Glucolipotoxicity of the pancreatic β-cell: Myth or reality?

Biochemical Society Transactions

Volumn 36, Issue 5, 2008, Pages 901-904

  Poitout, Vincent ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

cell; Diabetes; Glucolipotoxicity; Glucose; Insulin; Islet

Indexed keywords

ACIPIMOX; FATTY ACID; GLUCOSE; INSULIN; INTRALIPID; LIPOPROTEIN LIPASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE B; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1;

APOPTOSIS; CELL ISOLATION; CONFERENCE PAPER; ENDOCRINE DISEASE; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLUCOLIPOTOXICITY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION;

ANIMALS; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS;

RATTUS;

EID: 53849106114     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360901     Document Type: Conference Paper

References (30)

1. UKPDS (UK Prospective Diabetes Study) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837-853
2. Unger, R.H. and Grundy, S. (1985) Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28, 119-121
3. Unger, R.H. (1995) Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes 44, 863-870
4. Prentki, M., Joly, F., El-Assaad, W. and Rocluit, R. (2002) Malonyl-CoA signalling, lipid partitioning, and glucolipotoxicity: role in β-cell adaptation and failure in the etiology of diabetes. Diabetes 51, S405-S413
5. Poitout, V. and Robertson, R.P. (2007) Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr. Rev. 29, 351-366
6. Moore, P.C., Ugas, M.A., Hagman, D.K., Parazzoli, S.D. and Poitout, V. (2004) Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 53, 2610-2616
7. Kelpe, C.L., Moore, P.C., Parazzoli, S.D., Wicksteed, B., Rhodes, C.J. and Poitout, V. (2003) Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J. Biol. Chem. 278, 30015-30021
8. Hagman, D.K., Hays, L.B., Parazzoli, S.D. and Poitout, V. (2005) Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J. Biol. Chem. 280, 32413-32418
9. da Silva Xavier, G., Rutter, J. and Rutter, G.A. (2004) involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. U.S.A. 101, 8319-8324
10. Unger, R.H. (2003) Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144, 5159-5165
11. Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M. et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401
12. Mason, T.M., Goh, T., Tchipashvili, V., Sanchu, H., Gupta, N., Lewis, G.F. and Giacca, A. (1999) Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 48, 524-530
13. Goh, T.T., Mason, T.M., Gupta, N., So, A., Lam, T.K., Lam, L., Lewis, G.F., Mari, A. and Giacca, A. (2007) Lipid-induced β-cell dysfunction in vivo in models of progressive β-cell failure. Am. J. Physiol. Endocrinol. Metab. 292, E549-ES60
14. Hagman, D.K., Latour, M.G., Chakrabarti, S.K., Fontes, G., Amyot, J., Tremblay, C., Semache, M., Lausier, J.A., Roskens, V., Mirmira, R.G. et al. (2008) Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 57, 424-431
15. Busch, A.K,, Cordery, D., Denyer, G.S. and Biden, T.J. (2002) Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function. Diabetes 51, 977-987
16. Prentki, M. and Nolan, C.J. (2006) Islet β cell failure in type 2 diabetes. J. Clin. Invest. 116, 1802-1812
17. Richieri, G.V., Anel, A, and Kleinfeld, A.M. (1993) Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32, 7574-7580
18. Richleri, G.V. and Kleinfeld, A.M. (1995) Unbound free fatty acid levels in human serum. J. Lipid Res. 36, 229-240
19. Cruz, W.S., Kwon, G., Marshall, C.A., McDaniel, M.L. and Semenkovich, C.F. (2001) Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells: a potential link between insulin resistance and 2b-cell dysfunction. J. Biol. Chem. 276, 12162-12168
20. Butler, A.E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R.A. and Butler, P.C. (2003) β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102-110
21. Boden, G., Chen, X., Rosner, J. and Barton, M. (1995) Effects of a 48 h fat infusion on insulin secretion and glucose utilization. Diabetes 44, 1239-1242
22. Boden, G. and Chen, X. (1999) Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 48, 577-583
23. Carpentier, A., Mittelman, S., Lamarche, B., Bergman, R., Giacca, A. and Lewis, G. (1999) Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am. J. Physiol. 276, E1055-E1066
24. Carpentier, A., Giacca, A. and Lewis, G.F. (2001) Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans. Diabetologia 44, 1989-1997
25. Carpentier, A., Mittelman, S.D., Bergman, R.N., Giacca, A. and Lewis, G.F. (2000) Prolonged elevation of plasma free fatty acids impairs pancreatic β-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes 49, 399-408
26. Leung, N., Sakaue, T., Carpentier, A., Uffelman, K., Giacca, A. and Lewis, G.F. (2004) Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 h of moderate hyperglycaemia on insulin sensitivity and pancreatic β-cell function in obese men. Diabetologia 47, 204-213
27. Kashyap, S., Belfort, R., Gastaldelli, A., Pratipanawatr, T., Berria, R., Pratipanawatr, W., Bajaj, M., Mandarino, L., DeFronzo, R. and Cusi, K. (2003) A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 52, 2461-2474
28. Cusi, K., Kashyap, S., Gastaldelli, A., Bajaj, M. and Cersosimo, E. (2007) Effects on insulin secretion and insulin action of a 48 h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 292, E1775-E1781
29. Fex, M., Nitert, M.D., Wierup, N., Sundler, F., Ling, C. and Mulder, H. (2006) Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet. Diabetologia 50, 74-83
30. Nolan, C.J., Leahy, J.L., Delghingaro-Augusto, V., Moibi, J., Soni, K., Peyot, M.L., Fortier, M., Guay, C., Lamontagne, J., Barbeau, A. et al. (2006) β Cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling. Diabetologia 49, 2120-2130