-
1
-
-
0028069771
-
Regulation of pancreatic beta-cell mass in vivo
-
Bonner-Weir S. Regulation of pancreatic beta-cell mass in vivo. Recent Prog Horm Res 49 (1994) 91-104
-
(1994)
Recent Prog Horm Res
, vol.49
, pp. 91-104
-
-
Bonner-Weir, S.1
-
2
-
-
0033867213
-
Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy
-
Montanya E., Nacher V., Biarnes M., and Soler J. Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. Diabetes 49 (2000) 1341-1346
-
(2000)
Diabetes
, vol.49
, pp. 1341-1346
-
-
Montanya, E.1
Nacher, V.2
Biarnes, M.3
Soler, J.4
-
3
-
-
0032841435
-
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
-
Withers D.J., Burks D.J., Towery H.H., Altamuro S.L., Flint C.L., and White M.F. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 23 (1999) 32-40
-
(1999)
Nat Genet
, vol.23
, pp. 32-40
-
-
Withers, D.J.1
Burks, D.J.2
Towery, H.H.3
Altamuro, S.L.4
Flint, C.L.5
White, M.F.6
-
4
-
-
0034781057
-
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
-
Tuttle R.L., Gill N.S., Pugh W., Lee J.P., Koeberlein B., Furth E.E., et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 7 (2001) 1133-1137
-
(2001)
Nat Med
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
Gill, N.S.2
Pugh, W.3
Lee, J.P.4
Koeberlein, B.5
Furth, E.E.6
-
5
-
-
33244464562
-
Critical nodes in signalling pathways: insights into insulin action
-
Taniguchi C.M., Emanuelli B., and Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Bio 7 (2006) 85-96
-
(2006)
Nat Rev Mol Cell Bio
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
6
-
-
0035955629
-
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2
-
Rui L., Fisher T.L., Thomas J., and White M.F. Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. J Biol Chem 276 (2001) 40362-40367
-
(2001)
J Biol Chem
, vol.276
, pp. 40362-40367
-
-
Rui, L.1
Fisher, T.L.2
Thomas, J.3
White, M.F.4
-
7
-
-
0036710280
-
IRS proteins and the common path to diabetes
-
White M.F. IRS proteins and the common path to diabetes. Am J Physiol-Endoc M 283 (2002) E413-E422
-
(2002)
Am J Physiol-Endoc M
, vol.283
-
-
White, M.F.1
-
8
-
-
0344035946
-
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway
-
Hirashima Y., Tsuruzoe K., Kodama S., Igata M., Toyonaga T., Ueki K., et al. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. J Endocrinol 179 (2003) 253-266
-
(2003)
J Endocrinol
, vol.179
, pp. 253-266
-
-
Hirashima, Y.1
Tsuruzoe, K.2
Kodama, S.3
Igata, M.4
Toyonaga, T.5
Ueki, K.6
-
9
-
-
12544252740
-
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
-
Briaud I., Dickson L.M., Lingohr M.K., McCuaig J.F., Lawrence J.C., and Rhodes C.J. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem 280 (2005) 2282-2293
-
(2005)
J Biol Chem
, vol.280
, pp. 2282-2293
-
-
Briaud, I.1
Dickson, L.M.2
Lingohr, M.K.3
McCuaig, J.F.4
Lawrence, J.C.5
Rhodes, C.J.6
-
10
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J., Zubovitz J., Petrocelli T., Kotchetkov R., Connor M.K., Han K., et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8 (2002) 1153-1160
-
(2002)
Nat Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
-
11
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs III W.H., Wright C.V., et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110 (2002) 1839-1847
-
(2002)
J Clin Invest
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.6
-
12
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
-
Shin I., Yakes F.M., Rojo F., Shin N.Y., Bakin A.V., Baselga J., et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8 (2002) 1145-1152
-
(2002)
Nat Med
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.Y.4
Bakin, A.V.5
Baselga, J.6
-
13
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
14
-
-
33745315716
-
Transcription factor Foxo1 mediates glucagon-like peptide-1 effects on pancreatic {beta}-cell mass
-
Buteau J., Spatz M.L., and Accili D. Transcription factor Foxo1 mediates glucagon-like peptide-1 effects on pancreatic {beta}-cell mass. Diabetes 55 (2006) 1190-1196
-
(2006)
Diabetes
, vol.55
, pp. 1190-1196
-
-
Buteau, J.1
Spatz, M.L.2
Accili, D.3
-
15
-
-
0038339191
-
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS-2
-
Jhala U.S., Canettieri G., Screaton R.A., Kulkarni R.N., Krajewski S., Reed J., et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS-2. Genes Dev 17 (2003) 1575-1580
-
(2003)
Genes Dev
, vol.17
, pp. 1575-1580
-
-
Jhala, U.S.1
Canettieri, G.2
Screaton, R.A.3
Kulkarni, R.N.4
Krajewski, S.5
Reed, J.6
-
16
-
-
20444491588
-
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic {beta}-cell survival is dependent upon phosphatidylinositol 3-kinase (pi3k)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
-
Kim S.J., Winter K., Nian C., Tsuneoka M., Koda Y., and McIntosh C.H. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic {beta}-cell survival is dependent upon phosphatidylinositol 3-kinase (pi3k)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J Biol Chem 280 (2005) 22297-22307
-
(2005)
J Biol Chem
, vol.280
, pp. 22297-22307
-
-
Kim, S.J.1
Winter, K.2
Nian, C.3
Tsuneoka, M.4
Koda, Y.5
McIntosh, C.H.6
-
17
-
-
0032768616
-
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (Ins-1)-cells
-
Buteau J., Roduit R., Susini S., and Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (Ins-1)-cells. Diabetologia 42 (1999) 856-864
-
(1999)
Diabetologia
, vol.42
, pp. 856-864
-
-
Buteau, J.1
Roduit, R.2
Susini, S.3
Prentki, M.4
-
18
-
-
0034751343
-
Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis
-
Okuya S., Tanabe K., Tanizawa Y., and Oka Y. Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis. Endocrinology 142 (2001) 4827-4830
-
(2001)
Endocrinology
, vol.142
, pp. 4827-4830
-
-
Okuya, S.1
Tanabe, K.2
Tanizawa, Y.3
Oka, Y.4
-
19
-
-
0032482988
-
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
-
Shimabukuro M., Wang M.Y., Zhou Y.T., Newgard C.B., and Unger R.H. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. P Natl Acad Sci USA 95 (1998) 9558-9561
-
(1998)
P Natl Acad Sci USA
, vol.95
, pp. 9558-9561
-
-
Shimabukuro, M.1
Wang, M.Y.2
Zhou, Y.T.3
Newgard, C.B.4
Unger, R.H.5
-
20
-
-
20044380925
-
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
-
Uchida T., Nakamura T., Hashimoto N., Matsuda T., Kotani K., Sakaue H., et al. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11 (2005) 175-182
-
(2005)
Nat Med
, vol.11
, pp. 175-182
-
-
Uchida, T.1
Nakamura, T.2
Hashimoto, N.3
Matsuda, T.4
Kotani, K.5
Sakaue, H.6
-
21
-
-
2942523253
-
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice
-
Gorogawa S., Fujitani Y., Kaneto H., Hazama Y., Watada H., Miyamoto Y., et al. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Bioph Res Co 319 (2004) 1159-1170
-
(2004)
Biochem Bioph Res Co
, vol.319
, pp. 1159-1170
-
-
Gorogawa, S.1
Fujitani, Y.2
Kaneto, H.3
Hazama, Y.4
Watada, H.5
Miyamoto, Y.6
-
22
-
-
0029959818
-
Cross-talk between the insulin and angiotensin signaling systems
-
Velloso L.A., Folli F., Sun X.J., White M.F., Saad M.J., and Kahn C.R. Cross-talk between the insulin and angiotensin signaling systems. P Natl Acad Sci USA 93 (1996) 12490-12495
-
(1996)
P Natl Acad Sci USA
, vol.93
, pp. 12490-12495
-
-
Velloso, L.A.1
Folli, F.2
Sun, X.J.3
White, M.F.4
Saad, M.J.5
Kahn, C.R.6
-
23
-
-
0037228018
-
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver
-
Carvalheira J.B., Ribeiro E.B., Folli F., Velloso L.A., and Saad M.J. Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 384 (2003) 151-159
-
(2003)
Biol Chem
, vol.384
, pp. 151-159
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Folli, F.3
Velloso, L.A.4
Saad, M.J.5
-
24
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
-
Choudhury A.I., Heffron H., Smith M.A., Al-Qassab H., Xu A.W., Selman C., et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115 (2005) 940-950
-
(2005)
J Clin Invest
, vol.115
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
Smith, M.A.3
Al-Qassab, H.4
Xu, A.W.5
Selman, C.6
-
25
-
-
33745747676
-
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells
-
Ning K., Miller L.C., Laidlaw H.A., Burgess L.A., Perera N.M., Downes C.P., et al. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells. EMBO J 25 (2006) 2377-2387
-
(2006)
EMBO J
, vol.25
, pp. 2377-2387
-
-
Ning, K.1
Miller, L.C.2
Laidlaw, H.A.3
Burgess, L.A.4
Perera, N.M.5
Downes, C.P.6
-
27
-
-
0032169556
-
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B
-
Zhao A.Z., Bornfeldt K.E., and Beavo J.A. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 102 (1998) 869-873
-
(1998)
J Clin Invest
, vol.102
, pp. 869-873
-
-
Zhao, A.Z.1
Bornfeldt, K.E.2
Beavo, J.A.3
-
28
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8 (2002) 1288-1295
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
-
29
-
-
0037983775
-
Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
-
Wu X.D., Motoshima H., Mahadev K., Stalker T.J., Scalia R., and Goldstein B.J. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52 (2003) 1355-1363
-
(2003)
Diabetes
, vol.52
, pp. 1355-1363
-
-
Wu, X.D.1
Motoshima, H.2
Mahadev, K.3
Stalker, T.J.4
Scalia, R.5
Goldstein, B.J.6
-
30
-
-
21244487830
-
Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
-
Huypens P., Moens K., Heimberg H., Ling Z., Pipeleers D., and Van de Casteele M. Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. Life Sci 77 (2005) 1273-1282
-
(2005)
Life Sci
, vol.77
, pp. 1273-1282
-
-
Huypens, P.1
Moens, K.2
Heimberg, H.3
Ling, Z.4
Pipeleers, D.5
Van de Casteele, M.6
-
31
-
-
0345171412
-
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc
-
van de Casteele M., Kefas B.A., Cai Y., Heimberg H., Scott D.K., et al. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Bioph Res Co 312 (2003) 937-944
-
(2003)
Biochem Bioph Res Co
, vol.312
, pp. 937-944
-
-
van de Casteele, M.1
Kefas, B.A.2
Cai, Y.3
Heimberg, H.4
Scott, D.K.5
-
32
-
-
1542284737
-
Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line Ins-1
-
Rakatzi I., Mueller H., Ritzeler O., Tennagels N., and Eckel J. Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line Ins-1. Diabetologia 47 (2004) 249-258
-
(2004)
Diabetologia
, vol.47
, pp. 249-258
-
-
Rakatzi, I.1
Mueller, H.2
Ritzeler, O.3
Tennagels, N.4
Eckel, J.5
-
33
-
-
28744439955
-
Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis
-
Staiger K., Stefan N., Staiger H., Brendel M.D., Brandhorst D., Bretzel R.G., et al. Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis. J Clin Endocr Metab 90 (2005) 6707-6713
-
(2005)
J Clin Endocr Metab
, vol.90
, pp. 6707-6713
-
-
Staiger, K.1
Stefan, N.2
Staiger, H.3
Brendel, M.D.4
Brandhorst, D.5
Bretzel, R.G.6
-
34
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster D.R., Crozier S.J., Kimball S.R., and Jefferson L.S. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277 (2002) 23977-23980
-
(2002)
J Biol Chem
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
35
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw R.J., Bardeesy N., Manning B.D., Lopez L., Kosmatka M., DePinho R.A., et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6 (2004) 91-99
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
-
36
-
-
0036678916
-
Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women
-
Matsubara M., Maruoka S., and Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 147 (2002) 173-180
-
(2002)
Eur J Endocrinol
, vol.147
, pp. 173-180
-
-
Matsubara, M.1
Maruoka, S.2
Katayose, S.3
|