Systemic and acute administration of parathyroid hormone-related peptide(1-36) stimulates endogenous beta cell proliferation while preserving function in adult mice

Diabetologia

Volumn 54, Issue 11, 2011, Pages 2867-2877

  Williams, K ^a   Abanquah, D ^a   Joshi Gokhale, S ^a   Otero, A ^a   Lin, H ^a   Guthalu, N K ^a   Zhang, X ^a   Mozar, A ^a   Bisello, A ^a   Stewart, A F ^a   Garcia Ocana A ^a   Vasavada, R C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Amino terminal parathyroid hormone related protein; Beta cell proliferation; Cyclin D2; In vivo; p16 INK4a

Indexed keywords

AMINO TERMINAL PARATHYROID HORMONE RELATED PROTEIN[1-36]; CALCIUM; CYCLIN D2; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN[1-139]; UNCLASSIFIED DRUG;

ACUTE DRUG ADMINISTRATION; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL MASS; CELL PROLIFERATION; CELL SIZE; CELLULAR PARAMETERS; CONTROLLED STUDY; DRUG DOSE COMPARISON; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN D2; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; RNA, MESSENGER; SECRETORY PATHWAY;

EID: 80054708176     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2260-z     Document Type: Article

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