Metabolic adaptations to chronic glucose infusion in rats

Diabetologia

Volumn 47, Issue 9, 2004, Pages 1602-1610

  Topp, B G ^a   McArthur, M D ^a   Finegood, D T ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Beta cell function; Beta cell mass; Diabetes mellitus; Glucose infusion; Insulin sensitivity; Islets of Langerhans; Mathematical modelling

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; SODIUM CHLORIDE;

ACINAR CELL; ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL HYPERPLASIA; CELL SIZE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; HISTOLOGY; INNER CELL MASS; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; MATHEMATICAL MODEL; METABOLISM; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROVOCATION TEST; RAT;

ACCLIMATIZATION; ANIMALS; BODY WEIGHT; CATHETERS, INDWELLING; GLUCOSE; INFUSIONS, INTRAVENOUS; ISLETS OF LANGERHANS; JUGULAR VEINS; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 5644251769     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1493-5     Document Type: Article

References (40)

1. Leahy JL, Cooper HE, Deal DA, Weir GC (1986) Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77:908-915
2. Hager SR, Jochen AL, Kalkhoff RK (1991) Insulin resistance in normal rats infused with glucose for 72 h. Am J Physiol Endocrinol Metab 260:E353-E362
3. Laybutt DR, Chisholm DJ, Kraegen EW (1997) Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am J Physiol Endocrinol Metab 273:E1-E9
4. Takao F, Laury MC, Ktorza A, Picon L, Penicaud L (1990) Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles. Biochem J 15:255-257
5. Bedoya F, Jeanrenaud B (1991) Evolution of insulin secretory response to glucose by perifused islets from lean (Fa/Fa) rats chronically infused with glucose. Diabetes 40:7-14
6. Bernard C, Thibault C, Berthault MF et al. (1998) Pancreatic β-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement. Diabetes 47:1058-1065
7. Kuboi M, Egawa M, Udaka N, Ito T, Inoue S, Sekihara H (1998) Effects of a 7-day infusion of glucose on insulin secretion in vivo and in vitro ventromedial hypothalamic-lesioned obese rats. Acta Diabetol 35:26-33
8. Leahy JL, Cooper HE, Weir GC (1987) Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo infusions. Diabetes 36:459-464
9. Sako Y, Grill VE (1990) Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes 39:1580-1583
10. Bernard C, Berthault MF, Saulnier C, Ktorza A (1999) Neogenesis vs. apoptosis as main components of pancreatic β-cell mass changes in glucose-infused normal and mildly diabetic adult rats. FASEB J 13:1195-1205
11. Bonner-Weir S, Deery D, Leahy JL, Weir GC (1989) Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 38:49-53
12. Matthews DR, Hosker JP, Rudenski AS et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
13. Katz A, Nambi SS, Mather K et al. (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410
14. Finegood DT, Scaglia L, Bonner-Weir S (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249-256
15. Topp BG, Promislow K, de Vries G, Miura RM, Finegood DT (2000) A model of β-cell insulin, and glucose kinetics: pathways to diabetes. J Theor Biol 206:605-619
16. Pick A, Clark J, Kubstrup C et al. (1998) Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364
17. Finegood DT, Topp BG (2001) 7beta;-cell deterioration-prospects for reversal or prevention. Diabetes Obes Metab 3 [Suppl 1]:S20-S27
18. Kloppel G, Lohr M, Habich K, Oberholzer M, Heitz PU (1985) Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110-125
19. Leahy JL (1990) Natural history of β-cell dysfunction in NIDDM. Diabetes Care 13:992-1010
20. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S (2002) Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45:85-96
21. Bergman RN, Finegood DT, Ader M (1985) Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-58
22. Cerasi E (1995) Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible? Diabetologia 38:992-997
23. Poitout V, Robertson RP (2002) Secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinol 143:339-342
24. Rossetti L (1995) Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus. Clin Invest Med 18:255-260
25. Unger RH, Grundy S (1985) Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28:119-121
26. Unger RH (2002) Lipotoxicity diseases. Annu Rev Med 53:319-336
27. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A (2001) Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 50 [Suppl 1]:S154-S159
28. Efanova IB, Zaitsev SV, Zhivotovsky B et al. (1998) Glucose and tolbutamide induce apoptosis in pancreatic β-cells. J Biol Chem 273:33501-33507
29. Hugl SR, White MF, Rhodes CJ (1998) Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. J Biol Chem 273:17771-17779
30. Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D (1996) Glucose promotes survival of rat pancreatic β-cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574
31. Liu YQ, Montanya E, Leahy JL (2001) Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60% pancreatectomy rats. Diabetologia 44:1026-1033
32. Swenne I (1982) The role of glucose in the in-vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic β-cells. Diabetes 31:754-760
33. Lipsett M, Finegood DT (2002) β-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51:1834-1841
34. Unger RH, Grundy S (1985) Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28:119-121
35. Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E (2003) Phosphoinositide 3-kinase-mediated reduction of IRS-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J Biol Chem 18:15641-15651
36. Steil GM, Trivedi N, Jonas JC et al (2001) Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab 280:E788-E796
37. Laury MC, Takao F, Bailbe D et al (1991) Differential effects of prolonged hyperglycemia on in vivo and in vitro insulin secretion in rats. Endocrinology 128:2526-2533
38. Maedler K, Sergeev P, Ris F et al. (2002) Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860
39. O'Brien BA, Fieldus WE, Field CJ, Finegood DT (2002) Clearance of apoptotic beta-cells is reduced in neonatal autoimmune diabetes-prone rats. Cell Death Differ 9:457-464
40. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720