Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes

Journal of Biological Chemistry

Volumn 274, Issue 20, 1999, Pages 14112-14121

  Jonas, Jean Christophe ^a   Sharma, Arun ^a   Hasenkamp, Wendy ^a   Ilkova, Hasan ^a,b   Patanè, Giovanni ^a,c   Laybutt, Ross ^a   Bonner Weir, Susan ^a   Weir, Gordon C ^a  

^a JOSLIN DIABETES CENTER   (United States)

^b ISTANBUL UNIVERSITY   (Turkey)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AMYLIN; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER; HEXOKINASE; INSULIN; ISOENZYME; LACTATE DEHYDROGENASE; MYC PROTEIN; PHLORIZIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; CELL DIFFERENTIATION; CELL SIZE; CONTROLLED STUDY; EXPERIMENTAL DIABETES MELLITUS; FATTY ACID BLOOD LEVEL; GENE REPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CELL DIFFERENTIATION; CHRONIC DISEASE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DNA PRIMERS; FATTY ACIDS, NONESTERIFIED; HUMANS; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; MALE; PANCREATIC HORMONES; PHLORHIZIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0033553462     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.20.14112     Document Type: Article

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