Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

Diabetologia

Volumn 45, Issue 9, 2002, Pages 1263-1273

  Wang, Q ^b   Brubaker, P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Akt1; Apoptosis; Beta cell mass; Exendin 4; GLP 1; Insulin; OGTT; Pancreas; Perfusion; Proliferation

Indexed keywords

ANTIDIABETIC AGENT; CASPASE 3; DRUG VEHICLE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIET RESTRICTION; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVATION; FEMALE; GLUCOSE TOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPOTHESIS; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INNER CELL MASS; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONSET AGE; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL DIVISION; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN PRECURSORS; VENOMS;

EID: 0036381989     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0828-3     Document Type: Article

References (49)

1. Bonner-Weir S (2000) Life and death of the pancreatic beta cells. Trends Endocrinol Metab 11:375-378
2. Finegood DT, Scaglia L, Bonner-Weir S (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249-256
3. Finegood DT, McArthur MD, Kojwang D et al. (2001) Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50:1021-1029
4. Nielson JH, Galsgaard ED, Moldrup A et al. (2001) Regulation of beta-cell mass by hormones and growth factors. Diabetes 50:S25-S29
5. Rhodes CJ (2000) IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication. Mol Endocrinol 24:303-311
6. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V (1993) Glucagon-like peptide-1(7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: Acute post-prandial and 24-h secretion patterns. Endocrinol 138:159-166
7. Drucker DJ (1998) Glucagon-like peptides. Diabetes 47:159-169
8. Sandhu H, Wiesenthal S, MacDonald PE et al. (1999) Glucagon-like peptide-1 increases insulin sensitivity in depancreatized dogs. Diabetes 48:1045-1053
9. Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M (1999) Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48:1026-1034
10. Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W (1993) Normalization of fasting hyperglycaemia by exogenous glucagon- like peptide 1 (7-36 amide) in Type II (non-insulin-dependent) diabetic patients. Diabetologia 36:741-744
11. Thorens B (1992) Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Nat Acad Sci USA 89:8641-8645
12. Gromada J, Bokvist K, Ding WG, Holst JJ, Nielsen JH, Rorsman P (1998) Glucagon-like peptide 1(7-36) amide stimulates exocytosis in human pancreatic β-cells by both proximal and distal regulatory steps in stimulus-secretion coupling. Diabetes 47:57-65
13. Buteau J, Roduit R, Susini S, Prentki M (1999) Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in β (INS-1)-cells. Diabetologia 42:856-864
14. Frodin M, Sekine N, Roche E et al. (1995) Glucose, other secretagogues, and nerve growth factors stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1. J Biol Chem 270:7882-7889
15. Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
16. Perfetti R, Zhou J, Doyle ME, Egan JM (2000) Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141:4600-4605
17. Stoffers DA, Kieffer TJ, Hussain MA et al. (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748
18. Edvell A, Lindström P (1999) Initiation of increased pancreatic islet growth in young normoglycemic mice (Umeå +/?). Endocrinology 140:778-783
19. DeFronzo RA (1999) Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131:281-303
20. Tourrel C, Bailbe D, Meile MJ, Portha B (2001) Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistantly improved glucose homeostasis at adult age. Diabetes 50:1562-1570
21. Leiter EH (1989) The genetics of diabetes susceptibility in mice. FASEB 3:2241
22. Goke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Goke B (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)- amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 268:19650-19655
23. Joseph JW, Kalitsky J, St-Pierre S, Brubaker PL (2000) Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice. Diabetologia 43:1319-1328
24. Wang Q, Somwar R, Bilan PJ et al. (1999) Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19:4008-4018
25. Chen K, Petrella E, Young A (1999) Effects of functional nephrectomy on clearance of exendin-4 in rats. Diabetes 48:A426
26. Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S (1997) Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138:1736-1741
27. Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267
28. Holst LS, Mulder H, Manganiella V et al. (1998) Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I. Biochem Biophys Res Commun 250:181-186
29. Dickson LM, Lingohr MK, McCuaig J et al. (2001) Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276:21110-21120
30. Cobb MH, Goldsmith EJ (1995) How MAP kinases are regulated. J Biol Chem 270:14843-14846
31. Davis RJ (1995) Transcriptional regulation by MAP kinases. Mol Reprod Dev 42:459-467
32. Kubota A, Yamada Y, Yasuda K et al. (1997) Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways. Biochem Biophys Res Commun 235:171-175
33. Slee EA, Adrain C, Martin SJ (1999) Serial killers: Ordering caspase activation events in apoptosis. Cell Death Differentiation 6:1067-1074
34. Helle KB, Angeletti RH (1994) Chromogranin A: A multipurpose prohormone. Acta Physiol Scand 152:1-10
35. Greig NH, Holloway HW, De Ore KA et al. (1999) Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia 42:45-50
36. Szayna M, Doyle ME, Betkey JA et al. (2000) Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology 141:1936-1941
37. Wang Y, Kole HK, Montrose-Rafizadeh C, Perfetti R, Bernier M, Egan JM (1997) Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: Glucagon-like peptide-1 and insulin interactions. J Mol Endocrinol 19:241-248
38. Dachicourt N, Serradas P, Bailbe D, Kergoat M, Doare L, Portha B (1997) Glucagon-like peptide-1(7-36)-amide confers glcuose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: In vivo and in vitro studies. J Endocrinol 155:369-376
39. Ahrén B, Larsson H, Holst JJ (1997) Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 82:473-478
40. Turner RC (1998) The U.K. Prospective Diabetes Study. A review. Diabetes Care 21:C35-C38
41. Hajduch E, Litherland GJ, Hundal HS (2001) Protein kinase B (PKB/Akt) - a key regulator of glucose transport? FEBS Lett 492:199-203
42. Aikin R, Rosenberg L, Maysinger D (2000) Phosphatidylinosital 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans. Biochem Biophys Res Commun 277:455-461
43. Trumper K, Trumper A, Trusheim H, Arnold R, Goke B, Horsch D (2000) Integrative mitogenic role of protein kinase B/Akt in beta-cells. Ann NY Acad Sci 921:242-250
44. Cho H, Mu J, Kim JK et al. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292:1728-1731
45. Parrizas M, Slatiel AR, LeRoith D (1997) Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinosital 3′-kinase and mitogen-activated protein kinase pathways. J Biol Chem 272:154-161
46. Benes C, Roisin MP, Van Tan H, Creuzet C, Miyazaki J, Fagard R (1998) Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line. J Biol Chem 273:15507-15513
47. Montrose-Rafizadeh C, Avdonin P, Garant MJ et al. (1999) Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140:1132-1140
48. Khoo S, Cobb MH (1997) Activation of mitogen-activated protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94:5599-5604
49. Bullock BP, Heller RS, Habener JF (1996) Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-2978