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Volumn 429, Issue 6987, 2004, Pages 41-46

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL CULTURE; GENETIC ENGINEERING; PLANTS (BOTANY); SKIN; TISSUE;

EID: 2342510386     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02520     Document Type: Article
Times cited : (1984)

References (38)
  • 3
    • 0023194486 scopus 로고
    • Demonstration of expanding cell populations in mouse pancreatic acini and islets
    • Tsubouchi, S., Kano, E. & Suzuki, H. Demonstration of expanding cell populations in mouse pancreatic acini and islets. Anat. Rec. 218, 111-115 (1987).
    • (1987) Anat. Rec. , vol.218 , pp. 111-115
    • Tsubouchi, S.1    Kano, E.2    Suzuki, H.3
  • 4
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir, S. & Sharma, A. Pancreatic stem cells. J. Pathol. 197, 519-526 (2002).
    • (2002) J. Pathol. , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 5
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir, S., Baxter, L. A., Schuppin, G. T. & Smith, F. E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42, 1715-1720 (1993).
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 7
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski, H. et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521-533 (2001).
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1
  • 8
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus, A., Holz, G. G., Theise, N. D. & Hussain, M. A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111, 843-850 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 9
    • 0036266272 scopus 로고    scopus 로고
    • Beta-cell neogenesis during prolonged hyperglycemia in rats
    • Lipsett, M. & Finegood, D. T. Beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51, 1834-1841 (2002).
    • (2002) Diabetes , vol.51 , pp. 1834-1841
    • Lipsett, M.1    Finegood, D.T.2
  • 10
    • 0034748027 scopus 로고    scopus 로고
    • Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes
    • Guz, Y., Nasir, I. & Teitelman, G. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142, 4956-4968 (2001).
    • (2001) Endocrinology , vol.142 , pp. 4956-4968
    • Guz, Y.1    Nasir, I.2    Teitelman, G.3
  • 11
    • 0242582180 scopus 로고    scopus 로고
    • Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    • Kodama, S., Kuhtreiber, W., Fujimura, S., Dale, E. A. & Faustman, D. L. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302, 1223-1227 (2003).
    • (2003) Science , vol.302 , pp. 1223-1227
    • Kodama, S.1    Kuhtreiber, W.2    Fujimura, S.3    Dale, E.A.4    Faustman, D.L.5
  • 12
    • 0033770540 scopus 로고    scopus 로고
    • Life and death of the pancreatic beta cells
    • Bonner-Weir, S. Life and death of the pancreatic beta cells. Trends Endocrinol. Metab. 11, 375-378 (2000).
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 375-378
    • Bonner-Weir, S.1
  • 13
    • 0028987251 scopus 로고
    • Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
    • Finegood, D. T., Scaglia, L. & Bonner-Weir, S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249-256 (1995).
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 14
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack, J. M. Developmental biology of the pancreas. Development 121, 1569-1580 (1995).
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 15
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan, D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-122 (1985).
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 16
    • 0032481124 scopus 로고    scopus 로고
    • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    • Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K. & McMahon, A. P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323-1326 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 1323-1326
    • Danielian, P.S.1    Muccino, D.2    Rowitch, D.H.3    Michael, S.K.4    McMahon, A.P.5
  • 17
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu, G., Dubauskaite, J. & Melton, D. A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457 (2002).
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 18
    • 0033561410 scopus 로고    scopus 로고
    • Z/AP, a double reporter for cre-mediated recombination
    • Lobe, C. G. et al. Z/AP, a double reporter for cre-mediated recombination. Dev. Biol. 208, 281-292 (1999).
    • (1999) Dev. Biol. , vol.208 , pp. 281-292
    • Lobe, C.G.1
  • 19
    • 0028793314 scopus 로고
    • Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
    • Wang, R. N., Kloppel, G. & Bouwens, L. Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38, 1405-1411 (1995).
    • (1995) Diabetologia , vol.38 , pp. 1405-1411
    • Wang, R.N.1    Kloppel, G.2    Bouwens, L.3
  • 20
    • 0033668752 scopus 로고    scopus 로고
    • Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion
    • Yamamoto, K. et al. Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. Diabetes 49, 2021-2027 (2000).
    • (2000) Diabetes , vol.49 , pp. 2021-2027
    • Yamamoto, K.1
  • 21
    • 0030747894 scopus 로고    scopus 로고
    • Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
    • Waguri, M. et al. Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 46, 1281-1290 (1997).
    • (1997) Diabetes , vol.46 , pp. 1281-1290
    • Waguri, M.1
  • 22
    • 0038522555 scopus 로고    scopus 로고
    • Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats
    • Paris, M., Bernard-Kargar, C., Berthault, M. F., Bouwens, L. & Ktorza, A. Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats. Endocrinology 144, 2717-2727 (2003).
    • (2003) Endocrinology , vol.144 , pp. 2717-2727
    • Paris, M.1    Bernard-Kargar, C.2    Berthault, M.F.3    Bouwens, L.4    Ktorza, A.5
  • 23
    • 0036310118 scopus 로고    scopus 로고
    • Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
    • Rooman, I., Lardon, J. & Bouwens, L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 51, 686-690 (2002).
    • (2002) Diabetes , vol.51 , pp. 686-690
    • Rooman, I.1    Lardon, J.2    Bouwens, L.3
  • 24
    • 0036920156 scopus 로고    scopus 로고
    • Liver regeneration with reference to stem cells
    • Alison, M. R. Liver regeneration with reference to stem cells. Semin. Cell Dev. Biol. 13, 385-387 (2002).
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 385-387
    • Alison, M.R.1
  • 25
    • 0036930173 scopus 로고    scopus 로고
    • Hepatic oval 'stem' cell in liver regeneration
    • Oh, S. H., Hatch, H. M. & Petersen, B. E. Hepatic oval 'stem' cell in liver regeneration. Semin. Cell Dev. Biol. 13, 405-409 (2002).
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 405-409
    • Oh, S.H.1    Hatch, H.M.2    Petersen, B.E.3
  • 26
    • 0034887929 scopus 로고    scopus 로고
    • Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60% pancreatectomy rats
    • Liu, Y. Q., Montanya, E. & Leahy, J. L. Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60% pancreatectomy rats. Diabetologia 44, 1026-1033 (2001).
    • (2001) Diabetologia , vol.44 , pp. 1026-1033
    • Liu, Y.Q.1    Montanya, E.2    Leahy, J.L.3
  • 27
    • 0026684894 scopus 로고
    • Mitotic activity and DNA synthesis of rat islet cells following partial pancreatectomy
    • Fong, I., Hulinsky, I., Fortuna, R. & Silink, M. Mitotic activity and DNA synthesis of rat islet cells following partial pancreatectomy. Pancreas 7, 453-459 (1992).
    • (1992) Pancreas , vol.7 , pp. 453-459
    • Fong, I.1    Hulinsky, I.2    Fortuna, R.3    Silink, M.4
  • 28
    • 0033045376 scopus 로고    scopus 로고
    • Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
    • Finegood, D. T., Weir, G. C. & Bonner-Weir, S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am. J. Physiol. 276, E822-E827 (1999).
    • (1999) Am. J. Physiol. , vol.276
    • Finegood, D.T.1    Weir, G.C.2    Bonner-Weir, S.3
  • 29
    • 0032798195 scopus 로고    scopus 로고
    • Effect of partial pancreatectomy on diabetic status in BALB/c mice
    • Hardikar, A. A., Karandikar, M. S. & Bhonde, R. R. Effect of partial pancreatectomy on diabetic status in BALB/c mice. J. Endocrinol. 162, 189-195 (1999).
    • (1999) J. Endocrinol. , vol.162 , pp. 189-195
    • Hardikar, A.A.1    Karandikar, M.S.2    Bhonde, R.R.3
  • 30
    • 0037213389 scopus 로고    scopus 로고
    • The role of hepatocytes and oval cells in liver regeneration and repopulation
    • Fausto, N. & Campbell, J. S. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev. 120, 117-130 (2003).
    • (2003) Mech. Dev. , vol.120 , pp. 117-130
    • Fausto, N.1    Campbell, J.S.2
  • 31
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet, P. Angiogenesis in health and disease. Nature Med. 9, 653-660 (2003).
    • (2003) Nature Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 32
    • 0013931415 scopus 로고
    • Postnatal neogenesis of islets of Langerhans in the mouse
    • Bunnag, S. C. Postnatal neogenesis of islets of Langerhans in the mouse. Diabetes 15, 480-491 (1966).
    • (1966) Diabetes , vol.15 , pp. 480-491
    • Bunnag, S.C.1
  • 33
    • 0036246856 scopus 로고    scopus 로고
    • Pdx1 restores beta cell function in Irs2 knockout mice
    • Kushner, J. A. et al. Pdx1 restores beta cell function in Irs2 knockout mice. J. Clin. Invest. 109, 1193-1201 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1193-1201
    • Kushner, J.A.1
  • 34
    • 0035434116 scopus 로고    scopus 로고
    • Linear correlation between the total islet mass and the volume-weighted mean islet volume
    • Skau, M., Pakkenberg, B., Buschard, K. & Bock, T. Linear correlation between the total islet mass and the volume-weighted mean islet volume. Diabetes 50, 1763-1770 (2001).
    • (2001) Diabetes , vol.50 , pp. 1763-1770
    • Skau, M.1    Pakkenberg, B.2    Buschard, K.3    Bock, T.4
  • 35
    • 0037677695 scopus 로고    scopus 로고
    • Increased islet volume but unchanged islet number in ob/ob mice
    • Bock, T., Pakkenberg, B. & Buschard, K. Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52, 1716-1722 (2003).
    • (2003) Diabetes , vol.52 , pp. 1716-1722
    • Bock, T.1    Pakkenberg, B.2    Buschard, K.3
  • 36
    • 0030873949 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 3β is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
    • Wu, K. L. et al. Hepatocyte nuclear factor 3β is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 17, 6002-6013 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6002-6013
    • Wu, K.L.1
  • 38
    • 0023007412 scopus 로고
    • Isolation of ducts from the pancreas of copper-deficient rats
    • Arkle, S., Lee, C. M., Cullen, M. J. & Argent, B. E. Isolation of ducts from the pancreas of copper-deficient rats. Q. J. Exp. Physiol. 71, 249-265 (1986).
    • (1986) Q. J. Exp. Physiol. , vol.71 , pp. 249-265
    • Arkle, S.1    Lee, C.M.2    Cullen, M.J.3    Argent, B.E.4


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