-
1
-
-
0033028297
-
Is glucagon-like peptide 1 an incretin hormone?
-
Nauck MA: Is glucagon-like peptide 1 an incretin hormone? Diabetologia 42:373-379, 1999
-
(1999)
Diabetologia
, vol.42
, pp. 373-379
-
-
Nauck, M.A.1
-
2
-
-
4344675057
-
Therapeutic strategies based on glucagon-like peptide 1
-
Deacon CF: Therapeutic strategies based on glucagon-like peptide 1. Diabetes 53:2181-2189, 2004
-
(2004)
Diabetes
, vol.53
, pp. 2181-2189
-
-
Deacon, C.F.1
-
3
-
-
0036869408
-
Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
-
Holst JJ: Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 18:430-441, 2002
-
(2002)
Diabetes Metab Res Rev
, vol.18
, pp. 430-441
-
-
Holst, J.J.1
-
4
-
-
0141446228
-
Enhancing incretin action for the treatment of type 2 diabetes
-
Drucker DJ: Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 26:2929-2940, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2929-2940
-
-
Drucker, D.J.1
-
5
-
-
0037066694
-
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1: Importance of chromatin structure in directing promoter binding
-
Chakrabarti SK, James JC, Mirmira RG: Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1: importance of chromatin structure in directing promoter binding. J Biol Chem 277:13286-13293, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 13286-13293
-
-
Chakrabarti, S.K.1
James, J.C.2
Mirmira, R.G.3
-
6
-
-
0242584873
-
Increased islet apoptosis in Pdx1+/- Mice
-
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS: Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 111:1147-1160, 2003
-
(2003)
J Clin Invest
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
7
-
-
0345257136
-
Glucagon-like peptide-1 and the islet beta-cell: Augmentation of cell proliferation and inhibition of apoptosis
-
Drucker DJ: Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 144:5145-5148, 2003
-
(2003)
Endocrinology
, vol.144
, pp. 5145-5148
-
-
Drucker, D.J.1
-
8
-
-
0028869514
-
Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
-
Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G: Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11-18, 1995
-
(1995)
Development
, vol.121
, pp. 11-18
-
-
Guz, Y.1
Montminy, M.R.2
Stein, R.3
Leonard, J.4
Gamer, L.W.5
Wright, C.V.6
Teitelman, G.7
-
9
-
-
0028149890
-
Insulin-promoter-factor 1 is required for pancreas development in mice
-
Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609, 1994
-
(1994)
Nature
, vol.371
, pp. 606-609
-
-
Jonsson, J.1
Carlsson, L.2
Edlund, T.3
Edlund, H.4
-
10
-
-
0029868156
-
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
-
Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV: PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995, 1996
-
(1996)
Development
, vol.122
, pp. 983-995
-
-
Offield, M.F.1
Jetton, T.L.2
Labosky, P.A.3
Ray, M.4
Stein, R.W.5
Magnuson, M.A.6
Hogan, B.L.7
Wright, C.V.8
-
11
-
-
0031031571
-
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence
-
Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence. Nat Genet 15:106-110, 1997
-
(1997)
Nat Genet
, vol.15
, pp. 106-110
-
-
Stoffers, D.A.1
Zinkin, N.T.2
Stanojevic, V.3
Clarke, W.L.4
Habener, J.F.5
-
12
-
-
0037192799
-
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
-
Brissova M, Shiota M, Nicholson WE, Gartnon M, Knobel SM, Piston DW, Wright CV, Powers AC: Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277:11225-11232, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 11225-11232
-
-
Brissova, M.1
Shiota, M.2
Nicholson, W.E.3
Gartnon, M.4
Knobel, S.M.5
Piston, D.W.6
Wright, C.V.7
Powers, A.C.8
-
13
-
-
0035816695
-
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation
-
Wang H, Maechler P, Ritz-Laser B, Hagenfeldt KA, Ishihara H, Philippe J, Wollheim CB: Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J Biol Chem 276:25279-25286, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 25279-25286
-
-
Wang, H.1
Maechler, P.2
Ritz-Laser, B.3
Hagenfeldt, K.A.4
Ishihara, H.5
Philippe, J.6
Wollheim, C.B.7
-
14
-
-
0036246856
-
Pdx1 restores beta cell function in Irs2 knockout mice
-
Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF: Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest 109:1193-1201, 2002
-
(2002)
J Clin Invest
, vol.109
, pp. 1193-1201
-
-
Kushner, J.A.1
Ye, J.2
Schubert, M.3
Burks, D.J.4
Dow, M.A.5
Flint, C.L.6
Dutta, S.7
Wright, C.V.8
Montminy, M.R.9
White, M.F.10
-
15
-
-
0032525981
-
β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
-
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H: β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12:1763-1768, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
16
-
-
0027384997
-
IPF1, a homeodomain-containing transactivator of the insulin gene
-
Ohlsson H, Karlsson K, Edlund T: IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259, 1993
-
(1993)
EMBO J
, vol.12
, pp. 4251-4259
-
-
Ohlsson, H.1
Karlsson, K.2
Edlund, T.3
-
17
-
-
0033305721
-
Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription
-
Hill ME, Asa SL, Drucker DJ: Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Mol Endocrinol 13:1474-1486, 1999
-
(1999)
Mol Endocrinol
, vol.13
, pp. 1474-1486
-
-
Hill, M.E.1
Asa, S.L.2
Drucker, D.J.3
-
18
-
-
0036795454
-
Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine
-
Flock G, Drucker DJ: Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine. Mol Endocrinol 16:2349-2359, 2002
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2349-2359
-
-
Flock, G.1
Drucker, D.J.2
-
19
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
-
Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ: Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
Ris, F.4
Halban, P.A.5
Drucker, D.J.6
-
20
-
-
0037312818
-
Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
-
Drucker DJ: Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17:161-171, 2003
-
(2003)
Mol Endocrinol
, vol.17
, pp. 161-171
-
-
Drucker, D.J.1
-
21
-
-
2542479899
-
Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system
-
Brubaker PL, Drucker DJ: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 145:2653-2659, 2004
-
(2004)
Endocrinology
, vol.145
, pp. 2653-2659
-
-
Brubaker, P.L.1
Drucker, D.J.2
-
22
-
-
0030873949
-
Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
-
Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R: Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol 17:6002-6013, 1997
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6002-6013
-
-
Wu, K.L.1
Gannon, M.2
Peshavaria, M.3
Offield, M.F.4
Henderson, E.5
Ray, M.6
Marks, A.7
Gamer, L.W.8
Wright, C.V.9
Stein, R.10
-
23
-
-
0036323652
-
Foxa2 controls Pdx1 gene expression in pancreatic β-cells in vivo
-
Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH: Foxa2 controls Pdx1 gene expression in pancreatic β-cells in vivo. Diabetes 51:2546-2551, 2002
-
(2002)
Diabetes
, vol.51
, pp. 2546-2551
-
-
Lee, C.S.1
Sund, N.J.2
Vatamaniuk, M.Z.3
Matschinsky, F.M.4
Stoffers, D.A.5
Kaestner, K.H.6
-
24
-
-
0036326210
-
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3beta transcription factors
-
Zhou J, Pineyro MA, Wang X, Doyle ME, Egan JM: Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J Cell Physiol 192:304-314, 2002
-
(2002)
J Cell Physiol
, vol.192
, pp. 304-314
-
-
Zhou, J.1
Pineyro, M.A.2
Wang, X.3
Doyle, M.E.4
Egan, J.M.5
-
25
-
-
0038339191
-
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
-
Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M: cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17:1575-1580, 2003
-
(2003)
Genes Dev
, vol.17
, pp. 1575-1580
-
-
Jhala, U.S.1
Canettieri, G.2
Screaton, R.A.3
Kulkarni, R.N.4
Krajewski, S.5
Reed, J.6
Walker, J.7
Lin, X.8
White, M.9
Montminy, M.10
-
26
-
-
0026034765
-
Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line
-
Fehmann HC, Habener JF: Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett 279:335-340, 1991
-
(1991)
FEBS Lett
, vol.279
, pp. 335-340
-
-
Fehmann, H.C.1
Habener, J.F.2
-
27
-
-
0026775150
-
Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1
-
Thorens B: Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641-8645, 1992
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8641-8645
-
-
Thorens, B.1
-
28
-
-
0030975613
-
Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing α-cells of the rat endocrine pancreas
-
Heller RS, Kieffer TJ, Habener JF: Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing α-cells of the rat endocrine pancreas. Diabetes 46:785-791, 1997
-
(1997)
Diabetes
, vol.46
, pp. 785-791
-
-
Heller, R.S.1
Kieffer, T.J.2
Habener, J.F.3
-
29
-
-
0037385959
-
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells
-
Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB: Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330-335, 2003
-
(2003)
Nat Cell Biol
, vol.5
, pp. 330-335
-
-
Ishihara, H.1
Maechler, P.2
Gjinovci, A.3
Herrera, P.L.4
Wollheim, C.B.5
-
30
-
-
0035046251
-
Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism
-
Wang X, Zhou J, Doyle ME, Egan JM: Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology 142:1820-1827, 2001
-
(2001)
Endocrinology
, vol.142
, pp. 1820-1827
-
-
Wang, X.1
Zhou, J.2
Doyle, M.E.3
Egan, J.M.4
-
31
-
-
0033305746
-
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells
-
Wang X, Cahill CM, Pineyro MA, Zhou J, Doyle ME, Egan JM: Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology 140:4904-4907, 1999
-
(1999)
Endocrinology
, vol.140
, pp. 4904-4907
-
-
Wang, X.1
Cahill, C.M.2
Pineyro, M.A.3
Zhou, J.4
Doyle, M.E.5
Egan, J.M.6
-
32
-
-
0035970104
-
PDX PBX complexes are required for normal proliferation of pancreatic cells during development
-
Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M: PDX PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A 98:1065-1070, 2001
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1065-1070
-
-
Dutta, S.1
Gannon, M.2
Peers, B.3
Wright, C.4
Bonner-Weir, S.5
Montminy, M.6
-
33
-
-
0031898957
-
Mouse pancreatic beta cells exhibit preserved glucose competence after disruption of the glucagon-like peptide 1 receptor gene
-
Flamez D, Van Breuseghem A, Scrocchi LA, Quartier E, Pipeleers D, Drucker DJ, Schuit F: Mouse pancreatic beta cells exhibit preserved glucose competence after disruption of the glucagon-like peptide 1 receptor gene. Diabetes 47:646-652, 1998
-
(1998)
Diabetes
, vol.47
, pp. 646-652
-
-
Flamez, D.1
Van Breuseghem, A.2
Scrocchi, L.A.3
Quartier, E.4
Pipeleers, D.5
Drucker, D.J.6
Schuit, F.7
-
34
-
-
0035069103
-
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
-
Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC: Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Arch 438:382-387, 2001
-
(2001)
Virchows Arch
, vol.438
, pp. 382-387
-
-
Ling, Z.1
Wu, D.2
Zambre, Y.3
Flamez, D.4
Drucker, D.J.5
Pipeleers, D.G.6
Schuit, F.C.7
-
35
-
-
1842855402
-
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic (INS-1) beta-cells
-
Wang Q, Li L, Xu E, Wong V, Rhodes CJ, Brubaker PL: Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic (INS-1) beta-cells. Diabetologia 47:478-487, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 478-487
-
-
Wang, Q.1
Li, L.2
Xu, E.3
Wong, V.4
Rhodes, C.J.5
Brubaker, P.L.6
-
36
-
-
0037020148
-
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
-
Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA: Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem 277:37176-37183, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 37176-37183
-
-
Shiota, C.1
Larsson, O.2
Shelton, K.D.3
Shiota, M.4
Efanov, A.M.5
Hoy, M.6
Lindner, J.7
Kooptiwut, S.8
Juntti-Berggren, L.9
Gromada, J.10
Berggren, P.O.11
Magnuson, M.A.12
-
37
-
-
3843101644
-
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
-
Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB: Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279:31121-31130, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 31121-31130
-
-
Gauthier, B.R.1
Brun, T.2
Sarret, E.J.3
Ishihara, H.4
Schaad, O.5
Descombes, P.6
Wollheim, C.B.7
-
38
-
-
0037440025
-
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells
-
Tsuboi T, da Silva Xavier G, Holz GG, Jouaville LS, Thomas AP, Rutter GA: Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J 369:287-299, 2003
-
(2003)
Biochem J
, vol.369
, pp. 287-299
-
-
Tsuboi, T.1
Da Silva Xavier, G.2
Holz, G.G.3
Jouaville, L.S.4
Thomas, A.P.5
Rutter, G.A.6
-
39
-
-
0347990624
-
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell
-
Holz GG: Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell. Diabetes 53:5-13, 2004
-
(2004)
Diabetes
, vol.53
, pp. 5-13
-
-
Holz, G.G.1
|