V.E., Powers A. C., Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis American Journal of Physiology 2005 288 4 E707 E714
217. Liu Z., Tanabe K., Bernal-Mizrachi E., Permutt M. A., Mice with beta cell overexpression of glycogen synthase kinase-3 have reduced beta cell mass and proliferation Diabetologia 2008 51 4 623 631
218. Surjit M., Lal S. K., Glycogen synthase kinase-3 phosphorylates and regulates the stability of p27kip1 protein Cell Cycle 2007 6 5 580 588 (Pubitemid 46440432)
219. Diehl J. A., Cheng M., Roussel M. F., Sherr C. J., Glycogen synthase kinase-3 regulates cyclin D1 proteolysis and subcellular localization Genes and Development 1998 12 22 3499 3511 (Pubitemid 28553242)
220. Boucher M. J., Selander L., Carlsson L., Edlund H., Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms The Journal of Biological Chemistry 2006 281 10 6395 6403 (Pubitemid 43847571)
221. Downward J., Ras signalling and apoptosis Current Opinion in Genetics and Development 1998 8 1 49 54 (Pubitemid 28122140)
222. Benito M., Valverde A. M., Lorenzo M., IGF-I: a mitogen also involved in differentiation processes in mammalian cells International Journal of Biochemistry and Cell Biology 1996 28 5 499 510
223. Kadowaki T., Signal transduction mechanism of insulin and insulin-like growth factor-1 Endocrine Journal 1996 43 supplement S33 S41
224. Avruch J., Zhang X. F., Kyriakis J. M., Raf meets ras: completing the framework of a signal transduction pathway Trends in Biochemical Sciences 1994 19 7 279 283
225. Khoo S., Cobb M. H., Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion Proceedings of the National Academy of Sciences of the United States of America 1997 94 11 5599 5604 (Pubitemid 27241815)
226. Smit L. S., Meyer D. J., Billestrup N., Norstedt G., Schwartz J., Carter-Su C., The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH Molecular Endocrinology 1996 10 5 519 533 (Pubitemid 26142578)
227. Chow J. C., Ling P. R., Qu Z., Laviola L., Ciccarone A., Bistrian B. R., Smith R. J., Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo Endocrinology 1996 137 7 2880 2886 (Pubitemid 26192182)
228. Galsgaard E. D., Friedrichsen B. N., Nielsen J. H., Mldrup A., Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells Diabetes 2001 50 1, supplement S40 S41
229. Jensen J., Galsgaard E. D., Karlsen A. E., Lee Y. C., Nielsen J. H., STAT5 activation by human GH protects insulin-producing cells against interleukin-1, interferon- and tumour necrosis factor- -induced apoptosis independent of nitric oxide production Journal of Endocrinology 2005 187 1 25 36 (Pubitemid 41556398)
230. Krebs D. L., Hilton D. J., SOCS proteins: negative regulators of cytokine signaling Stem Cells 2001 19 5 378 387 (Pubitemid 32900080)
231. Lindberg K., Rnn S. G., Tornehave D., Richter H., Hansen J. A., Rmer J., Jackerott M., Billestrup N., Regulation of pancreatic -cell mass and proliferation by SOCS-3 Journal of Molecular Endocrinology 2005 35 2 231 243 (Pubitemid 41556172)
232. Jonas J. C., Laybutt D. R., Steil G. M., Trivedi N., Pertusa J. G., van de Casteele M., Weir G. C., Henquin J. C., High glucose stimulates early response gene c-Myc expression in rat pancreatic cells The Journal of Biological Chemistry 2001 276 38 35375 35381
233. Elouil H., Cardozo A. K., Eizirik D. L., Henquin J. C., Jonas J. C., High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NF B Diabetologia 2005 48 3 496 505 (Pubitemid 40487297)
234. Steiner P., Philipp A., Lukas J., Godden-Kent D., Pagano M., Mittnacht S., Bartek J., Eilers M., Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes EMBO Journal 1995 14 19 4814 4826
235. Berns K., Hijmans E. M., Bernards R., Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity Oncogene 1997 15 11 1347 1356 (Pubitemid 27429751)
236. Bouchard C., Thieke K., Maier A., Saffrich R., Hanley-Hyde J., Ansorge W., Reed S., Sicinski P., Bartek J., Eilers M., Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27 EMBO Journal 1999 18 19 5321 5333 (Pubitemid 29465582)
237. Hermeking H., Rago C., Schuhmacher M., Li Q., Barrett J. F., Obaya A. J., O'Connell B. C., Mateyak M. K., Tam W., Kohlhuber F., Dang C. V., Sedivy J. M., Eick D., Vogelstein B., Kinzler K. W., Identification of CDK4 as a target of c-MYC Proceedings of the National Academy of Sciences of the United States of America 2000 97 5 2229 2234 (Pubitemid 30134051)
238. Pelengaris S., Khan M., Oncogenic co-operation in -cell tumorigenesis Endocrine-Related Cancer 2001 8 4 307 314
239. Perez-Roger I., Kim S. H., Griffiths B., Sewing A., Land H., Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27 Kip1 and p21 Cip1 EMBO Journal 1999 18 19 5310 5320 (Pubitemid 29465581)
240. Hogan P. G., Chen L., Nardone J., Rao A., Transcriptional regulation by calcium, calcineurin, and NFAT Genes and Development 2003 17 18 2205 2232 (Pubitemid 37128637)
241. Demozay D., Tsunekawa S., Briaud I., Shah R., Rhodes C. J., Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca 2+ -dependent calcineurin/NFAT signaling in primary pancreatic islet -cells Diabetes 2011 60 11 2892 2902
242. Soleimanpour S. A., Crutchlow M. F., Ferrari A. M., Raum J. C., Groff D. N., Rankin M. M., Liu C., De Len D. D., Naji A., Kushner J. A., Stoffers D. A., Calcineurin signaling regulates human islet -cell survival The Journal of Biological Chemistry 2010 285 51 40050 40059
243. Bernal-Mizrachi E., Cras-Méneur C., Ye B. R., Johnson J. D., Permutt M. A., Transgenic overexpression of active calcineurin in -cells results in decreased -cell mass and hyperglycemia PLoS ONE 2010 5 8, article e11969
244. Fatrai S., Elghazi L., Balcazar N., Cras-Méneur C., Krits I., Kiyokawa H., Bernal-Mizrachi E., Akt induces -cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity Diabetes 2006 55 2 318 325 (Pubitemid 43343259)
245. Pei X. H., Bai F., Tsutsui T., Kiyokawa H., Xiong Y., Genetic evidence for functional dependency of p18Ink4c on Cdk4 Molecular and Cellular Biology 2004 24 15 6653 6664 (Pubitemid 38944345)
246. Rane S. G., Reddy E. P., Cell cycle control of pancreatic beta cell proliferation Front Biosci 2000 5 D1 19
247. Sherr C. J., The INK4a/ARF network in tumour suppression Nature Reviews Molecular Cell Biology 2001 2 10 731 737 (Pubitemid 33679835)
248. Kassem S. A., Ariel I., Thornton P. S., Hussain K., Smith V., Lindley K. J., Aynsley-Green A., Glaser B., p57KIP2 expression in normal islet cells and in hyperinsulinism of infancy Diabetes 2001 50 12 2763 2769 (Pubitemid 33733127)
249. Georgia S., Bhushan A., p27 regulates the transition of -cells from quiescence to proliferation Diabetes 2006 55 11 2950 2956 (Pubitemid 44923631)
250. Ambros V., The functions of animal microRNAs Nature 2004 431 7006 350 355 (Pubitemid 39265675)
251. Bartel D. P., MicroRNAs: genomics, biogenesis, mechanism, and function Cell 2004 116 2 281 297
252. Lovis P., Roggli E., Laybutt D. R., Gattesco S., Yang J. Y., Widmann C., Abderrahmani A., Regazzi R., Alterations in microRNA expression contribute to fatty acid-induced pancreatic -cell dysfunction Diabetes 2008 57 10 2728 2736
253. Roggli E., Britan A., Gattesco S., Lin-Marq N., Abderrahmani A., Meda P., Regazzi R., Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic -cells Diabetes 2010 59 4 978 986
254. Van Assche F. A., Aerts L., De Prins F., A morphological study of the endocrine pancreas in human pregnancy British Journal of Obstetrics and Gynaecology 1978 85 11 818 820 (Pubitemid 9009998)
255. Scaglia L., Smith F. E., Bonner-Weir S., Apoptosis contributes to the involution of cell mass in the post partum rat pancreas Endocrinology 1995 136 12 5461 5468
256. Parsons J. A., Bartke A., Sorenson R. L., Number and size of islets of langerhans in pregnant, human growth hormone- expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones Endocrinology 1995 136 5 2013 2021
257. Rieck S., White P., Schug J., Fox A. J., Smirnova O., Gao N., Gupta R. K., Wang Z. V., Scherer P. E., Keller M. P., Attie A. D., Kaestner K. H., The transcriptional response of the islet to pregnancy in mice Molecular Endocrinology 2009 23 10 1702 1712
258. Butler A. E., Cao-Minh L., Galasso R., Rizza R. A., Corradin A., Cobelli C., Butler P. C., Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy Diabetologia 2010 53 10 2167 2176
259. Vasavada R. C., Garcia-Ocaa A., Zawalich W. S., Sorenson R. L., Dann P., Syed M., Ogren L., Talamantes F., Stewart A. F., Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia The Journal of Biological Chemistry 2000 275 20 15399 15406 (Pubitemid 30337270)
260. Kim H., Toyofuku Y., Lynn F. C., Chak E., Uchida T., Mizukami H., Fujitani Y., Kawamori R., Miyatsuka T., Kosaka Y., Yang K., Honig G., van der Hart M., Kishimoto N., Wang J., Yagihashi S., Tecott L. H., Watada H., German M. S., Serotonin regulates pancreatic beta cell mass during pregnancy Nature Medicine 2010 16 7 804 808
261. Bole-Feysot C., Goffin V., Edery M., Binart N., Kelly P. A., Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice Endocrine Reviews 1998 19 3 225 268 (Pubitemid 29117815)
262. Stout L. E., Svensson A. M., Sorenson R. L., Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation Endocrinology 1997 138 4 1592 1603 (Pubitemid 27137111)
263. Brelje T. C., Scharp D. W., Lacy P. E., Ogren L., Talamantes F., Robertson M., Friesen H. G., Sorenson R. L., Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy Endocrinology 1993 132 2 879 887 (Pubitemid 23056153)
264. Cozar-Castellano I., Weinstock M., Haught M., Velzquez-Garcia S., Sipula D., Stewart A. F., Evaluation of -cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21 cip Diabetes 2006 55 1 70 77 (Pubitemid 43343300)
265. Freemark M., Avril I., Fleenor D. O. N., Driscoll P., Petro A. N. N., Opara E., Kendall W., Oden J. O. N., Bridges S., Binart N., Breant B., Kelly P. A., Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance Endocrinology 2002 143 4 1378 1385 (Pubitemid 34274368)
266. Huang C., Snider F., Cross J. C., Prolactin receptor is required for
267. Brelje T. C., Stout L. E., Bhagroo N. V., Sorenson R. L., Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of Langerhans Endocrinology 2004 145 9 4162 4175 (Pubitemid 39120565)
268. Amaral M. E. C., Cunha D. A., Anh G. F., Ueno M., Carneiro E. M., Velloso L. A., Bordin S., Boschero A. C., Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy Journal of Endocrinology 2004 183 3 469 476 (Pubitemid 40057577)
269. Amaral M. E. C., Ueno M., Carvalheira J. B., Carneiro E. M., Velloso L. A., Saad M. J. A., Boschero A. C., Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway Hormone and Metabolic Research 2003 35 5 282 289 (Pubitemid 37011513)
270. Hughes E., Huang C., Participation of Akt, menin, and p21 in pregnancy-induced -cell proliferation Endocrinology 2011 152 3 847 855
271. Sone H., Kagawa Y., Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice Diabetologia 2005 48 1 58 67 (Pubitemid 40174657)