Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

Diabetologia

Volumn 51, Issue 4, 2008, Pages 623-631

  Liu, Z ^a   Tanabe, K ^a   Bernal Mizrachi, E ^a   Permutt, M A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glycogen synthase kinase 3; Islet beta cells; Islet mass; Pancreas; PDX 1; Proliferation

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; ENZYME ACTIVATION; ENZYME REGULATION; HISTOPATHOLOGY; IMPAIRED GLUCOSE TOLERANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL DIVISION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KINETICS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS);

EID: 41149154404     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0914-7     Document Type: Article

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