The functions of animal microRNAs

Nature

Volumn 431, Issue 7006, 2004, Pages 350-355

  Ambros, Victor ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; LIVING SYSTEMS STUDIES;

CELL DEATH; PROLIFERATION;

RNA;

COMPLEMENTARY RNA; MESSENGER RNA; MICRORNA; NUCLEOTIDE; TRANSCRIPTION FACTOR;

RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; BASE PAIRING; CELL DEATH; CELL PROLIFERATION; EMBRYO PATTERN FORMATION; GENE EXPRESSION; GENETIC ANALYSIS; HEMATOPOIESIS; MOLECULAR CLONING; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

ANIMALS; GENE EXPRESSION REGULATION; GENOMICS; MICRORNAS; MULTIGENE FAMILY; SUBSTRATE SPECIFICITY;

ANIMALIA; ARACHNIDA; HEXAPODA;

EID: 4644309196     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02871     Document Type: Review

References (51)

1. Barrel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
2. Hutvágner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
3. Zeng, Y., Wagner, E. J. & Cullen, B. R. Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333 (2002).
4. Zeng, Y., Yi, R. & Cullen, B. R. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100, 9779-9784 (2003).
5. Doench, J. G., Peterson, C. P. & Sharp, P. A. siRNAs can function as miRNAs. Genes Dev. 17, 438-442 (2003).
6. Rhoades, M. W. et al. Prediction of plant microRNA targets. Cell 110, 513-520 (2002).
7. Tang, G., Reinhart, B. J., Bartel, D. P. & Zamore, P. D. A biochemical framework for RNA silencing in plants. Genes Dev. 17, 49-63 (2003).
8. Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671-680 (1999).
9. Seggerson, K., Tang, L. & Moss, E. G. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243, 215-225 (2002).
10. Lau, N. C., Lim, L. P., Weinstein, E. G. & Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001).
11. Lee, R. C. & Ambros, V. An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864 (2001).
12. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
13. Ambros, V., Lee, R. C., Lavanway, A., Williams, P. T., & Jewell, D. MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr. Biol. 13, 807-818 (2003).
14. Lai, E. C., Tomancak, P., Williams, R. W. & Rubin, G. M. Computational identification of Drosophila microRNA genes. Genome Biol. 4(R42), 1-20 (2003).
15. Lim, L. P. et al. The microRNAs of Caenorhabditis elegans. Genes Dev. 17, 991-1008 (2003).
16. Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W. & Tuschl, T. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735-739 (2002).
17. Lagos-Quintana, M., Rauhut, R., Meyer, J., Borkhardt, A. & Tuschl, T. New microRNAs from mouse and human. RNA 9, 175-179 (2003).
18. Lim, L. P., Giasner, M. E., Yekta, S., Burge, C. B. & Bartel, D. P. Vertebrate microRNA genes. Science 299, 1540 (2003).
19. Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854 (1993).
20. Reinhart, B. J. et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906 (2000).
21. Ambros, V. et al. A uniform system for microRNA annotation. RNA 9, 277-279 (2003).
22. Wightman, B., Ha, I. & Ruvloin, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-802 (1993).
23. Slack, F. J. et al. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell 5, 659-669 (2000).
24. Moss, E, G., Lee, R. C. & Arabros, V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88, 637-646 (1997).
25. Hipfner, D. R., Weigmann, K. & Cohen, S. M. The bantam gene regulates Drosophila growth. Genetics 161, 1527-1537 (2002).
26. Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B. & Cohen, S. M. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36 (2003).
27. Xu, P., Vernooy, S. Y., Guo, M. & Hay, B. A. The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Curr. Biol. 13, 790-795 (2003).
28. Chang, S., Johnston, R. J. Jr & Hubert, O. A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans. Genes Dev. 17, 2123-2137 (2003).
29. Johnston, R. J. & Hobert, O. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature 426, 845-849 (2003).
30. Chang, S., Johnston, R. J. Jr, Frøkjær-Jensen, C., Lockery, S. & Hobert, O. Micro RNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Nature 430, 785-798 (2004).
31. Grad, Y. et al. Computational and experimental identification of C. elegans microRNAs. Mol. Cell 11, 1253-1263 (2003).
32. Houbaviy, H. B., Murray, M. F. & Sharp, P. A. Embryonic stem-cell-specific microRNAs. Dev. Cell 5, 351-358 (2003).
33. Chen, C. Z., Li, L., Lodish, H. F. & Bartel, D. P. MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86 (2004).
34. Sempere, L. F., Sokol, N. S., Dubrovsky, E. B., Berger, E. M. & Ambros, V. Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-complex geneactivity. Dev. Biol. 259, 9-18 (2003).
35. Bashirullah, A. et al. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biol. 259, 1-8 (2003).
36. Feinbaum, R. & Ambros, V. The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. Dev. Biol. 210, 87-95 (1999).
37. Seitz, H. et al. Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-likegene. Nature Genet. 34, 261-262 (2003).
38. Bartel, D. P. & Chen, C.-Z. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nature Rev. Genet. 5, 396-401 (2004).
39. Stark, A., Brennecke, J., Russell, R. B. & Cohen, S. M. Identification of Drosophila microRNA targets. PLoS Biol. 1 E60 (2003).
40. Enright, A. J. et al. MicroRNA targets in Drosophila. Genome Biol. 5, R1 (2003).
41. Rajewskya, N. & Socci, N. D. Computational identification of microRNA targets. Dev. Biol. 267, 529-535 (2004).
42. Lewis, B. P., Shih, I., Jones-Rhoades, M. W., Bartel, D. P. & Burge, C. B. Prediction of mammalian microRNA targets. Cell 115, 787-798 (2003).
43. Kiriakidou, M. et al. A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 18, 1165-1178 (2004).
44. Vella, M. C., Choi, E. Y., Lin, S. Y., Reinert, K. & Slack, F. J. The C. elegant microRNA let-7 binds to imperfect let-7 complementary sites fromthe lin-41 3′ UTR. Genes Dev. 18, 32-37 (2004).
45. Doench, J. G. & Sharp, P. A. Specificity of microRNA target selection in translational repression. Genes Dev. 18, 504-511 (2004).
46. Moss, E. G. & Tang, L. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev. Biol. 258, 432-442 (2003).
47. Yekta, S., Shih, I.-h. & Bartel, D. P. MicroRNA-directed cleavage of HOXBS mRNA. Science, 304, 594-596 (2004).
48. Abrahante, J. E. et al. The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls develop mental time and is regulated by microRNAs. Dev. Cell 4, 625-637 (2003).
49. Lin, S. Y. et al. The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev. Cell 4, 639-650 (2003).
50. Hutvágner, G., Simard, M. J., Mello, C. C. & Zamore, P. D. Sequence-specific inhibition of small RNA function. PLoS Biol. 2, E98 (2004).
51. Meister, G., Landthaler, M., Dorsett, Y. & Tuschl, T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 10, 544-550 (2004).