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Volumn 49, Issue 3, 2000, Pages 399-408

Prolonged elevation of plasma free fatty acids impairs pancreatic β- cell function in obese nondiabetic humans but not in individuals with type 2

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; HEPARIN; INSULIN; INTRALIPID;

EID: 0034005968     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.3.399     Document Type: Article
Times cited : (180)

References (51)
  • 1
    • 0028229508 scopus 로고
    • Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM?
    • Taylor SI, Accili D, Imai Y: Insulin resistance or insulin deficiency: which is the primary cause of NIDDM? Diabetes 43:735-740, 1994
    • (1994) Diabetes , vol.43 , pp. 735-740
    • Taylor, S.I.1    Accili, D.2    Imai, Y.3
  • 3
    • 0026110135 scopus 로고
    • Banting Lecture 1990: Beta-cells in type II diabetes mellitus
    • Porte D Jr: Banting Lecture 1990: beta-cells in type II diabetes mellitus. Diabetes 40:166-180, 1991
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte D., Jr.1
  • 4
    • 0028997729 scopus 로고
    • Lilly Lecture 1994: The beta-cell in diabetes: From molecular genetics to clinical research
    • Polonsky KS: Lilly Lecture 1994: the beta-cell in diabetes: from molecular genetics to clinical research. Diabetes 44:705-717, 1995
    • (1995) Diabetes , vol.44 , pp. 705-717
    • Polonsky, K.S.1
  • 5
    • 0024995157 scopus 로고
    • A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 6
    • 0028833276 scopus 로고
    • Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, lost of beta-cell GLUT2 and glucose incompetence
    • Ohneda M, Inman LR, Unger RH: Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, lost of beta-cell GLUT2 and glucose incompetence. Diabetologia 38:173-179, 1995
    • (1995) Diabetologia , vol.38 , pp. 173-179
    • Ohneda, M.1    Inman, L.R.2    Unger, R.H.3
  • 7
    • 0026493330 scopus 로고
    • Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism
    • Capito K, Hansen SE, Hedeskov CJ, Islin H, Thams P: Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism. Acta Diabetol 28:193-198, 1992
    • (1992) Acta Diabetol , vol.28 , pp. 193-198
    • Capito, K.1    Hansen, S.E.2    Hedeskov, C.J.3    Islin, H.4    Thams, P.5
  • 8
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
    • Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes 44:863-870, 1995
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 9
    • 0030029605 scopus 로고    scopus 로고
    • Are the beta-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
    • Prentki M, Corkey BE: Are the beta-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
    • (1996) Diabetes , vol.45 , pp. 273-283
    • Prentki, M.1    Corkey, B.E.2
  • 10
    • 0030759095 scopus 로고    scopus 로고
    • The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: Results of the Paris Prospective Study
    • Charles MA, Eschwège E, Thibault N, Claude J-R, Warnet J-M, Rosselin GE, Girard J, Balkau B: The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 40:1101-1106, 1997
    • (1997) Diabetologia , vol.40 , pp. 1101-1106
    • Charles, M.A.1    Eschwège, E.2    Thibault, N.3    Claude, J.-R.4    Warnet, J.-M.5    Rosselin, G.E.6    Girard, J.7    Balkau, B.8
  • 11
    • 0025000188 scopus 로고
    • Diabetes mellitus in the Pima Indians: Incidence, risk factors and pathogenesis
    • Knowler WC, Pettitt DJ, Saad MF, Bennett PH: Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev 6:1-27, 1990
    • (1990) Diabetes Metab Rev , vol.6 , pp. 1-27
    • Knowler, W.C.1    Pettitt, D.J.2    Saad, M.F.3    Bennett, P.H.4
  • 12
    • 0015882267 scopus 로고
    • Stimulation of insulin secretion by long-chain free fatty acids: A direct pancreatic effect
    • Crespin SR, Greenough WB 3d, Steinberg D: Stimulation of insulin secretion by long-chain free fatty acids: a direct pancreatic effect. J Clin Invest 52:1979-1984, 1973
    • (1973) J Clin Invest , vol.52 , pp. 1979-1984
    • Crespin, S.R.1    Greenough W.B. III2    Steinberg, D.3
  • 13
    • 0028221978 scopus 로고
    • Mechanisms of the stimulation of insulin release by saturated fatty acids: A study of palmitate effects in mouse β-cells
    • Warnotte C, Gilon P, Nenquin M, Henquin JC: Mechanisms of the stimulation of insulin release by saturated fatty acids: a study of palmitate effects in mouse β-cells. Diabetes 43:703-711, 1994
    • (1994) Diabetes , vol.43 , pp. 703-711
    • Warnotte, C.1    Gilon, P.2    Nenquin, M.3    Henquin, J.C.4
  • 15
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extra-hepatic effects of insulin on hepatic glucose production in humans
    • Lewis GF, Vranic M, Harley P, Giacca A: Fatty acids mediate the acute extra-hepatic effects of insulin on hepatic glucose production in humans. Diabetes 46:1111-1119, 1997
    • (1997) Diabetes , vol.46 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 19
    • 0032102146 scopus 로고    scopus 로고
    • A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion
    • Dobbins RL, Chester MW, Stevenson BE, Daniels MB, Stein DT, McGarry JD: A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion. J Clin Invest 101:2370-2376, 1998
    • (1998) J Clin Invest , vol.101 , pp. 2370-2376
    • Dobbins, R.L.1    Chester, M.W.2    Stevenson, B.E.3    Daniels, M.B.4    Stein, D.T.5    McGarry, J.D.6
  • 20
    • 0031683543 scopus 로고    scopus 로고
    • Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans
    • Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT: Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Diabetes 47:1613-1618, 1998
    • (1998) Diabetes , vol.47 , pp. 1613-1618
    • Dobbins, R.L.1    Chester, M.W.2    Daniels, M.B.3    McGarry, J.D.4    Stein, D.T.5
  • 21
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 22
    • 0028988135 scopus 로고
    • Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets
    • Zhou YP, Grill VE: Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44:394-399, 1995
    • (1995) Diabetes , vol.44 , pp. 394-399
    • Zhou, Y.P.1    Grill, V.E.2
  • 23
    • 0029036835 scopus 로고
    • Long tenu exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP, Grill V: Long tenu exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1590, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 24
    • 0033042342 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
    • Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A: Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 48:524-530, 1999
    • (1999) Diabetes , vol.48 , pp. 524-530
    • Mason, T.M.1    Goh, T.2    Tchipashvili, V.3    Sandhu, H.4    Gupta, N.5    Lewis, G.F.6    Giacca, A.7
  • 25
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Chen X, Rosner J, Barton M: Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44:1239-1242, 1995
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 27
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 91:10878-10882, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 28
    • 1842334456 scopus 로고    scopus 로고
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
  • 29
    • 0028833041 scopus 로고
    • Insulin secretion and clearance during low-dose graded glucose infusion
    • Byrne MM, Sturis J, Polonsky KS: Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol 268:E21-E27, 1995
    • (1995) Am J Physiol , vol.268
    • Byrne, M.M.1    Sturis, J.2    Polonsky, K.S.3
  • 30
    • 0026504160 scopus 로고
    • Estimation of insulin secre7 tion rates from C-peptide levels: Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS: Estimation of insulin secre7 tion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetis 41:308-377, 1992
    • (1992) Diabetis , vol.41 , pp. 308-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 33
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10, 1997
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 34
    • 0031716376 scopus 로고    scopus 로고
    • Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
    • Boden G, Chen X, Iqbal N: Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes 47:1609-1612, 1998
    • (1998) Diabetes , vol.47 , pp. 1609-1612
    • Boden, G.1    Chen, X.2    Iqbal, N.3
  • 35
    • 0033009463 scopus 로고    scopus 로고
    • Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes
    • Boden G, Chen X: Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 48:577-583, 1999
    • (1999) Diabetes , vol.48 , pp. 577-583
    • Boden, G.1    Chen, X.2
  • 36
    • 0029983884 scopus 로고    scopus 로고
    • A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse
    • Zhou YP, Berggren PO, Grill V: A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse. Diabetes 45:580-586, 1996
    • (1996) Diabetes , vol.45 , pp. 580-586
    • Zhou, Y.P.1    Berggren, P.O.2    Grill, V.3
  • 37
    • 0030823179 scopus 로고    scopus 로고
    • Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)
    • Liang Y, Buettger C, Berner DK, Matschinsky FM: Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9). Diabetologia 40:1018-1027, 1997
    • (1997) Diabetologia , vol.40 , pp. 1018-1027
    • Liang, Y.1    Buettger, C.2    Berner, D.K.3    Matschinsky, F.M.4
  • 38
    • 0029731662 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
    • Lemberger T, Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Ann Rev Cell Dev Biol 12:335-363, 1996
    • (1996) Ann Rev Cell Dev Biol , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 39
    • 0030731946 scopus 로고    scopus 로고
    • Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    • Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 272:30261-30269, 1997
    • (1997) J Biol Chem , vol.272 , pp. 30261-30269
    • Gremlich, S.1    Bonny, C.2    Waeber, G.3    Thorens, B.4
  • 40
    • 0033059201 scopus 로고    scopus 로고
    • Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic β-cell line MIN6
    • Furukawa H, Carroll RJ, Swift HH, and Steiner DF: Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic β-cell line MIN6. Diabetes 48:1395-1401, 1999
    • (1999) Diabetes , vol.48 , pp. 1395-1401
    • Furukawa, H.1    Carroll, R.J.2    Swift, H.H.3    Steiner, D.F.4
  • 41
    • 0040503709 scopus 로고    scopus 로고
    • Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
    • Björklund A and Grill V: Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets. Diabetes 48:1409-1414, 1999
    • (1999) Diabetes , vol.48 , pp. 1409-1414
    • Björklund, A.1    Grill, V.2
  • 42
    • 0024062933 scopus 로고
    • Insulin degradation: Mechanisms, products, and significance
    • Duckworth WC: Insulin degradation: mechanisms, products, and significance. Endocr Rev 9:319-345, 1988
    • (1988) Endocr Rev , vol.9 , pp. 319-345
    • Duckworth, W.C.1
  • 43
    • 0025296906 scopus 로고
    • Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes
    • Svedberg J, Bjorntorp P, Smith U, Lonnroth P: Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 39:570-574, 1990
    • (1990) Diabetes , vol.39 , pp. 570-574
    • Svedberg, J.1    Bjorntorp, P.2    Smith, U.3    Lonnroth, P.4
  • 44
    • 0022527340 scopus 로고
    • Reduced hepatic insulin clearance in rats with dietary-induced obesity
    • Stromblad G, Bjorntorp P: Reduced hepatic insulin clearance in rats with dietary-induced obesity. Metabolism 35:323-327, 1986
    • (1986) Metabolism , vol.35 , pp. 323-327
    • Stromblad, G.1    Bjorntorp, P.2
  • 45
    • 0026341637 scopus 로고
    • Fatty acids in the portal vein of the rat regulate hepatic insulin clearance
    • Svedberg J, Stromblad G, Wirth A, Smith U, Bjorntorp P: Fatty acids in the portal vein of the rat regulate hepatic insulin clearance. J Clin Invest 88:2054-2058, 1991
    • (1991) J Clin Invest , vol.88 , pp. 2054-2058
    • Svedberg, J.1    Stromblad, G.2    Wirth, A.3    Smith, U.4    Bjorntorp, P.5
  • 46
    • 0025762372 scopus 로고
    • Prevention of inhibitory effect of free fatty acids on insulin binding and action in isolated rat hepatocytes by etomoxir
    • Svedberg J, Bjorntorp P, Lonnroth P, Smith U: Prevention of inhibitory effect of free fatty acids on insulin binding and action in isolated rat hepatocytes by etomoxir. Diabetes 40:783-786, 1991
    • (1991) Diabetes , vol.40 , pp. 783-786
    • Svedberg, J.1    Bjorntorp, P.2    Lonnroth, P.3    Smith, U.4
  • 48
    • 0031032274 scopus 로고    scopus 로고
    • Effects of free fatty acids and glucose on splanchnic insulin dynamics
    • Hennes MM, Dua A, Kissebah AH: Effects of free fatty acids and glucose on splanchnic insulin dynamics. Diabetes 46:57-62, 1997
    • (1997) Diabetes , vol.46 , pp. 57-62
    • Hennes, M.M.1    Dua, A.2    Kissebah, A.H.3
  • 49
    • 0030753653 scopus 로고    scopus 로고
    • Engineering of glycerol-stimulated insulin secretion in islet beta cells: Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling
    • Noel RJ, Antinozzi PA, McGarry JD, Newgard CB: Engineering of glycerol-stimulated insulin secretion in islet beta cells: differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. J Biol Chem 272:18621-18627, 1997
    • (1997) J Biol Chem , vol.272 , pp. 18621-18627
    • Noel, R.J.1    Antinozzi, P.A.2    McGarry, J.D.3    Newgard, C.B.4
  • 50
    • 25544440974 scopus 로고    scopus 로고
    • Hypertriglyceridemia blunts insulin response to hyperglycemia in normal humans
    • Calles-Escandon J, Mirza S: Hypertriglyceridemia blunts insulin response to hyperglycemia in normal humans (Abstract). Diabetes 48 (Suppl. 1):A289, 1999
    • (1999) Diabetes , vol.48 , Issue.1 SUPPL.
    • Calles-Escandon, J.1    Mirza, S.2


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