p27 regulates the transition of β-cells from quiescence to proliferation

Diabetes

Volumn 55, Issue 11, 2006, Pages 2950-2956

  Georgia, Senta ^a   Bhushan, Anil ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PROTEIN P27;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; EMBRYO DEVELOPMENT; GLUCOSE INTOLERANCE; INSULIN RELEASE; INSULIN SENSITIVITY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DNA PRIMERS; FASTING; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUCOSE INTOLERANCE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 33845513370     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0249     Document Type: Article

References (29)

1. Edlund H: Pancreatic organogenesis: developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532, 2002
2. Wilson ME, Scheel D, German MS: Gene expression cascades in pancreatic development. Mech Dev 120:65-80, 2003
3. Kim SK, MacDonald RJ: Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 12:540-547, 2002
4. Gu G, Dubauskaite J, Melton DA: Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457, 2002
5. Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P: Independent development of pancreatic α- and β-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49:163-176, 2000
6. Bonner-Weir S: Life and death of the pancreatic beta cells. Trends Endocrinol Metab 11:375-378, 2000
7. Finegood DT, Scaglia L, Bonner-Weir S: Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44:249-256, 1995
8. Svenstrup K, Skau M, Pakkenberg B, Buschard K, Bock T: Postnatal development of beta-cells in rats: proposed explanatory model. APMIS 110:372-378, 2002
9. Georgia S, Bhushan A: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass J Clin Invest 114:963-968, 2004
10. Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46, 2004
11. Sherr CJ: Mammalian G1 cyclins and cell cycle progression. Proc Assoc Am Physicians 107:181-186, 1995
12. Peeper DS, Upton TM, Ladha MH, Neuman E, Zalvide J, Bernards R, DeCaprio JA, Ewen ME: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386:177-181, 1997
13. Cheng M, Sexl V, Sherr CJ, Roussel MF: Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci U S A 95:1091-1096, 1998
14. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995
15. Taya Y: RB kinases and RB-binding proteins: new points of view. Trends Biochem Sci 22:14-17, 1997
16. Dyson N: The regulation of E2F by pRB-family proteins. Genes Dev 12:2245-2262, 1998
17. Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512, 1999
18. Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M: Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11:175-182, 2005
19. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, andfemale sterility in p27(Kip1)-deficient mice. Cell 85:733-744, 1996
20. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685, 1995
21. Hengst L, Gopfert U, Lashuel HA, Reed SI: Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). Genes Dev 12:3882-3888, 1998
22. Gradwohl G, Dierich A, LeMeur M, Guillemot F: Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97:1607-1611, 2000
23. Ahlgren U, Pfaff SL, Jessell TM, Edlund T, Edlund H: Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385:257-260, 1997
24. Thyssen S, Arany E, Hill DJ: Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 147:2346-2356, 2006
25. Georgia S, Bhushan A: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114:963-968, 2004
26. Karnik SK, Hughes CM, Gu X, Rozenblatt-Rosen O, McLean GW, Xiong Y, Meyerson M, Kim SK: Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 102:14659-14664, 2005
27. Meier JJ, Butler CP: Insulin secretion. In Endocrinology. DeGroot L, Jameson JL, Eds. Philadelphia, Elsevier Saunders, 2006, p. 961-973
28. Naaz A, Holsberger DR, Iwamoto GA, Nelson A, Kiyokawa H, Cooke PS: Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. FASEB J 18:1925-1927, 2004
29. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N: Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51:2951-2958, 2002